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Central And Peripheral Dopamine Receptors


Central And Peripheral Dopamine Receptors
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Central And Peripheral Dopamine Receptors


Central And Peripheral Dopamine Receptors
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Author : P.F. Spano
language : en
Publisher: Springer
Release Date : 1988-11-14

Central And Peripheral Dopamine Receptors written by P.F. Spano and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988-11-14 with Medical categories.




Central And Peripheral D B1 S Dopamine Receptors


Central And Peripheral D B1 S Dopamine Receptors
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Author : Clare M. Hollis
language : en
Publisher:
Release Date : 1991

Central And Peripheral D B1 S Dopamine Receptors written by Clare M. Hollis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with categories.




Dopamine Receptor Agonists


Dopamine Receptor Agonists
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Author : George Poste
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11

Dopamine Receptor Agonists written by George Poste and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.


Dopamine, in addition to its importance as a precursor of norepinephrine, is now known to be an important neurotransmitter in regulating functional activities in a number of major organ systems, including the central ner vous system. the cardiovascular system, the kidney, and the gut. Recent advances in our understanding of the functional role of dopamine, its mechanism of action and the pharmacology of dopaminergic agents have occurred on a broad front. The last few years have witnessed significant progress in the identification and classification of central and peripheral dopamine receptors and the factors that affect their responsiveness to inhibitory and stimulatory ligands. These advances have been paralleled by new insights into the contribution of alterations in dopaminergic reg ulation in causing disease and the utility of dopamine agonists and an tagonists as therapeutic modalities. This volume, the first in a series of publications arising from the annual Smith Kline and French Research Symposium on New Horizons in Therapeutics, provides a comprehensive survey of current research on peripheral dopamine receptors and the physiologic and therapeutic con sequences of stimulating pre-and postsynaptic dopamine receptors. Research in dopamine pharmacology mirrors the remarkable ad vances that are occurring in the field of pharmacology at large as a con sequence of the involvement of an ever-larger number of scientific dis ciplines in the study of drug action.



Central And Peripheral D0 Dopamine Receptors


Central And Peripheral D0 Dopamine Receptors
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Author : Clare M. Hollis
language : en
Publisher:
Release Date : 1991

Central And Peripheral D0 Dopamine Receptors written by Clare M. Hollis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Biochemistry categories.




Central And Peripheral D1 Dopamine Receptors


Central And Peripheral D1 Dopamine Receptors
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Author : C. M. Hollis
language : en
Publisher:
Release Date : 1991

Central And Peripheral D1 Dopamine Receptors written by C. M. Hollis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with categories.




Central And Peripheral Dss1 Dopamine Receptors


Central And Peripheral Dss1 Dopamine Receptors
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Author : Clare M. Hollis
language : en
Publisher:
Release Date : 1991

Central And Peripheral Dss1 Dopamine Receptors written by Clare M. Hollis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with categories.




Peripheral Dopamine Pathophysiology


Peripheral Dopamine Pathophysiology
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Author : Francesco Amenta
language : en
Publisher: CRC Press
Release Date : 2019-06-04

Peripheral Dopamine Pathophysiology written by Francesco Amenta and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-04 with Medical categories.


First Published in 1989, this book offers a full, comprehensive guide into the role of Dopamine in the Periphery. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for Students of Medicine, and other practitioners in their respective fields.



Central And Peripheral Dopamine Receptors Biochemistry And Pharmacology


Central And Peripheral Dopamine Receptors Biochemistry And Pharmacology
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Author : Pier Franco Spano
language : en
Publisher:
Release Date : 1988

Central And Peripheral Dopamine Receptors Biochemistry And Pharmacology written by Pier Franco Spano and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with categories.




Neurobiology Of Central D1 Dopamine Receptors


Neurobiology Of Central D1 Dopamine Receptors
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Author : George Breese
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09

Neurobiology Of Central D1 Dopamine Receptors written by George Breese and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.


Our understanding of the functional mechanisms relating dopamine activity to normal and abnormal behavior has been turned "upside-down" by the recent developments described in the chapters of this volume. Heretofore, it was generally agreed that all of the pharmacological and behavioral properties ascribed to dopamine systems were mediated via activation or inhibition of the subtype of dopamine receptors termed D2. The properties of these receptors were first characterized in 1975 following their identification by receptor binding techniques utilizing 3H-butyrophenones, potent antipsychotic drugs, used in the treatment of schizophrenia. Although another subtype of dopamine receptor had already been identified a few years earlier, now termed the Dl receptor, its functional properties were unknow- other than the fact that it was associated with the activation of the enzyme adenylate cyclase. Our absence of knowledge of the behavioral functions of this receptor stemmed primarily from the lack of selective agonist and antagonists for DI receptors - drugs which did not also interact with D2 receptors. Selective agents for D2 receptors did exist and hence the behavioral roles of D2 receptors were easily ascribed. The work described in this text is primarily stimulated by the development of two selective Dl receptor drugs - the antagonist SCH 23390 and the agonist SKF 38393. The studies described herein clearly show that D1 receptors do indeed have many behavioral functions, on the surface often similar to those responses mediated by D2 receptors.



Central D1 Dopamine Receptors


Central D1 Dopamine Receptors
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Author : M. J. Goldstein
language : en
Publisher: Springer
Release Date : 2013-11-21

Central D1 Dopamine Receptors written by M. J. Goldstein and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-21 with Science categories.


The development of a selective D1 dopamine (DA) receptor antagonist SCH 23390 stimulated a number of studies on the functions mediated by central DA receptor subtypes. It was generally assumed that the central D1 DA receptor isa molecular entity whose function awaits further discovery. The papers presented in this volume clearly show that this is no longer the case and that D1 DA receptors have many behavioral fuctions which might be altered in pathological states. A number of papers have recognized the interdependence of the regulatory functions of the D1 DA receptors with D2 and other receptor proteins, and vice versa. The biochemical, pharmacological and morphological characterization of the D1 and D2 DA receptor binding proteins, as well as of DARPP-32, illustrates the complex interactions between various macromolecules. Procedures described for the purification of the D1 and D2 DA receptor subtypes are fundamental for future studies on the mechanisms involved in the coupling of the receptor proteins with signal transducing systems. Several studies in this volume show that D1 DA receptors have behavioral functions and that they are often similar to the responses mediated by D2 DA receptors, but in some instances reflect divergent neuronal activity of both systems. The knowledge of the physiology and biochemistry of the central DA receptor subtypes could lead to the development of a new generation of drugs which ameliorate some mental and neurological dysfunctions without producing severe undesirable side effects.