Dna Deamination In Immunity Virology And Cancer
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Dna Deamination In Immunity Virology And Cancer
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Author : Frances M. Ashcroft
language : en
Publisher:
Release Date : 2009
Dna Deamination In Immunity Virology And Cancer written by Frances M. Ashcroft and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Camouflage (Biology) categories.
Dna Deamination In Immunity Virology And Cancer
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Author : Patricia J. Gearhart
language : en
Publisher:
Release Date : 2009
Dna Deamination In Immunity Virology And Cancer written by Patricia J. Gearhart and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Deamination categories.
Dna Deamination In Immunity Virology And Cancer
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Author : Patricia J. Gearhart
language : en
Publisher:
Release Date : 2009
Dna Deamination In Immunity Virology And Cancer written by Patricia J. Gearhart and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
Runx Proteins In Development And Cancer
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Author : Yoram Groner
language : en
Publisher: Springer
Release Date : 2017-03-15
Runx Proteins In Development And Cancer written by Yoram Groner and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-15 with Medical categories.
This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other mammals have three RUNX genes that are known to play specific roles in blood, bone and neuronal development. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy. The pleiotropic effects of RUNX in development are mirrored in cancer, where RUNX genes can function as oncogenes that collaborate strongly with Myc family oncogenes or as tumour suppressor genes. In the latter role, they display hallmarks of both ‘gatekeepers’ that modulate p53 responses and ‘caretakers’ that protect the genome from DNA damage. Several chapters focus on the importance of these genes in leukemia research, where RUNX1 and CBFB are frequently affected by chromosomal translocations that generate fusion oncoproteins, while recent studies suggest wider roles for RUNX modulation in solid cancers. Moreover, RUNX genes are intimately involved in the development and regulation of the immune system, while emerging evidence suggests a role in innate immunity to infectious agents, including HIV. At the biochemical level, the RUNX family can serve as activators or repressors of transcription and as stable mediators of epigenetic memory through mitosis. Not surprisingly, RUNX activity is controlled at multiple levels, this includes miRNAs and a plethora of post-translational modifications. Several chapters highlight the interplay between the three mammalian RUNX genes, where cross-talk and partial functional redundancies are evident. Finally, structural analysis of the RUNX/CBFB interaction has led to the development of small molecule inhibitors that provide exciting new tools to decipher the roles of RUNX in development and as targets for therapy. This volume provides a compendium and reference source that will be of broad interest to cancer researchers, developmental biologists and immunologists.
Dna Repair Part A
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Author :
language : en
Publisher: Elsevier
Release Date : 2006-06-06
Dna Repair Part A written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-06-06 with Science categories.
DNA Repair, Part A provides detailed coverage of modern methods for molecular analysis of enzymes and enzyme systems that function in the maintenance of genome integrity. Coverage areas include base excision repair, nucleotide excision repair, translesion DNA polymerases, mismatch repair, genetic recombination, and double strand break repair. A laboratory standard for more than 40 years Over 400 volumes strong Also available on ScienceDirect Part A of a 2-part series
Intrinsic Immunity
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Author : Bryan R. Cullen
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-05-17
Intrinsic Immunity written by Bryan R. Cullen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-17 with Medical categories.
Recent research has focused attention on the importance of intrinsic antiviral immunity, i.e. immunity mediated by factors that are constitutively expressed in many cells. In this volume, leading experts provide a comprehensive overview of this relatively new and rapidly evolving field. They cover intrinsic proteinaceous antiviral immune effectors, such as the APOBEC3 and TRIM protein families as well as Tetherin and SAMHD1, which were initially discovered by researchers studying HIV-1. Furthermore, the role of RNA interference in antiviral defense in plants and invertebrates, as well as the interplay between microRNAs and viruses in mammalian cells, are analysed. One chapter discusses how intrinsic immunity and viral countermeasures to intrinsic immune effectors drive both pathogen and host evolution, and finally the emerging evidence that DNA damage response proteins restrict infection by DNA viruses is highlighted.
Molecular Virology
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Author : Susanne Modrow
language : en
Publisher: Springer
Release Date : 2013-09-18
Molecular Virology written by Susanne Modrow and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-18 with Science categories.
The book gives a comprehensive overview on the knowledge of virus infection relevant for humans and animals. For each virus family the molecular details of the virus particle and the viral replication cycle are described. In the case of virus types with relevance for human and/or animal health the data on molecular biology, genetics and virus-cell interaction are combined with those concerning, pathogenesis, epidemiology, clinics, prevention and therapy.
Molecular Determinants Of Head And Neck Cancer
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Author : Barbara Burtness
language : en
Publisher: Springer
Release Date : 2018-08-03
Molecular Determinants Of Head And Neck Cancer written by Barbara Burtness and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-03 with Medical categories.
Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining surgery or irradiation with chemotherapy; even successfully treated patients frequently experience durable and severe side effects. Improving cure rates and reducing chronic morbidity are urgent clinical needs for head and neck cancer. However, in contrast to cancer types such as breast or prostate that have been much studied and have well-defined biology, until recently, relatively few researchers investigated the molecular basis of HNC, making it difficult to design targeted treatments with better efficacy and less debilitating side effects. This volume will provide an overview of the factors contributing to disease pathogenesis, including the recognition of discrete molecular subtypes with distinct etiology, prognosis, and treatment response. This volume will familiarize the reader with the critical signaling pathways and oncogenic drivers for HNC. It will outline the differences between HPV-positive and HPV-negative disease, and how these differences affect treatment choice and outcome. The book will emphasize developments in the past five years, including the growing understanding of the genomic and epigenomic features of the disease based on analysis of next generation sequencing (NGS) data, and timely topics such as the analysis of HNC stem cell populations, non-coding mRNAs, and inflammatory response. It will address exciting new therapeutic approaches such as the use of immunotherapies to treat HNC patients. Overall, the book will provide the reader with current understanding of the biology and treatment of the disease, and describe timely questions that will guide future research aimed at controlling and curing this disease.
B Cells In Immunity And Tolerance
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Author : Ji-Yang Wang
language : en
Publisher: Springer
Release Date : 2021-05-07
B Cells In Immunity And Tolerance written by Ji-Yang Wang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-07 with Medical categories.
This book contains twelve chapters contributed by prestigious international experts who are at the forefront of B cell research, and aims to provide a cutting-edge and comprehensive overview of all aspects of B cells, including B cell development, maturation and activation, germinal center reaction, memory and plasma cell differentiation, and antibody-mediated positive and negative regulation of humoral immune responses. There are also three chapters describing human diseases caused by B cell abnormalities, including primary antibody deficiencies, autoimmune diseases, and B cell malignancies. We hope that this book will become a standard and routine reference for both basic researchers and clinicians.
Current Research On Cancer Virology
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Author : Current Cancer Research Project Analysis Center (U.S.)
language : en
Publisher:
Release Date : 1975
Current Research On Cancer Virology written by Current Cancer Research Project Analysis Center (U.S.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1975 with Cancer categories.
1275 references to research projects being conducted in the United States and elsewhere. Entries arranged under 9 topics, e.g., Antiviral procedures, Viral transmission, and Other viral carcinogenesis. Entries include title, researcher, address, contract number, summary, and supporting agency. Indexes by subjects, investigators, contractors, supporting agencies, and contractor numbers.