Dna Methyltransferases Role And Function
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Dna Methyltransferases Role And Function
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Author : Albert Jeltsch
language : en
Publisher: Springer
Release Date : 2016-11-08
Dna Methyltransferases Role And Function written by Albert Jeltsch and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-08 with Science categories.
DNA methyltransferases are important enzymes in a broad range of organisms. Dysfunction of DNA methyltransferases in humans leads to many severe diseases, including cancer. This book focuses on the biochemical properties of these enzymes, describing their structures and mechanisms in bacteria, humans and other species, including plants, and also explains the biological processes of reading of DNA methylation and DNA demethylation. It covers many emerging aspects of the biological roles of DNA methylation functioning as an essential epigenetic mark and describes the role of DNA methylation in diseases. Moreover, the book explains modern technologies, like targeted rewriting of DNA methylation by designed DNA methyltransferases, as well as technological applications of DNA methyltransferases in DNA labelling. Finally, the book summarizes recent methods for the analysis of DNA methylation in human DNA. Overall, this book represents a comprehensive state-of-the-art- work and is a must-have for advanced researchers in the field of DNA methylation and epigenetics.
Role Of Dna Methyltransferases In The Epigenome
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Author : Albert Jeltsch
language : en
Publisher: MDPI
Release Date : 2020-03-05
Role Of Dna Methyltransferases In The Epigenome written by Albert Jeltsch and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-05 with Science categories.
DNA methylation, a modification found in most species, regulates chromatin functions in conjunction with other epigenome modifications, such as histone post-translational modifications and non-coding RNAs. In mammals, DNA methylation has an essential role in development by orchestrating the generation and maintenance of the phenotypic diversity of human cell types. Recent years have brought spectacular advances in our understanding of the mechanism, function and regulation of DNA methyltransferases through their interaction with other epigenome modifications, chromatin factors and post-translational modifications, which are described in this Special Issue of Genes. Manuscripts are specifically addressing describing the targeting and regulation of DNA methyltransferases by interacting factors and their roles in cellular differentiation and the development of diseases. Prof. Dr. Albert Jeltsch and Prof. Dr. Humaira Gowher, Guest Editors
The Role Of Dna Methyltransferases In Development And Function Of The Central Nervous System
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Author : Jian Feng
language : en
Publisher:
Release Date : 2007
The Role Of Dna Methyltransferases In Development And Function Of The Central Nervous System written by Jian Feng and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.
Role Of Dna Methyltransferases In The Epigenome
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Author : Albert Jeltsch
language : en
Publisher:
Release Date : 2020
Role Of Dna Methyltransferases In The Epigenome written by Albert Jeltsch and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Biology (General) categories.
DNA methylation, a modification found in most species, regulates chromatin functions in conjunction with other epigenome modifications, such as histone post-translational modifications and non-coding RNAs. In mammals, DNA methylation has an essential role in development by orchestrating the generation and maintenance of the phenotypic diversity of human cell types. Recent years have brought spectacular advances in our understanding of the mechanism, function and regulation of DNA methyltransferases through their interaction with other epigenome modifications, chromatin factors and post-translational modifications, which are described in this Special Issue of Genes. Manuscripts are specifically addressing describing the targeting and regulation of DNA methyltransferases by interacting factors and their roles in cellular differentiation and the development of diseases. Prof. Dr. Albert Jeltsch and Prof. Dr. Humaira Gowher, Guest Editors.
S Adenosylmethionine Dependent Methyltransferases
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Author : Xiaodong Cheng
language : en
Publisher: World Scientific
Release Date : 1999
S Adenosylmethionine Dependent Methyltransferases written by Xiaodong Cheng and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Science categories.
This invaluable volume, written by an international group of scientists, presents an overview of the AdoMet-dependent methyltransferases, with special emphasis on structure-function relationships. S-adenosyl-L-methionine (AdoMet) is the second most commonly used enzyme cofactor after ATP. The AdoMet-dependent methyltransferases act on a wide variety of target molecules, including DNA, RNA, protein, polysaccharides, lipids and a range of small molecules. The well-conserved architecture of these enzymes, and the implications of this conservation for their evolutionary history, are major themes of this book. The thirteen chapters describe in detail the structures, enzyme kinetics and biological roles of the AdoMet-dependent methyltransferases from a wide range of cell types: plant, animal, bacterial and archaeal.
Dna Methylation
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Author : Manel Esteller
language : en
Publisher: CRC Press
Release Date : 2004-09-29
Dna Methylation written by Manel Esteller and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-09-29 with Medical categories.
DNA Methylation: Approaches, Methods and Applications describes the relation DNA methylation has to gene silencing in disease, and explores its promising role in treating cancer. Written by leaders in the field, this exceptional compilation of articles outlines the best techniques to use when addressing questions concerning the cytosine methylation
Epigenetic Alterations In Oncogenesis
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Author : Adam R. Karpf
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-09-06
Epigenetic Alterations In Oncogenesis written by Adam R. Karpf and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-06 with Medical categories.
The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means “above” genetics, and consists of heritable gene expression or other phenotypic states not accounted for by DNA base sequence. Epigenetic changes are now known to make a large contribution to various aspects of tumorigenesis. These changes include alterations in global and promoter specific DNA methylation, activating and repressive histone modifications, and changes in higher order chromatin structures. Each of these topics will be covered in this book.
Defining The Functions Of De Novo Dna Methyltransferases In Mantle Cell Lymphoma
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Author : Nguyet minh ngoc ton nu Hoang
language : en
Publisher:
Release Date : 2023
Defining The Functions Of De Novo Dna Methyltransferases In Mantle Cell Lymphoma written by Nguyet minh ngoc ton nu Hoang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
Mantle cell lymphoma (MCL) is an incurable, rare type of B-cell non-Hodgkin lymphoma, accounting for 5-6% of all lymphoma cases. A hallmark of MCL is the t(11;14)(q13;q32) translocation, juxtaposing the cyclin D 1 proto-oncogene (CCND1) to the immunoglobulin heavy chain gene (IgH), leading to CCND1 constitutive expression at the pre-B cell stage. Additionally, constitutively activated B cell receptor signaling (BCR) is required for the survival of MCL cells as demonstrated by the clinical use of selective inhibitors of BCR such as ibrutinib or acalabrutinib. De novo DNA methyltransferase 3A (DNMT3A), whose canonical function is to catalyze the transfer of methyl group onto the cytosine of unmethylated DNA, is known to be essential for the activation of B cells against pathogens and is highly expressed in a subset of MCL patients who are resistant to ibrutinib, suggesting that DNMT3A is a potential oncogene in MCL. In contrast, DNMT3A is reported as a tumor suppressor in acute myeloid leukemia (AML). In addition to the canonical function of DNA methylation, DNMT3A interacts with other epigenetic enzymes and transcription factors such as HDAC1 and PU.1 to regulate gene expression. However, little is known about the oncogenic functions of DNMT3A and its binding partners to regulate gene expression in the context of B-cell lymphoma. This thesis will examine the role of DNMT3A and propose the mechanisms by which it regulates gene expression in MCL. Additionally, I will test whether inhibiting DNMT3A by decitabine, an FDA-approved small molecule that leads to the degradation of all DNA methyltransferases (DNMTs), is a potential effective strategy in treating MCL. In the first chapter, I will discuss the current understanding of mantle cell lymphoma from both basic and translational perspectives. In chapter II, I will discuss the roles of DNMTs in normal B cell development and in hematological malignancies. In the third chapter, I will describe the experiments, the results, and my interpretations of the data to test the hypothesis that DNMT3A is required for the optimal growth of MCL cells. Here, I showed that DNMT3A is required for the optimal growth of MCL cells by regulating mitochondrial biogenesis independently of its methyltransferase activity. Mechanistically, DNMT3A induces the expression of MYC target genes through interaction with the transcription factors myocyte enhancer binding factor 2B (MEF2B) and MYC to enhance mitochondrial biogenesis and thus oxidative phosphorylation (OXPHOS). I further revealed that DNMT3A is involved in ibrutinib resistance as its expression is upregulated upon ibrutinib treatment in ibrutinib-resistant MCL cells and that the depletion of DNMT3A sensitizes these cells to ibrutinib. Targeting DNMT3A with low dose decitabine inhibits the growth of ibrutinib-resistant lymphoma cells and enhances the efficacy of ibrutinib both in vitro and in a patient-derived xenograft mouse model. In the last chapter, I will discuss the implications of my findings as well as unanswered questions for future studies. Most importantly, I will present evidence that DNMT3B is also a potential oncogene in mantle cell lymphoma and should be further studied.
Plant Gene Silencing
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Author : M.A. Matzke
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Plant Gene Silencing written by M.A. Matzke and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This book is an up-to-date and comprehensive collection of reviews on various aspects of epigenetic gene silencing in plants. Research on this topic has undergone explosive growth during the past decade and has revealed novel features of gene regulation and plant defense responses that also apply to animals and fungi. Gene silencing is relevant for agricultural biotechnology because stable expression of transgenes is required for the successful commercialization of genetically engineered crops. The reviews have been written by distinguished authors who have made significant contributions to plant gene silencing research. This volume supersedes other books on gene silencing by focussing on plant systems, where many pioneering experiments have been performed, and by including the latest developments from top laboratories. The book is geared toward advanced students of genetics and plant sciences as well as applied and basic research scientists who work with transgenic organisms and epigenetic regulation of gene expression.
Modifications Of Nuclear Dna And Its Regulatory Proteins
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Author :
language : en
Publisher: Academic Press
Release Date : 2011-06-02
Modifications Of Nuclear Dna And Its Regulatory Proteins written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-02 with Science categories.
DNA methylation is essential for the normal development and functioning of organisms. This volume discusses the latest developments in this very active field of research. It presents the evolution of DNA methylation, mammalian DNA methyltransferases, DNA methylation and demethlyation, DNA methylation and silencing and the role it plays in medicine including cancer. Discusses new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields