Cartas M Ximas Principais
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Jacques Ellul And The Technological Society In The 21st Century
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Author : Helena M. Jerónimo
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-07-08
Jacques Ellul And The Technological Society In The 21st Century written by Helena M. Jerónimo and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-08 with Philosophy categories.
This volume rethinks the work of Jacques Ellul (1912-1994) on the centenary of his birth, by presenting an overview of the current debates based on Ellul's insights. As one of the most significant twentieth-century thinkers about technology, Ellul was among the first thinkers to realize the importance of topics such as globalization, terrorism, communication technologies and ecology, and study them from a technological perspective. The book is divided into three sections. The first discusses Ellul’s diagnosis of modern society, and addresses the reception of his work on the technological society, the notion of efficiency, the process of symbolization/de-symbolization, and ecology. The second analyzes communicational and cultural problems, as well as threats and trends in early twenty-first century societies. Many of the issues Ellul saw as crucial – such as energy, propaganda, applied life sciences and communication – continue to be so. In fact they have grown exponentially, on a global scale, producing new forms of risk. Essays in the final section examine the duality of reason and revelation. They pursue an understanding of Ellul in terms of the depth of experience and the traditions of human knowledge, which is to say, on the one hand, the experience of the human being as contained in the rationalist, sociological and philosophical traditions. On the other hand there are the transcendent roots of human existence, as well as “revealed knowledge,” in the mystical and religious traditions. The meeting of these two traditions enables us to look at Ellul’s work as a whole, but above all it opens up a space for examining religious life in the technological society.
Jack Kirby S Omac
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Author : Jack Kirby
language : en
Publisher: Dc Comics
Release Date : 2013
Jack Kirby S Omac written by Jack Kirby and has been published by Dc Comics this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Comics & Graphic Novels categories.
In one of his last major works for DC, Kirby envisions a 1984-inspired dystopia starring corporate nobody Buddy Blank, who is changed by a satellite called Brother Eye into the super-powered O.M.A.C. (One Man Army Corps). Enlisted by the Global Peace Agency, who police the world using pacifistic means, O.M.A.C. battles the forces of conformity in this short-lived but legendary series! Witness the early tales of Jack Kirby's legendary creation O.M.A.C. in this new graphic novel collecting stories from O.M.A.C. #1-8 (1974-1975) plus artwork from WHO'S WHO!
A Life In Parts
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Author : Bryan Cranston
language : en
Publisher: Simon and Schuster
Release Date : 2016-10-11
A Life In Parts written by Bryan Cranston and has been published by Simon and Schuster this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-11 with Biography & Autobiography categories.
“Nothing short of riveting...an engrossing first-person account by one of our finest actors” (Huffington Post)—both a coming-of-age story and a meditation on creativity, devotion, and craft—Bryan Cranston, beloved and acclaimed star of one of history’s most successful TV shows, Breaking Bad. Bryan Cranston began his acting career at the age of seven, when his father, a struggling actor and sometime director, cast him in a commercial for United Way. By fifth grade he was starring in the school play, spending hours at the local movie theater, and re-enacting favorite scenes with his brother in their living room. Cranston seemed destined to be an actor. But then his father left. And his family fell apart. Troubled by his father’s missteps, Cranston abandoned his acting aspirations and resolved to pursue a steadier career in law enforcement. Then, on a two-year cross-country motorcycle journey, Cranston re-discovered his talent for acting and found his mission and his calling. In this “must-read memoir” (The Philadelphia Inquirer), Cranston traces the many roles he inhabited throughout his remarkable life, both on and off screen. For the first time he shares the story of his early years as an actor on the soap opera Loving, his recurring spots on Seinfeld, and his time as bumbling father Hal on Malcolm in the Middle, to his tour-de-force, Tony-winning performance as Lyndon Baines Johnson in Broadway’s All the Way, to his most iconic role of all: Breaking Bad’s Walter White. “An illuminating window into the actor’s psyche” (People), Cranston has much to say about creativity, devotion, and craft, as well as innate talent and its challenges and benefits and proper maintenance. “By turns gritty, funny, and sad” (Entertainment Weekly), ultimately A Life in Parts is a story about the joy, the necessity, and the transformative power of simple hard work.
Seis Cartas Ir Nico
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Author : Fèlix Amat de Palou i Pont
language : es
Publisher:
Release Date : 1817
Seis Cartas Ir Nico written by Fèlix Amat de Palou i Pont and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1817 with Església i Estat categories.
Prison Letters
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Author : Antonio Gramsci
language : en
Publisher: Pluto Press (UK)
Release Date : 1988
Prison Letters written by Antonio Gramsci and has been published by Pluto Press (UK) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Literary Collections categories.
'An extraordinary philosopher ... probably the most original communist thinker of twentieth-century Europe' Eric Hobsbawm'These letters are a noble and moving testament both to Mussolini's failure and to the courage and strength of will that drove Gramsci throughout his life' The Observer'Gramsci's letters ... demonstrate the originality of his brand of communist thought ... An extraordinary character, who does not deserve to be solely the property of academics and name-dropping cultural critics' The ScotsmanAntonio Gramsci is one of the great European Marxists, hailed by Eric Hobsbawm as 'an extraordinary philosopher ... probably the most original communist thinker of twentieth-century Europe'. His primary contribution has been in his insistence on an understanding of popular culture in the battle to create a revolutionary consciousness. It is this humanitarian aspect of his thinking that illuminates the vivid personal testimony of his prison letters, written between 1926 and 1937.
Carta Capital
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Author :
language : pt-BR
Publisher:
Release Date : 2001
Carta Capital written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Brazil categories.
Epistolario Espa Ol Cartas De Personajes Varios Cartas Del Cardenal Jimenez De Cisneros Cartas De E De Salazar Cartas De Algunos Padres De La Compa Ia De Jesus Cartas De F Cascales Cartas Del Conde Cabarr S Lamentos Politicos De Un Pobrecito Holgazan Del Doctor Don S Mi Ano Y Bedoya
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Author : Eugenio de Ochoa
language : es
Publisher:
Release Date : 1870
Epistolario Espa Ol Cartas De Personajes Varios Cartas Del Cardenal Jimenez De Cisneros Cartas De E De Salazar Cartas De Algunos Padres De La Compa Ia De Jesus Cartas De F Cascales Cartas Del Conde Cabarr S Lamentos Politicos De Un Pobrecito Holgazan Del Doctor Don S Mi Ano Y Bedoya written by Eugenio de Ochoa and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1870 with Spanish letters categories.
A Carta
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Author :
language : pt-BR
Publisher:
Release Date : 1977
A Carta written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with Brazil categories.
Preclinical Safety Evaluation Of Biopharmaceuticals
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Author : Joy A. Cavagnaro
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-07
Preclinical Safety Evaluation Of Biopharmaceuticals written by Joy A. Cavagnaro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.
"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.