Cellular Respiration And Carcinogenesis
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Cellular Respiration And Carcinogenesis
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Author : Shireesh Apte
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-18
Cellular Respiration And Carcinogenesis written by Shireesh Apte and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-18 with Science categories.
Cellular Respiration and Carcinogenesis presents leading experts in the field as it informs the reader about both basic and recent research in the field of cellular respiration and the effects of its dysfunction, alteration or attenuation on the development of cancer. This masterfully compiled text offers the reader a fundamental understanding about how oxygen sensing and/or availability, programmed cell death, immune recognition and response and glucose metabolism are intimately linked with the two major mechanism or pathways of cellular respiration; oxidative phosphorylation and glycolysis. The editors and contributing authors proficiently and unequivocally address the effects of dysfunction of the mitochondrial oxidative phosphorylation/glycolysis (cellular respiration) mechanisms and pathways on the development of cancer. While it remains true that there are no universal truths in cancer, Cellular Respiration and Carcinogenesis opens the dialogue that the etiology of cancer can usually be associated with, and significantly attributed to the failure of one or multiple pathways of oxidative phosphorylation (cellular respiration) to normally burn fuel to generate energy, vis-à-vis the Warburg hypothesis. Keeping with its cutting-edge nature, Cellular Respiration and Carcinogenesis provides the first glimpse to a cautionary evidence based counterbalance to the recent and rapidly proliferating notion that utilization of fuel primarily via glycolysis is a hallmark of cancer development.
Cellular Respiration And Carcinogenesis
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Author : Shireesh Apte
language : en
Publisher: Humana Press
Release Date : 2009-03-23
Cellular Respiration And Carcinogenesis written by Shireesh Apte and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-23 with Science categories.
Cellular Respiration and Carcinogenesis presents leading experts in the field as it informs the reader about both basic and recent research in the field of cellular respiration and the effects of its dysfunction, alteration or attenuation on the development of cancer. This masterfully compiled text offers the reader a fundamental understanding about how oxygen sensing and/or availability, programmed cell death, immune recognition and response and glucose metabolism are intimately linked with the two major mechanism or pathways of cellular respiration; oxidative phosphorylation and glycolysis. The editors and contributing authors proficiently and unequivocally address the effects of dysfunction of the mitochondrial oxidative phosphorylation/glycolysis (cellular respiration) mechanisms and pathways on the development of cancer. While it remains true that there are no universal truths in cancer, Cellular Respiration and Carcinogenesis opens the dialogue that the etiology of cancer can usually be associated with, and significantly attributed to the failure of one or multiple pathways of oxidative phosphorylation (cellular respiration) to normally burn fuel to generate energy, vis-à-vis the Warburg hypothesis. Keeping with its cutting-edge nature, Cellular Respiration and Carcinogenesis provides the first glimpse to a cautionary evidence based counterbalance to the recent and rapidly proliferating notion that utilization of fuel primarily via glycolysis is a hallmark of cancer development.
Cancer Between Glycolysis And Physical Constraint
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Author : Laurent Schwartz
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-03-22
Cancer Between Glycolysis And Physical Constraint written by Laurent Schwartz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-03-22 with Medical categories.
Considerable effort has gone into the research of common cancers - lung, bowel, ovarian, cervical, and prostate cancer. In recent years, however, there has been a lack of breakthroughs in therapeutic advances. By challenging many established beliefs, Cancer explores these issues by offering new perspectives on the study of cancer and exploring the areas of mathematics, physics and chemistry in cancer research. This book is for cancer specialists, clinicians, and researchers interested in an innovative view in cancer research.
The Prime Cause Of Cancer
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Author : Otto Warburg
language : en
Publisher: EnCognitive.com
Release Date : 2015-12-02
The Prime Cause Of Cancer written by Otto Warburg and has been published by EnCognitive.com this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-02 with Health & Fitness categories.
This is book 2 of 5 of the “Understand Cancer” series. It is based on the best-available science. The SECONDARY causes of cancer were discussed in book one. This book continues from book one and discusses the PRIME cause of cancer as discovered by Nobel Prize Laureate Dr. Otto Warburg—considered by many as the founder of modern biochemistry. “There are prime and secondary causes of diseases. For example, the prime cause of the plague is the plague bacillus, but secondary causes of the plague are filth, rats, and the fleas that transfer the plague bacillus from rats to man. By a prime cause of a disease I mean one that is found in every case of the disease...Cancer, above all other diseases, has countless secondary causes. But, even for cancer, there is only one prime cause. Summarized in a few words, the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar. All normal body cells meet their energy needs by respiration of oxygen, whereas cancer cells meet their energy needs in great part by fermentation. All normal body cells are thus obligate aerobes, whereas all cancer cells are partial anaerobes. From the standpoint of the physics and chemistry of life this difference between normal and cancer cells is so great that one can scarcely picture a greater difference. Oxygen gas, the donor of energy in plants and animals is dethroned in the cancer cells and replaced by an energy yielding reaction of the lowest living forms, namely, a fermentation of glucose.” —Dr. Otto Warburg
Mitochondrial Respiration Promotes Non Small Cell Lung Cancer Cell Proliferation And Function
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Author : Md Maksudul Alam
language : en
Publisher:
Release Date : 2016
Mitochondrial Respiration Promotes Non Small Cell Lung Cancer Cell Proliferation And Function written by Md Maksudul Alam and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Actin categories.
Lung cancer is the leading cause of cancer related death both in the USA and worldwide. More than 80% of the lung cancer cases are non-small cell lung cancer (NSCLC). Since Otto Warburg made the first observation that the rate of aerobic glycolisis is increased in tumor cells, substantial amount of research has been done on altered cancer cell metabolism and bioenergetics. Recently, the use of more advanced metabolomics and genomics technologies has revealed the remarkable plasticity of tumor metabolism and bioenergetics. Many types of tumor cells have been shown to generate most of the cellular energy via mitochondrial respiration and oxidative phosphorylation. In this dissertation project it has been shown that the rate of respiration is intensified in an array of NSCLCs compared to the normal lung cell line. We also found that the respiration is greatly reduced when NSCLCs are grown in glutamine deprived media, whereas the respiration is unaffected when the cells are grown in glucose deprived media. In this project we have also shown that Hedgehog (Hh) signaling inhibitors Cyclopamine tartrate (CycT) and SNAT1 disrupt mitochondrial function and aerobic respiration. Our results showed that CycT, like glutamine depletion, caused a substantial decrease in oxygen consumption in a number of NSCLC cell lines, suppressed NSCLC cell proliferation, and induced apoptosis. Further, we found that CycT increased reactive oxygen species (ROS) generation, causes mitochondrial membrane hyperpolarization, and mitochondrial fragmentation, thereby disrupting mitochondrial function in NSCLC cells. Furthermore, using two isogenic cell lines representing matched pairs of normal and cancer cells, we have identified changes in protein levels accompanying transformation of normal lung epithelial cells to cancer cells. Surprisingly, a substantial number of proteins involved in actin cytoskeleton were preferentially downregualted in cancer cells. However, similar numbers of proteins in other organelles were either up or down regulated. The formation of stress fibers and focal adhesions were also markedly decreased in cancer cells. Protein network analysis showed that the altered proteins are highly connected.
Advances In Respiratory Cancerogenesis
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Author : Mieczyslaw Pokorski
language : en
Publisher: Springer
Release Date : 2018-05-30
Advances In Respiratory Cancerogenesis written by Mieczyslaw Pokorski and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-30 with Medical categories.
Lung cancer is the leading cause of mortality worldwide, with a low survival rate. Carcinogenesis generally requires a constellation of entwined steps, involving both innate cellular and environmental factors. This book shares the updated knowledge on the origin and development of cancer through genotypic changes which upset the physiological balance between cell proliferation, differentiation, growth control, and apoptosis. The emphasis is put on the role of microRNA proteins involved in the cellular processes above outlined. Cognitive changes, related to dysregulated cellular mechanisms in cancer cells, as yet unchartered area of research, also are tackled. A better understanding of the molecular and cellular biology of lung cancer is the key source of breakthroughs in the diagnosis and prognosis, and finding more effective therapies that target specific mutations. The book provides a source of current facts and trends in clinical research and practice. It will be of interest to clinicians, researchers, and other medical professionals.
Oxidation The Cornerstone Of Carcinogenesis
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Author : John C. Stavridis
language : en
Publisher: Springer
Release Date : 2008-01-21
Oxidation The Cornerstone Of Carcinogenesis written by John C. Stavridis and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-21 with Medical categories.
This book is unique due to its collective approach to the key aspects of the interdependency between three entities: oxidative stress, tobacco smoke and carcinogenesis, operating in a cause-effect sequence, in a concise and to the point manner. This book will prove to be a helpful companion to the internist, the oncologist and the research scientist in molecular biology as well as a work of reference for the general practitioner and physician interested in cancer research.
Oxidation The Cornerstone Of Carcinogenesis
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Author : John C. Stavridis
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-08
Oxidation The Cornerstone Of Carcinogenesis written by John C. Stavridis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-08 with Medical categories.
This book is unique due to its collective approach to the key aspects of the interdependency between three entities: oxidative stress, tobacco smoke and carcinogenesis, operating in a cause-effect sequence, in a concise and to the point manner. This book will prove to be a helpful companion to the internist, the oncologist and the research scientist in molecular biology as well as a work of reference for the general practitioner and physician interested in cancer research.
Basic Cancer Programs
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Author : Werner Schwemmler
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 1998
Basic Cancer Programs written by Werner Schwemmler and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.
Cancer has one of the highest mortality rates and its incidence in the modern industrialized world continues to rise. The objective of this book is to elucidate the biological roots of carcinogenesis. A spectacular result of this analysis is the concept of the five basic cancer programs, which are the exact reverse of the five basic programs for cell control: division, growth, differentiation, function, and apoptosis. Each of these cell programs is characterized according to the interaction between the cell's genes, signals, and metabolites. Understanding the regulatory processes in normal cells allows profound insights into those of cancer cells. The findings on cancer development are then integrated into a general framework, a 'Unified Holistic Theory of Evolution'. In conclusion, new approaches to cancer diagnosis, prophylaxis and therapy are discussed against this background.
Dr Otto Warburg S Cancer Research Papers
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Author : Otto Warburg
language : en
Publisher: EnCognitive.com
Release Date : 2015-12-04
Dr Otto Warburg S Cancer Research Papers written by Otto Warburg and has been published by EnCognitive.com this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-04 with Health & Fitness categories.
This collection includes the original cancer research papers by Dr. Otto Warburg and his colleagues in their original text. It includes additional articles NOT found in “The Metabolism of Tumours.” The collection includes these articles: —The Prime Cause and Prevention of Cancer —On the Origin of Cancer Cells —The Metabolism of Tumours in the Body —On the Respiratory Impairment of Cancer Cells —The Chemical Constitution of Respiration Ferment —The Oxygen Transferring Ferment of Respiration —The Metabolism of Carcinoma Cells —The Carbohydrate Metabolism of Tumours —Observation on the Carbohydrate Metabolism of Tumours —Enzymic Studies on Ascitic Tumours and Their Host’s Blood Plasmas If a lowered oxygen pressure during cell growth may cause cancer, or, more generally, if any inhibition of respiration during growth may cause cancer, then a next problem is to show why reduced respiration induces cancer. Since we already know that with a lowering of respiration fermentation results, we can re- express our question: Why does cancer result if oxygen-respiration is replaced by fermentation? The early history of life on our planet indicates that life existed on earth before the earth’s atmosphere contained free oxygen gas. The living cells must therefore have been fermenting cells then, and, as fossils show, they were undifferentiated single cells. Only when free oxygen appeared in the atmosphere - some billion years ago - did the higher development of life set in, to produce the plant and animal kingdoms from the fermenting, undifferentiated single cells. What the philosophers of life have called "Evolution créatrice" has been and is therefore the work of oxygen. The reverse process, the dedifferentiation of life, takes place today in greatest amount before our eyes in cancer development, which is another expression for dedifferentiation. To be sure, cancer development takes place even in the presence of free oxygen gas in the atmosphere, but this oxygen may not penetrate in sufficient quantity into the growing body cells, or the respiratory apo-enzymes of the growing body cells may not be saturated with the active groups. In any case, during the cancer development the oxygen-respiration always falls, fermentation appears, and the highly differentiated cells are transformed to fermenting anaerobes, which have lost all their body functions and retain only the now useless property of growth. Thus, when respiration disappears, life does not disappear, but the meaning of life disappears, and what remains are growing machines that destroy the body in which they grow.