Craniopharyngioma
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Basic Research And Clinical Aspects Of Adamantinomatous Craniopharyngioma
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Author : Juan Pedro Martinez-Barbera
language : en
Publisher: Springer
Release Date : 2017-04-19
Basic Research And Clinical Aspects Of Adamantinomatous Craniopharyngioma written by Juan Pedro Martinez-Barbera and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-19 with Medical categories.
This astute volume brings together the latest expert research on adamantinomatous craniopharyngiomas (ACPs). ACPs are histologically benign but clinically aggressive tumors exhibiting a high propensity for local invasion into the hypothalamus, optic and vascular structures. These tumors, as well as the current treatments, may result in pan-hypopituitarism, diabetes insipidus, morbid obesity followed by type II diabetes mellitus, blindness, as well as serious behavioral and psychosocial impairments. Exploring in detail advances in both the understanding of tumor biology as well as clinical advances in patient management are explored in detail, this book will also look towards potential new treatment approaches. Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma is the first book compiling all current research on ACPs. Mouse and human studies have unequivocally demonstrated that mutations in CTNNB1 encoding -catenin underlie the etiology of the majority, if not all ACP tumors. Genetic studies in mice have shown that ACPs are tumors of the pituitary gland and not of the hypothalamus as previously thought, and are derived from Rathke’s pouch precursors. In addition, a role for tissue-specific adult pituitary stem cells has been revealed as causative of ACP. Together, these studies have provided novel insights into the molecular and cellular etiology as well as the pathogenesis of human ACP. Finally, this volume covers new treatment approaches that have been shown to be effective both in reducing ACP burden as well as reducing the morbidity associated with therapy.
Craniopharyngioma
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Author : Giovanni Broggi
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Craniopharyngioma written by Giovanni Broggi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
Craniopharyngioma represents a major challenge for neurosurgeons, pediatricians, and endocrinologists. This so-called benign tumor is a real threat to quality of life and life itself. This book discusses the various therapeutic strategies and suggests multimodal treatment approaches, including microsurgery, stereotaxis, and alternative treatments. The rationale for choice of therapy is supported by biological, clinical, and neuroradiological data and therapeutic results of a large series of case studies from all over the world are reported. Finally, guidelines for further development and new topics for research and treatment are offered.
Atlas Of Craniopharyngioma
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Author : Songtao Qi
language : en
Publisher: Springer Nature
Release Date : 2019-10-17
Atlas Of Craniopharyngioma written by Songtao Qi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-17 with Medical categories.
This book aims to facilitate readers to understand the origin, growth pattern and relationship between tumor and adherent structure of craniopharyngioma, so as to improve the cure rate and safety of surgery. It’s contributed by Neurosurgery Department of Nanfang Hospital, Southern Medical University, China, which focuses on the management of craniopharyngioma. This book covers histoembryology of craniopharyngioma, together with anatomical morphology and abundant clinical data, systematically showing an innovative classification method, i.e. QST classification. This classification method can better reflect the different origin and growth pattern of craniopharyngioma,the relationship between tumors and surrounding structure of the tumor growth pattern, and clinical significance in surgery. The 70 clinical cases with different classification and treatment history are discussed as an important reference for surgical treatment of craniopharyngioma. The anatomy, morphology and pathology of sellar region also have great reference value for researchers in the field of neural science. The underlying intention of this book is to help bring a change in the concept that “craniopharyngioma is an incurable benign tumor only due to its anatomical location”.
Diagnosis And Management Of Craniopharyngiomas
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Author : Andrea Lania
language : en
Publisher: Springer
Release Date : 2016-04-06
Diagnosis And Management Of Craniopharyngiomas written by Andrea Lania and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-06 with Medical categories.
This book provides up-to-date coverage of the most relevant topics in the diagnosis and management of craniopharyngiomas. After introductory discussion of natural history and clinical presentation, individual chapters are devoted to pathological and molecular aspects, use of diagnostic imaging techniques, the surgical approach to craniopharyngiomas, radiotherapy and radiosurgery, and associated endocrine disturbances. A particular feature of the book is the detailed attention devoted to the metabolic consequences of the disease and related treatments, including obesity and electrolyte disturbances, and to cognitive alterations. This book will be of value to oncologists, neurosurgeons, and endocrinologists by assisting in diagnostic workup, delivery of appropriate treatment, and management of the serious metabolic and endocrine consequences.
Craniopharyngiomas
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Author : James J. Evans
language : en
Publisher: Academic Press
Release Date : 2014-12-26
Craniopharyngiomas written by James J. Evans and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-26 with Medical categories.
Craniopharyngiomas: A Comprehensive Guide to Diagnosis, Treatment and Outcome is a comprehensive guide to the science, diagnosis and treatment of craniopharyngiomas, rare brain tumors that grow near the pituitary gland. Even though these tumors are generally benign, due to the location, prognosis was often bleak. This reference provides a resource for specialists requiring a comprehensive overview of this rare form of tumor, outlining new diagnostic, imaging and surgical techniques, including endoscopic endonasal cranial base surgery, which enable successful neurosurgical intervention. With a better prognosis, patients require multidisciplinary management from neurology, otolaryngology, radiation oncology, endocrinology, and neuropathology. The only comprehensive guide to the science, diagnosis and treatment of craniopharyngiomas Includes multidisciplinary management from neurology, otolaryngology, radiation oncology, endocrinology, and neuropathology Detailed coverage of the impacts of new diagnostic, imaging and neurosurgical techniques including endoscopic endonasal cranial base surgery
Craniopharyngioma A Childhood And Adult Disease With Different Characteristics
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Author : Hermann L. Mueller
language : en
Publisher: Frontiers E-books
Release Date :
Craniopharyngioma A Childhood And Adult Disease With Different Characteristics written by Hermann L. Mueller and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Craniopharyngiomas are benign, partly cystic embryogenic malformations of the sellar region, presumably derived from Rathke cleft epithelium. With an overall incidence of 0.5–2 new cases per million population per year, approximately 30-50% of all cases represent childhood craniopharyngioma. Typical manifestations at primary diagnosis are headache, visual impairment, polyuria/polydypsia, growth retardation, and weight gain. One of the biggest challenges in treating craniopharyngioma is identifying the best candidates for the radical versus the conservative approach. It appears there is a trend towards radiotherapy in centers with past prevalent surgical approaches, and towards more radical surgical treatment strategies in centers historically conservative-oriented. There are current prospective studies underway on a national and multinational level to adopt strategies tailored to risk factors for morbidity and QOL. Therapy of choice in patients with favorable tumor localization is total resection with the intention to maintain optical nerve and hypothalamic-pituitary functions. In patients with unfavorable tumor localization (hypothalamic tumor involvement), a limited resection followed by local irradiation is recommended. The overall survival rates are high (92%). Recurrences after complete resection and progressions of residual tumor after incomplete resection are anticipated subsequent events after primary surgery. In clinical practice, the timing of postoperative residual tumor irradiation is both unclear and inconsistently regarded. Some favor immediate postoperative irradiation in the event of life-impairing clinical conditions, proactively preventing tumor progression. On the other hand, some favor a wait-and-see procedure, delaying irradiation in order to reduce both its necessity and the negative consequences associated with radiation therapy. Inarguably, immediate postoperative irradiation significantly delays tumor progression. However, progression-contingent irradiation has proved effective, as overall survival is statistically unaffected by this wait-and-see strategy. Accordingly, the appropriate time point of irradiation after incomplete resection is currently under investigation in a randomized trial (KRANIOPHARYNGEOM 2007). Quality of life is substantially reduced in appr. 50% of long-term survivors due to sequelae, notably extreme obesity due to hypothalamic involvement. Due to the lack of satisfactory long-term treatment modalities for hypothalamic sequelae, further research on molecular characteristics of craniopharyngioma, pathophysiology of hypothalamic disorders, and pharmaceutical agents to treat hypothalamic obesity are warranted. Risk-adapted surgical strategies at initial diagnosis should aim at a maximal degree of resection, respecting the integrity of optical and hypothalamic structures in order to prevent severe sequelae and therein minimizing consequences that could negative impact patient QOL. Because initial hypothalamic tumor involvement has an apriori effect on the clinical course, childhood craniopharyngioma should be recognized as a chronic disease requiring constant monitoring of the consequences and medical resources for treatment in order to provide not only optimal QOL for patients, but also to garner additional information with the intent of minimizing what at present are severe consequences of both the disease and its treatment.
Adult Craniopharyngiomas
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Author : Emmanuel Jouanneau
language : en
Publisher: Springer Nature
Release Date : 2020-04-09
Adult Craniopharyngiomas written by Emmanuel Jouanneau and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-09 with Medical categories.
This volume focuses on adult craniopharyngiomas, offering various perspectives. The first part of the book provides an up-to-date overview of the pathogenesis and management of adult craniopharyngiomas, helping readers understand the pathogenesis and molecular pathways. It highlights the importance of animal models for addressing molecular keys and for developing targeted therapies. The second part deals with clinical management, detailing the latest results in the era of endoscopic surgery, including the major contribution of the extended nasal endoscopic approaches for suprasellar and retrochiasmatic tumors. The book also discusses the key aspects of these tumors and how to manage them. The last part of the book addresses the future therapies and recurrences after surgery and radiotherapy. This volume is of interest to neurosurgeons, endocrinologists, paediatricians, radiologists and oncologists.
Craniopharyngiomas Classification And Surgical Treatment
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Author : Songtao Qi
language : en
Publisher: Bentham Science Publishers
Release Date : 2017-12-05
Craniopharyngiomas Classification And Surgical Treatment written by Songtao Qi and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-05 with Medical categories.
Craniopharyngiomas are a type of brain tumour in the suprasellar region with benign histological and cellular features. Clinical manifestations of craniopharyngiomas include decreased vision, hypopituitarism, hypothalamus dysfunction, fluid and electrolyte imbalance, glycometabolism, lipid metabolism and obesity. Craniopharyngiomas can show some characteristics of malignant tumours, such as invasion to the surrounding tissues, repetitious recurrence, and rapid growth. These characteristics cause considerable difficulty in patient treatment for neurosurgeons all over the world. This volume presents detailed information about craniopharyngioma anatomy, classification and treatment.
Advances In Craniopharyngioma From Physiology To Clinical Management
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Author : Songbai Gui
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-16
Advances In Craniopharyngioma From Physiology To Clinical Management written by Songbai Gui and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-16 with Science categories.
Craniopharyngioma
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Author : Fred Epstein
language : en
Publisher: S Karger Ag
Release Date : 1994-01-01
Craniopharyngioma written by Fred Epstein and has been published by S Karger Ag this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-01-01 with Brain categories.