Cardiovascular Calcification
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Cardiovascular Calcification And Bone Mineralization
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Author : Elena Aikawa
language : en
Publisher: Springer Nature
Release Date : 2020-07-01
Cardiovascular Calcification And Bone Mineralization written by Elena Aikawa and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-01 with Medical categories.
The book covers the basic science and clinical aspects of cardiovascular calcification and bone mineralization. Cardiovascular calcification is the leading predictor of cardiovascular morbidity and mortality, with a predictive value more significant than blood lipid levels. The presence of calcific mineral in cardiovascular tissues alters biomechanical performance, increasing workload on the heart and potentiating atherosclerotic plaque rupture and subsequent heart attack and stroke. This book examines the role of calcification in cardiovascular disease covering topics such as calcification in the atherosclerotic plaques and aortic valves arteries and valves, aortic valve replacement, peripheral artery disease, imaging of early calcification and target discovery. In addition, various forms of ectopic calcification as well as mechanisms of bone mineralization are discussed. Cardiovascular Calcification and Bone Mineralization is an essential resource for clinicians, researchers, and other medical professionals in cardiology, pathology, and biomedical engineering.
Cardiovascular Calcification
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Author : Michael Henein
language : en
Publisher: Springer Nature
Release Date : 2021-09-20
Cardiovascular Calcification written by Michael Henein and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-20 with Medical categories.
The book systematically describes the clinical and scientific aspects of cardiovascular calcification. Chapters detail the mechanisms associated with arterial and valve calcification, relevant risk factors, pathophysiology and the latest therapeutic techniques. Recent diagnostic technological developments including how computed tomography (CT) scanning can be utilized along with Agatston score to quantify coronary arterial calcification when investigating whether a patient for sub-clinical atherosclerosis are covered. The correlation with the presence of arterial calcification and extent of coronary stenosis is also explored. Cardiovasular Calcification details relevant aspects of the basic science and reviews the latest pathological and therapeutic techniques used in treating patients with cardiovascular calcification. It is therefore an essential resource for practicing cardiologists, cardiac surgeons, vascular specialists and radiologists.
Osteocardiology
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Author : Nalini M. Rajamannan
language : en
Publisher: Springer
Release Date : 2017-10-24
Osteocardiology written by Nalini M. Rajamannan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-24 with Medical categories.
This book describes the field of osteocardiology, an exciting and new sub-discipline within cardiovascular science, which will become the cornerstone for defining the timing and treatment of cardiovascular calcification in the future. With the advent of large cohort databases and experimental mechanistic studies, research has elucidated evidence confirming that traditional cardiovascular risk factors are responsible for the development of atherosclerotic calcification and identified the critical elements of atherosclerosis, including foam cell formation, vascular smooth muscle cell proliferation and extracellular matrix synthesis, which over time forms bone in the heart. Osteocardiology: Cardiac Bone Formation is a practical overview of bone formation in the heart and is destined to become the cornerstone for education of medical students, residents, fellows, graduate students, physician scientists and scientists, for future research and ongoing development in medical therapies to slow or halt the progression of bone formation in the heart.
Coronary Calcium
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Author : Aloke Virmani Finn
language : en
Publisher: Academic Press
Release Date : 2019-08-20
Coronary Calcium written by Aloke Virmani Finn and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-20 with Science categories.
Coronary Calcium: A Comprehensive Understanding of Its Biology, Use in Screening, and Interventional Management provides a comprehensive update on the current understanding of the significance of coronary artery calcification, showing the connection to the development of advanced atherosclerosis that will lead to better risk evaluations. Coverage includes information on the basic science behind the development of coronary calcium in atherosclerotic lesions, the pathology of calcified coronary lesions in humans, its differential development by race, and its relationship to plaque progression. Computed tomography is also covered to show the significance of coronary calcium for risk prediction and the potential role of various pharmacologic interventions. Each chapter contains summaries with salient and important points, making this book perfect for researchers and physicians interested in the field of vascular calcification. Provides an easy-to-read update on the current understanding of coronary calcium from a pathologic perspective Offers cutting-edge knowledge on the future of coronary calcium screening and authoritative opinions from experts Delivers relevant information for the evaluation of patients who may have coronary artery disease using coronary calcium as evaluated by CT in risk stratification and treatment
Understanding The Molecular Mechanisms Of Cardiovascular Calcification
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Author : Ophélie Gourgas
language : en
Publisher:
Release Date : 2019
Understanding The Molecular Mechanisms Of Cardiovascular Calcification written by Ophélie Gourgas and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
"Deposition of calcium phosphate (Ca-P) minerals in cardiovascular tissues, also known as cardiovascular calcification, is a major health disorder with increasing prevalence and high morbidity and mortality facing the elderly and patients with life-threatening diseases. Currently, there are no approved therapeutic options available for this pathologic condition, except invasive surgeries and costly transcatheter procedures to which not all the patients are suited. The main reason behind this lack of effective therapies is that the molecular mechanisms underlying both vascular and valvular calcifications are unknown. Specifically, the physicochemical details of mineral formation and transformation in this process are still elusive. In our first study, we analyzed mineral formation and evolution in an animal model that faithfully recapitulates medial calcification in humans, to understand how this type of calcification is initiated on the vascular extracellular matrix. Using a combination of material science techniques, we studied how minerals form and transform over time and space in this in vivo system. Calcium was adsorbed first on the elastin (ELN)-rich elastic laminae, and then precursor phases formed which then transformed into more crystalline apatite phases. These events were repeated after each nucleation event, providing a snapshot of the overall mineral evolution at each time point analyzed. This work suggested the importance of analyzing mineral phases rather than just overall calcification extent, to diagnose and possibly prevent disease progression. In our next study, we developed an in vitro model involving ELN to study medial arterial calcification. We used crosslinked ELN-like polypeptide (ELP) membranes immersed in simulated body fluid (SBF) as models to study medial calcification. We showed that Ca-P minerals first deposited on fibers and filaments and then spread out to globular structures present in the membranes. Mineral phase evolution matched that previously observed in our mouse model of medial calcification, showing that this simple system captured some of the key in vivo findings. Overall, this work clarified the mechanism of mineral formation on ELN and provided an in vitro model that can be tuned to further understand the molecular mechanism involved and/or to design effective strategies to face this pathologic condition.Next, we studied the effect of increasing SBF ionic concentration on mineral formation and transformation on crosslinked ELP membranes in vitro. Our results showed that increasing SBF ionic concentration significantly enhanced the kinetics of mineral deposition, and strongly affected the chemistry and morphology of the minerals deposited on the ELP membranes and the overall mineralization process. While the use of low concentration SBF seems to be more appropriate to study medial calcification associated with the loss of calcification inhibitors, higher SBF ion concentration may be more relevant to study medial calcification in patients with life-threatening diseases, such as chronic kidney disease. Finally, we studied the physicochemical properties of mineral deposits found in human aortic valve calcification (AVC). We showed that minerals in AVC have different composition and morphology in men than in women. Calcifications in women were overall less crystalline and contained larger amounts of precursor phases. These phase differences were mirrored by differences in morphology. We identified compact material, calcified fibers, and spherical particles in women, while compact material was the only mineral morphology found in men. Overall, this work suggested that mineralization is slower in women than in men and follows a different pathway. These results paved the way for new, sex-specific methods to diagnose, prevent and treat this disease"--
Cardiovascular Imaging
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Author : Elena Aikawa
language : en
Publisher: Springer
Release Date : 2014-11-03
Cardiovascular Imaging written by Elena Aikawa and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-03 with Medical categories.
This book provides comprehensive reviews on our most recent understanding of the molecular and cellular mechanisms underlying atherosclerosis and calcific aortic valve disease (CAVD) as visualized in animal models and patients using optical molecular imaging, PET-CT, ultrasound and MRI. In addition to presenting up-to-date information on the multimodality imaging of specific pro-inflammatory or pro-calcification pathways in atherosclerosis and CAVD, the book addresses the intriguing issue of whether cardiovascular calcification is an inflammatory disease, as has been recently supported by several preclinical and clinical imaging studies. In order to familiarize researchers and clinicians from other specialties with the basic mechanisms involved, chapters on the fundamental pathobiology of atherosclerosis and CAVD are also included. The imaging chapters, written by some of the foremost investigators in the field, are so organized as to reveal the nature of the involved mechanisms as disease progresses.
Calcifications Of The Heart
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Author : Jerome H. Shapiro
language : en
Publisher:
Release Date : 1963
Calcifications Of The Heart written by Jerome H. Shapiro and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1963 with Calcium categories.
Genetic Studies Of Cardiovascular Calcification And Traits Related To Atherosclerosis
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Author : Veronica Villa Colinayo
language : en
Publisher:
Release Date : 2001
Genetic Studies Of Cardiovascular Calcification And Traits Related To Atherosclerosis written by Veronica Villa Colinayo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.
Coronary Artery Calcification And Cardiovascular Risk Prediction
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Author : Suzette Emere Smale
language : en
Publisher:
Release Date : 2011
Coronary Artery Calcification And Cardiovascular Risk Prediction written by Suzette Emere Smale and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Vascular Calcification And Cardiovascular Risk In Chronic Kidney Disease
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Author : Ana Paula Andrade da Silva
language : en
Publisher:
Release Date : 2018
Vascular Calcification And Cardiovascular Risk In Chronic Kidney Disease written by Ana Paula Andrade da Silva and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Electronic books categories.
Cardiovascular disease is the primary cause of morbidity and mortality in chronic kidney disease (CKD) population, particularly in end stage renal disease (ESRD). This could be explained in part due to the presence of traditional cardiovascular risk factors, such as older age, hypertension, dyslipidemia and diabetes, but is also associated with nontraditional cardiovascular risk factors related to CKD, like inflammation, anemia, abnormal calcium and phosphate metabolism and extracellular fluid volume overload, which may contribute to intimal or medial wall arterial calcification. Vascular calcification (VC) is a dynamic process, resulting from the dysregulation of the balance of molecules that promote and those that inhibit this course. It is important for clinicians to both acknowledge and recognize the pathways and risk factors of VC in order to improve cardiovascular health in CKD patients. This chapter will focus on the biology of VC, the association with CKD, risk factor modification, screening and prevention of VC and cardiovascular disease in CKD patients.