Cytokines And Chemokines In Autoimmune Disease
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Cytokines And Chemokines In Autoimmune Disease
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Author : Pere Santamaria
language : en
Publisher: Springer
Release Date : 2003-01-31
Cytokines And Chemokines In Autoimmune Disease written by Pere Santamaria and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-01-31 with Medical categories.
This book attempts to capture recent knowledge on the role of cytokines and chemokines in autoimmunity by focusing on some of the most prevalent organ-specific or systemic autoimmune disorders. After beginning chapters on the function and structure of cytokines and chemokines, sections cover their genetics and mechanisms of action in the context of autoimmunity, and the role of different cytokines and chemokines in various autoimmune disorders. Santamaria teaches in the Department of Microbiology and Infectious Diseases at the University of Calgary, Canada.
Cytokines And Autoimmune Diseases
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Author : Vijay K. Kuchroo
language : en
Publisher: Springer Science & Business Media
Release Date : 2001-11-09
Cytokines And Autoimmune Diseases written by Vijay K. Kuchroo and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-11-09 with Medical categories.
Leading researchers synthesize scattered experimental data to help develop an intimate understanding of how cytokines and chemokines are involved in the pathogenesis of autoimmune diseases. The many chapters offer critical reviews the basic mechanisms controlling cytokine induction and regulation, as well as the resulting production of proinflammatory and anti-inflammatory cytokines, the former of which induces organ-specific autoimmune diseases. From the vantage of these insights, they address the role of cytokines in a wide variety of autoimmune diseases, uvetis, encephalomyelitis, multiple sclerosis, human type 1 diabetes, rheumatoid arthritis, SLE, and myasthenia gravis. Authoritative and state-of-the-art, Cytokines and Autoimmune Disease highlights the enormous therapeutic potential of cytokine modulation in the treatment of autoimmune disease.
Cytokines And Chemokines In Autoimmune Disease
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Author : Santamaria, Pere
language : en
Publisher: Eurekah.Com Incorporated
Release Date : 2003
Cytokines And Chemokines In Autoimmune Disease written by Santamaria, Pere and has been published by Eurekah.Com Incorporated this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Medical categories.
This book attempts to capture recent knowledge on the role of cytokines and chemokines in autoimmunity by focusing on some of the most prevalent organ-specific or systemic autoimmune disorders. After beginning chapters on the function and structure of cytokines and chemokines, sections cover their genetics and mechanisms of action in the context of autoimmunity, and the role of different cytokines and chemokines in various autoimmune disorders. Santamaria teaches in the Department of Microbiology and Infectious Diseases at the University of Calgary, Canada.
Cytokine Frontiers
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Author : Takayuki Yoshimoto
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-10-28
Cytokine Frontiers written by Takayuki Yoshimoto and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-28 with Medical categories.
This book guides the reader through the latest research on the cytokine network, covering signaling pathways, control of the immune response, and potential therapeutics. Different cytokines stimulate diverse responses in various phases of inflammation and immunity, including the innate immune response, the generation of effector T cells, and the development of antibodies by the humoral immune system. It is now clear that the pathophysiology of many infectious, autoimmune, allergic, and malignant diseases can be largely explained by which cytokines are induced and subsequently regulate the cellular responses. In clinical medicine, cytokines are involved in a wide spectrum of diseases. This book describes in three parts the properties and roles of 15 key cytokines under physiological and pathological conditions. Part I presents nine cytokines associated with inflammatory disorders, pro-inflammatory cytokines, and the recently identified new helper T (Th) subset: Th17 cells. Part II gives details of three cytokines associated with allergic disorders, including Th2 responses and recently identified types of innate cells. Part III describes three cytokines that are associated with immunological tolerance and anti-inflammation, including regulatory T (Treg) cells, IL-10-producing Treg (Tr1) cells, and inducible IL-35-producing Treg (iTr35) cells. Cytokines are considered to be important as therapeutic targets for specific agonists or antagonists in numerous immune and inflammatory diseases. The ultimate goal of this book is to facilitate the development of therapeutic treatments for such diseases which has been limited by an insufficient understanding of the biology of cytokines and the complicated network that they create.
Modulating Cytokines As Treatment For Autoimmune Diseases And Cancer
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Author : Erwan Mortier
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-11
Modulating Cytokines As Treatment For Autoimmune Diseases And Cancer written by Erwan Mortier and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-11 with Medical categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Cytokines As Potential Therapeutic Targets For Inflammatory Skin Diseases
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Author : R. Numerof
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-01-19
Cytokines As Potential Therapeutic Targets For Inflammatory Skin Diseases written by R. Numerof and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-19 with Medical categories.
Cytokines and cytokine receptors remain an area of great interest for the development of targeted therapies for cutaneous inflammatory diseases. Anti-TNF therapeutics have proven to be effective in the treatment of psoriasis, and clinical investigations have now begun for other cytokine-directed therapies, such as those targeting IFN-g, IL-12p40, and IL-18. In addition to therapeutics that target cytokines directly, strategies that target cytokine signaling pathways are in development. This book summarizes the findings of the 56th International Workshop of the Ernst Schering Research Foundation that focused on "Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases".
The Dual Roles Of Inflammatory Cytokines And Chemokines In The Regulation Of Autoimmune Diseases And Their Clinical Implications
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Author :
language : en
Publisher:
Release Date : 2013
The Dual Roles Of Inflammatory Cytokines And Chemokines In The Regulation Of Autoimmune Diseases And Their Clinical Implications written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Secretion Of Cytokines And Chemokines By Innate Immune Cells
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Author : Paige Lacy
language : en
Publisher: Frontiers Media SA
Release Date : 2015-05-19
Secretion Of Cytokines And Chemokines By Innate Immune Cells written by Paige Lacy and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-19 with Immunologic diseases. Allergy categories.
The release of cytokines, chemokines, and other immune-modulating mediators released from innate immune cells, including eosinophils, neutrophils, macrophages, dendritic cells, mast cells, and epithelial cells, is an important event in immunity. Cytokine synthesis and transportation occurs through the canonical protein trafficking pathway associated with endoplasmic reticulum and Golgi. How cytokines are released upon their exit from the trans-Golgi network varies enormously between cell types, and in many cells this has not yet been characterized. This issue delves into the plethora of cytokines released by innate immune cells, and where possible, shines light on specific mechanisms that regulate trafficking and release of Golgi-derived vesicles. Each cell type also shows varying degrees of dependency on microtubule organization and actin cytoskeleton remodeling for cytokine secretion. Understanding the mechanisms of cytokine secretion will reveal the inner workings of individual innate immune cell types, and allow identification of critical regulatory steps in cytokine release.
Th 17 Cells Role In Inflammation And Autoimmune Disease
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Author : Valérie Quesniaux
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-03-12
Th 17 Cells Role In Inflammation And Autoimmune Disease written by Valérie Quesniaux and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-12 with Medical categories.
The IL-17 cytokines represent a novel family of cytokines, which defines a new effector T cell, the Th17 cell, and extend the Th1-Th2 paradigm. Th17 cells in part co-express at least IL-17A and IL-17F, IL-21 and IL-22. IL-17 A/F are produced by T cells ( and ), iNKT cells, and possibly neutrophils, dendritic cells and Paneth cells. The regulation of IL-17 family member’s expression, and the identification of effector mechanisms are an area of intense current research. Recognized regulators of IL-17A expression include the nuclear receptor ROR t, proinflammatory cyt- ines such as IL-1, IL-6 with TGF- , IL-21, IL-23 IL-25 in the absence of IFN- and IL-4, which are discussed. Recent data suggest that IL-17A may have a dual fu- tion – pro-inflammatory and anti-inflammatory- suggesting that IL-17A may also contribute to terminate inflammation. Further, a reciprocal regulation of Th17 and regulatory T cells including the role of retinoic acid and TGF- is discussed. The discovery that patients with rheumatoid arthritis, allergic disorders, psor- sis and inflammatory bowel disease express IL-17A generated interest in the medical community and instigated a flurry of experimental research on the potential role of Th17 in inflammatory diseases. Experimental studies confirmed that IL-17A is induced and is critical for the development of allergic lung inflammation, arthritis, bacterial sepsis, experimental allergic encephalomyelitis and myocarditis, as well as other inflammatory con- tions including organ transplantation. The role of IL-17F and IL-22 is still poorly defined and is only slowly emerging.
The Cytokines Of The Immune System
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Author : Zlatko Dembic
language : en
Publisher: Academic Press
Release Date : 2015-05-23
The Cytokines Of The Immune System written by Zlatko Dembic and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-23 with Medical categories.
The Cytokines of the Immune System catalogs cytokines and links them to physiology and pathology, providing a welcome and hugely timely tool for scientists in all related fields. In cataloguing cytokines, it lists their potential for therapeutic use, links them to disease treatments needing further research and development, and shows their utility for learning about the immune system. This book offers a new approach in the study of cytokines by combining detailed guidebook-style cytokine description, disease linking, and presentation of immunologic roles. Supplies new ideas for basic and clinical research Provides cytokine descriptions in a guidebook-style, cataloging the origins, structures, functions, receptors, disease-linkage, and therapeutic potentials Offers a textbook-style view on the immune system with the immunologic role of each cytokine