Dopamine 90
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Dopamine 90
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Author : Pier Franco Spano
language : en
Publisher:
Release Date : 1992
Dopamine 90 written by Pier Franco Spano and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Dopamine categories.
Dopamine 90
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Author :
language : en
Publisher:
Release Date : 1992
Dopamine 90 written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with categories.
Advances In Dopamine Research And Application 2013 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2013-06-21
Advances In Dopamine Research And Application 2013 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-21 with Medical categories.
Advances in Dopamine Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Advances in Dopamine Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Dopamine Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Dopamine Handbook
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Author : Leslie L. Iversen
language : en
Publisher:
Release Date : 2010
Dopamine Handbook written by Leslie L. Iversen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
The discovery of dopamine in 1957-1958 was one of the seminal events in the development of modern neuroscience, and has been extremely important for the development of modern therapies of neurological and psychiatric disorders. Dopamine has a fundamental role in almost all aspects of behavior: from motor control to mood regulation, cognition and addiction and reward, and dopamine research has been unique within the neurosciences in the way it has bridged basic science and clinical practice. Over the decades research into the role of dopamine in health and disease has been in the forefront of modern neuroscience. The Dopamine Handbook is the first single-volume publication to capture current progress and excitement in this dynamic research field.
Examining The Effects Of Kratom Alkaloids On Mesolimbic Dopamine Release
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Author : James Paul Manus
language : en
Publisher:
Release Date : 2021
Examining The Effects Of Kratom Alkaloids On Mesolimbic Dopamine Release written by James Paul Manus and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
Kratom, derived from the plant Mitragyna speciosa, is reported to produce stimulant-like effects at low doses and opiate-like effects at high doses. Mitragynine (MG) and 7-hydroxymitragynine (7-HMG) are the major psychoactive constituents of kratom, but the neural mechanisms of these alkaloids are not clear. Given that the effects of kratom are often compared to those of drugs with a high abuse liability, the current study aimed to determine the effect of MG and 7-HMG on reward-related neurotransmission. In vivo fixed potential amperometry was used to quantify stimulation-evoked phasic dopamine release in the nucleus accumbens (NAc) of anesthetized male and female mice. During dopamine recordings, mice received an i.p. injection of either MG (1,15, or 30 mg/kg i.p.), 7-HMG (0.5, 1, or 2 mg/kg i.p.), or vehicle, and dopamine recordings continued for 90 min. Using specific stimulation parameters, dopamine autoreceptor functioning was measured 30 min post injection. Sex effects were observed following MG but not 7-HMG. In males, there was a significant time x MG dose interaction with the low dose seeming to increase dopamine release relative to vehicle and the higher doses towards the end of the recording period. However, follow-up tests revealed no significant dopamine release differences between doses at specific time points. Low dose MG also increased dopamine autoreceptor functioning (+50% from vehicle) in males. Regarding 7-HMG, both sexes responded similarly with a significant time x 7-HMG dose interaction effect on dopamine release. Follow-up tests revealed significant differences between 7-HMG doses from 60-90 min post injection, with the low dose increasing dopamine release (+18% from vehicle) compared to the high dose (-22% from vehicle). 7-HMG did not alter dopamine autoreceptor functioning. Neither MG nor 7-HMG altered the clearance rate of stimulation-evoked dopamine, indicating no drug effect on dopamine transporter functioning. In conclusion, dose effects were observed following both MG and 7-HMG. The low dose of MG (1 mg/kg) affected dopamine release in males more than females, potentially through actions on dopamine autoreceptors, and in both sexes the low dose of 7-HMG (0.5 mg/kg) increased dopamine release while the high dose (2 mg/kg) had the opposite effect. Although these increases in dopamine release are considerably less than those normally observed in stimulants with a high abuse liability, these findings do suggest that MG and 7-HMG alter dopamine transmission. An increased understanding of the neural mechanisms of kratom may provide insight on its potential uses and abuse liability. .
Dopamine Nation
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Author : Dr. Anna Lembke
language : en
Publisher: Penguin
Release Date : 2021-08-24
Dopamine Nation written by Dr. Anna Lembke and has been published by Penguin this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-24 with Psychology categories.
INSTANT NEW YORK TIMES and LOS ANGELES TIMES BESTSELLER “Brilliant . . . riveting, scary, cogent, and cleverly argued.”—Beth Macy, author of Dopesick, as heard on Fresh Air This book is about pleasure. It’s also about pain. Most important, it’s about how to find the delicate balance between the two, and why now more than ever finding balance is essential. We’re living in a time of unprecedented access to high-reward, high-dopamine stimuli: drugs, food, news, gambling, shopping, gaming, texting, sexting, Facebooking, Instagramming, YouTubing, tweeting . . . The increased numbers, variety, and potency is staggering. The smartphone is the modern-day hypodermic needle, delivering digital dopamine 24/7 for a wired generation. As such we’ve all become vulnerable to compulsive overconsumption. In Dopamine Nation, Dr. Anna Lembke, psychiatrist and author, explores the exciting new scientific discoveries that explain why the relentless pursuit of pleasure leads to pain . . . and what to do about it. Condensing complex neuroscience into easy-to-understand metaphors, Lembke illustrates how finding contentment and connectedness means keeping dopamine in check. The lived experiences of her patients are the gripping fabric of her narrative. Their riveting stories of suffering and redemption give us all hope for managing our consumption and transforming our lives. In essence, Dopamine Nation shows that the secret to finding balance is combining the science of desire with the wisdom of recovery.
Electrochemical Methods For Neuroscience
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Author : Adrian C. Michael
language : en
Publisher: CRC Press
Release Date : 2006-12-13
Electrochemical Methods For Neuroscience written by Adrian C. Michael and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-13 with Medical categories.
Since the first implant of a carbon microelectrode in a rat 35 years ago, there have been substantial advances in the sensitivity, selectivity and temporal resolution of electrochemical techniques. Today, these methods provide neurochemical information that is not accessible by other means. The growing recognition of the versatility of electrochemi
Dopamine
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Author : Nira Ben-Jonathan
language : en
Publisher: CRC Press
Release Date : 2020-04-12
Dopamine written by Nira Ben-Jonathan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-12 with History categories.
Dopamine is a small molecule traditionally regarded as a brain-derived neuronal modulator implicated in many neurological and psychiatric disorders. Outside the brain, dopamine fulfills all the criteria of a circulating hormone which affects normal and abnormal functions of multiple organs and regulatory systems and is also involved in many aspects of cancer formation and progression. This book provides a much needed systematic account of dopamine as an endocrine and autocrine/paracrine hormone and fills a major gap in the overall understanding of the production, distribution and actions of this very important molecule. Key Features: Explores the many different faces of dopamine as autocrine, paracrine and endocrine molecule Documents the adverse effects of antipsychotics on dopamine functions Reviews the many ways dopamine affects the cardiovascular, renal and reproductive systems Provides updates on receptor oligomerization and signaling Examines the role of dopamine in tumorigenesis Related Titles Jones, S. ed. Dopamine - Glutamate Interactions in the Basal Ganglia (ISBN 978-0-3673-8197-4) Luo, L. Principles of Neurobiology (ISBN 978-0-8153-4494-0) Sidhu, A. et al., eds. Dopamine Receptors and Transporters (ISBN 978-0-8247-0854-2)
Dopamine Neurotoxicity Oxidative Stress And Schizophrenia
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Author : Phillip Grant
language : en
Publisher:
Release Date : 2011
Dopamine Neurotoxicity Oxidative Stress And Schizophrenia written by Phillip Grant and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Dopamine Receptor Agonists
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Author : George Poste
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Dopamine Receptor Agonists written by George Poste and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
Dopamine, in addition to its importance as a precursor of norepinephrine, is now known to be an important neurotransmitter in regulating functional activities in a number of major organ systems, including the central ner vous system. the cardiovascular system, the kidney, and the gut. Recent advances in our understanding of the functional role of dopamine, its mechanism of action and the pharmacology of dopaminergic agents have occurred on a broad front. The last few years have witnessed significant progress in the identification and classification of central and peripheral dopamine receptors and the factors that affect their responsiveness to inhibitory and stimulatory ligands. These advances have been paralleled by new insights into the contribution of alterations in dopaminergic reg ulation in causing disease and the utility of dopamine agonists and an tagonists as therapeutic modalities. This volume, the first in a series of publications arising from the annual Smith Kline and French Research Symposium on New Horizons in Therapeutics, provides a comprehensive survey of current research on peripheral dopamine receptors and the physiologic and therapeutic con sequences of stimulating pre-and postsynaptic dopamine receptors. Research in dopamine pharmacology mirrors the remarkable ad vances that are occurring in the field of pharmacology at large as a con sequence of the involvement of an ever-larger number of scientific dis ciplines in the study of drug action.