Digestive Involvement In Systemic Autoimmune Diseases

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Digestive Involvement In Systemic Autoimmune Diseases

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Author : Manuel Ramos-Casals
language : en
Publisher: Elsevier
Release Date : 2011-09-02

Digestive Involvement In Systemic Autoimmune Diseases written by Manuel Ramos-Casals and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-02 with Medical categories.

The Digestive System in Systemic Autoimmune Diseases represents the state-of-the-art in the field of digestive disorders in the most common systemic autoimmune diseases.The volume consists of an introductory chapter on imaging techniques in digestive diseases, followed by eight chapters on digestive manifestations in specific systemic autoimmune diseases. The final five chapters deal with digestive diseases with an autoimmune pathogenesis and systemic manifestations.International in scope, the table of contents reads like a Who's who in clinical research on systemic autoimmune diseases. More than 20 contributors from the European Union, the United States, Mexico and South Africa share their knowledge in this detailed volume. *One book of leading international clinical and scientific experts on autoimmune and digestive diseases*A practical guide to the identification, diagnosis and treatment of digestive involvement in patients with autoimmune diseases that will be useful for all medical specialties*Several diseases and conditions not included in other text books are included, some of which are of recent emergence*Each chapter is designed to serve as a “Guide to Clinical Practice for each disease

The Digestive Involvement In Systemic Autoimmune Diseases

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Author : Manuel Ramos-Casals
language : en
Publisher: Elsevier
Release Date : 2017-01-18

The Digestive Involvement In Systemic Autoimmune Diseases written by Manuel Ramos-Casals and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-18 with Medical categories.

The Digestive System in Systemic Autoimmune Diseases, Second Edition, represents the state-of-the-art in the field of digestive disorders in the most common systemic autoimmune diseases. This volume consists of an introductory chapter on imaging techniques in digestive diseases, followed by eight chapters on digestive manifestations in specific systemic autoimmune diseases. The final five chapters deal with digestive diseases with an autoimmune pathogenesis and systemic manifestations. International in scope, the table of contents reads like a Who's who in clinical research on systemic autoimmune diseases. More than 20 contributors from the European Union, the United States, Mexico, and South Africa share their knowledge in this detailed volume. The book provides an overview of our current understanding of digestive disorders in the most common systemic autoimmune diseases. Completely updated, including five new chapters Presents up-to-date information, giving the reader easy access to individual topics in one place Written by leading international clinical and scientific experts on autoimmune and digestive diseases Provides a practical guide to the identification, diagnosis, and treatment of digestive involvement in patients with autoimmune diseases that will be useful for all medical specialties Includes several diseases and conditions not included in other texts, some of which have only recently emerged Designed to serve as a guide to clinical practice

The Digestive Involvement In Systemic Autoimmune Diseases 2nd Edition

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Author : Manuel Ramos-Casals
language : en
Publisher:
Release Date : 2017

The Digestive Involvement In Systemic Autoimmune Diseases 2nd Edition written by Manuel Ramos-Casals and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.

The Digestive System in Systemic Autoimmune Diseases, Second Edition , represents the state-of-the-art in the field of digestive disorders in the most common systemic autoimmune diseases. This volume consists of an introductory chapter on imaging techniques in digestive diseases, followed by eight chapters on digestive manifestations in specific systemic autoimmune diseases. The final five chapters deal with digestive diseases with an autoimmune pathogenesis and systemic manifestations. International in scope, the table of contents reads like a Who's who in clinical research on systemic autoimmune diseases. More than 20 contributors from the European Union, the United States, Mexico, and South Africa share their knowledge in this detailed volume. The book provides an overview of our current understanding of digestive disorders in the most common systemic autoimmune diseases. Completely updated, including five new chapters Presents up-to-date information, giving the reader easy access to individual topics in one place Written by leading international clinical and scientific experts on autoimmune and digestive diseases Provides a practical guide to the identification, diagnosis, and treatment of digestive involvement in patients with autoimmune diseases that will be useful for all medical specialties Includes several diseases and conditions not included in other texts, some of which have only recently emerged Designed to serve as a guide to clinical practice.

Autoimmune Diseases In Pediatric Gastroenterology

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Author : Faruk Hadziselimovic
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-09-30

Autoimmune Diseases In Pediatric Gastroenterology written by Faruk Hadziselimovic and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-09-30 with Medical categories.

This book is the proceedings of the Falk Symposium No. 127 on `Autoimmune Diseases in Paediatric Gastroenterology' (IV International Falk Symposium on Paediatric Gastroenterology), held in Basel, Switzerland, on November 8-9, 2001. The symposium focused on the role of the immune system, both the acquired and the innate systems, in inflammatory bowel disease (IBD) in children and adolescents. The innate system has an important fundamental role in host defence by initiating immune responses against potentially deleterious matter. However, a mutation within the innate system may elicit an immune response against the host: hence, an autoimmune response. Chronic autoimmune hepatitis occurs predominantly in young people, and especially in women. Immunological changes are conspicuous. Tissue antibodies are found in a large number of patients. This is a disease of disordered immunoregulation marked by a deficit in suppressor T cells causing the production of autoantibodies against specific hepatocyte surface antigen. Liver membrane protein is found in the sera of patients with autoimmune chronic acute hepatitis and with primary biliary cirrhosis (PBC). The latter condition of progressive granulomatous destruction of intrahepatic bile ducts is, in many respects, analogous to the graft-versus-host syndrome where the immune system has become sensitized to foreign HLA-molecules. Primary sclerosing cholangitis (PSC) is another condition of unknown origin. All parts of the biliary tree can be involved in a chronic, fibrosing, inflammatory process that results in obliteration of the biliary tree and ultimately in biliary cirrhosis. About half of the patients also suffer from ulcerative colitis and rarely from Crohn's disease. Circulating antibodies to some antigens are found in obstructed portal tracts, as well as increased concentrations of biliary immune complexes in patients with PBC. In all three previous Falk symposia on paediatric gastroenterology, attention was focused on the role of the innate immune system in the aetiology of IBD. It has become increasingly clear in recent years that the innate system has a much more important and fundamental role in host defence. The decision to initiate an immune response is one of the major roles of the innate system. Mutations within this system could transform it into becoming constitutively active, resulting in an inflammatory reaction and thus eliciting an autoimmune response. Following an introduction to the basic phenomena of autoimmunity, the proceedings discuss clinical aspects of autoimmune diseases. In particular, current knowledge and the state of the art about the diagnosis and treatment of the autoimmune diseases of the gastrointestinal tract are described by world-renowned experts. The book also contains the short presentations on selected topics, as well as abstracts of the mini-posters read by title, which were included in the symposium.

Autoimmune Diseases

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Author : Munther A Khamashta
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-05-26

Autoimmune Diseases written by Munther A Khamashta and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-26 with Medical categories.

Autoimmune Diseases: Acute and Complex Situations provides a detailed overview of conditions associated with autoimmune diseases that are considered either life-threatening or requiring complex management. These include abdominal pain, arthritis, cutaneous ulcers, gastrointestinal hemorrhage, epilepsy, pancreatitis, stroke and white-matter CNS lesions. Autoimmune Diseases: Acute and Complex Situations addresses the latest clinical and immunological prognostic factors that may help to identify patients at higher risk of developing potentially life-threatening involvement. This book comprehensively helps the reader to diagnose these patients, in whom an early therapeutic approach is essential. Autoimmune Diseases: Acute and Complex Situations is a valuable reference tool for rheumatologists, internists, immunologists, and all the specialists involved in the multidisciplinary care of patient with rheumatic and systemic autoimmune diseases.

Skills In Rheumatology

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Author : Hani Almoallim
language : en
Publisher: Springer Nature
Release Date : 2021-01-05

Skills In Rheumatology written by Hani Almoallim and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-05 with Medical categories.

This Open Access book presents practical approaches to managing patients affected by various rheumatological diseases, allowing readers to gain a better understanding of the various clinical expressions and problems experienced by these patients. Discussing rheumatology from an organ systems perspective, it highlights the importance ofdetailed musculoskeletal examinations when treating patients affected by rheumatological diseases. The book first explores the latest diagnostic approaches and offers key tips for accurate musculoskeletal examinations before addressing the various treatment modalities, with a particular focus on the most common joints involved in rheumatoid arthritis: the wrists and the metacarpophalangeal joints (2nd and 3rd). Featuring easy-to-understand flow diagrams and explaining the common medical problems associated with rheumatic disease, such as shortness of breath and anemia, it is not only a valuable resource to rheumatologists, but will also appeal to medical students, junior residents, and primary healthcare physicians.

Gut Microbial Taxa And Products That Regulate Immune Responses And Disease Features

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Author : Yu-Ling Chang
language : en
Publisher:
Release Date : 2017

Gut Microbial Taxa And Products That Regulate Immune Responses And Disease Features written by Yu-Ling Chang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.

Gut microbiome has a profound effect on human health and disease. The burgeoning body of research investigating the gut microbiome has illustrated its important roles on not only the local inflammatory diseases, such as inflammatory bowel disease, but also on systemic immunological disorders, such as autoimmune diseases. Many of these associations were determined at the level of metagenome analysis. This provides categorical information on both taxonomic composition and predicted functional capacities of the microbial community. This thesis tackles the problem of how gut microbiota affect human diseases using both these categories of assessment. Although the accumulating evidence suggested the important roles of gut microbiota in the human immune system and Crohn's disease (CD), the molecular mechanisms of how microbiome directly modulates immune responses and leads to CD progression remain unclear. To advance the current understanding of microbial roles in CD, we developed a systems biology approach to assess the human immune function in response to disease-associated microbial products. Progress in computational omics analysis of the microbiome in CD enables the functional inference and prediction of microbial metabolites. Both genetic and clinical studies suggested the involvement of human CD4+ T cells in CD progression. We therefore tabulated a set of microbial metabolites predicted to be differentially abundant in CD, and screened these microbial metabolites for their bioactivity in human CD4+ T cell functions. Our screen revealed 15 bioactive microbial metabolites, 3 previously reported and 12 unprecedented, with selective action on CD4+ T cell cytokine production. Mechanistic assessment of one novel microbe-derived metabolite, ascorbate, revealed apoptosis of activated human CD4+ T cells associated with selective inhibition of glycolytic energy metabolism. These findings suggest a substantial rate (11%) of bioactive metabolites among the predicted CD-associated metabolite reservoirs and provide evidence for novel modes of microbial activity targeting T cell metabolism. Emerging studies have characterized the association of taxonomic composition with systemic autoimmune diseases with various clinical phenotypes and modes of pathologic immune responses. In this thesis, we assessed systemic sclerosis (SSc), a previously unstudied autoimmune disease with respect to the microbiome, notable for both systemic manifestations and gastrointestinal involvement. The metagenomic study of mucosal-luminal interface (MLI) samples revealed a unique microbial composition associated with disease state. Patients with SSc had decreased abundances of Faecalibacterium and Clostridium, and increased abundances of Bifidobacterium, Lactobacillus, Fusobacterium and -Proteobacteria compared with healthy controls. In addition, the increase of Fusobacterium species and the decrease of Bacteroides fragilis were associated with moderate/severe gastrointestinal symptoms. We conducted an independent study of faecal samples from two independent cohorts of patients, from United States and Norway, that revealed a similar group of microbial taxa associations, and a greater dysbiosis in patients from the United States. These studies enable the specific targets for intervention to avert or treat the gastrointestinal involvement in systemic sclerosis. The study of gut microbiota is beginning to evolve from association toward causality. The functions of gut microbiota are not only restricted to local inflammatory responses but expanded to systemic immune regulations.i We hypothesized that gut microbiome may regulate host immune cellular responses by producing metabolites. We investigated the bioactive microbial factors regulating Crohn's disease, and explored the potential microbial taxonomic biomarkers in a systemic autoimmune disorder, SSc. Those improved understandings of the microbiome activity and metabolism may inform therapeutic strategies and ultimately improve patient health.

Digestive And Hepatic Aspects Of The Rheumatic Diseases An Issue Of Rheumatic Disease Clinics Of North America E Book

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Author : Liron Caplan
language : en
Publisher: Elsevier Health Sciences
Release Date : 2017-11-27

Digestive And Hepatic Aspects Of The Rheumatic Diseases An Issue Of Rheumatic Disease Clinics Of North America E Book written by Liron Caplan and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-27 with Medical categories.

This issue of Rheumatic Disease Clinics, guest edited by Dr. Liron Caplan, will cover a number of key topics related to the digestive and hepatic aspects of rheumatic disease. The articles in this issue will include: Gastrointestinal and Hepatic Disease in Systemic sclerosis, Gastrointestinal and Hepatic Disease in Spondyloarthritis, Gastrointestinal and Hepatic Disease in Systemic Lupus erythematosus, Gastrointestinal and Hepatic Disease in Rheumatoid Arthritis, Gastrointestinal and Hepatic Disease in Behcets, Gastrointestinal and Hepatic Disease in Fibromyalgia, Gastrointestinal and Hepatic Disease in Sjogren's, among others.

Dermatologic Immunity

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Author : Brian J. Nickoloff
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2008-01-01

Dermatologic Immunity written by Brian J. Nickoloff and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-01 with Medical categories.

Nickeloff (skin cancer research, Cardinal Bernardin Cancer Center, Chicago) and Nestle (cutaneous medicine and immunotherapy, King's College, London School of Medicine at Guy's, UK) assemble 19 review articles on autoimmune disease processes that affect the skin, covering both humoral and cellular immunity. The etiology, cellular and molecular mechanisms, therapeutic strategies, and pathophysiology of diseases such as psoriasis, dermatitis, cutaneous lupus erythematosus, vitiligo, and scleroderma are discussed by individuals in dermatology, genetics, immunology, and pathology who are based around the world. The book is aimed at clinical researchers, students, allergists, immunologists, dermatologists, and internists.

Mayo Clinic Gastroenterology And Hepatology Board Review

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Author : Stephen C. Hauser
language : en
Publisher: CRC Press
Release Date : 2005-08-29

Mayo Clinic Gastroenterology And Hepatology Board Review written by Stephen C. Hauser and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-08-29 with Medical categories.

Written in a quick-review format perfect for the busy student and clinician, this Second Edition stands as the most illustrative and in-depth guide available to prepare for the gastroenterology board and recertification exams. Supplying readers with an armamentarium of case-based presentations, 219 quality images, and more than 400 references for f