Design Of Controlled Anti Cancer Drug Delivery Systems Using Natural Products
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Design Of Controlled Anti Cancer Drug Delivery Systems Using Natural Products
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Author : James Z. Crouse
language : en
Publisher:
Release Date : 2014
Design Of Controlled Anti Cancer Drug Delivery Systems Using Natural Products written by James Z. Crouse and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Advanced Drug Delivery Systems In The Management Of Cancer
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Author : Kamal Dua
language : en
Publisher: Elsevier
Release Date : 2021-06-24
Advanced Drug Delivery Systems In The Management Of Cancer written by Kamal Dua and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-24 with Business & Economics categories.
Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems
Novel Drug Delivery Systems For Phytoconstituents
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Author : Madhu Gupta
language : en
Publisher: CRC Press
Release Date : 2019-07-23
Novel Drug Delivery Systems For Phytoconstituents written by Madhu Gupta and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-23 with Health & Fitness categories.
Novel Drug Delivery Systems for Phytoconstituents discusses general principles of drug targeting, construction material and technological concerns of different phytoconstituent in delivery systems. It focuses on the development of novel herbal formulations and summarizes their method of preparation, type of active ingredients, route of administration, biological activity and their applications. It dicusses therapeutic activities of plant derived chemicals, their limitations in clinical applications and novel drug delivery solutions to overcome them to provide better therapeutic effects with controlled and targeted drug delivery. Focus on drug delivery of phytomolecules Act as bridge between natural product scientist and clinical doctors Discusses mechanism of poor bioavailability of herbal molecules Increases awareness towards phytochemical efficacy Summarizes efficient novel delivery systems-based formulations. It extensively covers the applications of novel drug delivery systems including polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid capsules, liposomes, phytosomes, microsphere, transferosomes, and ethosomes. Some chapters are especially focused on anticancer phytodrugs, silymarin, andrographolide, berberine, and curcumin delivery with special emphasis on their application.
Drug Delivery Systems Of Phytochemicals As Therapeutic Strategies In Cancer Therapy
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Author : Akhileshwar Kumar Srivastava
language : en
Publisher: Elsevier
Release Date : 2023-11-07
Drug Delivery Systems Of Phytochemicals As Therapeutic Strategies In Cancer Therapy written by Akhileshwar Kumar Srivastava and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-07 with Science categories.
Phytochemicals and derivatives have become promising alternatives to increase treatment potential in cancer patients with minimal side effects. Drug-delivery Systems of Phytochemicals as Therapeutic Strategies in Cancer Therapy elucidates the importance of various phytochemicals in cancer therapy and explains various routes/methods to deliver phytochemicals for overcoming the problems associated with delivery system in cancer treatment. Several nanotechnological methods are followed to enhance drug solubility, sustainability, bioavailability and gastrointestinal permeability of these phytochemicals. The advanced field of drug-delivery systems explains that combination therapy for cancer treatment has important benefits over mono-delivery therapeutics. Natural compounds, because of their biobased origin, have drawn higher attention than synthetic drugs. Synthesis of nano-phytomedicines has impacted the bioavailability of phytochemicals. Novel formulations have been synthesized loaded with phytochemicals and have revealed extraordinary results in treatment of various cancers. Current understanding of the relevant information presented in Drug-delivery systems of phytochemicals as therapeutic strategies in cancer therapy fulfils the requirements of oncologists, molecular biologists, pharmacologist and related researchers, who want to work in the areas of drug development targeting phytochemicals for cancer therapy Explains the significance of phytochemicals in cancer therapy, along with their pharmacologic action Elucidates the importance of various phytochemicals in cancer therapy Explains the emerging need of drug-delivery system for plant metabolites Deciphers the various drug-delivery systems for phytomedicines involved in cancer treatments Describes the crucial role of nanotechnology in the development of drug-delivery systems for anticancer phytochemicals Explores the challenges associated with developing drug-delivery systems for phytochemicals to cure cancer
Design Of Controlled Release Drug Delivery Systems
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Author : Xiaoling Li
language : en
Publisher: McGraw Hill Professional
Release Date : 2005-11-24
Design Of Controlled Release Drug Delivery Systems written by Xiaoling Li and has been published by McGraw Hill Professional this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-11-24 with Technology & Engineering categories.
The goal of every drug delivery system is to deliver the precise amount of a drug at a pre-programmed rate to the desired location in order to achieve the drug level necessary for the treatment. An essential guide for biomedical engineers and pharmaceutical designers, this resource combines physicochemical principles with physiological processes to facilitate the design of systems that will deliver medication at the time and place it is most needed.
Formulation Design And In Vitro In Vivo Characterization Of Anticancer Drug Delivery Systems
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Author : Min Sung Suh
language : en
Publisher:
Release Date : 2018
Formulation Design And In Vitro In Vivo Characterization Of Anticancer Drug Delivery Systems written by Min Sung Suh and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Cancer categories.
The present dissertation focuses on formulation design of and in vitro/in vivo characterization of anticancer drug delivery systems for metastatic cancer treatment. There are two aspects to this work: i) formulation design and development of a nanoparticle platform for chemotherapy; and ii) characterization of in situ forming implants for hormone cancer therapy. The main goal of the first aim is to overcome side effects of chemotherapy that are significant concerns in the use of anticancer drugs through cancer active targeting and controlled drug release. A nanoparticle platform equipped with active targeting and pH-responsive functionalities was engineered using biocompatible materials with simple preparation methods, which may facilitate the development of nanoparticle drug products for cancer therapy. Nanoparticle uptake, therapeutic efficacy, and cytotoxicity were investigated using metastatic cancer cell models to evaluate anticancer performance of the nanoparticles. The main goal of the second aim is to identify critical factors affecting drug release kinetics of an in situ forming implant formulation. In vitro/in vivo characterization of in situ forming implants were investigated to understand implant formation and drug release mechanism. The characterization demonstrated that implant formation significantly impacts on drug release kinetics of ISFI formulations. A dissolution device was designed and created using 3D printing to generate biorelevant and reproducible drug release profiles of ISFIs. Water-dissolvable PVA films were combined with open window shaped 3D printed devices. This design allows implant formation without exposure to sink conditions. The results demonstrated that the 3D printed devices not only maintain consistent shape and size of ISFI formulations, but also generate reproducible in vitro release profiles. The 3D printed dissolution devices may prove a useful tool bioequivalence studies of ISFI formulations. Moreover, this work reports the first morphological and microstructural demonstration of in situ forming PLGA implants in a rabbit model.
Cancer Drug Delivery Systems Based On The Tumor Microenvironment
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Author : Yasuhiro Matsumura
language : en
Publisher: Springer Nature
Release Date : 2020-01-07
Cancer Drug Delivery Systems Based On The Tumor Microenvironment written by Yasuhiro Matsumura and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-07 with Medical categories.
This book proposes the importance of new systems of drug design and delivery based on cancer pathophysiology in addition to cancer molecular and cellular biology. The current studies based on molecular and cellular biology while ignoring pathophysiology and pharmacology may be leading the development of antitumor drugs in the wrong direction and wasting a lot of money. Although there have been numerous reports of genetic and phenotypic changes in tumors, a large body of pathological and clinical evidence supports the conclusion that there are no pivotal changes in tumor cells that distinguish them consistently and reliably from normal dividing cells. Unlike using antibiotics against bacterial infection, therefore, anticancer agents (ACAs) need to be delivered selectively to tumor tissues and should be kept there long enough to reproduce the concentrations they reach in the Petri dish, which is a closed space where the cytocidal effects of any anticancer agents (ACAs) including molecular targeting agents are very strong. In the body, however, administered ACAs are cleared with the passage of time. Furthermore, most human cancers possess abundant stroma that hinders the penetration of drugs into the tumor microenvironment. Therefore, to overcome these difficulties, novel drug delivery systems have been designed, such as nanoparticles and ACA conjugated antibodies to stromal components and to cancer cell surface antigens. These advances are described in this book after the first section, which describes core features of the pathophysiology of the cancer microenvironment, on which these new developments are based.
Modeling And Control Of Drug Delivery Systems
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Author : Ahmad Taher Azar
language : en
Publisher: Academic Press
Release Date : 2021-02-06
Modeling And Control Of Drug Delivery Systems written by Ahmad Taher Azar and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-06 with Technology & Engineering categories.
Modeling and Control of Drug Delivery Systems provides comprehensive coverage of various drug delivery and targeting systems and their state-of-the-art related works, ranging from theory to real-world deployment and future perspectives. Various drug delivery and targeting systems have been developed to minimize drug degradation and adverse effect and increase drug bioavailability. Site-specific drug delivery may be either an active and/or passive process. Improving delivery techniques that minimize toxicity and increase efficacy offer significant potential benefits to patients and open up new markets for pharmaceutical companies. This book will attract many researchers working in DDS field as it provides an essential source of information for pharmaceutical scientists and pharmacologists working in academia as well as in the industry. In addition, it has useful information for pharmaceutical physicians and scientists in many disciplines involved in developing DDS, such as chemical engineering, biomedical engineering, protein engineering, gene therapy. Presents some of the latest innovations of approaches to DDS from dynamic controlled drug delivery, modeling, system analysis, optimization, control and monitoring Provides a unique, recent and comprehensive reference on DDS with the focus on cutting-edge technologies and the latest research trends in the area Covers the most recent works, in particular, the challenging areas related to modeling and control techniques applied to DDS
Controlled Drug Delivery Systems
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Author : Filippo Rossi
language : en
Publisher: Springer
Release Date : 2015-11-07
Controlled Drug Delivery Systems written by Filippo Rossi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-07 with Science categories.
This book offers a state-of-the-art overview of controlled drug delivery systems, covering the most important innovative applications. The principles of controlled drug release and the mechanisms involved in controlled release are clearly explained. The various existing polymeric drug delivery systems are reviewed, and new frontiers in material design are examined in detail, covering a wide range of polymer modification techniques. The concluding chapter is a case study focusing on use of a drug-eluting stent. The book is designed to provide the reader with a complete understanding of the mechanisms and design of controlled drug delivery systems, and to this end includes numerous step-by-step tutorials. It illustrates how chemical engineers can advance medical care by designing polymeric delivery systems that achieve either temporal or spatial control of drug delivery and thus ensure more effective therapy that eliminates the potential for both under-and overdosing.
Design Of Controlled Release Drug Delivery Systems
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Author : Xiaoling Li
language : en
Publisher:
Release Date : 2000
Design Of Controlled Release Drug Delivery Systems written by Xiaoling Li and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with categories.