Correlation Of Imaging And Pathology To Advance The Study Of Prostate Cancer Focal Therapy
DOWNLOAD
Download Correlation Of Imaging And Pathology To Advance The Study Of Prostate Cancer Focal Therapy PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Correlation Of Imaging And Pathology To Advance The Study Of Prostate Cancer Focal Therapy book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Correlation Of Imaging And Pathology To Advance The Study Of Prostate Cancer Focal Therapy
DOWNLOAD
Author : Alan Martin Priester
language : en
Publisher:
Release Date : 2017
Correlation Of Imaging And Pathology To Advance The Study Of Prostate Cancer Focal Therapy written by Alan Martin Priester and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Prostate cancer, a disease diagnosed in approximately 220,000 men in the U.S. annually, has historically been treated through extirpation of the entire gland. Unfortunately, whole-gland interventions exact a heavy toll, often resulting in incontinence and impotence. One proposed alternative is focal therapy, wherein MR-visible tumor foci are treated locally while sparing the majority of healthy tissue. This approach has great potential to deliver curative treatment while reducing costs and risks. In order to demonstrate the safety, efficacy, and practicality of focal therapy, several key questions remain: 1. How reliably can tumor location be distinguished? 2. What treatment margins are necessary? 3. Can treatment be delivered safely in a clinic setting? This thesis presents a concerted effort to answer these questions, guided by the central hypothesis that focal therapy can be made safe and effective by registering MRI with ultrasound, pathology, and thermal data. To this end, we characterized and clinically implemented a means of accurately correlating MRI with histopathology. We discovered that many tumors extend far beyond the confines of MR-visibility, and the average tumor was three times its predicted volume. Isotropic margins in excess of 1 cm would have been necessary to treat the majority of focal therapy eligible men. However, by registering tracked biopsy data with MRI, we demonstrated that patient-specific treatment margins can greatly improve cancer prediction. We performed clinical trials investigating the safety of focal laser ablation (FLA) of prostate cancer, a modality wherein an interstitial laser delivers thermal energy and induces coagulative necrosis. Through analysis of MRI thermometry data, we found that thermal damage could be predicted with less than 15% volumetric error (0.5 cc). In a second clinical trial, FLA was performed under the guidance of MRI-US fusion imaging. This trial demonstrated that focal therapy could be performed safely, in a clinic setting, and without risk of incontinence or impotence. Furthermore, clinically significant cancer was eliminated from 60% of men, demonstrating the potential efficacy of localized treatment. Future work is necessary to refine all aspects of prostate focal therapy. However, this thesis lays a foundation for safe and effective treatment of localized prostate cancer.
Imaging And Focal Therapy Of Early Prostate Cancer
DOWNLOAD
Author : Thomas J. Polascik
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-02
Imaging And Focal Therapy Of Early Prostate Cancer written by Thomas J. Polascik and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Medical categories.
Imaging and Focal Therapy of Early Prostate Cancer evaluates the scientific evidence for the evolving trend to treat low to intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, focal therapy methods. Various ablative devices such as high intensity focused ultrasound, irreversible electroporation, photodynamic therapy, cryotherapy and laser ablation, among others, are discussed in regard to their strengths and limitations as a therapeutic modality. Emphasis is placed on tumor stage shift towards early stage disease with an increase in unilateral versus bilateral cancers validated by final pathology assessment of large prostatectomy series. Current and new approaches to image cancer foci within the prostate (3-Dimensional contrast-enhanced transrectal ultrasonography, multiparametric magnetic resonance image with spectroscopy, ETC) are presented along with biopsy techniques to map prostate cancer. Patient selection, treatment strategy, outcomes and safety concerns that may provide acceptable cancer control and improved quality of life for patients are all covered in detail. Written by experts in the field and lavishly illustrated with detailed line-art and photographs, Imaging and Focal Therapy of Early Prostate Cancer is a resourceful volume beneficial to practitioners specializing in the treatment and management of prostate cancer.
Active Surveillance For Localized Prostate Cancer
DOWNLOAD
Author : Laurence Klotz
language : en
Publisher: Humana
Release Date : 2018-08-26
Active Surveillance For Localized Prostate Cancer written by Laurence Klotz and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-26 with Medical categories.
This fully updated and revised new edition provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in prostate cancer. The book reviews new data about molecular characteristics of the disease, profiles the new grading system for prostate cancer introduced in 2015, and provides new perspectives about imaging of prostate cancer, as well as the role of targeted biopsies. The text summarizes the role of biomarkers and MRI in patient selection and management and details the world wide results of active surveillance. Specific chapters address communication and ethical issues, QOL outcomes, economic aspects, and psycho-social aspects of surveillance. The role of focal therapy for low risk disease is summarized, and the data supporting preventive interventions during surveillance reviewed. This text will serve as a very useful resource for physicians and researchers dealing with, and interested in this common malignancy, as it provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.
Gynecologic And Urologic Pathology
DOWNLOAD
Author : Maria Rosaria Raspollini
language : en
Publisher: Cambridge University Press
Release Date : 2019-02-21
Gynecologic And Urologic Pathology written by Maria Rosaria Raspollini and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-21 with Medical categories.
This book highlights the similarities and differences in the pathology of the genital and urinary tracts in males and females.
Mri Guided Focused Ultrasound Surgery
DOWNLOAD
Author : Ferenc A. Jolesz
language : en
Publisher: CRC Press
Release Date : 2007-09-26
Mri Guided Focused Ultrasound Surgery written by Ferenc A. Jolesz and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-26 with Medical categories.
MRI-Guided Focused Ultrasound Surgery will be the first publication on this new technology, and will present a variety of current and future clinical applications in tumor ablation treatment. This source helps surgeons and specialists evaluate, analyze, and utilize MRI-guided focused ultrasound surgery - bridging the gap between phase 3 clinical tr
Radioguided Surgery
DOWNLOAD
Author : Giuliano Mariani
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-05-10
Radioguided Surgery written by Giuliano Mariani and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-10 with Medical categories.
This multidisciplinary textbook is designed to be the standard on the subject and is geared for use by physicians who are involved in the care and/or diagnosis of cancer patients. Comprehensive coverage is provided on all aspects of radioguided surgery. Practical information is readily accessible and throughout there is an emphasis on improved decision making. Tables present the indications, performance, and interpretation of procedures at a glance. A wealth of illustrations, including a full-color insert, enhances the application of new concepts.
Urological Pathology
DOWNLOAD
Author : David J. Grignon
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2013-12-18
Urological Pathology written by David J. Grignon and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-18 with Medical categories.
Urological Pathology Knowledge in the field of urologic pathology is growing at an explosive pace. Today's pathologists, specialists, and residents require a comprehensive and authoritative text that examines the full range of urological diseases and their diagnosis. Written by recognized leaders and educators in the field, the text provides readers with a detailed understanding of all diagnostic aspects of urological disease. Inside this unique resource, readers will explore a broad spectrum of practical information—including etiology, diagnostic criteria, molecular markers, differential diagnosis, ancillary tests, and clinical management. This is sure to be the new definitive text for urological pathology! Features: Practical organization presents discussions by organ and by neoplastic/non-neoplastic nature of diseases to help readers access and retrieve essential facts quickly. Expert editors are highly respected academic urologic pathologists. Detailed guidance helps readers identify a range of pathologic entities, recognize typical and atypical presentations, refine diagnosis, and make sound treatment choices. Accompanying website with image bank and fully searchable text allows readers to view critical pathologic features and related discussions at a glance.
Focal Therapy In Prostate Cancer
DOWNLOAD
Author : Hashim Uddin Ahmed
language : en
Publisher: John Wiley & Sons
Release Date : 2011-12-27
Focal Therapy In Prostate Cancer written by Hashim Uddin Ahmed and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-27 with Medical categories.
This book comprehensively reviews the potential of focal therapy and discusses why the changing face of prostate cancer warrants a change in the way we treat men with the disease. It deals with the mechanisms by which disease can be localized within the gland and then the different technologies used for focal ablation. Bringing together eminent contributors in one accessible reference, this book introduces focal therapy to all urologists, oncologists, and radiologists who are involved in the treatment of men with prostate cancer.
Mri And Ct Of The Female Pelvis
DOWNLOAD
Author : Bernd Hamm
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-01-19
Mri And Ct Of The Female Pelvis written by Bernd Hamm and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-19 with Medical categories.
This volume provides a comprehensive account of the use of MRI and CT cross-sectional imaging techniques to identify and characterize developmental anomalies and acquired diseases of the female genital tract. Benign and malignant diseases are considered, and attention is also paid to normal anatomical findings and variants. Emphasis is on the most recent diagnostic and technical advances, and the text is complemented by detailed illustrations.
Adenocarcinoma Of The Prostate
DOWNLOAD
Author : Andrew W. Bruce
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Adenocarcinoma Of The Prostate written by Andrew W. Bruce and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Carcinoma of the prostate increasingly dominates the attention of urologists for both scientific and clinical reasons. The search for an explanation and the prediction of the variable behaviour of the malignant prostatic cell continues unabated. The search for more precise tumour staging and more effective treatment is equally vigorous. Editors Andrew Bruce and John Trachtenberg have assembled acknowledged leaders in prostate cancer to present those areas of direct interest to the clinician. There are a number of other topics that might have been considered but most of these, such as experimental tumour models or biochemical factors affecting cell growth, still lack immediate application for the clinician. Carcinoma of the prostate continues to have its highest incidence in the western world, and the difference in comparison with the incidence in the Far East appears to be real and not masked by diagnostic or other factors. A number of other epidemiological aspects need careful analysis: Is the incidence increasing? Is the survival improving? Is the prognosis worse in the younger patient? Epidemiological data are easily misused and misinterpreted so that a precise analysis of the known facts makes an important opening chapter to this book.