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Clinical Applications Of Physiome Models


Clinical Applications Of Physiome Models
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Clinical Applications Of Physiome Models


Clinical Applications Of Physiome Models
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Author : Eun Bo Shim
language : en
Publisher: Frontiers Media SA
Release Date : 2020-08-05

Clinical Applications Of Physiome Models written by Eun Bo Shim and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-05 with categories.




From Medical Images To Individualized Cardiac Mechanics


From Medical Images To Individualized Cardiac Mechanics
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Author : Chun Lok Wong
language : en
Publisher:
Release Date : 2010

From Medical Images To Individualized Cardiac Mechanics written by Chun Lok Wong and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Heart categories.


"Cardiac mechanics is a branch of science that deals with forces, kinematics, and material properties of the heart, which is valuable for clinical applications and physiological studies. Although anatomical and biomechanical experiments are necessary to provide the fundamental knowledge of cardiac mechanics, the invasive nature of the procedures limits their further applicability. In consequence, noninvasive alternatives are required, and cardiac images provide an excellent source of subject-specific and in vivo information. Noninvasive and individualized cardiac mechanical studies can be achieved through coupling general physiological models derived from invasive experiments with subject-specific information extracted from medical images. Nevertheless, as data extracted from images are gross, sparse, or noisy, and do not directly provide the information of interest in general, the couplings between models and measurements are complicated inverse problems with numerous issues [that] need to be carefully considered. The goal of this research is to develop a noninvasive framework for studying individualized cardiac mechanics through systematic coupling between cardiac physiological models and medical images according to their respective merits. More specifically, nonlinear state-space filtering frameworks for recovering individualized cardiac deformation and local material parameters of realistic nonlinear constitutive laws have been proposed. to ensure the physiological meaningfulness, clinical relevance, and computational feasibility of the frameworks, five key issues have to be properly addressed, including the cardiac physiological model, the heart representation in the computational environment, the information extraction from cardiac images, the coupling between models and image information, and also the computational complexity. For the cardiac physiological model, a cardiac physiome model tailored fro cardiac image analysis has been proposed to provide a macroscopic physiological foundation for the study. For the heart representation, a meshfree method has been adopted to facilitate implementations and spatial accuracy refinements. For the information extraction from cardiac images, a registration method based on free-form deformation has been adopted for robust motion tracking. For the coupling between models and images, state-space filtering has been applied to systematically couple the models with the measurements. For the computational complexity, a mode superposition approach has been adopted to project the system into an equivalent mathematical space with much fewer dimensions for computationally feasible filtering. Experiments were performed on both synthetic and clinical data to verify the proposed frameworks."--Abstract.



The Digital Patient


The Digital Patient
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Author : C. D. Combs
language : en
Publisher: John Wiley & Sons
Release Date : 2015-12-11

The Digital Patient written by C. D. Combs and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-11 with Mathematics categories.


A modern guide to computational models and constructive simulation for personalized patient care using the Digital Patient The healthcare industry’s emphasis is shifting from merely reacting to disease to preventing disease and promoting wellness. Addressing one of the more hopeful Big Data undertakings, The Digital Patient: Advancing Healthcare, Research, and Education presents a timely resource on the construction and deployment of the Digital Patient and its effects on healthcare, research, and education. The Digital Patient will not be constructed based solely on new information from all the “omics” fields; it also includes systems analysis, Big Data, and the various efforts to model the human physiome and represent it virtually. The Digital Patient will be realized through the purposeful collaboration of patients as well as scientific, clinical, and policy researchers. The Digital Patient: Advancing Healthcare, Research, and Education addresses the international research efforts that are leading to the development of the Digital Patient, the wealth of ongoing research in systems biology and multiscale simulation, and the imminent applications within the domain of personalized healthcare. Chapter coverage includes: The visible human The physiological human The virtual human Research in systems biology Multi-scale modeling Personalized medicine Self-quantification Visualization Computational modeling Interdisciplinary collaboration The Digital Patient: Advancing Healthcare, Research, and Education is a useful reference for simulation professionals such as clinicians, medical directors, managers, simulation technologists, faculty members, and educators involved in research and development in the life sciences, physical sciences, and engineering. The book is also an ideal supplement for graduate-level courses related to human modeling, simulation, and visualization.



Modeling Of Physiological Flows


Modeling Of Physiological Flows
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Author : Davide Ambrosi
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-10-31

Modeling Of Physiological Flows written by Davide Ambrosi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-31 with Mathematics categories.


This book offers a mathematical update of the state of the art of the research in the field of mathematical and numerical models of the circulatory system. It is structured into different chapters, written by outstanding experts in the field. Many fundamental issues are considered, such as: the mathematical representation of vascular geometries extracted from medical images, modelling blood rheology and the complex multilayer structure of the vascular tissue, and its possible pathologies, the mechanical and chemical interaction between blood and vascular walls, and the different scales coupling local and systemic dynamics. All of these topics introduce challenging mathematical and numerical problems, demanding for advanced analysis and efficient simulation techniques, and pay constant attention to applications of relevant clinical interest. This book is addressed to graduate students and researchers in the field of bioengineering, applied mathematics and medicine, wishing to engage themselves in the fascinating task of modeling the cardiovascular system or, more broadly, physiological flows.



Deformable Models


Deformable Models
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Author : Aly Farag
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-08-21

Deformable Models written by Aly Farag and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-21 with Medical categories.


This book covers the complete spectrum of deformable models, its evolution as an imagery field and its use in many biomedical engineering and clinical application disciplines. It includes level sets, PDEs, curve and surface evolution and their applications in biomedical fields covering both static and motion imagery.



Deformable Models


Deformable Models
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Author : Aly Farag
language : en
Publisher: Springer
Release Date : 2007-08-02

Deformable Models written by Aly Farag and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-02 with Medical categories.


This book covers the complete spectrum of deformable models, its evolution as an imagery field and its use in many biomedical engineering and clinical application disciplines. It includes level sets, PDEs, curve and surface evolution and their applications in biomedical fields covering both static and motion imagery.



Repair And Redesign Of Physiological Systems


Repair And Redesign Of Physiological Systems
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Author : Mark A. Atherton
language : en
Publisher: WIT Press
Release Date : 2008-07-15

Repair And Redesign Of Physiological Systems written by Mark A. Atherton and has been published by WIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-07-15 with Science categories.


In this volume the author highlights the role of engineering and relevant mathematics in medicine. Like engineering systems, human physiology can wear out or fail to an extent where it requires a clinical interventionist to repair or even redesign the system. There is a long tradition amongst clinicians of working with engineers and mathematicians, and this volume continues the theme with modern developments. Hence chapters deal with vascular surgery planning, cardiac and vascular devices, immunotherapeutics, plus nasal and dental repair. More generically, some of these chapters relate to preserving the integrity of the human 'surface structure', as well as the challenges in computer modeling the complexities and multiscale nature of the human physiome.



Principles Of Genetics And Molecular Epidemiology


Principles Of Genetics And Molecular Epidemiology
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Author : Juan Carlos Gomez-Verjan
language : en
Publisher: Springer Nature
Release Date : 2022-01-28

Principles Of Genetics And Molecular Epidemiology written by Juan Carlos Gomez-Verjan and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-28 with Science categories.


This book covers some of the most novel genetic and genomic concepts in epidemiology, such as geospatial statistics and systems biology from a clinical point of view by explaining molecular applications with accessible human studies. Featuring a comprehensive table of contents, it includes chapters from genomics and epidemiology surveillance to transcriptomics and alternative splicing principles. Across 17 well-organized chapters, this book meets attempt to explain easily to clinicians and students with basic principles of the genetics, genomics, molecular biology and its applications to epidemiology and public health. The text is distinct from other literature on the market because it covers useful genomic tools applied in epidemiology for clinicians who may not be experts in this branch of health science. Principles of Genetics and Molecular Epidemiology demystifies the idea that biomedicine is far from being applied in both epidemiology and clinical practice.



Medical Image Computing And Computer Assisted Intervention Miccai 2007


Medical Image Computing And Computer Assisted Intervention Miccai 2007
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Author : Nicholas Ayache
language : en
Publisher: Springer
Release Date : 2007-11-22

Medical Image Computing And Computer Assisted Intervention Miccai 2007 written by Nicholas Ayache and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-22 with Computers categories.


This title is part of a two-volume set that constitute the refereed proceedings of the 10th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2007. Coverage in this first volume includes diffusion tensor imaging and computing, cardiac imaging and robotics, image segmentation and classification, image guided intervention and robotics, innovative clinical and biological applications, brain atlas computing, and simulation of therapy.



Medical Image Computing And Computer Assisted Intervention Miccai 2010


Medical Image Computing And Computer Assisted Intervention Miccai 2010
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Author : Tianzi Jiang
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-09

Medical Image Computing And Computer Assisted Intervention Miccai 2010 written by Tianzi Jiang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09 with Computers categories.


The three-volume set LNCS 6361, 6362 and 6363 constitutes the refereed proceedings of the 13th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2010, held in Beijing, China, in September 2010. Based on rigorous peer reviews, the program committee carefully selected 251 revised papers from 786 submissions for presentation in three volumes. The first volume includes 84 papers organized in topical sections on computer-aided diagnosis, planning and guidance of interventions, image segmentation, image reconstruction and restoration, functional and diffusion-weighted MRI, modeling and simulation, instrument and patient localization and tracking, quantitative image analysis, image registration, computational and interventional cardiology, and diffusion tensor MR imaging and analysis.