Des G Nes Des Synapses Des Autismes
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Des G Nes Des Synapses Des Autismes
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Author : Thomas Bourgeron
language : fr
Publisher: Odile Jacob
Release Date : 2023-01-18
Des G Nes Des Synapses Des Autismes written by Thomas Bourgeron and has been published by Odile Jacob this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-18 with Science categories.
Plus de 650 000 en France, près de 80 millions dans le monde : c’est le nombre de personnes qui pourraient être concernées par l’autisme. Ce livre expose, pour la première fois, les découvertes du généticien Thomas Bourgeron, chercheur à l’Institut Pasteur. Ses travaux ont révolutionné notre compréhension de l’autisme en démontrant sa part génétique. Cet ouvrage réunit le bilan des immenses progrès scientifiques dans la connaissance de l’autisme aujourd’hui. Avec son équipe, l’auteur nous emmène dans une enquête passionnante, au cœur de l’ADN, à la recherche des gènes associés à l’autisme (ou plutôt à la diversité des personnes autistes !). Grâce à la génétique, Thomas Bourgeron a identifié dans l’autisme le rôle majeur des synapses, ces zones permettant la communication entre les neurones. L’auteur propose une approche de l’autisme reposant avant tout sur des données scientifiques solides. Il défend aussi l’idée qu’il faut travailler avec les personnes autistes et leurs proches pour développer de nouvelles pistes d’accompagnement personnalisé, pour améliorer leur qualité de vie et leur autonomie. Thomas Bourgeron est responsable du laboratoire Génétique humaine et fonctions cognitives à l’Institut Pasteur, professeur de génétique à l’université Paris-Cité. Il est membre de l’Académie des sciences et de l’Institut universitaire de France.
Des G Nes Des Synapses Des Autismes
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Author : Thomas Bourgeron
language : fr
Publisher:
Release Date : 2023
Des G Nes Des Synapses Des Autismes written by Thomas Bourgeron and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
Autism Spectrum Disorders
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Author : Andreas M. Grabrucker
language : en
Publisher:
Release Date : 2021
Autism Spectrum Disorders written by Andreas M. Grabrucker and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
Autism spectrum disorders are developmental disorders. Individuals with autism spectrum disorders develop differently. These differences are usually present in social interaction, communication, and sensory processing, and become visible through a wide variety of behavioral responses that differ from individuals without autism spectrum disorders. Despite significant research efforts, the exact causes of autism spectrum disorders remain poorly understood; however, researchers have gained extensive insights into possible pathomechanisms, even at the molecular level of cells. Many diagnostic criteria have been developed, adapted, and improved. The eight chapters in this book highlight the current state-of-the-art in many areas of autism spectrum disorders. Chapter 1 provides an overview of the epidemiology of autism spectrum disorders and the current knowledge of the underlying pathogenic mechanisms. Chapter 2 summarizes the diagnostic criteria and procedures and highlights present and upcoming therapeutic strategies. Chapter 3 reviews the adverse events and trauma in people with autism spectrum disorders. Chapters 4 and 5 focus on atypical sensory processing, and Chapter 6 discusses the genetic overlap of autism spectrum disorders with other neuropsychiatric disorders such as attention deficit hyperactivity disorder (ADHD), depression, and schizophrenia. Chapter 7 focuses on the contribution of abnormalities in mitochondria, and chapter 8 discusses gut-brain interactions and a potential role for microbiota in autism spectrum disorders. This book is aimed primarily at clinicians and scientists, but many areas will also be of interest to the layperson.
A Time For Metabolism And Hormones
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Author : Paolo Sassone-Corsi
language : en
Publisher: Springer
Release Date : 2016-04-04
A Time For Metabolism And Hormones written by Paolo Sassone-Corsi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-04 with Medical categories.
Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.
Autism Spectrum Disorders
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Author : Stephen Deutsch
language : en
Publisher: BoD – Books on Demand
Release Date : 2011-08-01
Autism Spectrum Disorders written by Stephen Deutsch and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-01 with Science categories.
Estimated prevalence rates of autism spectrum disorders (ASDs) have increased at an alarming rate over the past decade; current estimates stand as high as 1 in 110 persons in the population with a higher ratio of affected males to females. In addition to their emotional impact on the affected persons and their family members (in fact, the latter are often unrecognized unaffected “patients” themselves), the economic and social impacts of ASDs on society are staggering. Persons with ASDs will need interdisciplinary approaches to complex treatment and life planning, including, but not limited to, special education, speech and language therapy, vocational skills training and rehabilitation, social skills training and cognitive remediation, in addition to pharmacotherapy. The current book highlights some of the recent research on nosology, etiology, and pathophysiology. Additionally, the book touches on the implications of new research for treatment and genetic counseling. Importantly, because the field is advancing rapidly, no book can be considered the final word or finished product; thus, the availability of open access rapid publication is a mechanism that will help to assure that readers remain current and up-to-date.
Homeostatic Control Of Brain Function
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Author : Detlev Boison
language : en
Publisher: Oxford University Press
Release Date : 2016
Homeostatic Control Of Brain Function written by Detlev Boison and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Medical categories.
Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health. Key Features include · A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks. · Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise. · Incorporation of homeostatic therapies into existing basic and clinical research paradigms. · Extensive scientific basic and clinical research ranging from molecules to disorders. · Emerging practical information for improving homeostasis. · Examples of homeostatic therapies in preventing and delaying dysfunction. Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.
The Fragile X Syndrome
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Author : Kay E. Davies
language : en
Publisher: Oxford University Press, USA
Release Date : 1989
The Fragile X Syndrome written by Kay E. Davies and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Language Arts & Disciplines categories.
This new book is an up-to-date review of the clinical, epidemiological, and cytogenetic aspects of the fragile X (Martin-Bell) syndrome--the most common genetic cause of mental retardation after Down syndrome. The book includes the latest research findings concerning diagnosis on the basis of the appearance of a fragile site in cultured lymphocytes. It assumes little prior knowledge of the subject, and provides a clearly written, easy-to-understand discussion previously unavailable in a single reference source. The book will be of special interest to molecular biologists, cytogeneticists, medical geneticists, and clinicians and other professionals working with the mentally handicapped.
Mitochondrial Dysfunction
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Author : Lawrence H. Lash
language : en
Publisher: Elsevier
Release Date : 2013-10-22
Mitochondrial Dysfunction written by Lawrence H. Lash and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Science categories.
Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
Autism Spectrum Disorders
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Author : David Amaral
language : en
Publisher: Oxford University Press
Release Date : 2011-05-01
Autism Spectrum Disorders written by David Amaral and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-01 with Medical categories.
Autism is an emerging area of basic and clinical research, and has only recently been recognized as a major topic in biomedical research. Approximately 1 in 150 children are diagnosed as autistic, so it is also an intense growth area in behavioral and educational treatments. Financial resources have begun to be raised for more comprehensive research and an increasing number of scientists are becoming involved in autism research. In many respects, autism has become a model for conducting translational research on a psychiatric disorder. This text provides a comprehensive summary of all current knowledge related to the behavioral, experiential, and biomedical features of the autism spectrum disorders including major behavioral and cognitive syndromology, common co-morbid conditions, neuropathology, neuroimmunology, and other neurological correlates such as seizures, allergy and immunology, gastroenterology, infectious disease, and epidemiology. Edited by three leading researchers, this volume contains over 80 chapters and nine shorter commentaries by thought leaders in the field, making the book a virtual "who's who" of autism research. This carefully developed book is a comprehensive and authoritative reference for what we know in this area as well as a guidepost for the next several years in all areas of autism research.
Asperger S Children The Origins Of Autism In Nazi Vienna
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Author : Edith Sheffer
language : en
Publisher: W. W. Norton & Company
Release Date : 2018-05-01
Asperger S Children The Origins Of Autism In Nazi Vienna written by Edith Sheffer and has been published by W. W. Norton & Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-01 with History categories.
Shortlisted for the 2019 Mark Lynton History Prize A groundbreaking exploration of the chilling history behind an increasingly common diagnosis. Hans Asperger, the pioneer of autism and Asperger syndrome in Nazi Vienna, has been celebrated for his compassionate defense of children with disabilities. But in this groundbreaking book, prize-winning historian Edith Sheffer exposes that Asperger was not only involved in the racial policies of Hitler’s Third Reich, he was complicit in the murder of children. As the Nazi regime slaughtered millions across Europe during World War Two, it sorted people according to race, religion, behavior, and physical condition for either treatment or elimination. Nazi psychiatrists targeted children with different kinds of minds—especially those thought to lack social skills—claiming the Reich had no place for them. Asperger and his colleagues endeavored to mold certain "autistic" children into productive citizens, while transferring others they deemed untreatable to Spiegelgrund, one of the Reich’s deadliest child-killing centers. In the first comprehensive history of the links between autism and Nazism, Sheffer uncovers how a diagnosis common today emerged from the atrocities of the Third Reich. With vivid storytelling and wide-ranging research, Asperger’s Children will move readers to rethink how societies assess, label, and treat those diagnosed with disabilities.