Cardiac Mechano Electric Coupling And Arrhythmias
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Cardiac Mechano Electric Coupling And Arrhythmias
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Author : Peter Kohl
language : en
Publisher: OUP Oxford
Release Date : 2011-08-25
Cardiac Mechano Electric Coupling And Arrhythmias written by Peter Kohl and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-25 with Medical categories.
Cardiac Mechano-Electric Coupling and Arrhythmias offers a thoroughly reviewed compendium written by leading experts in the field on the mechanism and consequences of cardiac mechano-electrical coupling. Its coverage ranges from stretch-activated ion channels to mechanically induced arrhythmias and mechanical interventions for heart rhythm correction. Information is grouped into logical sections, from molecular mechanisms, to cell, tissue and whole organ responses, right through to patient-based observations and insight emerging from clinical trials. The information provided carefully highlights both consensus insight and current shortcomings in our understanding of cardiac mechano-electric coupling. The book has been thoroughly revised and expanded since publication of the first edition in 2005, extensively updated to reflect recent developments in the field, and now offers a more balanced view of mechano-electrical interactions in the heart and develops a more clinical focus. Written with the practising cardiologist and junior doctor in mind, it offers interesting new insight for the established physician with an interest in cardiac arrhythmogenesis and heart rhythm management.
Cardiac Mechano Electric Coupling And Arrhythmias
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Author : Peter Kohl (MD.)
language : en
Publisher:
Release Date : 2011
Cardiac Mechano Electric Coupling And Arrhythmias written by Peter Kohl (MD.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Arrhythmia categories.
Ranging from stretch-activated ion channels to mechanically induced arrhythmias and mechanical interventions for heart rhythm correction, this new edition offers a thoroughly reviewed compendium of chapters, written by the top-experts in the world on the mechanism and consequences of cardiac mechano-electrical coupling.
Cardiac Mechano Electric Feedback And Arrhythmias
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Author : Peter Kohl
language : en
Publisher: Saunders
Release Date : 2005
Cardiac Mechano Electric Feedback And Arrhythmias written by Peter Kohl and has been published by Saunders this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Medical categories.
Kohl (Cardio Mechano-Electric Feedback Lab, Oxford University) documents the role of mechano-electric feedback (MEF) in electrical and mechanical pathological remodeling of cardiac function. Sections cover sub-cellular mechanisms of cardiac MEF, effects of MEF on cardiac cellular electrophysiology, experimental manifestations of MEF in the heart, cardiac MEF in normal physiology, cardiac MEF as a pathogenic mechanism, MEF as a mechanism involved in therapeutic interventions, and the outlook for the future. B&w and color photos and medical images are included. Annotation: 2005 Book News, Inc., Portland, OR (booknews.com).
Mechano Electric Feedback And Cardiac Arrhythmias
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Author : Peter Kohl
language : en
Publisher:
Release Date : 2003
Mechano Electric Feedback And Cardiac Arrhythmias written by Peter Kohl and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Arrhythmia categories.
Remodeling Of Cardiac Passive Electrical Properties And Susceptibility To Ventricular And Atrial Arrhythmias
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Author : George E. Billman
language : en
Publisher: Frontiers Media SA
Release Date : 2015-09-25
Remodeling Of Cardiac Passive Electrical Properties And Susceptibility To Ventricular And Atrial Arrhythmias written by George E. Billman and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-25 with Physiology categories.
The effective management of cardiac arrhythmias, either of atrial or of ventricular origin, remains a major challenge. Sudden cardiac death due to ventricular tachyarrhythmias remains the leading cause of death in industrialized countries while atrial fibrillation is the most common rhythm disorder; an arrhythmia that’s prevalence is increasing and accounts for nearly one quarter of ischemic stokes the elderly population. Yet, despite the enormity of the problem, effective therapeutic interventions remain elusive. In fact, several initially promising antiarrhythmic agents were found to increase rather than decrease mortality in patients recovering from myocardial infarction. The question then is what went wrong, why have these interventions proven to be so ineffective? An obvious answer is the drugs were designed to attack the wrong therapeutic target. Clearly, targeting single ion channels (using either isolated ion channels or single myocytes preparations) has proven to be less than effective. What then is the appropriate target? It is well established that cardiac electrical properties can vary substantially between single cells and intact preparations. One obvious example is the observation that action potential duration is much longer in isolated cells as compared to multi-cellular preparations or intact hearts. Due to the low electrical resistance between adjacent myocytes, the cells act in coordinated fashion producing “electrotonic interdependence” between neighboring cells. Myocardial infarction and/or acute ischemia provoke profound changes in the passive electrical properties of cardiac muscle. In particular, electrotonic uncoupling of the myocytes disrupts the coordinated activation and repolarization of cardiac tissue. The resulting compensatory changes in ionic currents decrease cardiac electrical stability increasing the risk for life-threatening changes in the cardiac rhythm. Thus, the electrical properties of myocardial cells must be considered as a unit rather than in isolation. It is the purpose of this Research Topic to evaluate the largely neglected relationship between changes in passive electrical properties of cardiac muscle and arrhythmia formation.
Mechano Electric Feedback And Cardiac Arrhythmias
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Author :
language : en
Publisher:
Release Date : 2003
Mechano Electric Feedback And Cardiac Arrhythmias written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
Cardiac Rate And Rhythm
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Author : L.N. Bouman
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cardiac Rate And Rhythm written by L.N. Bouman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
In the denervated state the mammalian heart, both in vivo and in vitro, is excited at very regular intervals, the coefficient of variance of the interbeat intervals not exceeding 2%. The pacemaker that is the source of this regular ex citation is localised normally within the sinus node (" sino-atrial node " node of Keith and Flack), a most intriguing small piece of tissue in the caval corner of the right atrium. A small portion of this node containing a group of probably only a few thousands of cells fires spontaneously, that means without any exter nal influence to trigger their activity. The so called pacemaker cells do this by letting their membrane potential fall to the level where an action potential will start which subsequently activates surrounding cells to fire an action po tential. The first question which is tackled in this book is which processes underly this spontaneous diastolic depolarization. This is discussed in section I, concerning the fundamental properties of pacemaker cells with special refer ence to ionic membrane currents. Although views still quite differ about the exact nature of the membrane processes that cause the automatic pacemaker dis charge there is agreement that diastolic depolarization is brought about by the interaction of a number of ionic current systems, including both inward and out ward going currents.
Cardiac Mechanobiology In Physiology And Disease
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Author : Markus Hecker
language : en
Publisher: Springer Nature
Release Date : 2023-04-19
Cardiac Mechanobiology In Physiology And Disease written by Markus Hecker and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-19 with Science categories.
This book presents the latest findings in the field of cardiac mechanobiology in health and disease. Cardiac mechanobiology provides knowledge of all aspects of mechanobiology of the heart. Cardiomyogenesis is discussed as well as the mechanobiology of cardiac remodeling and regeneration. The molecular mechanisms of mechanoperception and mechanotransduction in cardiomyocytes are explained, as well as stretch induced differentiation of cardiomyocytes derived from induced pluripotent stem cells. This volume of the series Cardiac and Vascular Biology complements the volume Vascular Mechanobiology in Physiology and Disease (volume 8) published in this series. The book is aimed at clinicians as well as researchers in cardiovascular biology, bioengineering and biophysics, and also represents an educational resource for young researchers and students in these fields.
Cardiac Electrophysiology From Cell To Bedside E Book
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Author : Douglas P. Zipes
language : en
Publisher: Elsevier Health Sciences
Release Date : 2013-10-11
Cardiac Electrophysiology From Cell To Bedside E Book written by Douglas P. Zipes and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-11 with Medical categories.
Cardiac Electrophysiology: From Cell to Bedside puts the latest knowledge in this subspecialty at your fingertips, giving you a well-rounded, expert grasp of every cardiac electrophysiology issue that affects your patient management. Drs. Zipes, Jalife, and a host of other world leaders in cardiac electrophysiology use a comprehensive, multidisciplinary approach to guide you through all of the most recent cardiac drugs, techniques, and technologies. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Get well-rounded, expert views of every cardiac electrophysiology issue that affects your patient management from preeminent authorities in cardiology, physiology, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgery, and biomedical engineering from around the world. Visually grasp and easily absorb complex concepts through an attractive full-color design featuring color photos, tables, flow charts, ECGs, and more! Integrate the latest scientific understanding of arrhythmias with the newest clinical applications, to select the right treatment and management options for each patient. Stay current on the latest advancements and developments with sweeping updates and 52 NEW chapters - written by many new authors - on some of the hottest cardiology topics, such as new technologies for the study of the molecular structure of ion channels, molecular genetics, and the development of new imaging, mapping and ablation techniques. Get expert advice from Dr. Douglas P. Zipes - a leading authority in electrophysiology and editor of Braunwald’s Heart Disease and the Heart Rhythm Journal - and Dr. Jose Jalife - a world-renowned leader and researcher in basic and translational cardiac electrophysiology. Access the full text online at Expert Consult, including supplemental text, figures, tables, and video clips.
Emerging Technologies For Heart Diseases
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Author : Udi Nussinovitch
language : en
Publisher: Academic Press
Release Date : 2020-08-19
Emerging Technologies For Heart Diseases written by Udi Nussinovitch and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-19 with Medical categories.
The increasing pace of advances in cardiology throughout the last few decades has fundamentally altered the natural course of heart patients. In the last few years, available therapies have been revolutionized completely by new transcatheter therapeutic approaches, novel ventricular assist devices, and new drugs. Also, molecular biology and genetics have a rapidly growing impact on cardiovascular diseases, enabling the field of regenerative medicine to become increasingly closer to routine clinical implementation. Emerging Technologies for Heart Diseases was conceived to cover the recent extensive literature on current and novel therapeutic options for cardiac patients. The first volume is dedicated to heart failure and valvular disorders, and the second covers myocardial ischemia and arrhythmias. The clinical topic is addressed in several chapters divided according to the therapeutic approach (mechanical or electrical device-based, or cell and gene-based). Each of the 46 chapters focuses on clinically available solutions, new therapies currently under evaluation in clinical trials, promising preclinical technologies, and emerging concepts and innovations that have not yet been tested in a preclinical model. Also, the book discusses future challenges and opportunities for clinical implementation. Lessons learned from abandoned experimental practices are also covered, giving the readers the widest possible perspective of current therapeutic dilemmas. Overall, this textbook was designed for physicians who want to stay up-to-date with current therapies and those of the future, for biomedical companies, and for those who wish to broaden their knowledge of new cardiovascular therapeutic options. Provides a comprehensive review of the latest therapeutic developments for heart failure, valvular disorders, myocardial ischemia and arrhythmias, and their clinical implications Written by both specialists in the field and established researchers, it delivers a review of emerging medical technologies and presents insight into their therapeutic promise Chapters are arranged according to disease pathogeneses and relevance and include coverage of the mechanical, electrophysiological, and biological approaches for the management of patients with myocardial ischemia and arrhythmias