Crispr Activation Of Long Non Coding Rna In Mesenchymal Stem Cell For Bone Regeneration
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Crispr Activation Of Long Non Coding Rna In Mesenchymal Stem Cell For Bone Regeneration
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Author : 阮氏翹娘
language : en
Publisher:
Release Date : 2022
Crispr Activation Of Long Non Coding Rna In Mesenchymal Stem Cell For Bone Regeneration written by 阮氏翹娘 and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
Long Non Coding Rna Biology
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Author : M.R.S. Rao
language : en
Publisher: Springer
Release Date : 2017-08-16
Long Non Coding Rna Biology written by M.R.S. Rao and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-16 with Medical categories.
This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.
In Situ Tissue Regeneration
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Author : Sang Jin Lee
language : en
Publisher: Academic Press
Release Date : 2016-07-17
In Situ Tissue Regeneration written by Sang Jin Lee and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-17 with Medical categories.
In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body’s ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body’s own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications. Explores the body’s ability to mobilize endogenous stem cells to the site of injury Details the latest strategies developed for inducing and supporting the body’s own regenerating capacity Presents smart biomaterials in cell-based tissue engineering applications—from the cell level to applications—in the first unified volume Features chapter authors and editors who are authorities in this emerging field Prioritizes a discussion of the future direction of smart biomaterials for in situ tissue regeneration, which will affect an emerging and lucrative industry
Mesenchymal Stem Cell Derived Exosomes
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Author : Yaoliang Tang
language : en
Publisher: Academic Press
Release Date : 2015-09-02
Mesenchymal Stem Cell Derived Exosomes written by Yaoliang Tang and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-02 with Science categories.
Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies
Bone And Cartilage Regeneration
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Author : Phuc Van Pham
language : en
Publisher: Springer
Release Date : 2017-01-24
Bone And Cartilage Regeneration written by Phuc Van Pham and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-24 with Science categories.
This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in bone and cartilage regeneration. Each chapter is contributed by a pre-eminent scientist in the field and covers such topics as skeletal regeneration by mesenchymal stem cells, clinical improvement of mesenchymal stem cell injection in injured cartilage and osteoarthritis, Good manufacturing practice (GMP), minimal critera of stem cells for clinical applications, future directions of the discussed therapies and much more. Bone & Cartilage Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.
Tendon Regeneration
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Author : Manuela E. Gomes
language : en
Publisher: Academic Press
Release Date : 2015-08-08
Tendon Regeneration written by Manuela E. Gomes and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-08 with Science categories.
Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes is the first book to highlight the multi-disciplinary nature of this specialized field and the importance of collaboration between medical and engineering laboratories in the development of tissue-oriented products for tissue engineering and regenerative medicine (TERM) strategies. Beginning with a foundation in developmental biology, the book explores physiology, pathology, and surgical reconstruction, providing guidance on biological approaches that enhances tendon regeneration practices. Contributions from scientists, clinicians, and engineers who are the leading figures in their respective fields present recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field. Provides an overview of tendon biology, disease, and tissue engineering approaches Presents modern, alternative approaches to developing functional tissue solutions discussed Includes valuable information for those interested in tissue engineering, tissue regeneration, tissue physiology, and regenerative medicine Explores physiology, pathology, and surgical reconstruction, building a natural progression that enhances tendon regeneration practices Covers recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field
Cancer Drug Resistance
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Author : Beverly A. Teicher
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-09
Cancer Drug Resistance written by Beverly A. Teicher and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-09 with Medical categories.
Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.
Cells Biomaterials And Biophysical Stimuli For Bone Cartilage And Muscle Regeneration Volume Ii
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Author : Lorenzo Fassina
language : en
Publisher: Frontiers Media SA
Release Date : 2024-05-28
Cells Biomaterials And Biophysical Stimuli For Bone Cartilage And Muscle Regeneration Volume Ii written by Lorenzo Fassina and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-28 with Technology & Engineering categories.
This Research Topic is Volume II of the article collection, Cells, Biomaterials, and Biophysical Stimuli for Bone, Cartilage, and Muscle Regeneration Over the last few years, a variety of tissue engineering strategies have been developed to improve the regeneration of bone, cartilage, and skeletal muscle. Numerous studies have proven that physical factors (external mechanical forces, and biomaterials’ features), as well as biochemical factors, may induce cells to reprogram their functions and dynamically adapt to the cellular microenvironment conditions. The advances in understanding the role of biophysical cues in the stem cells microenvironment point out the importance of their application in biomedicine and biotechnology to drive and modulate cell behavior for therapeutic purposes. In this context, many efforts are dedicated to design different strategies to engineer the physical aspects of the natural cellular microenvironment. The development of these technologies may be useful for identifying and studying the physical factors and help to clarify their downstream mechanisms to control cell behavior. This Research Topic will promote an overview of recent advances and cutting-edge approaches based on primary cells, stem cells, extracellular vesicles (EVs), biomaterial scaffolds, bioreactors, biophysical stimuli (e.g., mechanical forces, electromagnetic waves), and biochemical cues. All research involving one or more of the aforementioned cells and methods is welcome to elucidate new basic-research findings (e.g., molecular insights, biochemical pathways toward regeneration) and possible new clinical strategies (e.g., bioreactors for cell factories). An interdisciplinary design (e.g., biology/biochemistry plus bioengineering) is very welcome.
Skin Tissue Engineering
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Author : Sophie Böttcher-Haberzeth
language : en
Publisher: Springer Nature
Release Date : 2019-05-30
Skin Tissue Engineering written by Sophie Böttcher-Haberzeth and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-30 with Science categories.
This volume provides protocols describing the isolation and culture of diverse cell types stemming from the skin and the use of these cells and cell constructs for wound healing, bioengineering applications, and translational medicine purposes. The book is divided into three sections describing the isolation and culture of diverse skin cells, managing these cells within co-culture systems and skin models, as well as using these skin models in a test setting. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Skin Tissue Engineering: Methods and Protocols serves as a vital aid to basic and clinical researchers such as biologists, physicians, and biomedical engineers working with and being interested in basic science, and clinically and laboratory-applicable translational regenerative medicine.
Mesenchymal Stem Cell Therapy
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Author : Lucas G. Chase
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-12
Mesenchymal Stem Cell Therapy written by Lucas G. Chase and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-12 with Science categories.
Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.