Design And Characterization Of Wireless Implant Systems With Ultrasonic Power And Data Links
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Design And Characterization Of Wireless Implant Systems With Ultrasonic Power And Data Links
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Author : Ting Chia Chang
language : en
Publisher:
Release Date : 2019
Design And Characterization Of Wireless Implant Systems With Ultrasonic Power And Data Links written by Ting Chia Chang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Implantable medical devices (IMDs) provide precise physiological monitoring and effective treatment by directly interfacing with specific organs and pathways. Current implants generally use large batteries for power and long wires to reach locations of interest, which makes them bulky and invasive; as a result, they are typically reserved for last resort treatments only. Miniaturization of IMDs down to millimeter-sized or smaller can mitigate undesirable immune response and operate in deep tissue for more targeted treatments. In addition, many of the medical applications of these implant systems, like neuromodulation can benefit from wireless data communication and networking capability for adaptive therapy and further improve treatment efficacy in a closed-loop fashion. To address these challenges and enable next-generation miniaturized wireless implant systems, we utilize ultrasound (US) for wireless power and data communication with a network of implantable devices. US has several advantages for powering and communication to miniaturized IMDs because it offers superior transduction efficiency and energy focusing due to its millimeter (mm) wavelength, low tissue attenuation through the body, and high safety limit which allows more power to be delivered for medical applications demanding more power. To provide design insights and optimize the performance of wireless implant systems using US, we present an analytical framework for optimizing end-to-end US link efficiency from transmitters to receivers to enable IMDs scaled down to mm or sub-mm dimensions. Key design objectives and trade-offs are considered for various parameters including the operating frequency, the transmission depth, the size of the transmitter, the impedance and the aperture efficiency of the miniaturized receiver, and the interface between the receiver and the power recovery chain on the implant. The design considerations and modeling for miniaturized US receivers using piezoelectric materials are then examined to obtain efficient scaled receivers. With the understanding of optimizing link performance, a mm-sized proof-of-concept implant for simultaneous US wireless power and bi-directional communication is designed and discussed. The fully packaged implant measures just 2.6 x 6.5 x 1.8 mm3, and it is the first such mm-sized implant that is able to operate with more than 6 cm in tissue. Finally, the system functionality and the networking aspect of the wireless implant systems are demonstrated at a large depth of more than 6 cm in tissue or tissue phantom with the customized US transmitter array.
Ultrasonic Wireless Power And Data Transmission To Miniaturized Biomedical Implants Using Phased Array
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Author : Zeinab Kashani
language : en
Publisher:
Release Date : 2023
Ultrasonic Wireless Power And Data Transmission To Miniaturized Biomedical Implants Using Phased Array written by Zeinab Kashani and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
This PhD dissertation focuses on developing efficient ultrasonic (US) wireless power and data transfer technologies for biomedical implants with millimeter (mm) dimensions. An ultrasonically interrogated (power/data) system with an external US array for beam focusing and steering through US beamforming is proposed to enable gastric electrical-wave mapping for diagnosing and eventually treating gastrointestinal motility disorders. The dissertation is divided into five parts. In the first part, the theory, design, and characterization of a wireless power transfer (WPT) link using mm-sized receivers (Rx) and a phased array (as external transmitter) are discussed. For given constraints imposed by the application and fabrication, such as the load (RL) and focal/powering distance (F), the optimal geometries of a US phased array and Rx transducer, as well as the optimal operation frequency (fc) are found through an iterative design procedure to maximize the power transfer efficiency (PTE). An optimal figure of merit (FoM) related to the link's PTE is proposed to simplify the US array design. In measurements, a fabricated 16-element array driven by 100 V pulses at an optimal frequency generated a US beam with a pressure output of 0.8 MPa and delivered up to 6 mW to a 1 mm3 Rx with a PTE of 0.14%. In the second part of this dissertation, a comprehensive study of wireless power transmission using a 32-element phased array capable of beam focusing and steering up to 50 mm depth and ±60o angle is provided. The performance of the US WPT link using mm-sized US receivers with different geometries and dimensions, the effect of different types of errors in the delay profile of the beamforming system on the delivered power, and the feasibility and efficacy of implant's localization with pulse-delay measurements with limited number of elements are investigated. The WPT link performance is evaluated based on the delivered power (within FDA safety limits) to mm-sized receivers with different geometries and diameters. In the third part of this dissertation, optimal US pulse transmission is demonstrated that could be used for data transmission to/from millimeter-sized biomedical implants in general or the self-image-guided ultrasonic (SIG-US) WPT. In SIG-US WPT, short pulses are transmitted by the implant periodically. The relative delays in the received signal by each external transducer in an array are then used to guide the beamformer for optimal steering of the power beam towards the implant. The effect of number of transmitted pulses on the iv amplitude of the received signal is studied, which is vital for low-power robust transmission. Furthermore, an adaptive application-specific integrated circuit (ASIC) for closed-loop low-power (and robust) US pulse-based data transmission is presented. The number of transmitted US pulses is changed based on the received voltage at the external unit in the closed-loop system to improve robustness and minimize the power consumption of the data transmitter. The ASIC, designed and fabricated in a 0.35[mu]m standard CMOS process, includes power management, controller/pulse driver, and envelope detector units. The fourth part of this dissertation includes ASIC design for low-frequency, low-power, and low-noise amplifiers that will be used to record gastric slow-wave signals. Simulation results and some limited measurement results are provided. The fifth part of this dissertation includes measurement results for a dual-mode ultrasonic- magnetic approach for wireless power transmission and energy harvesting. This dual-mode approach has the potential to solve the problem of power reduction when implant is rotating and to deliver high power within FDA safety limit using two different modalities. The future steps for circuit/system design, development, and testing are outlined. This dissertation represents an important step towards an implantable fully wireless gastric system, interrogated with a dual-mode ultrasonic-magnetic link for wireless power/data transfer, which can have a broad impact in the fields of health monitoring, diagnosis, and therapy.
Ultrasonic Wireless Links For Next Generation Miniaturized Implantable Sensors
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Author : Marcus Joseph Weber
language : en
Publisher:
Release Date : 2018
Ultrasonic Wireless Links For Next Generation Miniaturized Implantable Sensors written by Marcus Joseph Weber and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Today's implantable medical devices rely on bulky batteries for energy supply, requiring invasive implant procedures, which limits their use to only last-resort therapies. New applications of implantable devices are being proposed, such as: peripheral nerve stimulation for treating chronic pain and inflammatory disease, optogenetic stimulation for mapping of neural pathways, and even sensing applications of neural potential, pressure, and temperature monitoring. To realize these new applications, and to achieve widespread use of implantable device therapy, a new energy paradigm must be designed to replace the batteries and allow for extreme implant miniaturization for minimally invasive implant procedures. Extreme implant miniaturization is especially critical for developing sensors for continuous monitoring, due to a higher threshold for implantation. Towards this goal, we propose ultrasound for efficient power transfer to deeply implanted and miniaturized implantable devices, and demonstrate ultrasonic link utility with design of an implantable pressure sensor and optogenetic stimulator. A comprehensive analysis and methodology is presented for designing ultrasonic receivers for efficient powering of miniaturized implantable medical devices. Key ultrasonic receiver efficiencies, resonance characteristics, and the inductive band are defined, and a theoretical model is presented for first-order design insights. Methods are described to accurately characterize the ultrasonic receiver impedance and acoustic-to-electrical aperture efficiency. Ultrasonic receivers are shown to achieve favorable source resistances from kOhm to 100's of kOhm, for matching to typical implant loads, and high aperture efficiencies of 40-90%. An iterative design methodology, using the theoretical model and impedance measurements is demonstrated for an example ultrasonic receiver design. An ultrasonically powered, millimeter-sized implantable device is proposed for future optogenetic peripheral nerve stimulation in large animal models. Through system level analysis, the effective impedance match between the ultrasonic receiver and implant electronics is shown as the dominant component of the power recovery efficiency. We present a numerically solved time-domain impedance match analysis of the non-linear power electronics to derive the optimal ultrasonic receiver impedance, and the design of the ultrasonic receiver is shown to meet this specification. The implantable stimulator is characterized through both electrical and optical measurements, demonstrating high peak optical intensities of 1-15 mW/mm2 with safe levels of ultrasonic power. Finally, a high-precision implantable pressure sensor with ultrasonic power-up and data uplink is presented for applications in continuous pressure monitoring. The fully integrated implant measures 1.7 mm x 2.3 mm x 7.8 mm and includes a custom IC, a pressure transducer, an energy storage capacitor, and an ultrasonic transducer. In order to reduce overall dimensions, unique circuit and system design techniques are presented to enable a single time-multiplexed ultrasonic transducer for both power recovery and data uplink transmission. Implant performance is characterized at significant depths, 12 cm in a tissue phantom, offering a > 13x improvement over the state of the art in the depth/volume figure of merit, while demonstrating a robust ultrasonic data uplink with better than 1e-5 bit error rate. A transient charging analysis is presented to derive the optimal ultrasonic receiver impedance and charging specifications to maximize overall harvesting efficiency. The IC features a front-end with a 10-bit SAR ADC, achieving a pressure full-scale range of 800 mmHg with a pressure resolution of 0.78 mmHg, exceeding the requirements for a wide range of pressure sensing applications, while accounting for various nonidealities. The pressure sampling rate is fully externally controlled, up to 1 ksps, in order to significantly decrease implant energy consumption and to allow for adaptable programming for specific applications. The implantable sensor is packaged in biocompatible materials and wirelessly characterized in a custom-built pressure chamber, and in situ, using sheep tissue.
Ultrasound Energy And Data Transfer For Medical Implants
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Author : Francesco Mazzilli
language : en
Publisher: Springer Nature
Release Date : 2020-09-02
Ultrasound Energy And Data Transfer For Medical Implants written by Francesco Mazzilli and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-02 with Technology & Engineering categories.
This book presents new systems and circuits for implantable biomedical applications, using a non-conventional way to transmit energy and data via ultrasound. The authors discuses the main constrains (e.g. implant size, battery recharge time, data rate, accuracy of the acoustic models) from the definition of the ultrasound system specification to the in-vitro validation.The system described meets the safety requirements for ultrasound exposure limits in diagnostic ultrasound applications, according to FDA regulations. Readers will see how the novel design of power management architecture will meet the constraints set by FDA regulations for maximum energy exposure in the human body. Coverage also includes the choice of the acoustic transducer, driven by optimum positioning and size of the implanted medical device. Throughout the book, links between physics, electronics and medical aspects are covered to give a complete view of the ultrasound system described. Provides a complete, system-level perspective on the use of ultrasound as energy source for medical implants; Discusses system design concerns regarding wireless power transmission and wireless data communication, particularly for a system in which both are performed on the same channel/frequency; Describes an experimental study on implantable battery powered biomedical systems; Presents a fully-integrated, implantable system and hermetically sealed packaging.
Implanted Antennas In Medical Wireless Communications
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Author : Yahya Rahmat-Samii
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2006-12-01
Implanted Antennas In Medical Wireless Communications written by Yahya Rahmat-Samii and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-01 with Technology & Engineering categories.
One of the main objectives of this lecture is to summarize the results of recent research activities of the authors on the subject of implanted antennas for medical wireless communication systems. It is anticipated that ever sophisticated medical devices will be implanted inside the human body for medical telemetry and telemedicine. To establish effective and efficient wireless links with these devices, it is pivotal to give special attention to the antenna designs that are required to be low profile, small, safe and cost effective. In this book, it is demonstrated how advanced electromagnetic numerical techniques can be utilized to design these antennas inside as realistic human body environment as possible. Also it is shown how simplified models can assist the initial designs of these antennas in an efficient manner.
Wireless Power Transfer And Data Communication For Neural Implants
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Author : Gürkan Yilmaz
language : en
Publisher: Springer
Release Date : 2017-01-01
Wireless Power Transfer And Data Communication For Neural Implants written by Gürkan Yilmaz and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-01 with Technology & Engineering categories.
This book presents new circuits and systems for implantable biomedical applications targeting neural recording. The authors describe a system design adapted to conform to the requirements of an epilepsy monitoring system. Throughout the book, these requirements are reflected in terms of implant size, power consumption, and data rate. In addition to theoretical background which explains the relevant technical challenges, the authors provide practical, step-by-step solutions to these problems. Readers will gain understanding of the numerical values in such a system, enabling projections for feasibility of new projects.
Design And Development Of An Ultrasonic Power Transfer System For Active Implanted Medical Devices
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Author : Peeter Hugo Vihvelin
language : en
Publisher:
Release Date : 2015
Design And Development Of An Ultrasonic Power Transfer System For Active Implanted Medical Devices written by Peeter Hugo Vihvelin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Design Manufacture And Performance Characterization Of Wireless Power Transfer Systems For Biomedical Devices
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Author : Sadeque Reza Khan
language : en
Publisher:
Release Date : 2019
Design Manufacture And Performance Characterization Of Wireless Power Transfer Systems For Biomedical Devices written by Sadeque Reza Khan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Remote Powering And Data Communication For Implanted Biomedical Systems
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Author : Enver Gurhan Kilinc
language : en
Publisher: Springer
Release Date : 2015-09-17
Remote Powering And Data Communication For Implanted Biomedical Systems written by Enver Gurhan Kilinc and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-17 with Technology & Engineering categories.
This book describes new circuits and systems for implantable biomedical applications and explains the design of a batteryless, remotely-powered implantable micro-system, designed for long-term patient monitoring. Following new trends in implantable biomedical applications, the authors demonstrate a system which is capable of efficient, remote powering and reliable data communication. Novel architecture and design methodologies are used to transfer power with a low-power, optimized inductive link and data is transmitted by a reliable communication link. Additionally, an electro-mechanical solution is presented for tracking and monitoring the implantable system, while the patient is mobile.
High Density Integrated Electrocortical Neural Interfaces
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Author : Sohmyung Ha
language : en
Publisher: Academic Press
Release Date : 2019-08-03
High Density Integrated Electrocortical Neural Interfaces written by Sohmyung Ha and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-03 with Science categories.
High-Density Integrated Electrocortical Neural Interfaces provides a basic understanding, design strategies and implementation applications for electrocortical neural interfaces with a focus on integrated circuit design technologies. A wide variety of topics associated with the design and application of electrocortical neural implants are covered in this book. Written by leading experts in the field— Dr. Sohmyung Ha, Dr. Chul Kim, Dr. Patrick P. Mercier and Dr. Gert Cauwenberghs —the book discusses basic principles and practical design strategies of electrocorticography, electrode interfaces, signal acquisition, power delivery, data communication, and stimulation. In addition, an overview and critical review of the state-of-the-art research is included. These methodologies present a path towards the development of minimally invasive brain-computer interfaces capable of resolving microscale neural activity with wide-ranging coverage across the cortical surface. Written by leading researchers in electrocorticography in brain-computer interfaces Offers a unique focus on neural interface circuit design, from electrode to interface, circuit, powering, communication and encapsulation Covers the newest ECoG interface systems and electrode interfaces for ECoG and biopotential sensing