Chromatographic Techniques In The Forensic Analysis Of Designer Drugs
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Chromatographic Techniques In The Forensic Analysis Of Designer Drugs
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Author : Teresa Kowalska
language : en
Publisher: CRC Press
Release Date : 2018-01-31
Chromatographic Techniques In The Forensic Analysis Of Designer Drugs written by Teresa Kowalska and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-31 with Law categories.
There is a dramatic rise of novel drug use due to the increased popularity of so-called designer drugs. These synthetic drugs can be illegal in some countries, but legal in others and novel compounds unknown to drug chemistry emerge monthly. This thoughtfully constructed edited reference presents the main chromatographic methodologies and strategies used to discover and analyze novel designer drugs contained in diverse biological materials. The methods are based on molecular characteristics of the drugs belonging to each individual class of compounds, so it will be clear how the current methods are adaptable to future new drugs that appear in the market.
Chromatographic Techniques In The Forensic Analysis Of Designer Drugs
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Author : Teresa Kowalska
language : en
Publisher: CRC Press
Release Date : 2018-01-31
Chromatographic Techniques In The Forensic Analysis Of Designer Drugs written by Teresa Kowalska and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-31 with Law categories.
There is a dramatic rise of novel drug use due to the increased popularity of so-called designer drugs. These synthetic drugs can be illegal in some countries, but legal in others and novel compounds unknown to drug chemistry emerge monthly. This thoughtfully constructed edited reference presents the main chromatographic methodologies and strategies used to discover and analyze novel designer drugs contained in diverse biological materials. The methods are based on molecular characteristics of the drugs belonging to each individual class of compounds, so it will be clear how the current methods are adaptable to future new drugs that appear in the market.
Determination Of Target Xenobiotics And Unknown Compound Residues In Food Environmental And Biological Samples
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Author : Tomasz Tuzimski
language : en
Publisher: CRC Press
Release Date : 2018-10-25
Determination Of Target Xenobiotics And Unknown Compound Residues In Food Environmental And Biological Samples written by Tomasz Tuzimski and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-25 with Science categories.
Xenobiotics are chemical compounds foreign to a given biological system. In animals and humans, xenobiotics include drugs, drug metabolites, and environmental pollutants. In the environment, xenobiotics include synthetic pesticides, herbicides, and industrial pollutants. Many techniques are used in xenobiotics residue analysis; the method selected depends on the complexity of the sample, the nature of the matrix/analytes, and the analytical techniques available. This reference will help the analyst develop effective and validated analytical strategies for the analysis of hundreds of different xenobiotics on hundreds of different sample types, quickly, accurately and at acceptable cost.
Lc Nmr
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Author : Nina C. Gonnella
language : en
Publisher: CRC Press
Release Date : 2020-01-15
Lc Nmr written by Nina C. Gonnella and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-15 with Medical categories.
The isolation and structural characterization of substances present at very low concentrations, as is necessary to satisfy regulatory requirements for pharmaceutical drug degradants and impurities, can present scientific challenges. The coupling of HPLC with NMR spectroscopy has been at the forefront of cutting-edge technologies to address these issues. LC-NMR: Expanding the Limits of Structure Elucidation presents a comprehensive overview of key concepts in HPLC and NMR that are required to achieve definitive structure elucidation with very low levels of analytes. Because skill sets from both of these highly established disciplines are involved in LC-NMR, the author provides introductory background to facilitate readers’ proficiency in both areas, including an entire chapter on NMR theory. The much-anticipated second edition provides guidance in setting up LC-NMR systems, discussion of LC methods that are compatible with NMR, and an update on recent hardware and software advances for system performance, such as improvements in magnet design, probe technology, and solvent suppression techniques that enable unprecedented mass sensitivity in NMR. This edition features methods to quantify concentration and assess purity of isolated metabolites on the micro scale and incorporates computational approaches to accelerate the structure elucidation process. The author also includes implementation and application of qNMR and automated and practical use of computational chemistry combined with QM and DFT to predict highly accurate NMR chemical shifts. The text focuses on current developments in chromatographic-NMR integration, with particular emphasis on utility in the pharmaceutical industry. Applications include trace analysis, analysis of mixtures, and structural characterization of degradation products, impurities, metabolites, peptides, and more. The text discusses novel uses and emerging technologies that challenge detection limits as well future directions for this important technique. This book is a practical primary resource for NMR structure determination—including theory and application—that guides the reader through the steps required for isolation and NMR structure elucidation on the micro scale.
Information Resources In Toxicology Volume 2 The Global Arena
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-05-15
Information Resources In Toxicology Volume 2 The Global Arena written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-15 with Medical categories.
This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology's subdisciplines. This edition keeps pace with the digital world in directing and linking readers to relevant websites and other online tools.Due to the increasing size of the hardcopy publication, the current edition has been divided into two volumes to make it easier to handle and consult. Volume 1: Background, Resources, and Tools, arranged in 5 parts, begins with chapters on the science of toxicology, its history, and informatics framework in Part 1. Part 2 continues with chapters organized by more specific subject such as cancer, clinical toxicology, genetic toxicology, etc. The categorization of chapters by resource format, for example, journals and newsletters, technical reports, organizations constitutes Part 3. Part 4 further considers toxicology's presence via the Internet, databases, and software tools. Among the miscellaneous topics in the concluding Part 5 are laws and regulations, professional education, grants and funding, and patents. Volume 2: The Global Arena offers contributed chapters focusing on the toxicology contributions of over 40 countries, followed by a glossary of toxicological terms and an appendix of popular quotations related to the field.The book, offered in both print and electronic formats, is carefully structured, indexed, and cross-referenced to enable users to easily find answers to their questions or serendipitously locate useful knowledge they were not originally aware they needed. Among the many timely topics receiving increased emphasis are disaster preparedness, nanotechnology, -omics, risk assessment, societal implications such as ethics and the precautionary principle, climate change, and children's environmental health. - Opens with an overview of the international toxicology scene, organizations and activities involved with both the science and regulatory framework, and a specific look at the European Union's efforts - Offers an extensive collection of chapters covering over 40 countries and their toxicological infrastructure which includes listings of major books and journals, organizations, professional societies, universities, poison control centers, legislation, and online databases - Provides the Second Edition of the International Union of Pure and Applied Chemistry's Glossary of Terms Used in Toxicology, a carefully constructed and peer reviewed collation of critical terms in the science - Concludes with a potpourri of quotes concerning toxicology and their use in the arts and popular culture - Paired with Volume One, which offers chapters on a host of toxicology sub-disciplines, this set offers the most comprehensive compendium of print, digital, and organizational resources in the toxicological sciences with over120 chapters contributions by experts and leaders in the field
Gas Chromatography
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Author : Colin Poole
language : en
Publisher: Elsevier
Release Date : 2021-04-20
Gas Chromatography written by Colin Poole and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-20 with Science categories.
Gas Chromatography, Second Edition, offers a single source of authoritative information on all aspects relating to the practice of gas chromatography. A focus on short, topic-focused chapters facilitates the identification of information that will be of immediate interest for familiar or emerging uses of gas chromatography. The book gives those working in both academia and industry the opportunity to learn, refresh and deepen their understanding of fundamental and instrumental aspects of gas chromatography and tools for the interpretation and management of chromatographic data. Users will find a consolidated guide to the selection of separation conditions and the use of auxiliary techniques. This new edition restores the contemporary character of the book with respect to those involved in advancing the technology, analyzing the data produced, or applying the technique to new application areas. New topics covered include hyphenated spectroscopic detectors, micromachined instrument platforms, derivatization and related microchemical techniques, petrochemical applications, volatile compounds in the atmosphere, and more. - Includes chapters written by recognized authoritative and visionary experts in the field, thus providing an overview and focused treatments on a single topic - Provides comprehensive coverage of modern gas chromatography, from theory, to methods and selected applications - Places modern developments in research literature into a general context not always apparent to inexperienced users of the techniques
Designer Drugs
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Author : Roy Gerona
language : en
Publisher: Elsevier
Release Date : 2024-01-17
Designer Drugs written by Roy Gerona and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-17 with Health & Fitness categories.
Detection and Identification of Designer Drugs, the latest release in the Emerging Issues in Analytical Chemistry series, presents both an overview and a guide to techniques for anyone studying or engaging in designer drug analysis. Proliferation of the synthesis and use of designer drugs is a serious public health problem, with social, economic and legal implications. Whether abuse is studied at the population or individual level, researchers need both background and highly detailed technical information on specific drugs and drug classes in order to combat the proliferation and highly damaging consequences of these substances. Author Brian F. Thomas provides a comprehensive discussion that emphasizes the potential threat to society, presents the ongoing challenges confronting the various laboratory approaches to detection and identification of new chemical entities, and informs on the development of improved analytical solutions for use in legislation, law enforcement and treatment. Summarizes available literature and evaluates the strengths and weaknesses of analytical methods for detecting and identifying designer drugs Offers authoritative information from author Brian F. Thomas, an expert with over 30 years of experience in the field Directs the reader to sources of further reading at the conclusion of each chapter Emphasizes the potential threat to society Presents ongoing challenges confronting various laboratory approaches to detection and identification of new chemical entities
Novel Psychoactive Substances
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Author : Paul I. Dargan
language : en
Publisher: Academic Press
Release Date : 2013-08-06
Novel Psychoactive Substances written by Paul I. Dargan and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-06 with Medical categories.
Novel Psychoactive Substances: Classification, Pharmacology and Toxicology provides readers with background on the classification, detection, supply and availability of novel psychoactive substances, otherwise known as "legal highs." This book also covers individual classes of novel psychoactive substances that have recently emerged onto the recreational drug scene and provides an overview of the pharmacology of the substance followed by a discussion of the acute and chronic harm or toxicity associated with the substance. Written by international experts in the field, this multi-authored book is a valuable reference for scientists, clinicians, academics, and regulatory and law enforcement professionals. - Includes chapters written by international experts in the field. - Provides a comprehensive look at the classification, detection, availability and supply of novel psychoactive substances, in addition to the pharmacology and toxicology associated with the substance. - Offers a single source for all interested parties working in this area, including scientists, academics, clinicians, law enforcement and regulatory agencies. - Provides a full treatment of novel psychoactive substances that have recently emerged onto the recreational drug scene including mephedrone and the synthetic cannabinoid receptors in 'spice' / 'K2'.
Fundamentals Of Analytical Toxicology
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Author : Robert J. Flanagan
language : en
Publisher: John Wiley & Sons
Release Date : 2008-03-03
Fundamentals Of Analytical Toxicology written by Robert J. Flanagan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-03 with Science categories.
The analytical toxicologist may be required to detect, identify, and in many cases measure a wide variety of compounds in samples from almost any part of the body or in related materials such as residues in syringes or in soil. This book gives principles and practical information on the analysis of drugs and poisons in biological specimens, particularly clinical and forensic specimens. After providing some background information the book covers aspects of sample collection, transport, storage and disposal, and sample preparation. Analytical techniques - colour tests and spectrophotometry, chromatography and electrophoresis, mass spectrometry, and immunoassay – are covered in depth, and a chapter is devoted to the analysis of trace elements and toxic metals. General aspects of method implementation/validation and laboratory operation are detailed, as is the role of the toxicology laboratory in validating and monitoring the performance of point of care testing (POCT) devices. The book concludes with reviews of xenobiotic absorption, distribution and metabolism, pharmacokinetics, and general aspects of the interpretation of analytical toxicology results. A clearly written, practical, integrated approach to the basics of analytical toxicology. Focuses on analytical, statistical and pharmacokinetic principles rather than detailed applications. Assumes only a basic knowledge of analytical chemistry. An accompanying website provides additional material and links to related sites. Written by an experienced team of authors,Fundamentals of Analytical Toxicology is an invaluable resource for those starting out in a career in analytical toxicology across a wide range of disciplines including clinical and forensic science, food safety, and pharmaceutical development. Praise from the reviews: “This is an ambitious effort to describe in detail the many and varied aspects of the science of toxicological analysis. The 17 chapters cover every foreseeable aspect, from specimen collection through analytical techniques and quality control to pharmacological principles and interpretation of results. The authors bring together a great deal of experience in the field and have succeeded admirably in achieving their goal: "to give principles and practical information on the analysis of drugs, poisons and other relevant analytes in biological specimens...". The book is very readable and quite up-to-date, and contains many illustrative figures, charts and tables. Both the student and the practicing professional would do well to study this material carefully, as there is something here for every conceivable level of interest.” Review from Randall Baselt "This text comes highly recommended for any analytical toxicology trainee." The Bulletin of the Royal College of Pathologists “Overall, this book provides a comprehensive, thorough, clear, up to date and practical treatment of analytical toxicology at a high standard. Understanding of the text is enhanced by the use of many illustrations. Specifications, guidelines, and methods are highlighted in grey background “Boxes”. The many and up to date literature references in each chapter demonstrate the authors’ thorough work and permit easy access to deeper information. Therefore this book can be highly recommended as a valuable source of knowledge in analytical toxicology both as an introduction and for the advanced reader.” GTFCh Bulletin “Toxichem + Krimtech”, May 2008 (translated, original review in German) “Many toxicologists will add this important reference to their libraries because it competently fills a need ...” International Journal of Toxicology “The book is very well illustrated, easy to understand and pleasant to read, and contains a wealth of dedicated information.” International Journal of Environmental Analytical Chemistry
New Approaches In Forensic Analytical Chemistry
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Author : Alberto Salomone
language : en
Publisher: Frontiers Media SA
Release Date : 2021-02-17
New Approaches In Forensic Analytical Chemistry written by Alberto Salomone and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-17 with Science categories.