Cytokines And Bone Metabolism
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Cytokines And Bone Metabolism
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Author : Maxine Gowen
language : en
Publisher: CRC Press
Release Date : 1991-12-18
Cytokines And Bone Metabolism written by Maxine Gowen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-12-18 with Medical categories.
Cytokines and Bone Metabolism presents a comprehensive review of the research done to date on the role of cytokines in bone metabolism. All of the major groups of cytokines and growth factors are covered, and more than 2,000 references are included. In each chapter, the biochemistry and wider cellular actions of individual factors are reviewed before data detailing the in vitro and in vivo actions in bone are presented. Extensive reviews of the cell biology of bone, the potential role of cytokines in bone diseases, and the theoretical and practical possibilities for pharmacological intervention based on cytokines as targets are also provided. Cytokines and Bone Metabolism is an indispensable reference for researchers and students in a wide range of medical fields.
Principles Of Osteoimmunology
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Author : Peter Pietschmann
language : en
Publisher: Springer
Release Date : 2016-08-18
Principles Of Osteoimmunology written by Peter Pietschmann and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-18 with Medical categories.
This fully updated and extended second edition provides a comprehensive overview on the basic concepts of the rapidly developing field of osteoimmunology and also offers in-depth insights into the molecular mechanisms of bone diseases. Clinical data is presented and put into context with the latest research findings. This second edition in addition discusses the latest topics in transplantation immunology. The book addresses scientists and physicians working in immunology, pathophysiology and osteology.
Cytokines And Bone
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Author : Eva Bornefalk
language : en
Publisher:
Release Date : 1998
Cytokines And Bone written by Eva Bornefalk and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.
Factors Involved In Bone Metabolism And Osteoclast Function
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Author : Durda Pavasovic
language : en
Publisher:
Release Date : 2011
Factors Involved In Bone Metabolism And Osteoclast Function written by Durda Pavasovic and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Bones categories.
Cytokines such as transforming growth factor β (TGFβ) and tumour necrosis factor α (TNFα) have also been implicated in regulation of osteoclastogenesis and osteoclast function indirectly. These two cytokines exert their effects by acting upon OPG, RANK, RANKL, or M-CSF. From the literature TGFβ was presented with conflicting in vivo and in vitro effects on bone resorption. Our results support the inhibitory effect of TGFβ and demonstrate TNFα to be a stimulator of bone resorption. When it comes to immunity, interferons (IFNs) play a crucial role and they also play an important role in osteoclast biology. To study the effects of type 1 IFNs in vivo we generated Ifnar1 and Ifnar2 deficient mice. These mice were shown to be null for conventional IFN-induced Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling. Our studies on Ifnar1 and Ifnar2 knockout mice demonstrated enhanced generation of osteoclasts in vitro. Consequently the number of multinucleated TRAP positive cells was increased and as expected mice developed osteoporotic phenotype, characterised by reduced bone density. Many other cytokines, proteins and various other factors play an important role in the proliferative phase of osteoclast precursors and/or in the terminal differentiation phase and/or in the bone resorbing activity of fully matured osteoclasts. It is therefore of uttermost importance to account for the fact that osteoclast biology and bone metabolism (as a whole) are regulated via rather complex series/cycles of events that are accomplished at different levels and stages through different pathways.
Cytokines Growth Mediators And Physical Activity In Children During Puberty
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Author : Jaak Jürimäe
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2010-01-01
Cytokines Growth Mediators And Physical Activity In Children During Puberty written by Jaak Jürimäe and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-01 with Medical categories.
Linear growth and sexual maturation are influenced by the actions of the endocrine system as well as by the nutritional status and level of physical activity of an individual. This publication focuses on the latest research regarding different physical growth and energy balance-related mediators in puberty. It summarizes the complex relationship between inflammatory mediators/cytokines, growth factors, body composition, physical fitness and physical activity of children and adolescents. Special emphasis in the book is placed on the role of various recently discovered inflammatory mediators/cytokines in the development of possible metabolic risk factors, in bone metabolism and other body composition parameters. Further, the book considers the adaptation to acute and chronic exercise in children during puberty and the development of possible menstrual irregularities. Health professionals, particularly pediatricians, exercise and sport scientists, coaches, researchers and students will find the book an excellent source of up-to-date information written by leading international experts in the field.
Relationship Of Serum Cytokines And Leukocyte Gene Expression To Bone Mineral Density And Content In Postmenopausal Women
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Author : Erik Randolph Gertz
language : en
Publisher:
Release Date : 2007
Relationship Of Serum Cytokines And Leukocyte Gene Expression To Bone Mineral Density And Content In Postmenopausal Women written by Erik Randolph Gertz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.
Polyfunctional Cytokines
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Author : Gregory R. Bock
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-30
Polyfunctional Cytokines written by Gregory R. Bock and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-30 with Science categories.
Experts from a variety of areas compare and discuss IL-6 and LIF in order to provide a new understanding of their modes of action, the significance of their polyfunctionalization--why the body chooses to use one molecule to regulate various cell types--and their functional overlap. Covers such topics as actions of IL-6 and LIF on lymphoid populations, on megakaryocyte and platelet production, on bone metabolism, their effects on leukemic cells and much more. Includes contributions from researchers working on a variety of cell types and organ systems along with potential clinical applications regarding these two factors.
The Relationship Between Inflammation And Bone Mineral Density And Bone Mineral Content In Postmenopausal Women
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Author : Natalie Erin Silverman
language : en
Publisher:
Release Date : 2006
The Relationship Between Inflammation And Bone Mineral Density And Bone Mineral Content In Postmenopausal Women written by Natalie Erin Silverman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Current Topics In Bone Biology
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Author : Hong-wen Deng
language : en
Publisher: World Scientific
Release Date : 2005
Current Topics In Bone Biology written by Hong-wen Deng and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Science categories.
This book covers a wide spectrum of areas related to basic bone research. While bone remodeling, bone development, and osteoclast biology constitute the main contents, topics important to the understanding of bone metabolism and treatment of bone-related diseases are also intensively reviewed. Three chapters are dedicated to the classic topic of bone mechanics, which include a brief overview of the mechanostat hypothesis, a more detailed review on mechanotransduction and bone adaptation, and a chapter illustrating the basic principles of bone mechanical testing. New emerging fields such as skeletal stem cells, bone tissue engineering, phytoestrogens applications, and bone genetics study using mouse models, are also covered in detail. The book closes with a special chapter dedicated to state-of-the-art advances in bone biology research.
Updates On Osteoimmunology What S New On The Crosstalk Between Bone And Immune Cells
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Author : Giacomina Brunetti
language : en
Publisher: Frontiers Media SA
Release Date : 2020-03-24
Updates On Osteoimmunology What S New On The Crosstalk Between Bone And Immune Cells written by Giacomina Brunetti and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-24 with categories.