Dna As A Programmable Material
DOWNLOAD
Download Dna As A Programmable Material PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Dna As A Programmable Material book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Dna As A Programmable Material
DOWNLOAD
Author : Samuel James Hwang
language : en
Publisher:
Release Date : 2008
Dna As A Programmable Material written by Samuel James Hwang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Deoxyribonucleic acid (DNA), the polymeric molecule that carries the genetic code of all living organisms, is arguably one of the most programmable assembly materials available to chemists, biologists, and materials scientists. Scientists have used DNA to build many different structures for various applications in disparate areas of research from traditional biological applications to more recent non-biological applications. Although DNA isn't typically thought of as an assembly material by people not doing research in the area, the availability of decreasing cost synthetic oligonucleotides has led to advances in gene fabrication technology which in turn has enabled synthetic biology to flourish. Using DNA as a building material for small and large constructs of DNA is reliant on having effective gene synthesis techniques. Construction of synthetic DNA is limited by errors that pervade the final product. To address this problem, effective error correction methods are pivotal. Having extremely robust gene synthesis and error correction techniques will allow researchers to generate very large scale constructs potentially necessary in applications such as genome re-engineering.
Building Programmable Matter Through Dna Based Chemical Computing
DOWNLOAD
Author : Sifang Chen
language : en
Publisher:
Release Date : 2019
Building Programmable Matter Through Dna Based Chemical Computing written by Sifang Chen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Biology offers compelling proof that macroscopic "living materials" can emerge from reactions between diffusing biomolecules. This work presents how molecular self-organization could be a similarly powerful approach for engineering functional synthetic materials. We focus on programmable DNA-hydrogels that produces tunable patterns at the centimeter length scale. We generate these patterns by implementing chemical reaction networks through synthetic DNA complexes, embedding the complexes in hydrogel, and triggering with locally applied input DNA strands. Chapter 1 provides an overview of the state of the art in programmable matter research. It also examines where current approaches, such as modular robotics and nanoscale engineering, may fall short. Chapter 2 presents chemical reaction-diffusion as an alternative approach to synthesizing programmable materials. Chapter 3 describes DNA computing and why it is ideal for realizing programmable reaction-diffusion systems. Chapters 4 and 5 introduce the DNA-based reaction-diffusion systems we have implemented for making programmable spatial patterns. In Chapter 4, we demonstrate a DNA-based multi-layered cascade circuit where each layer consists of signal generation, signal suppression, and signal restoration modules. In Chapter 5, we couple in vitro experiments with computer simulation to demonstrate programmable spatial patterns that can be designed and simulated in advance.
Dna Nanotechnology
DOWNLOAD
Author : Chunhai Fan
language : en
Publisher: Springer Nature
Release Date : 2020-09-07
Dna Nanotechnology written by Chunhai Fan and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-07 with Technology & Engineering categories.
The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. The chapter "DNA-Programmed Chemical Synthesis of Polymers and Inorganic Nanomaterials" is available open access under a CC BY 4.0 License via link.springer.com.
Dna Nanostructures As A Printing Press For Dna Polymer Hybrid Materials
DOWNLOAD
Author : Sean Laxton
language : en
Publisher:
Release Date : 2022
Dna Nanostructures As A Printing Press For Dna Polymer Hybrid Materials written by Sean Laxton and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
"Block copolymers have widespread use in areas such as luminescence, photovoltaics, electronics, optics, shape memory, self healing, stimuli-responsiveness, photonics, and drug delivery due to their predictable, ordered nanostructures. However, block copolymer materials are usually restricted to highly symmetric spherical, cylindrical, lamellar, and vesicular morphologies, resulting from the non-covalent interactions that direct their assembly. Recent interest, inspired by natural systems, has emerged to break the symmetry in polymer self-assembly to achieve materials with new and unusual functional properties. To break the symmetry of polymer assembly, patchy particles, Janus particles, multicompartment particles, and lithography have been employed. Although these methods of polymer assembly have improved the range of polymer architectures, they have limited control of the compartmentalization and orientation of the binding sites on the particle surface. In contrast, DNA nanotechnology harnesses Watson-Crick-Franklin base pairing to create highly specific and programmable assemblies at the nanoscale. Therefore, transferring a pattern of DNA strands from a DNA nanostructure onto polymer particles ("printing") combines the materials properties of polymers with the high structural control of DNA nanotechnology. In this thesis, advances to make new DNA polymer hybrid materials are employed-with an emphasis of printing DNA patterns on polymer particle surfaces. First, the use of DNA cubes as a 2D printing press, placing DNA strands with controlled sequence, valency, and patterns on the surface of block copolymer micelles and spherical nucleic acids will be investigated. Second, using sequence-defined polymers, a polymer particle that can be assembled inside a DNA cube with a 3D DNA pattern attached will be examined. Again, these printed strands have controlled DNA sequence, valency, and pattern on the surface. Furthermore, these 3D cube printed particles can have polymers attached, with click chemistry, to the surface to change particle properties. All these cube printing methods are modular; changing the polymer composition of the DNA printed particles can further give assemblies with given polymer types at a given position, further tuning the material properties. Lastly, spherical nucleic acids will be used as a nanoreactor to incorporate hydrophobic drug-polymer conjugates for controlled drug release. These materials will be useful for drug delivery and building blocks for asymmetric polymer patterning. Overall, these DNA-polymer materials can be used to make new hierarchical and functional materials through their programmable assembly"--
Structural Dna Nanotechnology
DOWNLOAD
Author : Nadrian C. Seeman
language : en
Publisher: Cambridge University Press
Release Date : 2015
Structural Dna Nanotechnology written by Nadrian C. Seeman and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Computers categories.
Written by the founder of the field, this is a comprehensive and accessible introduction to structural DNA nanotechnology.
Programmable Biomolecular Integration And Dynamic Behavior Of Dna Based Systems For Development Of Biomedical Nano Devices
DOWNLOAD
Author : Jaeseung Hahn
language : en
Publisher:
Release Date : 2019
Programmable Biomolecular Integration And Dynamic Behavior Of Dna Based Systems For Development Of Biomedical Nano Devices written by Jaeseung Hahn and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Departing from the traditional role as a carrier of genetic information, DNA has emerged as an engineering material for construction of nano-devices. The advances in the field of DNA nanotechnology have enabled design and synthesis of DNA nanostructures of arbitrary shapes and manipulation of the nanostructures' conformations in a programmable way. DNA-based systems offer potential applications in medicine by manipulating the biological components and processes that occur at the nanometer scale. To accelerate the translation of DNA-based systems for medical applications, we identified some of the challenges that are hindering our ability to construct biomedical nano-devices and addressed these challenges through advances in both structural and dynamic DNA nanotechnology. First, we tested the stability of DNA nanostructures in biological environments to highlight the necessity of and path towards protection strategies for prolonged integrity of biomedical nano-devices. Then, we constructed a platform for robust 3D molecular integration using DNA origami technique and implemented the platform for a nanofactory capable of production of therapeutic RNA to overcome the challenges in RNA delivery. Moreover, we established a mechanism to drive DNA devices by changing temperature with prolonged dynamic behavior that was previously challenging to accomplish without special modification of DNA and/or equipment not readily available in a typical lab setting. Together, the progress made in this thesis bring us another step closer to realization of medical applications of DNA nanotechnology by focusing on the challenges in both structural and dynamic aspects of the technology.
Dna Computing And Molecular Programming
DOWNLOAD
Author : Robert Brijder
language : en
Publisher: Springer
Release Date : 2017-08-22
Dna Computing And Molecular Programming written by Robert Brijder and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-22 with Computers categories.
This book constitutes the refereed proceedings of the 23th International Conference on DNA Computing and Molecular Programming, DNA 23, held Austin, TX, USA, in September 2017. The 16 full papers presented were carefully selected from 23 submissions. Research in DNA computing aims to draw together mathematics, computerscience, physics, chemistry, biology, and nanotechnology to address the analysis, design, and synthesis of information-based molecular systems. The papers address all areas related to biomolecular computing such as: algorithms and models for computation with biomolecular systems; computational processes in vitro and in vivo; molecular motors and molecular robotics; studies of fault-tolerance and error correction; software tools for analysis, simulation, and design; synthetic biology and in vitro evolution; applications in engineering, physics, chemistry, biology, and medicine.
Materials Science Of Dna
DOWNLOAD
Author : Jung-II Jin
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Materials Science Of Dna written by Jung-II Jin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
The field of materials science and technology has undergone revolutionary advances due to the development of novel analytical tools, functional materials, and multidisciplinary approaches to engineering. Additionally, theoretical predictions combined with increasingly improved models and computational capabilities are making impressive contribution
Self Assembly Of Complex Dna Nanostructures And Reconfigurable Dna Devices
DOWNLOAD
Author : Fei Zhang
language : en
Publisher:
Release Date : 2015
Self Assembly Of Complex Dna Nanostructures And Reconfigurable Dna Devices written by Fei Zhang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with DNA. categories.
Deoxyribonucleic acid (DNA) has emerged as an excellent molecular building block for nanoconstruction in addition to its biological role of preserving genetic information. Its unique features such as predictable conformation and programmable intra- and inter-molecular Watson-Crick base pairing interactions make it a remarkable engineering material. A variety of convenient design rules and reliable assembly methods have been developed to engineer DNA nanostructures. The ability to create designer DNA architectures with accurate spatial control has allowed researchers to explore novel applications in directed material assembly, structural biology, biocatalysis, DNAcomputing, nano-robotics, disease diagnosis, and drug delivery. This dissertation focuses on developing the structural design rules for "static" DNA nano-architectures with increasing complexity. By using a modular self-assembly method, Archimedean tilings were achieved by association of different DNA motifs with designed arm lengths and inter-tile sticky end interactions. By employing DNA origami method, a new set of design rules was created to allow the scaffolds to travel in arbitrary directions in a designed geometry without local symmetry restrictions. Sophisticated wireframe structures of higher-order complexity were designed and constructed successfully. This dissertation also presents the use of "dynamic" DNA nanotechnology to construct DNA origami nanostructures with programmed reconfigurations.
Dna Programmed Assembly Of Active Matter At The Micro And Nano Scales
DOWNLOAD
Author : Ibon Santiago Gonzalez
language : en
Publisher:
Release Date : 2017
Dna Programmed Assembly Of Active Matter At The Micro And Nano Scales written by Ibon Santiago Gonzalez and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.