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Documenta O Paranaense I


Documenta O Paranaense I
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Boletim Paranaense De Geoci Ncias


Boletim Paranaense De Geoci Ncias
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Author :
language : en
Publisher:
Release Date : 2002

Boletim Paranaense De Geoci Ncias written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Brazil categories.




Translational Medicine


Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26

Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.


Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.



Documenta O Paranaense I


Documenta O Paranaense I
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Author : Biblioteca Pública do Paraná. Divisaão de Documentação Paranaense
language : pt-BR
Publisher:
Release Date : 1980

Documenta O Paranaense I written by Biblioteca Pública do Paraná. Divisaão de Documentação Paranaense and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Paraná (Brazil : State) categories.




Documenta O Paranaense


Documenta O Paranaense
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Author : Biblioteca Pública do Paraná. Divisão de Documentação Paranaense
language : pt-BR
Publisher:
Release Date : 1987

Documenta O Paranaense written by Biblioteca Pública do Paraná. Divisão de Documentação Paranaense and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with categories.




Documenta


Documenta
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Author : Conselho Federal de Educação (Brazil)
language : pt-BR
Publisher:
Release Date : 1977

Documenta written by Conselho Federal de Educação (Brazil) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with Education categories.




Boletim Paranaense De Geografia


Boletim Paranaense De Geografia
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Author :
language : pt-BR
Publisher:
Release Date : 1965

Boletim Paranaense De Geografia written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1965 with Geography categories.




Rarity


Rarity
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Author : K.J. Gaston
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Rarity written by K.J. Gaston and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.


To say you are writing about rarity is to invite two kinds of response. Either one provokes a discussion of what rarity is, or some comment on the complex ity of the subject. The objective of this book is to explore the nature of rarity, its complexity if you like, from one particular perspective on what rarity is. Primarily, it is an opportunity to review, to synthesize, and to question. The book is an attempt to draw together a vast body of literature, to extract from it some general principles, and to raise question marks over areas the founda tions of which appear to be either absent or crumbling. A perusal of prefaces suggests that they often dwell as long upon what a book is not about, as upon what it does concern. True to such a tradition, I should state that this is specifically not a book about conservation, although in some quarters anything about rarity is viewed as something about conser vation. Nor does it contain more than a passing reference to the undoubtedly important issues of the role of genetics in rarity. Examples have been drawn from a wide variety of taxa. They are, nonethe less, somewhat depauperate in cases from marine systems. In part this bias results from the unevenness of my familiarity with the literature, in part it perhaps also reflects differences in the questions asked and approaches to the study of communities and assemblages in terrestrial and marine systems.



D Dalo


D Dalo
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Author :
language : en
Publisher:
Release Date : 1973

D Dalo written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1973 with Archaeology categories.




Boletim Conselho Nacional De Geografia Brazil


Boletim Conselho Nacional De Geografia Brazil
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Author :
language : pt-BR
Publisher:
Release Date : 1961

Boletim Conselho Nacional De Geografia Brazil written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1961 with Brazil categories.




Boletim Geogr Fico


Boletim Geogr Fico
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Author : Instituto Brasileiro de Geografia
language : pt-BR
Publisher:
Release Date : 1961

Boletim Geogr Fico written by Instituto Brasileiro de Geografia and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1961 with Brazil categories.