Cell Survival Programs And Ischemia Reperfusion
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Cell Survival Programs And Ischemia Reperfusion
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Author : Maike Krenz
language : en
Publisher: Biota Publishing
Release Date : 2013-09-01
Cell Survival Programs And Ischemia Reperfusion written by Maike Krenz and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-01 with Science categories.
The major purpose of this book is to review the evidence supporting the concept that intrinsic cell survival programs can be activated by a variety of mildly noxious stimuli or pharmacologic agents to confer protection against the deleterious effects of ischemia/reperfusion (I/R). We begin with a discussion of the concept of hormesis (a term used most extensively in the toxicologic literature which refers to biphasic cellular responses that depend on concentration or intensity of a stimulus), review the seminal studies that led to the discovery of the cardioprotective effects of ischemic preconditioning, and outline its therapeutic potential (Chapter 1). This is followed by a summary of our current understanding of the mechanisms of I/R injury (Chapter 2), as this provides several points of intervention in limiting postischemic tissue injury that may be targeted by the adaptive programs invoked by conditioning stimuli. Chapters 3 and 4 focus on the mechanisms underlying ischemic pre-, post-, and remote conditioning, which establishes the mechanistic rationale for development of pharmacologic conditioning strategies that may mimic the remarkably powerful effects of ischemic conditioning (and are covered in Chapter 5). Lifestyle interventions, including exercise, caloric restriction, and consumption of alcoholic beverages and/or phytochemicals, that may induce hormetic responses will also be reviewed in this chapter. While the promise for conditioning as a therapeutic approach is enormous, there are obstacles to its practical application in patients, which are covered in Chapter 6. The final chapter (Chapter 7) examines the extension of our mechanistic understanding of the signaling pathways invoked by conditioning stimuli into the realm of gene therapy and to the preservation of stem cell viability in the harsh ischemic environment as natural translational outgrowths of preconditioning into therapeutics.
Adult Stem Cell Survival
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Author : Anatoly Konoplyannikov
language : en
Publisher:
Release Date : 2010
Adult Stem Cell Survival written by Anatoly Konoplyannikov and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Adult stem cells categories.
The authors have shown recently that for the two types of adult stem cells (hematopoietic stem cells and intestinal epithelium stem cells), the "ischemia/reperfusion" reaction can be developed in vivo. The damaging action of this reaction onto stem cells can be diminished by an injection of a source of NO-radicals into the animal's body during reperfusion, since NO-radicals are capable of decreasing the negative effect of radicals produced after oxygen access into the ischemic tissues. The authors believe that these data may be used in the development of new approaches for the protection of cell systems of organism renewal after the damaging action of various agents.
Pathophysiology Of Ischemia Reperfusion Injury And Use Of Fingolimod In Cardioprotection
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Author : Naseer Ahmed
language : en
Publisher: Academic Press
Release Date : 2019-05-30
Pathophysiology Of Ischemia Reperfusion Injury And Use Of Fingolimod In Cardioprotection written by Naseer Ahmed and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-30 with Science categories.
Pathophysiology of Ischemia-Reperfusion Injury and Use of Fingolimod in Cardioprotection is a deep examination into the mechanisms of myocardial ischemiareperfusion injury and role of fingolimod as a cardioprotective agent through its antioxidant, anti-apoptotic and anti-inflammatory effects. Dr. Ahmed explore the physiology and pathophysiology of myocardial metabolism under normal and ischemic conditions and focused on pharmacological cardioprotection. They provide a concise, yet rigorous discussion of Ischemia-Reperfusion Injury, Myocardial Ischemia during Circulatory Arrest, Myocardial Reperfusion, Myocardial Protection related to Ischemia-Reperfusion Injury and Role of Fingolimod in Cardioprotection. Pathophysiology of Ischemia-Reperfusion Injury and Use of Fingolimod in Cardioprotection is ideal for researchers, cardiovascular scientists, and clinical pharmacologists to further work in this challenging area and apply this knowledge to clinical trials for cardioprotection. Provides detailed and critical analysis of the latest research in the field from molecular basis to potential clinical relevance Examines the effect of fingolimod/sphingosine 1-phosphate in cardioprotection, pointing to future myocardial preventative strategies
Mechanisms Of Vascular Disease
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Author : Robert Fitridge
language : en
Publisher: University of Adelaide Press
Release Date : 2011
Mechanisms Of Vascular Disease written by Robert Fitridge and has been published by University of Adelaide Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
International Review Of Cell And Molecular Biology
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Author : Kwang W. Jeon
language : en
Publisher: Academic Press
Release Date : 2012-08-20
International Review Of Cell And Molecular Biology written by Kwang W. Jeon and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-20 with Science categories.
International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Impact factor for 2009: 6.088. Authored by some of the foremost scientists in the field Provides up-to-date information and directions for future research Valuable reference material for advanced undergraduates, graduate students and professional scientists
Pharmacological Preconditioning And Ischaemic Postconditioning In Experimental Jejunal Ischaemia In Horses
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Author : Nicole Verhaar
language : en
Publisher: Cuvillier Verlag
Release Date : 2021-06-01
Pharmacological Preconditioning And Ischaemic Postconditioning In Experimental Jejunal Ischaemia In Horses written by Nicole Verhaar and has been published by Cuvillier Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-01 with Medical categories.
Strangulating obstruction of the small intestine in the horse is associated with a high mortality rate. Although many intestinal lesions can be treated surgically, more effective strategies are needed to decrease the occurrence of complications related to the intestinal segments that are not amenable to intestinal resection. The aim of this PhD was to determine the feasibility and effect of two novel treatment modalities in equine small intestinal ischaemia. Therefore, ischaemic postconditioning and pharmacological preconditioning with lidocaine and xylazine were investigated in two experimental in vivo studies. By evaluating different variables for intestinal ischaemia reperfusion injury by use of histomorphology, immunohistochemistry and biochemical analysis, the results of this study demonstrate the applicability of these treatments in experimental small intestinal ischaemia in horses.
Hydrogen Sulfide In Redox Biology Part B
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Author :
language : en
Publisher: Academic Press
Release Date : 2015-03-03
Hydrogen Sulfide In Redox Biology Part B written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-03 with Science categories.
These new volumes of Methods in Enzymology (554 and 555) on Hydrogen Sulfide Signaling continue the legacy established by previous volumes on another gasotransmitter, nitric oxide (Methods in Enzymology volumes 359, 396, 440, and 441), with quality chapters authored by leaders in the field of hydrogen sulfide research. These volumes of Methods in Enzymology were designed as a compendium for hydrogen sulfide detection methods, the pharmacological activity of hydrogen sulfide donors, the redox biochemistry of hydrogen sulfide and its metabolism in mammalian tissues, the mechanisms inherent in hydrogen sulfide cell signaling and transcriptional pathways, and cell signaling in specific systems, such as cardiovascular and nervous system as well as its function in inflammatory responses. Two chapters are also devoted to hydrogen sulfide in plants and a newcomer, molecular hydrogen, its function as a novel antioxidant. Continues the legacy of this premier serial with quality chapters on hydrogen sulfide research authored by leaders in the field Covers conventional and new hydrogen sulfide detection methods Covers the pharmacological activity of hydrogen sulfide donors Contains chapters on important topics on hydrogen sulfide modulation of cell signaling and transcriptional pathways, and the role of hydrogen sulfide in the cardiovascular and nervous systems and in inflammation
The Science Of Hormesis In Health And Longevity
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Author : Suresh I. S. Rattan
language : en
Publisher: Academic Press
Release Date : 2018-10-23
The Science Of Hormesis In Health And Longevity written by Suresh I. S. Rattan and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-23 with Medical categories.
The Science of Hormesis in Health and Longevity provides a comprehensive review of mild stress-induced physiological hormesis and its role in the maintenance and promotion of health. Coverage includes the underlying mechanisms of hormesis, including details of stress-response signaling, an enriched environment, positive challenges and dose-response mechanisms, amongst others. Research from top experts is presented to provide suggestions for developing novel therapeutic strategies, along with lifestyle interventions to promote health and homoeostasis. Researchers in aging and physiology, gerontologists, clinicians and medical students will find this a valuable addition for their work. Provides a comprehensive, scholarly review of the current state of hormesis in physiology, health, disease and aging Includes multiple perspectives and in-depth analysis by top experts involved in cutting-edge research to provide developing, novel therapeutic strategies, as well as lifestyle interventions Offers a clear understanding of hormesis’ underlying mechanisms, including details of stress-response signaling, an enriched environment, positive challenges, dose-response mechanisms, and more
Yamada S Textbook Of Gastroenterology
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Author : Daniel K. Podolsky
language : en
Publisher: John Wiley & Sons
Release Date : 2015-10-22
Yamada S Textbook Of Gastroenterology written by Daniel K. Podolsky and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-22 with Medical categories.
Seit 20 Jahren ist Yamada's Textbook of Gastroenterology das umfassendste und weltweit anerkannte Lehrwerk für das Fachgebiet und vereint in Form einer Enzyklopädie die wissenschaftlichen Grundlagen von Magen-Darm- und Lebererkrankungen mit den neuesten klinischen Erkenntnissen, vor allem Entwicklungen in den Bereichen Diagnose und Therapie. Zu dem Herausgeberteam unter der Leitung von Tachi Yamada, einer der weltweit führenden Forscher des Fachgebiets, gehörten schon immer herausragende Namen. Gleiches gilt für die Autoren vieler Beiträge, die zu den Experten ihres Fachbereichs gehören. Mit dem neuen Chefherausgeber Dan Podolsky, Professor für Innere Medizin an dem Southwestern Medical Center der University of Texas, wurde die 6. Auflage dieses führenden Lehrbuchs aktualisiert und in vielerlei Hinsicht verbessert - Jetzt beim Kauf der Printversion mit kostenlosem Zugriff auf die digitale Ausgabe mit umfassenden Suchfunktionen. - Einheitliche Darstellung der einzelnen Themenabschnitte, unterteilt in wissenschaftliche Grundlagen, Krankheiten und deren Symptome, und damit eine Vereinheitlichung in Aufbau, Inhalt und Länge. - Neuer Abschnitt "Principles of Clinical Gastroenterology" mit Schwerpunkt auf klinische Aspekte. In 14 Kapiteln wird auf die jeweiligen Krankheitssymptome eingegangen. Ärzte können so ihre Patienten in der Klinik noch besser beurteilen und behandeln. - Wichtige Themen werden noch ausführlicher erläutert (autoimmune Pankreatitis, fäkale Biomarker, Genetik, chronisch-entzündliche Darmerkrankungen, systemische IgG4-assoziierte Erkrankungen, Morbus Crohn, Colitis ulcerosa und eosinophile Ösophagitis). - Podcasts international führender Experten zu aktuellen Themen. - Stärkerer Schwerpunkt auf klinische Studien/Versuchsreihen, evidenzbasierte Praxis, Richtlinien von Fachverbänden und Regierungsstellen. - Verweise auf Online-Referenzwerke, Hyperlinks zu Pubmed/CrossRef. Die wichtigsten Verweise sind weiterhin in der Printversion enthalten. - Noch internationaler und global: Neben den führenden Experten aus Nordamerika kommen renommierte Fachärzte aus Europa und Asien zu Wort. Yamada's Textbook of Gastroenterology ist das umfassende Standardwerk der Gastroenterologie. Die 6. Auflage orientiert sich noch stärker am Klinikalltag, ist aufgrund der Fülle an Informationen zu wissenschaftlichen Grundlagen nach wie vor Marktführer und gleichzeitig ein herausragendes Referenzwerk zum klinischen Management von Erkrankungen des Magen-Darm-Trakts. Jetzt noch besser: Kostenloser Online-Zugang zu allen Inhalten der Printausgabe mit weitreichenden Suchfunktionen. Genau das Richtige für Gastroenterologen, ob erfahrener Praktiker oder Berufsanfänger.
Molecular Mechanisms Of Cardiac Hypertrophy And Failure
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Author : Richard A. Walsh
language : en
Publisher: CRC Press
Release Date : 2005-11-29
Molecular Mechanisms Of Cardiac Hypertrophy And Failure written by Richard A. Walsh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-11-29 with Medical categories.
This title reviews current knowledge of the mechanisms contributing to heart failure. Editor Richard Walsh and an internationally renowned team of contributors discuss key advances in molecular and cell biology, biochemistry, and pharmacology, focusing on advances that have a direct bearing on current clinical studies. It highlights developments across a broad range of disciplines, with in-depth coverage of each topic providing background and perspective on current literature. By setting new advances in a broader context, this text allows readers to compare different ideas and evaluate their importance in their own areas of research or clinical practice.