Chromosome X
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The X In Sex
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Author : David. BAINBRIDGE
language : en
Publisher: Harvard University Press
Release Date : 2009-06-30
The X In Sex written by David. BAINBRIDGE and has been published by Harvard University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-30 with Science categories.
A tiny scrap of genetic information determines our sex; it also consigns many of us to a life of disease, directs or disrupts the everyday working of our bodies, and forces women to live as genetic chimeras. The culprit--so necessary and yet the source of such upheaval--is the X chromosome, and this is its story. An enlightening and entertaining tour of the cultural and natural history of this intriguing member of the genome, The X in Sex traces the journey toward our current understanding of the nature of X. From its chance discovery in the nineteenth century to the promise and implications of ongoing research, David Bainbridge shows how the X evolved and where it and its counterpart Y are going, how it helps assign developing human babies their sex--and maybe even their sexuality--and how it affects our lives in infinitely complex and subtle ways. X offers cures for disease, challenges our cultural, ethical, and scientific assumptions about maleness and femaleness, and has even reshaped our views of human evolution and human nature. Table of Contents: Prologue 1. Making a Difference Interlude: What Is It, Exactly? 2. The Duke of Kent's Testicles Interlude: How Sexy Is X? 3. The Double Life of Women Epilogue: The Chosen One Further Reading Glossary Index Reviews of this book: The author of Making Babies takes a lively, witty tour of the X chromosome, creator of "a delicious symmetry between men and women"...Entertaining and informative...A fine demonstration of science made accessible. --Kirkus Reviews Reviews of this book: A well-written, well-researched, easy-to-read study that explains what has been learned about the X and Y chromosomes using DNA sequencing and other molecular biology techniques. British biologist Bainbridge...has pulled together historical and current scientific research about how the X and Y chromosomes affect us and what the genes on these chromosomes actually do, like causing sex-linked diseases and color blindness...An excellent example of good science writing...Recommended. --Margaret Henderson, Library Journal Reviews of this book: Bainbridge is an essentialist, interested in understanding what aspects of gender are biologically driven, and why...He has a central question he wants to answer. The question is not so much why men and women are different (a worn topic that's the subject of too many Mars-and-Venus bestsellers) but, far more specific and far more interesting: Why are men and women more different than they need to be? --Liza Mundy, Washington Post Reviews of this book: Bainbridge summarizes our knowledge of the genetic information that determines one's sex by recounting the ancients' speculations about the genesis of gender, following with modern biologists' discovery of the X and Y chromosomes about a century ago, and of the sex-determining gene Sry in the 1990s. In a discussion rich with history, evolution, and philosophy, Bainbridge points out the dramatic effect that gender selection has on people's lives...A fascinating, often humorous analysis of the science of sexuality. --Gilbert Taylor, Booklist Reviews of this book: In The X in Sex, David Bainbridge explains the far-reaching effects of X. Bainbridge...moves with ease between straightforward accounts of biology and historical stories about its effect, like the chapter describing the progression of hemophilia through the royal houses of Europe. Bainbridge discusses cultural history as well as natural history, and his wit enlivens every page. --Christine Kenneally, New York Times Book Review Reviews of this book: There are many literary stars (such as Stephen Jay Gould, Richard Dawkins and Matt Ridley) in the firmament of writers on evolution, and to a man they write with dash and persuasive logic. David Bainbridge is one such and in his latest book he takes the reader through the glories of the X chromosome at a cracking pace. --Miriam Stoppard, Times Higher Education Supplement (UK) Reviews of this book: The truth is that the behaviours of [chromosomes] X and Y are inextricably linked. Bainbridge explores this link in a compelling tale that takes in how the sex chromosomes became sex chromosomes, and the very different consequences of this for women and men. Along the way we encounter the Duke of Kent's testicles, calico cats and non-identical identical twin girls. His story weaves science, history and the history of science (with a little religion for good measure) in a straightforward, anecdotal fashion that will appeal to scientists and non-scientists alike. --Mark T. Ross, New Scientist (UK) Reviews of this book: In his structure/function analysis of the X chromosome, Bainbridge provides a tongue-in-cheek, yet informative, description of one of the two human sex chromosomes. --R. Adler, Choice Reviews of this book: If you have ever been intrigued by some of the puzzles of genetics--why boys tend to get haemophilia or colour blindness while girls are more likely to have an identical twin or to develop rheumatoid arthritis later in life--then The X in Sex is for you. --Chris Tyler-Smith, Times Literary Supplement David Bainbridge takes us on a fascinating tour of X chromosomes and explains what the possession of these intricately folded, infinitessimally narrow, two-inch long strings of genetic codes weighing almost nothing, means for their bearers--that is for each one of us, male and female. History and personal anecdotes are woven together with up-to-date summaries of the science, punctuated with Bainbridge's zany--and very British--humor, so that this information-packed book is pure pleasure to read. --Sarah Blaffer Hrdy author of Mother Nature: A History of Mothers, Infants, and Natural Selection The X in Sex is absolutely fascinating, so intriguing, in fact, that I found myself unwilling to put it down. David Bainbridge surveys an astonishing amount of new information from recent genomic studies of the X chromosome, clearly explaining the findings in a way the average person can easily follow. The science is presented via amusing and highly appropriate metaphors and clever turns of phrase, all of which serve to brighten the prose and present the reader with catchy ways to think about complex ideas. This is an informative, authoritative, and thoroughly enjoyable read: one of the best books I have read in recent years. --Jane Lancaster, University of New Mexico This is wonderful stuff--beautifully written, clear, jargon-free, with anecdotes sure to hold the attention. --other hupauthorTim Birkhead, author of Promiscuity: An Evolutionary History of Sperm Competition
Females Are Mosaics
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Author : Barbara Migeon
language : en
Publisher: Oxford University Press
Release Date : 2007-03-15
Females Are Mosaics written by Barbara Migeon and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-03-15 with Medical categories.
Women can be described as genetic mosaics because they have two distinctly different types of cells throughout their bodies. Unlike males, who have one X chromosome (inherited from their mother), females have two X chromosomes in every cell (one from each parent). The fathers copy works in some cells, while the mothers copy works in others. These two X chromosomes often function differently, especially if one carries a defective gene. Much has been written about the Y chromosome and its role in inducing maleness. This will be the first book about the X chromosome as a key to female development and the role of X-related factors in the etiology of sex differences in human disease. Barbara Migeon, from the renowned McKusick-Nathan Institute at Johns Hopkins, is a major figure in clinical genetics and is eminently qualified to write this book, and she writes clearly and effectively. She describes both the underlying molecular mechanisms and the remarkable genetic consequences of X inactivation and its role in determining the biological concepts characteristic of women. Females are Mosaics will be valuable to geneticists, biologists, and all health professionals interested in women's health.
Cytogenetics Of The Mammalian X Chromosome
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Author :
language : en
Publisher:
Release Date : 1983
Cytogenetics Of The Mammalian X Chromosome written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with Cytogenetics categories.
Vol. A.
Genetic Analysis Of The X Chromosome
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Author : Henry F. Epstein
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Genetic Analysis Of The X Chromosome written by Henry F. Epstein and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The present volume contains the edited transcript of a collo quium sponsored by the Muscular Dystrophy Association and held at Mountain Shadows Inn, Scottsdale, Arizona, December 14-16, 1981. The participants, geneticists, molecular biologists, bio chemists and clinicians, explored in open dialogue ways and means of identifying and characterizing the genetic alterations responsible for X-linked muscular dystrophies, especially the Duchenne type. The clinicians, who urged the use of properly diagnosed and documented case material for study, emphasized the troublesome fact that the primary phenotypic expression of the gene (or genes) involved in the muscular dystrophies is yet to be identified. Discussions centered on the applicability of recent methodol ogical advances in DNA chemistry and molecular biology, cytogenetics and cell biology to mapping the X chromosome. Despite ignorance of the basic disorder in the muscular dystrophies, DNA technologies and chromosome mapping strategies for the discovery of genetic defects and phenotypic expressions were proposed. Beyond its stimulating intellectual exchange, the colloquium yielded important benefits. The participants agreed to share needed cell lines and endonuclease restriction enzymes and to organize interlaboratory communication and collaborative efforts to accelerate progress in the quest for the genetic lesion in Duchenne muscular dystrophy. The discussions were recorded, transcribed, edited and to some extent, rearranged to fit into a sequence of chapters. The editors are grateful to Joy Colarusso Lowe whose unusual skill, patience and persistence made it possible to convert a highly specialized technical discussion into a coherent manuscript.
X Y Chromosomal Variations
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Author : Carole A. Samango-Sprouse
language : en
Publisher: Biota Publishing
Release Date : 2016-10-11
X Y Chromosomal Variations written by Carole A. Samango-Sprouse and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-11 with Medical categories.
This is the first book on X and Y chromosomal disorders to address these common but rarely diagnosed conditions. This book seeks to present the latest in research and clinical care addressing neuroimaging, the interaction between hormones, brain development, and neurodevelopmental progression. This book will primarily focus on 47, XXY (Klinefelter syndrome, or KS), 47, XYY (Jacobs' syndrome), and 47, XXX (Triple X). More variant disorders such as 48, XXXX, 48, XXXY and 49, XXXXY will be discussed. Topics of interest include neurological functioning, neuroimaging, social language, and the evolving perspectives of these XY chromosomal disorders. The effects of testosterone supplementation in males with 47, XXY will also be examined.
X Linked Traits
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Author : James R. Miller
language : en
Publisher: Cambridge University Press
Release Date : 1990
X Linked Traits written by James R. Miller and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Medical categories.
This book provides a source of information on comparative aspects of mammalian genomes.
X Chromosome Inactivation
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Author : Takashi Sado
language : en
Publisher:
Release Date : 2018
X Chromosome Inactivation written by Takashi Sado and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Electronic books categories.
This book details recently developed technologies and conventionally employed cytological proceduresfor the study of X-Chromosome Inactivation. Chapters detail live imaging, bioinformatic methods, fluorescence in situ hybridization, and immunofluorescence, and procedures to optimize the study of molecular mechanism underlying X chromosome inactivation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, X-Chromosome Inactivation: Methods Protocols aims to be useful for researchers in the field of epigenetics, chromatin, noncoding RNA, and nuclear architecture.
X Linked Mental Retardation
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Author : Roger E. Stevenson
language : en
Publisher:
Release Date : 2000
X Linked Mental Retardation written by Roger E. Stevenson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medical categories.
This is a comprehensive and up-to-date survey of mental retardation caused by genes on the X chromosome. Clinical and laboratory data on 130 syndromes are presented in a concise and consistent manner. Each syndrome is defined and information is provided on somatic features, growth and development, neurological signs, cognitive performance, imaging and other laboratory findings, and when possible, the nature and localization of the responsible gene. Craniofacial and other somatic findings are extensively illustrated. A differential matrix accompanies each syndrome description to assist the reader in identifying other X-linked syndromes with overlapping features. As background, the X chromosome and the emergence of the concept of X-linked mental retardation are discussed. X-chromosome maps show the location and mapping limits of the responsible genes. The authors have extensive experience in the clinical and laboratory delineation of X-linked mental retardation. They have described new syndromes, regionally mapped disease loci on the X chromosome, and in several cases isolated the genes responsible for X-linked syndromes.
Sex Chromosomes
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Author : Cynthia N. Weingarten
language : en
Publisher: Nova Science Publishers
Release Date : 2009
Sex Chromosomes written by Cynthia N. Weingarten and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Sex chromosome abnormalities categories.
Sex chromosomes determine the sex of an organism. A human somatic cell has two sex chromosomes: XY in male and XX in female. A human germ cell has one sex chromosome: X or Y in a sperm and X in an egg. When an X-sperm is combined with an egg, the resulting zygote (fertilised egg) will contain two X chromosomes. A person developed from the XX-zygote will have the characteristics of a female. Combination of a Y-sperm and an egg will produce a male. Usually, a woman has two X chromosomes (XX) and a man one X and one Y (XY). However, both male and female characteristics can sometimes be found in one individual, and it is possible to have XY women and XX men. Analysis of such individuals has revealed some of the molecules involved in sex determination, including one called SRY, which is important for testis formation. SRY (which stands for sex-determining region Y gene) is found on the Y chromosome. In the cell, it binds to other DNA and in doing so distorts it dramatically out of shape. This alters the properties of the DNA and likely alters the expression of a number of genes, leading to testis formation. Most XX men who lack a Y chromosome do still have a copy of the SRY gene on one of their X chromosomes (moved there by chromosomal translocation). This copy accounts for their maleness. However, because the remainder of the Y chromosome is missing they frequently do not develop secondary sexual characteristics in the usual way. This book presents the latest research in the field from around the world.
X Chromosome Unabridged Guide
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Author : Bobby Brenda
language : en
Publisher: Tebbo
Release Date : 2012-10
X Chromosome Unabridged Guide written by Bobby Brenda and has been published by Tebbo this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10 with Reference categories.
Complete, Unabridged Guide to X chromosome. Get the information you need--fast! This comprehensive guide offers a thorough view of key knowledge and detailed insight. It's all you need. Here's part of the content - you would like to know it all? Delve into this book today!..... : It is estimated that about 10% of the genes encoded by the X chromosome are associated with a family of CT genes, so named because they encode for markers found in both tumor cells (in Cancer patients) as well as in the human testis (in healthy patients). ... Males with Klinefelter's syndrome typically have one extra copy of the X chromosome in each cell, for a total of two X chromosomes and one Y chromosome (47,XXY). It is less common for affected males to have two or three extra X chromosomes (48,XXXY or 49,XXXXY) or extra copies of both the X and Y chromosomes (48,XXYY) in each cell. ... About half of individuals with Turner syndrome have monosomy X (45,X), which means each cell in a woman's body has only one copy of the X chromosome instead of the usual two copies. There is absolutely nothing that isn't thoroughly covered in the book. It is straightforward, and does an excellent job of explaining all about X chromosome in key topics and material. There is no reason to invest in any other materials to learn about X chromosome. You'll understand it all. Inside the Guide: X chromosome, Y chromosome, XY sex-determination system, XX male syndrome, X0 sex-determination system, X-inactivation, Turner syndrome, Spermatozoon, Sex linkage, Sex-determination system, Pseudoautosomal region, Monosomy, Klinefelter's syndrome, Human genome, Genetic disorder, Chromosome 1 (human), Chromosome, Barr body, Autosome