Combatendo Doen As Financeiras
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
The Takeover Of Social Policy By Financialization
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Author : Lena Lavinas
language : en
Publisher: Springer
Release Date : 2017-03-25
The Takeover Of Social Policy By Financialization written by Lena Lavinas and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-25 with Business & Economics categories.
This book critically addresses the model of social inclusion that prevailed in Brazil under the rule of the Workers Party from the early 2000s until 2015. It examines how the emergence of a mass consumer society proved insufficient, not only to overcome underdevelopment, but also to consolidate the comprehensive social protection system inherited from Brazil’s 1988 Constitution. By juxtaposing different theoretical frameworks, this book scrutinizes how the current finance-dominated capitalism has reshaped the role of social policy, away from rights-based decommodified benefits and towards further commodification. This constitutes the Brazilian paradox: how a center-left government has promoted and boosted financialization through a market incorporation strategy using credit as a lever for expanding financial inclusion. In so doing, it has pushed the subjection of social policy further into the logic of financial markets.
The Power Of Habit
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Author : Charles Duhigg
language : en
Publisher: Random House
Release Date : 2012-02-28
The Power Of Habit written by Charles Duhigg and has been published by Random House this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-28 with Business & Economics categories.
NEW YORK TIMES BESTSELLER • This instant classic explores how we can change our lives by changing our habits. NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The Wall Street Journal • Financial Times In The Power of Habit, award-winning business reporter Charles Duhigg takes us to the thrilling edge of scientific discoveries that explain why habits exist and how they can be changed. Distilling vast amounts of information into engrossing narratives that take us from the boardrooms of Procter & Gamble to the sidelines of the NFL to the front lines of the civil rights movement, Duhigg presents a whole new understanding of human nature and its potential. At its core, The Power of Habit contains an exhilarating argument: The key to exercising regularly, losing weight, being more productive, and achieving success is understanding how habits work. As Duhigg shows, by harnessing this new science, we can transform our businesses, our communities, and our lives. With a new Afterword by the author “Sharp, provocative, and useful.”—Jim Collins “Few [books] become essential manuals for business and living. The Power of Habit is an exception. Charles Duhigg not only explains how habits are formed but how to kick bad ones and hang on to the good.”—Financial Times “A flat-out great read.”—David Allen, bestselling author of Getting Things Done: The Art of Stress-Free Productivity “You’ll never look at yourself, your organization, or your world quite the same way.”—Daniel H. Pink, bestselling author of Drive and A Whole New Mind “Entertaining . . . enjoyable . . . fascinating . . . a serious look at the science of habit formation and change.”—The New York Times Book Review
Preclinical Safety Evaluation Of Biopharmaceuticals
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Author : Joy A. Cavagnaro
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-07
Preclinical Safety Evaluation Of Biopharmaceuticals written by Joy A. Cavagnaro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.
"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.
Auditor Going Concern Reporting
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Author : Marshall A. Geiger
language : en
Publisher: Routledge
Release Date : 2021-06-09
Auditor Going Concern Reporting written by Marshall A. Geiger and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-09 with Business & Economics categories.
Auditor reporting on going-concern-related uncertainties remains one of the most challenging issues faced by external auditors. Business owners, market participants and audit regulators want an early warning of impending business failure. However, companies typically do not welcome audit opinions indicating uncertainty regarding their future viability. Thus, the auditor’s decision to issue a "going concern opinion" (GCO) is a complex and multi-layered one, facing a great deal of tension. Given such a rich context, academic researchers have examined many facets related to an auditor’s decision to issue a GCO. This monograph reviews and synthesizes 182 recent GCO studies that have appeared since the last significant review published in 2013 through the end of 2019. The authors categorize studies into the three broad areas of GCO: (1) determinants, (2) accuracy and (3) consequences. As an integral part of their synthesis, they summarize the details of each study in several user-friendly tables. After discussing and synthesizing the research, they present a discussion of opportunities for future research, including issues created or exacerbated as a result of the global COVID-19 pandemic. This monograph will be of assistance to researchers interested in exploring this area of auditor responsibility. It will also be of interest to auditing firms and individual practitioners wanting to learn what academic research has examined and found regarding this challenging aspect of audit practice. Auditing standard-setters and regulators will find it of interest as the authors review numerous studies examining issues related to audit policy and regulation, and their effects on GCO decisions. The examination of GCO research is extremely timely given the financial and business disruption caused by the worldwide COVID-19 pandemic. This unprecedented global event has caused companies, auditors and professional bodies to revisit and reassess their approach to going concern, and to think even more deeply about this fundamental business imperative.
Brazil Economic Program
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Author :
language : en
Publisher:
Release Date : 1993
Brazil Economic Program written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Monetary policy categories.
World Bank Atlas 2003
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Author :
language : en
Publisher: World Bank Publications
Release Date : 2003-01-01
World Bank Atlas 2003 written by and has been published by World Bank Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-01-01 with Business & Economics categories.
This atlas provides an overview of key development indicators regarding social, economic and environmental data for 208 countries in the form of informative colour maps, charts and tables. Drawing on the thematic discussions contained in the "World Development Indicators 2003" publication (ISBN 0821354221), it considers a range of aspects organised under three sections relating to: measuring the world, measuring development and measuring action. Topics discussed include: life expectancy, infant mortality, safe water, population below the poverty line, girls in school, energy efficiency and greenhouse gas emissions, as well as basic economic indicators such as income growth, income per capita, private capital and aid flows.
Rupture
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Author : Manuel Castells
language : en
Publisher: Polity
Release Date : 2018-12-03
Rupture written by Manuel Castells and has been published by Polity this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-03 with Social Science categories.
The majority of citizens in the world today do not trust their political representatives, the mainstream political parties, the established political institutions or their governments. This widespread crisis of legitimacy underlies a series of dramatic changes that have taken place in recent times in the global political landscape, such as the unexpected election of Donald Trump, Brexit, the demise of traditional political parties and the election of a political outsider in France, the transformation of the political system in Spain (including the secessionist movement in Catalonia), the rise of the extreme right in Europe and the nationalist challenges that threaten the European Union. In this short but wide-ranging book Manuel Castells analyses each of these processes and examines some of the potential causes of people’s disaffection towards the institutions of liberal democracy, including the effects of globalization, the impact of media politics and the internet, the increasing corruption of politicians, the insulation of a professional political class from civil society and the critique of the existing order by new social movements. He also examines the impact of global terrorism and war on the xenophobia and racism that are fuelling the surge of extremism among a growing proportion of the population. The fact that many of these trends are present in very different contexts suggests that we are witnessing a deep-seated crisis of the model of democracy that has been the cornerstone of stability and civility in the last half century.
International Convergence Of Capital Measurement And Capital Standards
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Author :
language : en
Publisher: Lulu.com
Release Date : 2004
International Convergence Of Capital Measurement And Capital Standards written by and has been published by Lulu.com this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Bank capital categories.
Cooperativas De Cr Dito
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Author : LENISE FARIA DE OLIVEIRA MENDES
language : pt-BR
Publisher: Editora Thoth
Release Date : 2024-04-30
Cooperativas De Cr Dito written by LENISE FARIA DE OLIVEIRA MENDES and has been published by Editora Thoth this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-30 with Antiques & Collectibles categories.
Este livro tem como tema o cooperativismo financeiro e o agronegócio, com recorte na sustentabilidade financeira das cooperativas de crédito ou financeiras, atuantes no agronegócio. Este tema foi escolhido em virtude da grande aclamação pública em apoiar o agronegócio “custe o que custar”, no entanto, quando se trata de uma instituição financeira, formada por meio de sociedade de pessoas, administrada por representantes dessas pessoas, que devem seguir diversos normativos, assim como as demais instituições financeiras, além dos princípios cooperativistas, a gestão deve ser bem fundamentada, sob pena de decretação de intervenção ou liquidação extrajudicial, no âmbito civil e penal. Portanto, diante da expansão do cooperativismo financeiro no país, até com incentivos por parte do Banco Central, a sua responsabilidade frente ao agronegócio também se expandiu. Sem deixar de cumprir com os princípios cooperativistas, a gestão de risco, de capital, os sistemas de Governança e ESG seguem lateralmente em busca da sustentabilidade financeira destas instituições financeiras cooperativas, a fim de garantir sua perenidade e o desenvolvimento de toda sociedade onde estão inseridas, sem esquecer que o sistema jurídico impacta o sistema econômico