Cell Biology Of Metals
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Cell Biology Of Metals And Nutrients
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Author : Rüdiger Hell
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-03-10
Cell Biology Of Metals And Nutrients written by Rüdiger Hell and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-10 with Science categories.
Plants are composed of 17 essential and at least 5 beneficial elements, and these must be taken up as metal or nutrient ions to allow for growth and cell division. Much effort has been devoted to studying the physiology and biochemistry of metals and nutrients in plants. The aspect of cell biology, however, is an emerging new field and much needs to be learned about sensing, long-distance communication within plants, and cellular signal transduction chains in response to environmental stress. Cellular malfunction and consequently disease result when any of the key steps in metal and nutrient homeostasis are disrupted. Working together, leading experts in their respective fields provide a new concept that reaches beyond plant nutrition and plasmalemma transport into cellular physiology. Each chapter contains basic information on uptake, physiological function, deficiency and toxicity syndromes, long-distance and intracellular transport. The discussion is devoted to metals and nutrients where recent progress has been made and highlights the aspects of homeostasis and sensing, signaling and regulation, drawing parallels to other organisms including humans. Finally, the book identifies gaps in our current knowledge and lays out future research directions.
Cellular And Molecular Biology Of Metals
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Author : Rudolfs K. Zalups
language : en
Publisher: CRC Press
Release Date : 2010-05-21
Cellular And Molecular Biology Of Metals written by Rudolfs K. Zalups and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-21 with Medical categories.
With chapter contributions from more than 30 metal biology experts, Cellular and Molecular Biology of Metals explains the role of key divalent metal ions involved in the molecular and cellular biology of various target cell populations. Although it primarily focuses on homeostatic metals, such as nickel, zinc, and chromium, the text also discusses
Cell Biology Of Metals And Nutrients
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Author : Rüdiger Hell
language : en
Publisher: Springer
Release Date : 2010-03-05
Cell Biology Of Metals And Nutrients written by Rüdiger Hell and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-05 with Science categories.
Plants are composed of 17 essential and at least 5 beneficial elements, and these must be taken up as metal or nutrient ions to allow for growth and cell division. Much effort has been devoted to studying the physiology and biochemistry of metals and nutrients in plants. The aspect of cell biology, however, is an emerging new field and much needs to be learned about sensing, long-distance communication within plants, and cellular signal transduction chains in response to environmental stress. Cellular malfunction and consequently disease result when any of the key steps in metal and nutrient homeostasis are disrupted. Working together, leading experts in their respective fields provide a new concept that reaches beyond plant nutrition and plasmalemma transport into cellular physiology. Each chapter contains basic information on uptake, physiological function, deficiency and toxicity syndromes, long-distance and intracellular transport. The discussion is devoted to metals and nutrients where recent progress has been made and highlights the aspects of homeostasis and sensing, signaling and regulation, drawing parallels to other organisms including humans. Finally, the book identifies gaps in our current knowledge and lays out future research directions.
Metals In Cells
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Author : Valeria Culotta
language : en
Publisher: John Wiley & Sons
Release Date : 2016-03-16
Metals In Cells written by Valeria Culotta and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-16 with Science categories.
Over the last three decades a lot of research on the role of metals in biochemistry and medicine has been done. As a result many structures of biomolecules with metals have been characterized and medicinal chemistry studied the effects of metal containing drugs. This new book (from the EIBC Book Series) covers recent advances made by top researchers in the field of metals in cells [the “metallome”] and include: regulated metal ion uptake and trafficking, sensing of metals within cells and across tissues, and identification of the vast cellular factors designed to orchestrate assembly of metal cofactor sites while minimizing toxic side reactions of metals. In addition, it features aspects of metals in disease, including the role of metals in neuro-degeneration, liver disease, and inflammation, as a way to highlight the detrimental effects of mishandling of metal trafficking and response to "foreign" metals. With the breadth of our recently acquired understanding of metals in cells, a book that features key aspects of cellular handling of inorganic elements is both timely and important. At this point in our understanding, it is worthwhile to step back and take an expansive view of how far our understanding has come, while also highlighting how much we still do not know. The content from this book will publish online, as part of EIBC in December 2013, find out more about the Encyclopedia of Inorganic and Bioinorganic Chemistry, the essential online resource for researchers and students working in all areas of inorganic and bioinorganic chemistry.
Cell Biology Of Metals
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Author : Jonathan D. Gitlin
language : en
Publisher:
Release Date : 2006
Cell Biology Of Metals written by Jonathan D. Gitlin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Molecular Biology Of Metal Homeostasis And Detoxification
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Author : Markus J. Tamás
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-07-07
Molecular Biology Of Metal Homeostasis And Detoxification written by Markus J. Tamás and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07-07 with Science categories.
One of the challenges faced by every cell as well as by whole organisms is to maintain appropriate concentrations of essential nutrient metals while excluding nonessential toxic metals. Toward that end, all organisms have developed mechanisms for metal homeostasis and detoxification to maintain metal levels within physiological limits. This book brings together current knowledge of the molecular basis of metal homeostasis and detoxification in various eukaryotic model systems, including yeasts, plants, and mammals. It focuses on the cellular systems controlling metal transport, intracellular distribution, and immobilization as well as on systems regulating metal-dependent transcription. In addition to environmental aspects (including phytoremediation), the book treats the pathophysiology of metal deficiency and overload in relation to disease.
Cellular Effects Of Heavy Metals
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Author : Gaspar Banfalvi
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-03-02
Cellular Effects Of Heavy Metals written by Gaspar Banfalvi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-02 with Medical categories.
The term “heavy metals” is used as a group name of toxic metals and metalloids (semimetals) causing contaminations and ecotoxicity. In strict chemical sense the density of heavy metals is higher than 5 g/cm3. From biological point of view as microelements they can be divided into two major groups. a. For their physiological function organisms and cells require essential microelements such as iron, chromium (III), cobalt, copper, manganese, molidenium, zinc. b. The other group of heavy metals is toxic to the health or environment. Of highest concern are the emissions of As, Cd, Co, Cu, Hg, Mn, Ni, Pb, Sn, Tl. The toxicity of heavy metals is well known at organizational level, while less attention has been paid to their cellular effects. This book describes the toxicity of heavy metals on microorganisms, yeast, plant and animal cells. Other chapters of the book deal with their genotoxic, mutagenic and carcinogenic effects. The toxicity of several metals touch upon the aspects of environmental hazard, ecosystems and human health. Among the cellular responses of heavy metals irregularities in cellular mechanisms such as gene expression, protein folding, stress signaling pathways are among the most important ones. The final chapters deal with biosensors and removal of heavy metals. As everybody is eating, drinking and exposed to heavy metals on a daily basis, the spirit of the book will attract a wide audience.
Development And Applications Of New Chemical Tools For Studying The Cell Biology Of Metals
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Author : Sheel Dodani
language : en
Publisher:
Release Date : 2013
Development And Applications Of New Chemical Tools For Studying The Cell Biology Of Metals written by Sheel Dodani and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Cells have evolved intricate mechanisms that coordinate the activity of transporters, chaperones, and small-molecule ligands to control the spatial and temporal positioning of metal ions. Alkali and alkaline earth metal ions are known to play essential roles in cellular signaling and charge balance whereas transition metals are typically found in the active sites of enzymes to carry out organic transformations. In order to carry out these functions the cell maintains static and labile metal ion pools. These pools can be characterized by bulk molecular biology and bioinorganic techniques on fixed samples in combination with fluorescent indicators that afford the ability to track metal ions in real-time through molecular imaging. In this regard, cellular calcium has been well characterized in variety of biological contexts, but methods to monitor biologically relevant transition metal ions in real-time have not been well established. This dissertation describes the synthesis, characterization, and applications of new fluorescent sensors for Ni(II) and Cu(I), as well as approaches to discover new roles of biological copper in cell signaling. Nickelsensor-1 is a new water-soluble, turn-on fluorescent sensor that is capable of selectively responding to Ni(II) in aqueous solution and in living cells. Coppersensor-3 and X-ray fluorescence microscopy reveal that neuronal cells mobilize significant pools of copper from their cell bodies to peripheral processes in a calcium dependent fashion upon depolarization with KCl. Mitochondrial Coppersensor-1 (Mito-CS1) is a bifunctional reporter that combines a Cu(I)-responsive fluorescent platform with a mitochondrial-targeting triphenylphosphonium moiety for the reversible detection of endogenous, exchangeable mitochondrial Cu(I) pools. Mito-CS1 in conjunction with ICP metal analyses, show that both the exchangeable Cu(I) and total mitochondrial copper pools are only mildly perturbed in fibroblasts with mutant SCO1 and SCO2 mitochondrial copper chaperones. Molecular imaging of neural calcium transients reveals that that endogenous copper is used to tune inhibitory and excitatory inputs during neural circuit development through the dynamic functions of CTR1. Finally, methods for high-throughput RNAi screening and immunofluorescence have been optimized to understand how the kinome regulates the copper mediated mobilization of ATP7A in mammalian cells.
Metallomics
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Author : Wolfgang Maret
language : en
Publisher: World Scientific Publishing Company
Release Date : 2016-05-12
Metallomics written by Wolfgang Maret and has been published by World Scientific Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-12 with Science categories.
Metallomics is an integrated biometal science as it unifies different disciplines into a mainstream subject that can be taught to students of the biological and biomedical sciences. Metallomics bridges chemistry and the biological sciences from a global and quantitative systems approach, while the biological context provides new insights into the functions of metals in biological cells. The book challenges the traditional view of relating biochemistry only to organic chemistry, and discusses the structure and function of metal ions in the context of their environment in organisms. This is an essential read for undergraduate and graduate students in the fields of biochemistry, cell biology, nutrition (trace element research), toxicology, pharmacology and ecology.
Molecular Biology And Toxicology Of Metals
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Author : Rudolfs K. Zalups
language : en
Publisher: CRC Press
Release Date : 2000-02-24
Molecular Biology And Toxicology Of Metals written by Rudolfs K. Zalups and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-02-24 with Medical categories.
Molecular Biology and Toxicology of Metals provides a critical review and analysis of the current state of knowledge of metal ion transport and metabolism in prokaryotic and eukaryotic cellular systems. It covers the latest information on specific metals and the biological molecules with which metals interact. It also details mechanisms in the handling and toxicity of metals in specific organ systems, and the role of metals in cell signalling and gene transcription in target cells. This book is sure to prove a fertile meeting ground for the disciplines of molecular genetics and metal toxicology.
