Cavalo De Tr Ia 8 Jord O

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Translational Medicine

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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26

Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.

Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

Dentists

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Author : Mary Meinking
language : en
Publisher: Raintree
Release Date : 2021-08-05

Dentists written by Mary Meinking and has been published by Raintree this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-05 with categories.

Open wide! Dentists care for people's teeth. Give readers the inside scoop on what it's like to be a dentist. Readers will learn what dentists do, the tools they use, and how people get this exciting job.

Preclinical Safety Evaluation Of Biopharmaceuticals

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Author : Joy A. Cavagnaro
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-07

Preclinical Safety Evaluation Of Biopharmaceuticals written by Joy A. Cavagnaro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.

"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.

Andrea Mantegna And The Italian Renaissance

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Author : Joseph Manca
language : en
Publisher: Parkstone International
Release Date : 2023-12-28

Andrea Mantegna And The Italian Renaissance written by Joseph Manca and has been published by Parkstone International this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-28 with Art categories.

Mantegna; humanist, geometrist, archaeologist, of great scholastic and imaginative intelligence, dominated the whole of northern Italy by virtue of his imperious personality. Aiming at optical illusion, he mastered perspective. He trained in painting at the Padua School where Donatello and Paolo Uccello had previously attended. Even at a young age commissions for Andrea’s work flooded in, for example the frescos of the Ovetari Chapel of Padua. In a short space of time Mantegna found his niche as a modernist due to his highly original ideas and the use of perspective in his works. His marriage with Nicolosia Bellini, the sister of Giovanni, paved the way for his entree into Venice. Mantegna reached an artistic maturity with his Pala San Zeno. He remained in Mantova and became the artist for one of the most prestigious courts in Italy – the Court of Gonzaga. Classical art was born. Despite his links with Bellini and Leonardo da Vinci, Mantegna refused to adopt their innovative use of colour or leave behind his own technique of engraving.

Four Romances Of England

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Author : Graham Drake
language : en
Publisher: Medieval Institute Publications
Release Date : 1999-04-01

Four Romances Of England written by Graham Drake and has been published by Medieval Institute Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-04-01 with Literary Collections categories.

Fitted with ample introductions, notes, and glosses, this volume will make an excellent text for a class of any level on Middle English romance. This excellent edition includes King Horn, Havelok the Dane, Bevis of Hampton, and Athelston. These romances all deal with the Matter of Britain-that is, they celebrate action and adventure tales taking place in England. Featuring all the hallmarks of a good romance, these works include disinherited nobles, thrilling battles, love stories, dragons, and all sorts of marvels and adventures. Spanning the mid thirteenth to the late fourteenth century, these works provide an excellent cross section of the wonderful world of Middle English romances featuring the escapades of their fantastical countrymen.

History

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Author : Adam Hart-Davis
language : en
Publisher: Dk Pub
Release Date : 2012

History written by Adam Hart-Davis and has been published by Dk Pub this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with History categories.

Chronologically traces the course of human history and civilization from prehistoric times to the present day, covering key events, people, inventions and discoveries, and ideas and beliefs.

My Sister The Vampire 1 Switched

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Author : Sienna Mercer
language : en
Publisher: Harper Collins
Release Date : 2009-03-03

My Sister The Vampire 1 Switched written by Sienna Mercer and has been published by Harper Collins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-03 with Juvenile Fiction categories.

Don't miss this fun tween vampire series, featuring regular girl Olivia and goth girl Ivy! When Olivia Abbott moves to town, she's excited to join the cheerleading team and make new friends. Then she meets Ivy Vega. At first, Ivy, pale and dressed all in black, looks like Olivia's opposite. Then the girls look beyond the glittery pink blush and thick black eyeliner to discover they're identical—identical twins! Olivia and Ivy are brimming with plans to switch places and pull every twin trick in the book. But Olivia soon discovers that she and Ivy aren't exactly the same. Ivy's a vampire. And she's not the only one in town. “Cute caper. For those who crave vampire lite, the novel features likable heroines and comical scenarios.” (Publishers Weekly)

Affective Health And Masculinities In South Africa

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Author : Hans Reihling
language : en
Publisher: Routledge
Release Date : 2021-12-13

Affective Health And Masculinities In South Africa written by Hans Reihling and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-13 with categories.

Affective Health and Masculinities in South Africa explores how different masculinities modulate substance use, interpersonal violence, suicidality, and AIDS as well as recovery cross-culturally. With a focus on three male protagonists living in very distinct urban areas of Cape Town, this comparative ethnography shows that men's struggles to become invulnerable increase vulnerability. Through an analysis of masculinities as social assemblages, the study shows how affective health problems are tied to modern individualism rather than African 'tradition' that has become a cliché in Eurocentric gender studies. Affective health is conceptualized as a balancing act between autonomy and connectivity that after colonialism and apartheid has become compromised through the imperative of self-reliance. This book provides a rare perspective on young men's vulnerability in everyday life that may affect the reader and spark discussion about how masculinities in relationships shape physical and psychological health. Moreover, it shows how men change in the face of distress in ways that may look different than global health and gender-transformative approaches envision. Thick descriptions of actual events over the life course make the study accessible to both graduate and undergraduate students in the social sciences. Contributing to current debates on mental health and masculinity, this volume will be of interest to scholars from various disciplines including anthropology, gender studies, African studies, psychology, and global health.

Idleness Indolence And Leisure In English Literature

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Author : M. Fludernik
language : en
Publisher: Springer
Release Date : 2014-11-11

Idleness Indolence And Leisure In English Literature written by M. Fludernik and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-11 with Literary Criticism categories.

Idleness, Indolence and Leisure in English Literature is the first study to provide transhistorical perspectives and cutting-edge critical analyses of debates concerning idleness in English literature. The topicality of the subject is emphasized by two pieces of sociological analysis.

Guy Lalibert

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Author : Ian Halperin
language : en
Publisher: Transit Publishing
Release Date : 2009

Guy Lalibert written by Ian Halperin and has been published by Transit Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Circus categories.

Laliberte means freedom in French, but Laliberte gives freedom new meaning. This title takes you inside Laliberte's world, followed by over-the-top partying by night. It lets you experience relentless drive of this visionary, his passion for life, the Cirque, and women.