Disorders Of The Monocyte Macrophage System
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Disorders Of The Monocyte Macrophage System
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Author : F. Schmalzl
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Disorders Of The Monocyte Macrophage System written by F. Schmalzl and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The origin and function of normal monocytes and macrophages have been clearly defined by extensive investigations in human and in animal models. The central importance ofthis cell system for the biological defense mecha nisms is well established: phagocytosis, inactivation and destruction of organic and inorganic materials, an important role in the initiation ofhumo ral and cell mediated immunological responses, and the secretion of a varie ty of chemical mediator and effector substances are the most important fea tures of this ontogenetically ancient cell system. However, the data on this cellular system are rather recent, and this may explain why relatively little attention has been payed to the pathology of the monocyte-macrophage system (MMS) until now. In addition, this monograph should focus attention on the secondarypa thophysiological implications of the MMS in disorders not primarily origi nating from this system. Several techniques are available to identify even abnormal individuals of this cell system and, therefore, can be employed for the study of severely altered or neoplastic monocytic cells.
Monocytes And Macrophages In Development Regeneration And Disease
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Author : Malgorzata Kloc
language : en
Publisher: Springer
Release Date : 2024-09-15
Monocytes And Macrophages In Development Regeneration And Disease written by Malgorzata Kloc and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-15 with Medical categories.
The study and therapeutic application of macrophages is a rapidly developing field. Tremendous progress has been made in understanding the phenotypes and functions of macrophages in healthy and diseased tissues and organs. Following the great success of Volume 62: "Macrophages - Origin, Functions and Biointervention" published in this series, this new book now focuses on the role of monocytes and macrophages in development, regeneration and disease. This new volume offers an overview of the latest developments in monocyte and macrophage subtypes and functions across various tissues including adipose tissue, bones, liver, lungs, testes, and the nervous system. The book also reviews existing and potential therapies targeted towards the macrophages and describes their homeostatic functions. It explores how macrophage cell cycle, metabolism, mitochondrial activity, histone acetylation status, and interaction with the extracellular matrix contribute to changes in macrophage phenotype and function in health and disease. Additionally, it examines the interactions between macrophages and cancer cells, bacteria, helminth parasites, and their role in the colonization and spread of HIV. For ease of reference, the volume is divided into three sections: Part I Nonimmunologic and immunologic functions of monocytes/macrophages Part II Tissue/organ specific functions of macrophages Part III Macrophage functions and dysfunction in diseases This book will be of interest to researchers working in the fields of developmental biology, immunology, cancer research, and therapeutic applications. It is written to inform and inspire experts and newcomers to the field of macrophages.
The Monocyte Macrophage System In Chronic Inflammation
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Author : Sunil Kumar Gupta
language : en
Publisher:
Release Date : 1984
The Monocyte Macrophage System In Chronic Inflammation written by Sunil Kumar Gupta and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with categories.
Hematology In Clinical Practice Fifth Edition
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Author : Robert S. Hillman
language : en
Publisher: McGraw Hill Professional
Release Date : 2010-10-22
Hematology In Clinical Practice Fifth Edition written by Robert S. Hillman and has been published by McGraw Hill Professional this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-22 with Medical categories.
The most practical and efficient guide to the diagnosis and management of blood disorders – now in full color 200 full-color illustrations! Hematology in Clinical Practice is a succinct, cutting-edge guide to the diagnosis and treatment of disorders of red blood cells, white blood cells, and hemostasis, and the use of blood components for transfusion. Each disease state is discussed in detail, incorporating the pathophysiology, clinical features, up-to-date laboratory testing, and current management strategies into a comprehensive and practical approach to hematologic disorders. Features: New full-color presentation includes over 200 superb illustrations and classic images of blood morphology, tissue pathology, and clinical findings New Case Histories introduce and continue through relevant chapters, highlighting critical clinical points for diagnosis and management New end-of-chapter Points to Remember encapsulate key clinical information New chapters include Anemia in the Elderly and expanded and updated coverage of Transplantation and treatment of hematologic malignancies Outstanding collection of tables, charts, and illustrations that translate basic science into valuable clinical context Strong focus on practical clinical management and supportive care Coverage of state-of-the-art drugs and chemotherapies and the latest advances in genetic testing and molecular pathways Conveniently organized into sections on Red Cells, White Cells, Hemostasis, and Transfusion Medicine
Regulatory Role Of Monocytes And Macrophages In Infection And Immunity
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Author : Adam Peres
language : en
Publisher:
Release Date : 2018
Regulatory Role Of Monocytes And Macrophages In Infection And Immunity written by Adam Peres and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
"The immune system uses a network of defense mechanisms that protects the host from infections. Although essential for host survival, this system can also be detrimental due to excessive inflammation and tissue damage. Therefore, hosts have evolved anti-inflammatory mechanisms aimed at controlling pro-inflammatory responses and contributing to host-commensal or -pathogen interactions and disease tolerance. Monocytes and macrophages are cells that are often the initiators and targets of both pro- and anti-inflammatory responses, and play major roles in the pathogenesis and regulation of many diseases. This thesis explored the role of two such immune-regulatory molecules, interleukin 10 (IL-10) and the aryl hydrocarbon receptor (AHR) in the regulation of monocyte responses.The first manuscript investigated the capacity of nasal Staphylococcus aureus isolates to induce the production of the anti-inflammatory cytokine IL-10 by human primary monocytes. Using laboratory strains of S. aureus, our lab had previously reported the importance of IL-10 in regulating T cell activation by staphylococcal superantigens (SAg). Here, we demonstrated that the induction of IL-10 by 16 nasal isolates of S. aureus differed by up to 3-fold. Mechanistically, the magnitude of IL-10 induction was due to differential degree of activation of the PI3K-Akt-mTOR pathway by S. aureus. The IL-10 response to S. aureus could also be uncoupled from the pro-inflammatory TNF-[alpha] response by both the signaling pathways used and the requirement for internalization and phagosome maturation. Lastly, the IL-10-inducing capacity of a nasal S. aureus isolate correlated with the suppression of SAg-induced T cell activation and lower Th1 cytokine production.The other manuscripts included in this thesis focused on the regulation of AHR in the context of monocyte and macrophage responses. We first examined the expression of the AHR gene program in monocytes during inflammation. To do this, we concomitantly stimulated human monocytes with either the toll-like receptor 4 (TLR4) ligand LPS or S. aureus, and an AHR ligand FICZ and found that LPS or S. aureus specifically blocked the induction of Cyp1a1 and Cyp1b1 mRNA. These enzymes metabolize AHR ligands to negatively regulate its activation. Interestingly, FICZ-induced CYP1 protein activity was restricted to monocyte-derived macrophages differentiated by GM-CSF (GM-MDMs) and was also regulated by LPS. Lastly, AHR ligands regulated cytokine production in GM-MDMs.Next, we explored the CYP1-AHR axis in the host response to endotoxin and endotoxin tolerance. Mice lacking AHR were more susceptible to endotoxemia than wild-type mice due to excessive cytokine production, but did not present an impairment in the establishment of endotoxin tolerance. We corroborated these findings in vitro using primary human monocytes. We also observed that, during endotoxemia, liver Cyp1a2 expression and activity was significantly reduced. We therefore hypothesized that Cyp1a2-deficient mice would be protected from LPS-driven immunopathology because of an increased bioavailability of AHR ligands that would dampen the inflammatory response by macrophages. However, we observed higher susceptibility of these mice to a primary LPS challenge. The mechanistic explanation for this finding is unclear and is still currently being investigated.Collectively, the work in this thesis furthered our understanding of the involvement of IL-10 and the AHR gene program in the immune regulatory role that monocytes and monocyte-derived macrophages play during commensalism and infectious diseases." --
The Impact Of Food Bioactives On Health
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Author : Kitty Verhoeckx
language : en
Publisher: Springer
Release Date : 2015-04-29
The Impact Of Food Bioactives On Health written by Kitty Verhoeckx and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-29 with Technology & Engineering categories.
“Infogest” (Improving Health Properties of Food by Sharing our Knowledge on the Digestive Process) is an EU COST action/network in the domain of Food and Agriculture that will last for 4 years from April 4, 2011. Infogest aims at building an open international network of institutes undertaking multidisciplinary basic research on food digestion gathering scientists from different origins (food scientists, gut physiologists, nutritionists...). The network gathers 70 partners from academia, corresponding to a total of 29 countries. The three main scientific goals are: Identify the beneficial food components released in the gut during digestion; Support the effect of beneficial food components on human health; Promote harmonization of currently used digestion models Infogest meetings highlighted the need for a publication that would provide researchers with an insight into the advantages and disadvantages associated with the use of respective in vitro and ex vivo assays to evaluate the effects of foods and food bioactives on health. Such assays are particularly important in situations where a large number of foods/bioactives need to be screened rapidly and in a cost effective manner in order to ultimately identify lead foods/bioactives that can be the subject of in vivo assays. The book is an asset to researchers wishing to study the health benefits of their foods and food bioactives of interest and highlights which in vitro/ex vivo assays are of greatest relevance to their goals, what sort of outputs/data can be generated and, as noted above, highlight the strengths and weaknesses of the various assays. It is also an important resource for undergraduate students in the ‘food and health’ arena.
Human Monocytes
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Author : Marek Zembala
language : en
Publisher:
Release Date : 1989
Human Monocytes written by Marek Zembala and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Medical categories.
Monocytes represent one of the major types of white blood cells in man which prevent infection by ingesting and killing invading pathogens and by releasing factors which stimulate and regulate lymphocytes. Monocytes "purify" the blood, removing immune complexes, mediating inflammatory responses, and initiating tissue repair. Human Monocytes represents an up-to-date, definitive account of this important cell. It covers the cells biochemical, immunological, and inflammatory functionsand its role in many diseases, including asthma, atherosclerosis, rheumatoid arthritis, and AIDS.
Histiocytic Disorders Of Children And Adults
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Author : Sheila Weitzman
language : en
Publisher: Cambridge University Press
Release Date : 2011-02-17
Histiocytic Disorders Of Children And Adults written by Sheila Weitzman and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-17 with Medical categories.
As a comprehensive reference on all aspects of the histiocytic disorders, Histiocytic Disorders of Children and Adults stands out a seminal text on the genetics, pathophysiology and clinical management of this wide range of diseases. The chapters, written by acknowledged experts in the field, cover all aspects of hystiocytic disorders, from Langerhans cell histiocytosis and hemophagocytic lymphohistiocytosis, to the uncommon cutaneous and extracutaneous histiocytic disorders. Views on the function of normal histiocytes in the immune system, the pathogenesis, underlying genetic defects, clinical presentation, treatment, controversies in therapy, salvage therapies and the late consequences are discussed in detail. Originally published in 2005, this book will be a valuable resource to clinicians and researchers who wish to learn more about histiocytic disorders.
Janeway S Immunobiology
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Author : Kenneth Murphy
language : en
Publisher: Garland Science
Release Date : 2010-06-22
Janeway S Immunobiology written by Kenneth Murphy and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-22 with Medical categories.
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Central Nervous System Diseases And Inflammation
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Author : Thomas E. Lane
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-24
Central Nervous System Diseases And Inflammation written by Thomas E. Lane and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-24 with Medical categories.
Edited and authored by top names in the field, this book provides a succinct reference on inflammatory central nervous system disease. It focuses on current areas of investigation in the fields of neuroimmunology, virology, pharmacology, and disease. Sections focus on specific categories of diseases, examining the pharmacological, virological, and immunological effects of and on the disease. This book’s unique organization provides a concise overview of inflammatory CNS disease.
