Contribution Of Heat Shock Protein 27 And Retinol Binding Protein To 11 Deoxy 16 16 Dimethyl Prostaglandin E2 Mediated Cytoprotection
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Contribution Of Heat Shock Protein 27 And Retinol Binding Protein To 11 Deoxy 16 16 Dimethyl Prostaglandin E2 Mediated Cytoprotection
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Author : Jean Lanette Lord-Garcia
language : en
Publisher:
Release Date : 2008
Contribution Of Heat Shock Protein 27 And Retinol Binding Protein To 11 Deoxy 16 16 Dimethyl Prostaglandin E2 Mediated Cytoprotection written by Jean Lanette Lord-Garcia and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
11-Deoxy-16,16-dimethyl prostaglandin E2 (DDM-PGE2) protects renal proximal tubular epithelial cells (LLC-PK1) against oncotic cell death induced by 2,3,5-tris(glutathione-S-yl)hydroquinone (TGHQ). Cytoprotection is associated with the up-regulation of several proteins including actin, heat shock protein 27 (Hsp27) and retinol binding protein (RBP). This dissertation reveals the induction and phosphorylation of Hsp27 by TGHQ treatment and DDM-PGE2 pretreatment. Treatment with TGHQ results in a dose-dependent disruption of the actin cytoskeleton that correlates with a decrease in cell viability, increased generation of reactive oxygen species, and the induction of Hsp27 nuclear translocation and co-localization with actin. Moreover, DDM-PGE2 pretreatment, but not co-treatment, prevents both TGHQ generation of ROS and actin cytoskeletal damage. DDM-PGE2 results in the enhanced induction and phosphorylation of nuclear Hsp27 that likely contributes to the inhibition of early effects of TGHQ induced ROS generation on the actin cytoskeleton. In correlation, we identify site specific phosphorylation of Hsp27 (p-Hsp27) at human Ser82 that negatively regulates cell survival, and p-Hsp27 at Ser15 associated with cell survival. We provide evidence that the TP receptor dependent increase in RBP expression is based on the ability of DDM-PGE2 to recruit the retinoid signalingpathway through activation of the RAR/RXR nuclear receptor heterodimers. All-trans retinoic acid (AtRA) pretreatment recapitulates the protective effects of DDM-PGE2 through a mechanism independent of TP receptor activation and the cytoprotective effects of AtRA were also investigated using an in vivo model. Finally, the ability of DDM-PGE2 to increase the cells antioxidant response, important in its cytoprotection against ROS is described. Taken together, these studies contribute to the mechanism of protection and will give insight into the affects of novel therapeutics in the modulation of chemical induced nephrotoxicity.
Mechanisms Of 11 Deoxy 16 16 Dimethyl Prostaglandin E2 Mediated Cytoprotection
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Author : Zhe Jia
language : en
Publisher:
Release Date : 2004
Mechanisms Of 11 Deoxy 16 16 Dimethyl Prostaglandin E2 Mediated Cytoprotection written by Zhe Jia and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Cell-mediated cytotoxicity categories.
Dissertation Abstracts International
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Author :
language : en
Publisher:
Release Date : 2008
Dissertation Abstracts International written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Dissertations, Academic categories.
Toxicoepigenetics
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Author : Shaun D. McCullough
language : en
Publisher: Academic Press
Release Date : 2018-11-02
Toxicoepigenetics written by Shaun D. McCullough and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-02 with Medical categories.
Toxicoepigenetics: Core Principles and Applications examines the core aspects of epigenetics, including chromatin biology, DNA methylation, and non-coding RNA, as well as fundamental techniques and considerations for studying each of these mechanisms of epigenetic regulation. Although its integration into the field of toxicology is in its infancy, epigenetics have taken center stage in the study of diseases such as cancer, diabetes, and neurodegeneration. Increasing the presence of epigenetics in toxicological research allows for a more in-depth understanding of important aspects of toxicology such as the role of the environment and lifestyle influencing the individual susceptibility to these effects and the trans-generational transmission of these health effects and susceptibilities. Methods chapters are included to help improve efficacy and efficiency of protocols in both the laboratory and the classroom. Toxicoepigenetics: Core Principles and Applications is an essential book for researchers and academics using epigenetics in toxicology research and study. Introduces the fundamental principles and practices for understanding the role of the epigenome in toxicology Presents the foundation of epigenetics for toxicologists with a broad range of backgrounds Discusses the incorporation of epigenetics and epigenomics into current toxicological studies and interpretation of epigenetic data in toxicological applications
Drugs Affecting Leukotrienes And Other Eicosanoid Pathways
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Author : G. Velo
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Drugs Affecting Leukotrienes And Other Eicosanoid Pathways written by G. Velo and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Benefits Of Resveratrol Supplementation
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Author : María P. Portillo
language : en
Publisher: MDPI
Release Date : 2019-07-23
Benefits Of Resveratrol Supplementation written by María P. Portillo and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-23 with Medical categories.
In recent years, great attention has been paid to polyphenols due to their positive effects on health. One of the most widely-studied phenolic compounds is resveratrol. This molecule, which is naturally present in some foods, shows beneficial effects on various physiological and biochemical processes, thus representing a potential tool for the prevention or the treatment of diseases highly prevalent in our society. Several of these beneficial effects have been observed in human beings, but others only in pre-clinical studies so far, and therefore, it is mandatory to continue with the scientific research in this field. Indeed, new knowledge concerning these issues could enable the development of novel functional foods or nutraceuticals, incorporating resveratrol, suitable for preventing or treating diseases such as cancer, cardiovascular diseases, obesity, dislipemia, insulin resistance and diabetes, liver diseases, etc.
Cancer Drug Design And Discovery
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Author : Stephen Neidle
language : en
Publisher: Elsevier
Release Date : 2011-04-28
Cancer Drug Design And Discovery written by Stephen Neidle and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-28 with Science categories.
The ultimate source of information on the design of new anticancer agents, emphasizing small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects. These advances have provided information on targets involved in specific cancers that are leading to effective medicines for at least some of the common solid tumors. Unique sections explain the basic underlying principles of cancer drug development and provide a practical introduction to modern methods of drug design. Appealing to a broad audience, this is an excellent reference for translational researchers interested in cancer biology and medicine as well as students in pharmacy, pharmacology, or medicinal and biological chemistry and clinicians taking oncology options. * Covers both currently available drugs as well as those under development * Provides a clinical perspective on trials of new anticancer agents * Presents drug discovery examples through the use of case histories
Ranunculales Medicinal Plants
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Author : Da-Cheng Hao
language : en
Publisher: Academic Press
Release Date : 2018-04-23
Ranunculales Medicinal Plants written by Da-Cheng Hao and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-23 with Medical categories.
Ranunculales Medicinal Plants: Biodiversity, Chemodiversity and Pharmacotherapy comprehensively covers this order of flowering plants, detailing the phytochemistry, chemotaxonomy, molecular biology, and phylogeny of selected medicinal plants families and genera and their relevance to drug efficacy. The book carries out an exhaustive survey of the literature in order to characterize global trends in the application of flexible technologies. The interrelationship between Chinese species, and between Chinese and non-Chinese species, is inferred through molecular phylogeny and based on nuclear and chloroplast DNA sequencing. The book discusses the conflict between chemotaxonomy and molecular phylogeny in the context of drug discovery and development. Users will find invaluable and holistic coverage on the study of Ranunculales that will make this the go-to pharmaceutical resource. Describes current perceptions of biodiversity and chemodiversity of Ranunculales Explains how the conceptual framework of plant pharmacophylogeny benefits the sustainable exploitation of Ranunculales Details how Ranunculales medicinal plants work from the chemical level upward Covers how the polypharmacology of Ranunculales compounds might inspire new chemical entity design and development for improved treatment outcomes
Medicinal And Aromatic Plants
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Author : Tariq Aftab
language : en
Publisher: Springer Nature
Release Date : 2021-03-27
Medicinal And Aromatic Plants written by Tariq Aftab and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-27 with Science categories.
Before the concept of history began, humans undoubtedly acquired life benefits by discovering medicinal and aromatic plants (MAPs) that were food and medicine. Today, a variety of available herbs and spices are used and enjoyed throughout the world and continue to promote good health. The international market is also quite welcoming for MAPs and essential oils. The increasing environment and nature conscious buyers encourage producers to produce high quality essential oils. These consumer choices lead to growing preference for organic and herbal based products in the world market. As the benefits of medicinal and aromatic plants are recognized, these plants will have a special role for humans in the future. Until last century, the production of botanicals relies to a large degree on wild-collection. However, the increasing commercial collection, largely unmonitored trade, and habitat loss lead to an incomparably growing pressure on plant populations in the wild. Therefore, medicinal and aromatic plants are of high priority for conservation. Given the above, we bring forth a comprehensive volume, “Medicinal and Aromatic Plants: Healthcare and Industrial Applications”, highlighting the various healthcare, industrial and pharmaceutical applications that are being used on these immensely important MAPs and its future prospects. This collection of chapters from the different areas dealing with MAPs caters to the need of all those who are working or have interest in the above topic.
Bioactive Natural Products In Drug Discovery
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Author : Joginder Singh
language : en
Publisher: Springer Nature
Release Date : 2020-04-30
Bioactive Natural Products In Drug Discovery written by Joginder Singh and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-30 with Medical categories.
This book highlights different natural products that are derived from the plants and microbes that have shown potential as the lead compounds against infectious diseases and cancer. Natural products represent an untapped source of strikingly diverse chemotypes with novel mechanisms of action and the potential to serve as anticancer and anti-infective agents. The book discusses a range of biotechnologically valuable bioactive compounds and secondary metabolites that have been derived from plant and microorganisms from various ecological niches. It also reviews the latest developments in the field of genomics, bioinformatics and industrial fermentation for harnessing the microbial products for commercial applications. In turn, the book’s closing section reviews important biotechnological applications of various natural products. Combining the expertise of specialists in this field, the book’s goal is to promote the further investigation of natural sources for the development of standardized, safe and effective therapies.