Design Development And Initial Characterization Of A Preclinical Pet Mri Insert
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Design Development And Initial Characterization Of A Preclinical Pet Mri Insert
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Author : Aaron Rohn Selfridge
language : en
Publisher:
Release Date : 2020
Design Development And Initial Characterization Of A Preclinical Pet Mri Insert written by Aaron Rohn Selfridge and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
Systems capable of simultaneous positron emission tomography (PET) and magnetic resonance imaging (MRI) have found both clinical and preclinical adoption, with a broad and expanding range of applications. Current preclinical PET/MRI systems demonstrate the maturity of MR compatible PET detectors and electronics but are not well suited for many of the emerging applications most relevant to simultaneous imaging. A PET/MRI system providing high detection sensitivity while maintaining the spatial resolution necessary for preclinical applications is necessary to bridge current applications for PET/MRI with future applications requiring quantitative and dynamic imaging. The objective of this work is to design, build, and demonstrate the imaging performance of a preclinical PET/MRI insert with detection sensitivity above 10%, targeted for quantitative and dynamic PET studies in rats and mice. Toward this end, we have developed a detector with 1.0 mm pitch and 20 mm thick lutetium yttrium oxyorthosilicate (LYSO) elements. To preserve spatial resolution across the PET field-of-view (FOV), the detector incorporates a dual-ended depth of interaction (DOI) encoding readout, achieving DOI resolution of 3.6 mm. To read out analog signals from the detector, we have developed compact electronics capable of digitizing signals within the bore of the MRI, minimizing cabling and electronic noise. Based on the optimized digitization circuit, we have built a highly integrated detector module containing four detector blocks and forty readout channels. The module showed excellent separation of the 1.0 mm crystal elements, energy resolution of 25%, and a timing resolution of 3.0 ns.Based on the single detector module, we have built a complete PET/MRI system consisting of sixteen modules. The insert fits within the standard gradient set of a Bruker Biospec 7T MRI, and can accommodate mouse whole body and rat brain imaging coils. Initial imaging results demonstrate approximately 11.4% sensitivity (350-650 kev energy window, point source), and separation of 2.4 mm rods in a Derenzo phantom before applying any corrections. These results support ongoing characterization, to ensure that the system described here is well suited for quantitative and dynamic imaging and other emerging applications for simultaneous preclinical PET/MRI.
Towards A Next Generation Preclinical Pet Mr Insert With Improved Timing And Count Rate Performance
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Author : Devin Van Elburg
language : en
Publisher:
Release Date : 2018
Towards A Next Generation Preclinical Pet Mr Insert With Improved Timing And Count Rate Performance written by Devin Van Elburg and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Our group has previously developed a PET insert for simultaneous PET/MRI imaging. The insert consists of silicon photomultipliers (SiPMs) with a resistor-based charge division multiplexing readout circuit. Some limitations include a 2.5ns coincidence time resolution (CTR), a relatively long signal duration of >1.5us, and a 1.3us paralyzable dead time. This thesis focuses on characterizing these limitations and demonstrating a second-generation detector module for improved timing and count rate performance. First, optical coupling optimization using acrylic polymer tapes versus conventional silicone optical grease was investigated. Second, CTR and signal duration was reduced by using an enhanced readout board equipped with three new SiPM-type detectors. Last, dead time of the system was reduced by minimizing the sampling number of the OpenPET acquisition system. Future work includes design modification to accommodate the first-generation scintillator footprint and potentially to adapt the OpenPET acquisition system to read in SiPM `fast' outputs.
Mr Compatibility Assessment Of The First Preclinical Pet Mri Insert Equipped With Digital Silicon Photomultipliers
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Author :
language : en
Publisher:
Release Date : 2015
Mr Compatibility Assessment Of The First Preclinical Pet Mri Insert Equipped With Digital Silicon Photomultipliers written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Petcoil
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Author : Qian Dong
language : en
Publisher:
Release Date : 2023
Petcoil written by Qian Dong and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
Simultaneous positron emission tomography/magnetic resonance imaging (PET/MRI) has shown promise in acquiring complementary multiparametric information of diseases. However, designing these hybrid imaging systems is challenging due to the propensity for mutual interference between the PET and MRI sub-systems. In addition, the current high cost of permanently-integrated PET/MRI systems limits their long-term development and deployment, as well as patient accessibility. To overcome these limitations, we explored a brain-dedicated PET insert for an existing MRI system to achieve simultaneous PET/MRI. Because of its brain-dedicated design, this insert also provides superior spatial resolution and sensitivity compared to whole-body scanners. The second-generation prototype builds upon the success of the first-generation prototype, which demonstrated radio-frequency (RF)-penetrability and MR-compatibility. The new design includes additional features such as a longer axial field of view, time-of-flight (TOF) functionality, and improved portability, resulting in improved PET performance but presenting greater technical challenges for MR-compatibility. This thesis presents the development of the second-generation brain-dedicated PET insert for simultaneous PET/MRI. Our objective is to achieve high levels of both PET performance and MR-compatibility. The detailed design, architecture, experiment setup, results and analysis of the second-generation brain-dedicated PET insert are presented, highlighting the progress towards realizing a cost-efficient and effective simultaneous PET/MRI system for neurological imaging.
Transpathology
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Author : Mei Tian
language : en
Publisher: Elsevier
Release Date : 2024-06-25
Transpathology written by Mei Tian and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-25 with Science categories.
Transpathology: Molecular Imaging-Based Pathology is a multidisciplinary reference on molecular imaging and pathology. The book is intended for professionals in the fields of molecular imaging, nuclear medicine, radiology, and pathology as well as students and clinical residents. The book describes the importance of non-invasive diagnosis-based precision medicine and presents a detailed description of current transpathological approaches in different aspects essential for the future development of precision medicine. It’s molecular imaging approach to experimental research and clinical practice will drive the field forward and improve research outcomes. Introduces a new concept of molecular imaging-guided precise biopsy Links in vivo and ex vivo information at various scales by using multi-modality imaging technologies Integrates future technologies for the non-invasive cross-validation of underlying mechanisms
Small Animal Imaging
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Author : Fabian Kiessling
language : en
Publisher: Springer
Release Date : 2017-05-22
Small Animal Imaging written by Fabian Kiessling and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-22 with Medical categories.
This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.
Molecular Imaging
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Author : Brian D. Ross
language : en
Publisher: Academic Press
Release Date : 2021-08-03
Molecular Imaging written by Brian D. Ross and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-03 with Science categories.
The detection and measurement of the dynamic regulation and interactions of cells and proteins within the living cell are critical to the understanding of cellular biology and pathophysiology. The multidisciplinary field of molecular imaging of living subjects continues to expand with dramatic advances in chemistry, molecular biology, therapeutics, engineering, medical physics and biomedical applications. Molecular Imaging: Principles and Practice, Volumes 1 and 2, Second Edition provides the first point of entry for physicians, scientists, and practitioners. This authoritative reference book provides a comprehensible overview along with in-depth presentation of molecular imaging concepts, technologies and applications making it the foremost source for both established and new investigators, collaborators, students and anyone interested in this exciting and important field. The most authoritative and comprehensive resource available in the molecular-imaging field, written by over 170 of the leading scientists from around the world who have evaluated and summarized the most important methods, principles, technologies and data Concepts illustrated with over 600 color figures and molecular-imaging examples Chapters/topics include, artificial intelligence and machine learning, use of online social media, virtual and augmented reality, optogenetics, FDA regulatory process of imaging agents and devices, emerging instrumentation, MR elastography, MR fingerprinting, operational radiation safety, multiscale imaging and uses in drug development This edition is packed with innovative science, including theranostics, light sheet fluorescence microscopy, (LSFM), mass spectrometry imaging, combining in vitro and in vivo diagnostics, Raman imaging, along with molecular and functional imaging applications Valuable applications of molecular imaging in pediatrics, oncology, autoimmune, cardiovascular and CNS diseases are also presented This resource helps integrate diverse multidisciplinary concepts associated with molecular imaging to provide readers with an improved understanding of current and future applications
Pet Mri In Oncology
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Author : Andrei Iagaru
language : en
Publisher: Springer
Release Date : 2018-01-23
Pet Mri In Oncology written by Andrei Iagaru and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-23 with Medical categories.
In this book, experts from premier institutions across the world with extensive experience in the field clearly and succinctly describe the current and anticipated uses of PET/MRI in oncology. The book also includes detailed presentations of the MRI and PET technologies as they apply to the combined PET/MRI scanners. The applications of PET/MRI in a wide range of oncological settings are well documented, highlighting characteristic findings, advantages of this dual-modality technique, and pitfalls. Whole-body PET/MRI applications and pediatric oncology are discussed separately. In addition, information is provided on PET technology designs and MR hardware for PET/MRI, MR pulse sequences and contrast agents, attenuation and motion correction, the reliability of standardized uptake value measurements, and safety considerations. The balanced presentation of clinical topics and technical aspects will ensure that the book is of wide appeal. It will serve as a reference for specialists in nuclear medicine and radiology and oncologists and will also be of interest for residents in these fields and technologists.
Magnetic Resonance Imaging
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Author : Robert W. Brown
language : en
Publisher: John Wiley & Sons
Release Date : 2014-06-23
Magnetic Resonance Imaging written by Robert W. Brown and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-23 with Medical categories.
New edition explores contemporary MRI principles and practices Thoroughly revised, updated and expanded, the second edition of Magnetic Resonance Imaging: Physical Principles and Sequence Design remains the preeminent text in its field. Using consistent nomenclature and mathematical notations throughout all the chapters, this new edition carefully explains the physical principles of magnetic resonance imaging design and implementation. In addition, detailed figures and MR images enable readers to better grasp core concepts, methods, and applications. Magnetic Resonance Imaging, Second Edition begins with an introduction to fundamental principles, with coverage of magnetization, relaxation, quantum mechanics, signal detection and acquisition, Fourier imaging, image reconstruction, contrast, signal, and noise. The second part of the text explores MRI methods and applications, including fast imaging, water-fat separation, steady state gradient echo imaging, echo planar imaging, diffusion-weighted imaging, and induced magnetism. Lastly, the text discusses important hardware issues and parallel imaging. Readers familiar with the first edition will find much new material, including: New chapter dedicated to parallel imaging New sections examining off-resonance excitation principles, contrast optimization in fast steady-state incoherent imaging, and efficient lower-dimension analogues for discrete Fourier transforms in echo planar imaging applications Enhanced sections pertaining to Fourier transforms, filter effects on image resolution, and Bloch equation solutions when both rf pulse and slice select gradient fields are present Valuable improvements throughout with respect to equations, formulas, and text New and updated problems to test further the readers' grasp of core concepts Three appendices at the end of the text offer review material for basic electromagnetism and statistics as well as a list of acquisition parameters for the images in the book. Acclaimed by both students and instructors, the second edition of Magnetic Resonance Imaging offers the most comprehensive and approachable introduction to the physics and the applications of magnetic resonance imaging.
Trends On The Role Of Pet In Drug Development
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Author : Philip H. Elsinga
language : en
Publisher: World Scientific
Release Date : 2012
Trends On The Role Of Pet In Drug Development written by Philip H. Elsinga and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
Drug development is very expensive and a fight against time. PET offers possibilities to speed up this process by adding unique in vivo information on pharmacokinetics/dynamics of a drug at an early stage. This information can help decision makers to move the drug in the drug development process or to decide to stop further developments. This unique and complete book highlights the different ways PET can be used and describes the latest trends in the various disciplines within nuclear medicine to further improve methodologies and increase the number of tools to accelerate drug development. Various topics within tracer development, instrumentation, data analysis and many clinical and preclinical topics are described by leading scientists from industry and academia.