Degenerative Cervical Myelopathy
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Degenerative Cervical Myelopathy And Radiculopathy
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Author : Michael G. Kaiser
language : en
Publisher: Springer
Release Date : 2018-12-22
Degenerative Cervical Myelopathy And Radiculopathy written by Michael G. Kaiser and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-22 with Medical categories.
Degenerative disorders of the cervical spine are among the more common reasons why patients seek medical attention or consult with a spine specialist. These conditions can lead to neck pain and/or neurological deficit that can significantly compromise an individual’s quality of life. Despite the regularity of these conditions, there remains both uncertainty and controversy regarding optimal management. No standard of care exists, however there are nuances related to a patients history, clinical presentation, and imaging that may make one approach more conducive to clinical success. This text is intended to serve as a comprehensive, up-to-date resource for clinicians involved in the management of patients with cervical degenerative disease. The text is divided into sections, organized in a clinically strategic manner. The initial chapters address the basics of cervical spine anatomy and biomechanics as well as the pathophysiology leading to various cervical degenerative disorders and the possible neurological sequelae. Subsequent chapters outline characteristics of the clinical presentation and the various diagnostic modalities to evaluate these patients. Key elements involved in the surgical-decision making process are covered, providing the necessary elements to establish a solid foundation for treatment planning. The final sections discusses specific procedures; including traditional approaches as well as more recent developments such as motion preservation surgery and minimally invasive techniques. The last section focuses on challenging clinical scenarios that require advanced surgical consideration. Individual chapters are organized with an introductory outline containing key chapter elements. Chapters focusing on specific pathological entities include discussions regarding pathophysiology, genetics, and risk factors. Those describing surgical procedures include a discussion on indications/contraindications, pre-operative planning, surgical technique, post-operative care, and complication avoidance. Chapter authors present their personal experience enhancing the information from current, evidence-based, referenced material. When appropriate, case presentations are added to provide a practical application of chapter’s key points. This text, based on relevant, up-to-date clinical information and the cumulative experience of current spine experts, offers physicians the necessary tools involved in the decision-making process to formulate the optimal treatment plan for an individual patient. In addition, identification of knowledge gaps will hopefully stimulate future research and the evolution of cervical spondylotic treatments.
Degenerative Cervical Myelopathy
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Author : Michael G. Fehlings
language : en
Publisher: Elsevier
Release Date : 2023-11-24
Degenerative Cervical Myelopathy written by Michael G. Fehlings and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-24 with Science categories.
Degenerative Cervical Myelopathy: From Basic Science to Clinical Practice lays the foundation for understanding DCM manifestation, pathophysiology, diagnosis and treatment strategies. The book covers the latest basic and clinical research, updates on patient management strategies, and discusses promising neuroprotective therapies for the future of DCM care. Written by international experts across a range of topics related to degenerative cervical myelopathy, the book helps readers understand the challenges and future directions of patient management. As degenerative cervical myelopathy (DCM) is the leading cause of spinal cord dysfunction and one of the most common indications for spinal surgery worldwide, the term DCM encompasses a group of chronic, non-traumatic spinal cord injuries that occur due to degenerative changes in the cervical spine (e.g. disc spondylosis or repetitive dynamic injury from hyper-mobility). Covers recent clinical trial advancements and the impact of trial findings Presents recent clinical guidelines for the management of degenerative cervical myelopathy, providing readers with insights regarding the translation of research from bench to bedside Provides readers with the skills needed to understand the translational pathway using real-life examples
Cervical Myelopathy An Issue Of Neurosurgery Clinics Of North America E Book
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Author : Michael G. Fehlings
language : en
Publisher: Elsevier Health Sciences
Release Date : 2017-12-01
Cervical Myelopathy An Issue Of Neurosurgery Clinics Of North America E Book written by Michael G. Fehlings and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-01 with Medical categories.
This issue of Neurosurgery Clinics, edited by Dr. Michael G. Fehlings and Dr. Junichi Mizuno, focuses on Cervical Myelopathy. Topics include, but are not limited to, Epidemiology and overview of the clinical spectrum of degenerative cervical myelopathy; Pathobiology of degenerative cervical myelopathy; Natural history of degenerative cervical myelopathy; Imaging evaluation of degenerative cervical myelopathy: current state of the art and future directions; Pathophysiology of CPPD and OYL(OLF); Radiological evaluation of OPLL with dural ossification; Relationship of OALL, OPLL and OYL (OLF); Importance of sagittal alignment of the cervical spine in the management of degenerative cervical myelopathy; Anterior cervical options to manage degenerative cervical myelopathy; Laminectomy with or without fusion to manage degenerative cervical myelopathy; History and evolution of laminoplasty; Prediction of outcomes in managing degenerative cervical myelopathy; Neurological complications in managing degenerative cervical myelopathy; Options to manage the patient with mild degenerative cervical myelopathy; Management of the patient with cervical cord compression but no evidence of myelopathy; Intraoperative neurophysiological monitoring for CDD; Future Directions and New Technology, and more!
Degenerative Cervical Myelopathy And The Aging Spine
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Author : Aria Nouri
language : en
Publisher:
Release Date : 2020
Degenerative Cervical Myelopathy And The Aging Spine written by Aria Nouri and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
This Special Issue contains articles discussing various topics surrounding degenerative cervical myelopathy. The Issue begins with an editorial summarizing the various articles, and is followed by an introductory narrative review focusing on past perspectives, present developments, and future directions. The remaining 11 articles involve a variety of topics, ranging from genetic factors to clinical assessments, imaging, sagittal balance, surgical treatment, and outcome prediction.
Degenerative Cervical Myelopathy
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Author : Eddie De Dios Perez
language : en
Publisher:
Release Date : 2023
Degenerative Cervical Myelopathy written by Eddie De Dios Perez and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
Aospine Masters Series Volume 3 Cervical Degenerative Conditions
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Author : Manabu Ito
language : en
Publisher: Thieme
Release Date : 2014-12-01
Aospine Masters Series Volume 3 Cervical Degenerative Conditions written by Manabu Ito and has been published by Thieme this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-01 with Medical categories.
A focused reference from the world's experts on degenerative cervical conditions This third volume in the AOSpine Masters Series covers the most common operative techniques for treating degenerative cervical conditions. The book provides expert guidance to help clinicians make the right treatment decisions and provide the best care for their patients. Chapter topics range from "Laminectomy and Fusion for Cervical Spondylotic Myelopathy" to "Complications on Anterior Surgery: VA Injury, Esophageal Perforation, and Dysphagia." Key Features: Synthesizes the best available evidence and consensus expert advice on each operative technique for degenerative cervical conditions, leading to optimal clinical recommendations Editors are internationally recognized authorities on the treatment of degenerative cervical conditions Each chapter includes tips and pearls from leaders in the field The AOSpine Masters Series, a co-publication of Thieme and the AOSpine Foundation, addresses current clinical issues whereby international masters of spine share their expertise and recommendations on a particular topic. The goal of the series is to contribute to an evolving, dynamic model of an evidence-based medicine approach to spine care. All neurosurgeons and orthopedic surgeons, along with residents and fellows in these areas, will find this book to be an excellent guide that they will consult often in their treatment of patients with degenerative cervical conditions.
Management Of Degenerative Cervical Myelopathy And Spinal Cord Injury
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Author : Allan R. Martin
language : en
Publisher:
Release Date : 2022
Management Of Degenerative Cervical Myelopathy And Spinal Cord Injury written by Allan R. Martin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
The present Special Issue is dedicated to presenting current research topics in DCM and SCI in an attempt to bridge gaps in knowledge for both of the two main forms of SCI. The issue consists of fourteen studies, of which the majority were on DCM, the more common pathology, while three studies focused on tSCI. This issue includes two narrative reviews, three systematic reviews and nine original research papers. Areas of research covered include image studies, predictive modeling, prognostic factors, and multiple systemic or narrative reviews on various aspects of these conditions. These articles include the contributions of a diverse group of researchers with various approaches to studying SCI coming from multiple countries, including Canada, Czech Republic, Germany, Poland, Switzerland, United Kingdom, and the United States.
Cervical Spondylosis And Similar Disorders
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Author : Keir? Ono
language : en
Publisher: World Scientific
Release Date : 1998
Cervical Spondylosis And Similar Disorders written by Keir? Ono and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.
With rapid advances in medical technology and progress in medicine during the last 27 years, severe disability or sustained neck-shoulder-arm pain secondary to cervical spondylosis can be detected much earlier. Excellent or good results of surgery can be achieved compared to the past, due mainly to advances in diagnostic imaging and surgical procedure.Through research into cervical spondylotic myelopathy, particularly the conditions combined with a narrow spinal canal, orthopaedic surgeons in Japan have revealed the key mechanism involved in myelopathy and the specific manifestation leading to early recognition of the affliction, the ?myelopathy hand?, and have invented a canal-expansive laminoplasty. Extensive decompression of the impinged spinal cord with remarkable ill effects such as instability or adhesion was accomplished for the first time. Further study has been ongoing to clarify the pathomechanism of ?spondylosis? through biomechanical and animal model studies.This volume consists of contributions by experts worldwide on the recent advances in the study of cervical spondylosis and will serve as a valuable reference for all researchers, surgeons and postgraduate students.
Mechanistic Insights And Neuroprotective Approaches To Enhance Recovery In Cervical Spondylotic Myelopathy
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Author : Spyridon Karadimas
language : en
Publisher:
Release Date : 2018
Mechanistic Insights And Neuroprotective Approaches To Enhance Recovery In Cervical Spondylotic Myelopathy written by Spyridon Karadimas and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
The overarching term degenerative cervical myelopathy (DCM) describes the cervical spinal cord compression induced by degenerative changes in the cervical spine. DCM appears as the most common cause of spinal cord dysfunction. Cervical spondylotic myelopathy (CSM), the most common form of DCM, causes significant neurological disabilities including motor, sensory and autonomic impairments. Surgical decompression represents the mainstay of treatment for this common disease. However, many patients do not exhibit full neurological recovery and a number of them can experience neurological deterioration in the acute or subacute phase after surgery. Currently, no pharmacological strategies are available to these patients. Riluzole, a sodium channel blocker, has been shown to be neuroprotective in models of acute spinal cord injury and to attenuate neural degeneration in clinical trials of amyotrophic lateral sclerosis. To test the efficacy of riluzole in experimental CSM, we initially administered riluzole in a rat model of CSM created by graduated mechanical compression of the cervical spinal cord. We found significant tissue sparing, alleviation of neuropathic pain and improvement in locomotor function. However, this model does not allow for surgical decompression and is not MRI compatible. This provided the impetus to develop a novel animal model of CSM that reproduces the chronic, progressive compression of the cervical spinal cord, mimics the clinical and histopathological features of human CSM, is MRI compatible and allows for microsurgical decompression. Using this novel model I discovered that surgical decompression induces early post-operative ischemia-reperfusion injury in the rat cervical spinal cord that was associated with subacute neurological deterioration. These changes were correlated to a subset of patients in the AOSpine CSM prospective study which also exhibited perioperative neurological decline. Of note, riluzole reduced the decompression-mediated reperfusion injury of neurons. Moreover, the combinatorial strategy of microsurgical decompression and riluzole administration resulted in superior preservation of neurons and improvement of neurological function compared to decompressive surgery alone. These results demonstrate the development of ischemia reperfusion injury after surgical decompression in CSM and the potential role of riluzole in alleviating this injury and promoting neurological recovery in CSM.
The Influence Of Symptom Presentation Spinal Cord Compression And Sex On Supraspinal Structure And Function In Patients With Degenerative Cervical Myelopathy
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Author : Talia Oughourlian
language : en
Publisher:
Release Date : 2023
The Influence Of Symptom Presentation Spinal Cord Compression And Sex On Supraspinal Structure And Function In Patients With Degenerative Cervical Myelopathy written by Talia Oughourlian and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
Degenerative cervical myelopathy (DCM) is a chronic, progressive disorder characterized by the age-related degeneration of osseocartilaginous structures within the cervical spine resulting in narrowing of the spinal canal and chronic compression of the spinal cord. Chronic spinal cord compression can result in persisting neck pain and neurological deficits including loss of fine motor skills, weakness or numbness in the upper limbs, and gait abnormalities and imbalance, ultimately requiring surgical intervention to relieve cord compression. DCM is the most common form of spinal cord injury in adults and as the elderly population continues to grow, incidence of DCM will rise alongside an increased demand on healthcare resources. Further investigation into the neural response to chronic spinal cord compression may not only inform disease progression and prognosis but may benefit patient monitoring and treatment planning.This dissertation aims to elucidate how symptom presentation, degree of spinal compression, microstructural and cellular integrity of the affected cord, and sex impact supraspinal structure and function in patients with DCM. To address the goals of the dissertation, we implemented a multimodal neuroimaging approach including anatomical, functional, and diffusion imaging of the brain and T2-weighted, diffusion, and metabolic imaging of the spine. First, we characterized and compared spinal cord compression induced alterations in cerebral morphometry and functional connectivity between symptomatic DCM and asymptomatic spinal cord compression (ASCC) patients to further uncover potential compensatory neural mechanisms driving symptom presentation and disease progression. Because the degree of cervical cord compression is not strongly linked to symptom severity, we investigated whether macrostructural, microstructural, and metabolic properties of the cervical spinal cord result in conventional anatomical and functional alterations within the brains of patients with DCM. Lastly, we identified sex-specific differences on cerebral structure and functional connectivity in patients with DCM. In summary, the dissertation revealed unique cerebral signatures between symptomatic and asymptomatic patients, novel insights into the interrelationship between spinal and supraspinal alterations, and sex-specific supraspinal reorganization in patients with DCM. Findings from this work contribute to our knowledge of disease characteristics and compensatory neural mechanisms; and may benefit future development of non-invasive imaging biomarkers, more precise predicative models to inform disease progression, and novel pharmacological strategies to enhance neuroprotective mechanisms and functional recovery in patients with DCM.