Channel Catfish Herpesvirus Systems Biology
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Channel Catfish Herpesvirus Systems Biology
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Author : Dušan Kunec
language : en
Publisher:
Release Date : 2010
Channel Catfish Herpesvirus Systems Biology written by Dušan Kunec and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Channel catfish virus disease categories.
Catfish production is the largest aquaculture industry in the United States and infectious agents are responsible for 45% of all economic losses. Ictalurid herpesvirus 1 or Channel catfish virus (CCV) has a great economic impact on channel catfish aquaculture; yet it also has the potential for becoming a highly efficient vaccine vector eliciting long-lived immune responses against itself and, as a recombinant, other important catfish pathogens (bacteria, myxosporean, and fungi). However, little is known about CCV's genome, its gene functions or genetic interactions with its host. Better understanding of CCV biology and pathogenesis could enable more rational vaccine design and other control strategies for CCV. My thesis is that "systems biology" can enable much more rapid understanding of CCV biology and pathogenesis. To test this thesis I needed to first more fully annotate the CCV genome, then construct a rapid system for generating CCV mutants and recombinants for systems biology research and then apply these tools in a systems biology experiment. I experimentally annotated the CCV proteome by proteogenomic mapping followed by real-time PCR and confirmed the expression of 37 of the 76 previously predicted ORFs (25 for the first time) as well as 17 novel ORFs. I next constructed two different infectious clones of CCV: one as three overlapping bacterial artificial chromosomes (BACs) and the other as a full length CCV BAC. These CCV BACs facilitate CCV mutant and recombinant production and I regenerated a genotypically wild-type and an attenuated virus. To further simplify CCV mutant production, I next adapted the CCV infectious clone for lambda phage crossover recombination cloning to enable sequence transfer into a specific CCV locus by a simple one-step in-vitro reaction. Finally, I used the CCV infectious clone, in combination with affinity purification, to identify interacting partners of the CCV zinc RING finger proteins ORF9, ORF11 and ORF12 to provide insight into the topology of one presumptive CCV-channel catfish molecular interaction network module. The work in this dissertation supports my thesis and the CCV BAC tools were patented; together these provide tools to facilitate and accelerate the development and testing of better CCV vaccines.
Channel Catfish Herpesvirus Systems Biology
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Author :
language : en
Publisher:
Release Date : 2004
Channel Catfish Herpesvirus Systems Biology written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
The Herpesvirus Of Channel Catfish
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Author : Moon Hong Lee
language : en
Publisher:
Release Date : 1979
The Herpesvirus Of Channel Catfish written by Moon Hong Lee and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with Catfishes categories.
Channel Catfish Virus Disease
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Author : John A. Plumb
language : en
Publisher:
Release Date : 1977
Channel Catfish Virus Disease written by John A. Plumb and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with Channel catfish virus disease categories.
Biology And Culture Of Channel Catfish
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Author : C.S. Tucker
language : en
Publisher: Elsevier
Release Date : 2004-09-30
Biology And Culture Of Channel Catfish written by C.S. Tucker and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-09-30 with Technology & Engineering categories.
The history of channel catfish farming in the United States serves as a model for the development of pond-based aquaculture industries worldwide. Channel catfish farming is the largest and economically most important aquaculture industry in the United States. In 2003, over 300,000 metric tons (662 million pounds) of channel catfish were processed, representing about half the total United States aquaculture production. Demand for farm-raised catfish is strong, with record processing years in 2002 and 2003. In 22 chapters written by active scientists in the field, Biology and Culture of Channel Catfish comprehensively synthesizes over 30 years of research on this American icon. Throughout the book, fundamental biological aspects of channel catfish are linked to practical culture techniques. Topics include: • Latest information on reproductive physiology, genetics, and breeding • Comprehensive treatment of catfish nutrition, feeds, and feeding practices • Water quality management and pond dynamics • In-depth review of immunology in channel catfish • Practical information on diseases and health management • Techniques for commercial culture, including innovative techniques such as raceways, recirculating systems, and partitioned aquaculture systems • Catfish economics and marketing • Exploration of environmental concerns, including recommended Best Management Practices
Cell Biology Of Herpes Viruses
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Author : Klaus Osterrieder
language : en
Publisher: Springer
Release Date : 2017-05-20
Cell Biology Of Herpes Viruses written by Klaus Osterrieder and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-20 with Medical categories.
Herpes viruses are widely distributed in nature, causing disease in organisms as diverse as bivalves and primates, including humans. Each virus appears to have established a long-standing relationship with its host, and the viruses have the ability to manipulate and control the metabolism of host cells, as well as innate and adaptive antiviral immune responses. Herpes viruses maintain themselves within hosts in a latent state resulting in virus persistence for years – usually for the life span of the hosts. Herpes viruses comprise a large number of pathogens with diverse cellular targets and biological consequences of infection. What they have in common is their structure and the fact that they establish a dormant (latent) infection in their hosts that usually persists for life. The reviews here will highlight the general principles of herpes virus infection, with equal attention to overall principle and important difference. Also, the cell type- and life-style dependent differences in the establishment and maintenance of virus persistence will be covered.
Some Biological Aspects Of Channel Catfish Virus Disease
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Author : John Alfred Plumb
language : en
Publisher:
Release Date : 1972
Some Biological Aspects Of Channel Catfish Virus Disease written by John Alfred Plumb and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1972 with Channel catfish virus disease categories.
The Establishment Of Recombinant Channel Catfish Virus Ictalurid Herpesvirus 1 Vector As A Potential Live Virus Vaccine Vector For The Catfish Industry
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Author : Huang Zhang (Ge)
language : en
Publisher:
Release Date : 1994
The Establishment Of Recombinant Channel Catfish Virus Ictalurid Herpesvirus 1 Vector As A Potential Live Virus Vaccine Vector For The Catfish Industry written by Huang Zhang (Ge) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Channel catfish virus disease categories.
Biochemical Characterization And Gene Mapping Of The Channel Catfish Herpesvirus Ccv Encoded Thymidine Kinase A Selectable Site For Homologous Recombination
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Author : Larry Allen Hanson
language : en
Publisher:
Release Date : 1990
Biochemical Characterization And Gene Mapping Of The Channel Catfish Herpesvirus Ccv Encoded Thymidine Kinase A Selectable Site For Homologous Recombination written by Larry Allen Hanson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with categories.
The Pathology Of Fishes
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Author : William E. Ribelin
language : en
Publisher: Univ of Wisconsin Press
Release Date : 1975
The Pathology Of Fishes written by William E. Ribelin and has been published by Univ of Wisconsin Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1975 with Medical categories.
Specific diseases. Lesions of organic systems. Chemical and physical agents of disease. Nutritional diseases. Neoplasia.
