Developmental Control Of Globin Gene Expression
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Developmental Control Of Globin Gene Expression
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Author : George Stamatoyannopoulos
language : en
Publisher:
Release Date : 1987
Developmental Control Of Globin Gene Expression written by George Stamatoyannopoulos and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Science categories.
Developmental Control Of Globin Gene Expression
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Author : George Stamatoyannopoulos
language : en
Publisher: John Wiley & Sons
Release Date : 1987-12-01
Developmental Control Of Globin Gene Expression written by George Stamatoyannopoulos and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987-12-01 with categories.
Expression And Developmental Control Of The Human Embryonic Beta Globin Gene In Transgenic Mice
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Author : Diana Mouhan Shih
language : en
Publisher:
Release Date : 1992
Expression And Developmental Control Of The Human Embryonic Beta Globin Gene In Transgenic Mice written by Diana Mouhan Shih and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Gene expression categories.
Developmental Biology Using Purified Genes
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Author : Donald D. Brown
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Developmental Biology Using Purified Genes written by Donald D. Brown and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Health & Fitness categories.
Developmental Biology Using Purified Genes is a compilation of papers presented at the 1981 ICN-UCLA Symposia on Developmental Biology Using Purified Genes, held in Keystone, Colorado. Contributors representing a wide range of disciplines explore the mechanisms underlying gene control of development and explain how purified genes are transcribed in cells, how DNA sequences and non-DNA molecules regulate development, and how gene-control molecules or other developmental determinants are unequally distributed among embryonic cells. Organized into nine sections comprised of 54 chapters, this volume begins with an overview of the mechanism by which gene activity is regionally controlled and its role in development. It then proceeds with a discussion on eukaryotic genes and their structure, including the collagen gene and the albumin gene family. The next chapters focus on the transcription and translation of yolk protein mRNA in the fat bodies of Drosophila, the organization and expression of the actin multi-gene family in Dictyostelium, the cDNA clones encoding mouse transplantation antigens, and the role of double minute chromosomes in unstable methotrexate resistance. The book also introduces the nucleosome core particle, regulatory factors involved in the transcription of mouse ribosomal genes, and developmental control of 5S RNA gene expression before concluding with a chapter on synthetic oligodeoxyribonucleotides and their use in the isolation of specific cloned DNA sequences. This book will be of interest to microbiologists, molecular biologists, embryologists, geneticists, and researchers working in the fields of genetics and developmental biology.
Levels Of Genetic Control In Development
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Author : Stephen Stanley Subtelny
language : en
Publisher: New York : A.R. Liss
Release Date : 1981
Levels Of Genetic Control In Development written by Stephen Stanley Subtelny and has been published by New York : A.R. Liss this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with Medical categories.
Transcription Factors Involved In Development And Growth Control
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Author : Giulio Superti-Furga
language : en
Publisher:
Release Date : 1990
Transcription Factors Involved In Development And Growth Control written by Giulio Superti-Furga and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with categories.
Long Range Control Of Gene Expression
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Author : Veronica van Heyningen
language : en
Publisher: Academic Press
Release Date : 2011-09-02
Long Range Control Of Gene Expression written by Veronica van Heyningen and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-02 with Science categories.
Long-Range Control of Gene Expression covers the current progress in understanding the mechanisms for genomic control of gene expression, which has grown considerably in the last few years as insight into genome organization and chromatin regulation has advanced. Discusses the evolution of cis-regulatory sequences in drosophila Includes information on genomic imprinting and imprinting defects in humans Includes a chapter on epigenetic gene regulation in cancer
The Study Of The Regulatory Elements Of The Human 221 Globin Gene
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Author : Ping-Kei Chan
language : en
Publisher: Open Dissertation Press
Release Date : 2017-01-26
The Study Of The Regulatory Elements Of The Human 221 Globin Gene written by Ping-Kei Chan and has been published by Open Dissertation Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-26 with categories.
This dissertation, "The Study of the Regulatory Elements of the Human {221}-globin Gene" by Ping-kei, Chan, 陳炳基, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled THE STUDY OF THE REGULATORY ELEMENTS OF THE HUMAN β-GLOBIN GENE Submitted by Chan Ping Kei For the degree of Doctor of Philosophy at The University of Hong Kong in June 2005 The human β-globin locus contains five developmentally regulated β-like globin G A genes arranged in the order of their developmental expression (5' ε-γ-γ-δ-β 3'). All five genes are regulated by an element located far upstream of the locus called the Locus Control Region (LCR). High level of β-globin gene expression is regulated by the LCR which consists of erythroid specific hypersensitive sites HS1 to HS5. Transcriptional regulation of the globin genes occurs through the cooperation of the LCR, the promoters of the globin genes and the interactions of trans-acting proteins. Recent studies show that activation of the β-globin locus involves the spatial formation of a LCR holocomplex that directly interacts with the transcribed genes. This complex is called the Active Chromatin Hub (ACH) (Palstra et al., 2003;Drissen et al., 2004). The objective of this project is to study the functional roles of two regulatory elements, namely, hypersensitive site 5 (HS5) of the LCR and the (AC) (AT) T motif n x y at the promoter of the β-globin gene. We study the enhancer blocking function of HS5 in transgenic mice by analyzing the conformational change in the context of the β-gene locus using the Chromatin Conformation Capture (3C) technique. The results show that HS5 functions as an enhancer blocking element in embryonic blood but not in adult erythroid cells. Interestingly, when HS5 is deleted form the locus, elements located upstream of the LCR are able to interact with the downstream regulatory elements within the β-globin gene locus. These results suggest that HS5 is a developmental stage specific border element. We determine whether CTCF, the only defined insulator protein in mammalian cells, binds to HS5 by using the CTCF-Chromatin immunoprecipitation (ChIP) assay. Our results demonstrate that CTCF binds to human HS5 and may mediate enhancer blocking activity in erythroid cell in vivo. In the second part of the thesis, we have examined the (AC) (AT) T motif n x y residing -530bp 5' upstream of the β-globin gene in Chinese thalassaemic patients. This motif is a putative binding site for a repressor protein, namely beta protein 1 (BP1) (Berg et al., 1989). It has been shown that variations in the (AC) (AT) T n x y repeats affect the binding affinity of BP1 thereby altering the expression of the β-globin gene. Eight different configurations of this repeat motif are identified in our population of Chinese β-thalassaemia patients in Hong Kong. A novel (AC) (AT) T 3 7 5 motif is identified among the thalassaemia patients and its influence in β-globin gene expression is studied using stable transfection assay in murine erythroleukemia (MEL) cells. Our results demonstrate that this motif has moderately strong repressor effect on the expression of the cis-linked β-globin gene. This may be due to the higher affinity of BP1 for the motif resulting in the suppression of the transcription of the β-globin gene. We conclude that the proper developmental expression pattern of the β-like globin gene cluster is absolutely dependent on the presence of both the LCR and the proximal cis-regulatory elements of the globin gene. DOI: 10.5353/th_b
Transcription Factors Involved In Development And Growth Control
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Author : Giulio Superti-Furga
language : fr
Publisher:
Release Date : 1990
Transcription Factors Involved In Development And Growth Control written by Giulio Superti-Furga and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with categories.
Disorders Of Hemoglobin
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Author : Martin H. Steinberg
language : en
Publisher: Cambridge University Press
Release Date : 2009-08-17
Disorders Of Hemoglobin written by Martin H. Steinberg and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-08-17 with Medical categories.
Completely revised new edition of the definitive reference on disorders of hemoglobin.