Chemistry And Applications Of Benzimidazole And Its Derivatives

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Chemistry And Applications Of Benzimidazole And Its Derivatives

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Author : Maria Marinescu
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-10-02

Chemistry And Applications Of Benzimidazole And Its Derivatives written by Maria Marinescu and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-02 with Science categories.

Finding new strategies for synthesizing benzimidazole derivatives and functionalizing the benzimidazole core has proved to be important due to the compound's various applications in medicine, chemistry, and other areas. The multitude of benzimidazole derivatives marketed as drugs has led to intensive research in the field for the discovery of new biologically active structures. The general applications of benzimidazole derivatives in materials chemistry, electronics, technology, dyes, pigments, and agriculture open up new research horizons. This book guides the rational design of benzimidazole derivatives synthesis with certain applications. Chapters cover such topics as therapeutic use of benzimidazole in conditions like diabetes, viruses, and parasitic diseases; X-ray crystal structure of selected benzimidazole derivatives; benzimidazole compounds for cancer therapy; and others.

Chemistry And Applications Of Benzimidazole And Its Derivatives

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Author : Maria Marinescu
language : en
Publisher:
Release Date : 2019

Chemistry And Applications Of Benzimidazole And Its Derivatives written by Maria Marinescu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Biology (General) categories.

Finding new strategies for synthesizing benzimidazole derivatives and functionalizing the benzimidazole core has proved to be important due to the compound's various applications in medicine, chemistry, and other areas. The multitude of benzimidazole derivatives marketed as drugs has led to intensive research in the field for the discovery of new biologically active structures. The general applications of benzimidazole derivatives in materials chemistry, electronics, technology, dyes, pigments, and agriculture open up new research horizons. This book guides the rational design of benzimidazole derivatives synthesis with certain applications. Chapters cover such topics as therapeutic use of benzimidazole in conditions like diabetes, viruses, and parasitic diseases; X-ray crystal structure of selected benzimidazole derivatives; benzimidazole compounds for cancer therapy; and others.

Benzimidazole

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Author : Aksel A. Vestergaard
language : en
Publisher:
Release Date : 2020

Benzimidazole written by Aksel A. Vestergaard and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Benzimidazoles categories.

Benzimidazole: Preparation and Applications first defines the structure, physical and chemical properties of the benzimidazole compound class. Further conventional and alternative synthesis methods and important reactions of these compound derivatives are illustrated with examples. The authors provide an overview of benzimidazole-based synthetic medicine and their significant applications in treating various ailments. The chemical reactions of benzimidazole with other heterocyclic compounds/chemical reagents produce a lot of new substituted molecules, which have potential pharmaceutical applications. A literature review is presented focusing on the synthesis of chiral compounds and their subsequent applications as therapeutic compounds in order to better evaluate the results so far. Additionally, the authors discuss how nenzimidazole derivatives play a vital role in organic light emitting diodes as emissive materials, host materials, electron transport materials, hole blocking materials, etc., and have pharmaceutical applications such as antimicrobial, antihypertensive, anti-HIV and anticancer. Following this, this collection examines classes of potential chemosensors possessing benzimidazole moieties which are capable of both visual and optical estimation of target analytes over a broad concentration range and without interference of contemporary analytes. Important methodologies used for the synthesis of variedly substituted benzimidazoles are presented along with their multi-target therapeutic uses. The latest research on anti-tumor and antimicrobial benzimidazole compounds, as well as structure-activity correlations, drug design, clinical and preclinical studies is also presented. Benzimidazole-based polymers with various architecture and copolymers are discussed with a variation of properties such as mechanical, thermal stability, thermo-oxidative stability and enhanced performance. The penultimate chapter covers a critical analysis of the recent developments in benzimidazole framework research and the future scope of benzimidazole framework in ligand designing. In closing, the synthesis and biological properties of coordination compounds containing benzimidazole derivatives are presented and discussed.

Expanding The Scope Of Benzimidazole Derivatives Synthesis From A Green Chemistry Perspective

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Author : Fabrizio Politano
language : en
Publisher:
Release Date : 2020

Expanding The Scope Of Benzimidazole Derivatives Synthesis From A Green Chemistry Perspective written by Fabrizio Politano and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.

Nitrogen-containing heterocycles have a wide range of medicinal and industrial applications. Benzimidazole and its derivatives belong to this group and their synthesis is of importance. Environmental concerns, and consequently, new legislation imposed on industrial processes, means that chemists are having to re-think their practices and to develop more sustainable synthetic methods. Herein, the results of a synthetic methodology to synthetize benzimidazole N-oxides by a sustainable approach are presented. The synthesis and isolation processes are fast, easy, and environmentally friendly, allowing for the preparation of large numbers of products in a short time and producing a small amount of non-hazardous waste. The analysis of this methodology employing green metrics allows for corroboration of this. Additionally, in some cases, the benzimidazole N-oxide formation reaction proceeds via an unexpected pathway involving a carbon-carbon bond-cleavage. This process was studied here, and a rational explanation for the observation is presented.

Benzimidazole

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Author :
language : en
Publisher: BoD – Books on Demand
Release Date : 2022-07-13

Benzimidazole written by and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-13 with Science categories.

Benzimidazole is a comprehensive survey of the known and new methods of benzimidazole synthesis, the spectral and theoretical aspects of existing benzimidazole derivatives, and the anticancer properties of a new class of benzimidazole derivatives. This book examines aspects and newer mechanisms of benzimidazoles containing heterocyclic moiety. Chapters report on anticancer properties of benzimidazole derivatives, novel methods of synthesis of benzimidazoles, versatile nature of the benzimidazoles, spectral and theoretical studies of benzimidazole derivatives, and medicinal importance and pharmacological aspects of benzimidazole derivatives.

Supramolecular Assembly Of Benzimidazole Derivatives And Applications

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Author : Ana Beloqui
language : en
Publisher:
Release Date : 2019

Supramolecular Assembly Of Benzimidazole Derivatives And Applications written by Ana Beloqui and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Electronic books categories.

Herein, we focus on the chemical and physical properties of benzimidazole and its derivatives used for the synthesis of supramolecular materials. The design and modification of benzimidazole opens the scope of the diversity of structures (different sizes and morphologies) that can be built. The synthesized materials include not only small coordination complexes but also isolated crystals, metal-organic frameworks, metal-coordination polymers, smart nanocontainers, and more advanced macrostructures such as microflowers and nanowires. These supramolecular structures are based on noncovalent interactions, mostly on metal coordination chemistry and π-π stacking interactions. Moreover, the same molecule, due to its chemical structure, can undergo both sorts of interactions in order to induce the self-assembly into supramolecular materials. In this process, as it is shown in this chapter, the conditions used for the assembly determine the final structure and morphology of the fabricated macromolecule. Finally, we show most recent applications of these materials in the field of sensing, photoluminescence, fuel cell, and fabrication of new nanostructures.

Utilities Of 2 Bromoacetyl Benzimidazole In Heterocyclic Synthesis

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Author : Eldebss Taha
language : en
Publisher: LAP Lambert Academic Publishing
Release Date : 2015-10-23

Utilities Of 2 Bromoacetyl Benzimidazole In Heterocyclic Synthesis written by Eldebss Taha and has been published by LAP Lambert Academic Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-23 with categories.

Benzimidazole and its derivatives were synthesized from o-phenylenediamine and different reagents and they exhibited high and wide range of biological activities in medicinal, pharmacological and pharmaceutical chemistry and in corrosion chemistry in addition to industrial chemistry In addition to, their applications in the textile industry as dyeing agents and pesticide and veterinary medicine.

Imidazole Based Drug Discovery

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Author : Shikha Agarwal
language : en
Publisher: Elsevier
Release Date : 2021-12-02

Imidazole Based Drug Discovery written by Shikha Agarwal and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-02 with Science categories.

Imidazole-Based Drug Discovery covers all categories of imidazole and its derivatives, synthesis, pharmacological applications and drug-based studies. Imidazole scaffolds act as a channel between organic synthesis and medicinal chemistry and compel researchers to explore new drug candidates. This book provides detailed coverage of several greener synthetic protocols and pharmacological applications of imidazole derivatives that are useful to researchers working on designing more promising clinical lead compounds with this scaffold. It also includes information on past decades of research on the synthesis and biological applications of imidazole derivatives. This is an ideal resource for researchers in organic chemistry both in academic and industrial settings, as well as postgraduates in chemistry and medicinal chemistry. Reviews the most current developments and future perspectives of imidazole on different disease therapies to achieve the ultimate goal of disease eradication Discusses the role of imidazole in contemporary science, technological innovation, drug development, critical challenges and future research directions Covers emerging trends on different eco-benign pathways to synthesize imidazole derivatives for the development of simpler synthetic protocols

Key Heterocycle Cores For Designing Multitargeting Molecules

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Author : Om Silakari
language : en
Publisher: Elsevier
Release Date : 2018-06-11

Key Heterocycle Cores For Designing Multitargeting Molecules written by Om Silakari and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-11 with Science categories.

Key Heterocycle Cores for Designing Multitargeting Molecules provides a helpful overview of current developments in the field. Following a detailed introduction to the manipulation of heterocycle cores for the development of dual or multitargeting molecules, the book goes on to describe specific examples of such developments, focusing on compounds such as Benzimidazole, Acridine, Flavones, Thiazolidinedione and Oxazoline. Drawing on the latest developments in the field, this volume provides a valuable guide to current approaches in the design and development of molecules capable of acting on multiple targets. Adapting the heterocyclic core of a single-target molecule can facilitate its development into an agent capable of acting on multiple targets. Such multi-targeting drugs have the potential to become essential components in the design of novel, holistic treatment plans for complex diseases, making the design of such active agents an increasingly important area of research. Emphasizes the chemical development of heterocyclic nuclei, from single to multitargeting molecules Provides chapter-by-chapter coverage of the key heterocyclic compounds used in synthesizing multitargeting agents Outlines current trends and future developments in multitarget molecule design for the treatment of various diseases

Imidazole And Benzimidazole Synthesis

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Author : M. R. Grimmett
language : en
Publisher: Academic Press
Release Date : 1997-06-02

Imidazole And Benzimidazole Synthesis written by M. R. Grimmett and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-06-02 with Science categories.

Imidazole and Benzimidazole Synthesis is a comprehensive survey of the known methods of syntheses and ring modification. It brings together the multitude of synthesis of the imidazole ring in a systemic way interms of specific bond formation, and recommends the most attractive synthetic approaches. It also collects non-ring-synthetic approaches to classes of compounds such as nitro-, halogeno-, and amino-imidazoles, and covers the synthesis of N-substituted compounds and preparations of specific isomers. The only book in print dealing specifically with this topic Comprehensive survey of the known methods of synthesis and ring modification Recommends the most attractive synthetic approaches