Comparison Of 68ga Hbed Cc Psma Pet Ct And Multiparametric Mri For Gross Tumour Volume Detection In Patients With Primary Prostate Cancer Based On Slice By Slice Comparison With Histopathology
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Comparison Of 68ga Hbed Cc Psma Pet Ct And Multiparametric Mri For Gross Tumour Volume Detection In Patients With Primary Prostate Cancer Based On Slice By Slice Comparison With Histopathology
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Author : Constantinos Zamboglou
language : en
Publisher:
Release Date : 2017
Comparison Of 68ga Hbed Cc Psma Pet Ct And Multiparametric Mri For Gross Tumour Volume Detection In Patients With Primary Prostate Cancer Based On Slice By Slice Comparison With Histopathology written by Constantinos Zamboglou and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Abstract: Purpose: The exact detection and delineation of the intraprostatic tumour burden is crucial for treatment planning in primary prostate cancer (PCa). We compared 68Ga-HBED-CC-PSMA PET/CT with multiparametric MRI (mpMRI) for diagnosis and tumour delineation in patients with primary PCa based on slice by slice correlation with histopathological reference material. Methodology: Seven patients with histopathologically proven primary PCa underwent 68Ga-HBED-CC-PSMA PET/CT and MRI followed by radical prostatectomy. Resected prostates were scanned by ex-vivo CT in a special localizer and prepared for histopathology. Invasive PCa was delineated on a HE stained histologic tissue slide and matched to ex-vivo CT to obtain gross tumor volume (GTV-)histo. Ex-vivo CT including GTV-histo and MRI data were matched to in-vivo CT(PET). Consensus contours based on MRI (GTV-MRI), PSMA PET (GTV-PET) or the combination of both (GTV-union/-intersection) were created. In each in-vivo CT slice the prostate was separated into 4 equal segments and sensitivity and specificity for PSMA PET and mpMRI were assessed by comparison with histological reference material. Furthermore, the spatial overlap between GTV-histo and GTV-PET/-MRI and the Sørensen-Dice coefficient (DSC) were calculated. In the case of multifocal PCa (4/7 patients), SUV values (PSMA PET) and ADC-values (diffusion weighted MRI) were obtained for each lesion. Results: PSMA PET and mpMRI detected PCa in all patients. GTV-histo was detected in 225 of 340 segments (66.2%). Sensitivity and specificity for GTV-PET, GTV-MRI, GTV-union and GTV-intersection were 75% and 87%, 70% and 82%, 82% and 67%, 55% and 99%, respectively. GTV-histo had on average the highest overlap with GTV-union (57±22%), which was significantly higher than overlap with GTV-MRI (p=0.016) and GTV-PET (p=0.016), respectively. The mean DSC for GTV-union, GTV-PET and GTV-MRI was 0.51 (±0.18), 0.45 (±0.17) and 0.48 (±0.19), respectively. In every patient with multifocal PCa there was one lesion which had both the highest SUV and the lowest ADC-value (mean and max). Conclusion: In a slice by slice analysis with histopathology, 68Ga-HBED-CC-PSMA PET/CT and mpMRI showed high sensitivity and specificity in detection of primary PCa. A combination of both methods performed even better in terms of sensitivity (GTV-union) and specificity (GTV-intersection). A moderate to good spatial overlap with GTV-histo was observed for PSMA PET/CT and mpMRI alone which was significantly improved by GTV-union. Further studies are warranted to analyse the impact of these preliminary findings for diagnostic (multimodal guided TRUS biopsy) and therapeutic (focal therapy) strategies in primary PCa
Exploring The Potential Of Psma Pet Imaging On Personalized Prostate Cancer Treatment
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Author : Constantinos Zamboglou
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-04
Exploring The Potential Of Psma Pet Imaging On Personalized Prostate Cancer Treatment written by Constantinos Zamboglou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-04 with Medical categories.
Target Volume Definition In Radiation Oncology
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Author : Anca-Ligia Grosu
language : en
Publisher: Springer Nature
Release Date :
Target Volume Definition In Radiation Oncology written by Anca-Ligia Grosu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Pet Based Novel Imaging Techniques With Recently Introduced Radiotracers An Issue Of Pet Clinics
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Author : Mona-Elisabeth R. Revheim
language : en
Publisher: Elsevier Health Sciences
Release Date : 2021-03-04
Pet Based Novel Imaging Techniques With Recently Introduced Radiotracers An Issue Of Pet Clinics written by Mona-Elisabeth R. Revheim and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-04 with Medical categories.
This issue of PET Clinics focuses on PET-Based Novel Imaging Techniques with Recently Introduced Radiotracers and is edited by Drs. Mona-Elisabeth R. Revheim and Abass Alavi. Articles will include: Prostate-Specific Membrane Antigen PET in Prostate Cancer: 68Ga/18F labelled; Critical Role of FDG in Hormonally Active Malignancies; Role of Amino-Acid Tracers and FDG in the Diagnosis of Brain Tumors; FACBC/Fluciclovine PET Imaging in Prostate Cancer; Somatostatin PET in NEN: DOTA-peptides + 68Ga/64Cu labelled; Imaging of Insulinoma with PET: DOTA-peptides, Exendin-4 PET/CT; Preclinical Evaluation of TSPO and MAO-B PET Radiotracers in an LPS Model of Neuroinflammation; Molecular Imaging of Movement Disorders; Imaging of Cardiac Amyloidosis; and more!
Advances In Radiotherapy For Prostate Cancer
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Author : Constantinos Zamboglou
language : en
Publisher: Frontiers Media SA
Release Date : 2023-01-30
Advances In Radiotherapy For Prostate Cancer written by Constantinos Zamboglou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-30 with Medical categories.
Imaging And Interventional Radiology For Radiation Oncology
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Author : Regina G.H. Beets-Tan
language : en
Publisher: Springer Nature
Release Date : 2020-08-10
Imaging And Interventional Radiology For Radiation Oncology written by Regina G.H. Beets-Tan and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-10 with Medical categories.
This book, edited by leading experts in radiology, nuclear medicine, and radiation oncology, offers a wide-ranging, state of the art overview of the specifics and the benefits of a multidisciplinary approach to the use of imaging in image-guided radiation treatments for different tumor types. The entire spectrum of the most important cancers treated by radiation are covered, including CNS, head and neck, lung, breast, gastrointestinal, genitourinary, and gynecological tumors. The opening sections of the book address background issues and a range of important technical aspects. Detailed information is then provided on the use of different imaging techniques for T staging and target volume delineation, response assessment, and follow-up in various parts of the body. The focus of the book ensures that it will be of interest for a multidisciplinary forum of readers comprising radiation oncologists, nuclear medicine physicians, radiologists and other medical professionals.
Pet Ct In Prostate Cancer
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Author : Gary Cook
language : en
Publisher: Springer
Release Date : 2017-07-24
Pet Ct In Prostate Cancer written by Gary Cook and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-24 with Medical categories.
This pocket book explains the significant and well-documented impact that PET/CT can have on the management of prostate cancer through the provision of high-quality evidence regarding function and structure. Up-to-date information is supplied on the relevance of PET/CT to diagnosis, treatment planning, and therapy, including the emerging role of PET/CT with PSMA. Readers will also find clear explanation of the relation of the clinical and pathological background to imaging and the value of PET/CT compared with conventional radiological imaging. The book will be an excellent asset for referring clinicians, nuclear medicine/radiology physicians, radiographers/technologists, and nurses who routinely work in nuclear medicine and participate in multidisciplinary meetings. It is published within the Springer series Clinicians’ Guides to Radionuclide Hybrid Imaging, which presents contributions from professionals worldwide who share a common purpose in promoting nuclear medicine as an important imaging specialty for the diagnosis and management of oncological and non-oncological conditions.
Radioguided Surgery
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Author : Giuliano Mariani
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-05-10
Radioguided Surgery written by Giuliano Mariani and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-10 with Medical categories.
This multidisciplinary textbook is designed to be the standard on the subject and is geared for use by physicians who are involved in the care and/or diagnosis of cancer patients. Comprehensive coverage is provided on all aspects of radioguided surgery. Practical information is readily accessible and throughout there is an emphasis on improved decision making. Tables present the indications, performance, and interpretation of procedures at a glance. A wealth of illustrations, including a full-color insert, enhances the application of new concepts.
Salvage Therapy For Prostate Cancer
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Author : Sanchia S. Goonewardene
language : en
Publisher: Springer Nature
Release Date : 2020-11-23
Salvage Therapy For Prostate Cancer written by Sanchia S. Goonewardene and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-23 with Medical categories.
This book comprehensively covers application of salvage therapy in reccurrent prostate cancer. Chapters focus on specific issues associated with a range of surgical and oncological management techniques and strategies including hormone therapy, lymphnode dissection, robotic prostatectomy and salvage reirradiation after locoregional failure. Learning objectives, and definitions of keywords are provided to aid the reader develop a thorough understanding of the topic and reinforce the key points covered in each chapter. Salvage Therapy for Prostate Cancer provides a detailed practically applicable guide on how salvage therapy can be utilised in the treatment of prostate cancer. It represents a valuable resource for trainee and practicing urologists, oncologists, and specialist nurses.
Anatomy For Urologic Surgeons In The Digital Era
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Author : Emre Huri
language : en
Publisher: Springer Nature
Release Date : 2021-11-01
Anatomy For Urologic Surgeons In The Digital Era written by Emre Huri and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-01 with Medical categories.
This book provides a practical guide in the use of imaging and visualization technologies in urology. It details how output from diagnostic systems, can be represented through synthetic, virtual and augmented reality tools, such as holograms and three dimensional (3D) modelling and how they can improve everyday surgical procedures including laparoscopic, robotic-assisted, open, endoscopic along with the latest and most innovative approaches. Anatomy for Urologic Surgeons in the Digital Era: Scanning, Modelling and 3D Printing systematically reviews diagnostic imaging, visualization tools available in urology and is a valuable resource for all practicing and in-training urological surgeons.