Dopamine Receptors
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The Dopamine Receptors
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Author : Kim Neve
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-01
The Dopamine Receptors written by Kim Neve and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-01 with Medical categories.
As sites of action for drugs used to treat schizophrenia and Parkinson’s disease, dopamine receptors are among the most validated drug targets for neuropsychiatric disorders. Dopamine receptors are also drug targets or potential targets for other disorders such as substance abuse, depression, Tourette’s syndrome, and attention deficit hyperactivity disorder. Updated from the successful first edition, "The Dopamine Receptors" serves as a reference work on dopamine receptors while also highlighting the areas of research that are most active today. To achieve this goal, authors have written chapters that set a broad area of research in its historical context, rather than focusing on the research output of their own laboratories.
Dopamine Receptors And Transporters
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Author : Anita Sidhu
language : en
Publisher: CRC Press
Release Date : 2003-01-31
Dopamine Receptors And Transporters written by Anita Sidhu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-01-31 with Medical categories.
"Details the function, characterization, and physiology of various dopamine receptor/transporter systems and explores their role in etiology, diagnosis, and disease management."
Central D1 Dopamine Receptors
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Author : M. J. Goldstein
language : en
Publisher: Springer
Release Date : 2013-11-21
Central D1 Dopamine Receptors written by M. J. Goldstein and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-21 with Science categories.
The development of a selective D1 dopamine (DA) receptor antagonist SCH 23390 stimulated a number of studies on the functions mediated by central DA receptor subtypes. It was generally assumed that the central D1 DA receptor isa molecular entity whose function awaits further discovery. The papers presented in this volume clearly show that this is no longer the case and that D1 DA receptors have many behavioral fuctions which might be altered in pathological states. A number of papers have recognized the interdependence of the regulatory functions of the D1 DA receptors with D2 and other receptor proteins, and vice versa. The biochemical, pharmacological and morphological characterization of the D1 and D2 DA receptor binding proteins, as well as of DARPP-32, illustrates the complex interactions between various macromolecules. Procedures described for the purification of the D1 and D2 DA receptor subtypes are fundamental for future studies on the mechanisms involved in the coupling of the receptor proteins with signal transducing systems. Several studies in this volume show that D1 DA receptors have behavioral functions and that they are often similar to the responses mediated by D2 DA receptors, but in some instances reflect divergent neuronal activity of both systems. The knowledge of the physiology and biochemistry of the central DA receptor subtypes could lead to the development of a new generation of drugs which ameliorate some mental and neurological dysfunctions without producing severe undesirable side effects.
Neurobiology Of Central D1 Dopamine Receptors
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Author : George Breese
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Neurobiology Of Central D1 Dopamine Receptors written by George Breese and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.
Our understanding of the functional mechanisms relating dopamine activity to normal and abnormal behavior has been turned "upside-down" by the recent developments described in the chapters of this volume. Heretofore, it was generally agreed that all of the pharmacological and behavioral properties ascribed to dopamine systems were mediated via activation or inhibition of the subtype of dopamine receptors termed D2. The properties of these receptors were first characterized in 1975 following their identification by receptor binding techniques utilizing 3H-butyrophenones, potent antipsychotic drugs, used in the treatment of schizophrenia. Although another subtype of dopamine receptor had already been identified a few years earlier, now termed the Dl receptor, its functional properties were unknow- other than the fact that it was associated with the activation of the enzyme adenylate cyclase. Our absence of knowledge of the behavioral functions of this receptor stemmed primarily from the lack of selective agonist and antagonists for DI receptors - drugs which did not also interact with D2 receptors. Selective agents for D2 receptors did exist and hence the behavioral roles of D2 receptors were easily ascribed. The work described in this text is primarily stimulated by the development of two selective Dl receptor drugs - the antagonist SCH 23390 and the agonist SKF 38393. The studies described herein clearly show that D1 receptors do indeed have many behavioral functions, on the surface often similar to those responses mediated by D2 receptors.
Dopamine Receptors And Transporters
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Author : Hyman B. Niznik
language : en
Publisher: CRC Press
Release Date : 1994
Dopamine Receptors And Transporters written by Hyman B. Niznik and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medical categories.
"Details the function, characterization, and physiology of various dopamine receptor/transporter systems and explores their role in etiology, diagnosis, and disease management."
Dopamine Receptor Subtypes
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Author : Peter Jenner
language : en
Publisher: IOS Press
Release Date : 1998
Dopamine Receptor Subtypes written by Peter Jenner and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Dopamine categories.
Multiple subtypes of dopamine receptors exist in the brain. This volume reviews the characteristics of D-1, D-2, D-3 and D-4 receptors and describes the current concepts of their involvement in motor disorders and in the control of schizophrenia. Readers: the book will be of great interest to professionals in pharmacology, medicinal chemistry, neuroscience, cell biology and therapeutic applications in clinical medicine as antipsychotics, anti-Parkinson's disease and related areas.
Peripheral Dopaminergic Receptors
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Author : Jean Louis
language : en
Publisher: Elsevier
Release Date : 2013-10-22
Peripheral Dopaminergic Receptors written by Jean Louis and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Nature categories.
Peripheral Dopaminergic Receptors contains the proceedings of the Satellite Symposium of the 7th International Congress of Pharmacology held in Strasbourg, France, on July 24-25, 1978. The papers explore advances that have been made in understanding peripheral dopaminergic receptors and cover topics organized around five themes: dopamine measurement; structure-activity relationships; peripheral actions of dopamine; effects of dopamine on the kidney; and the physiological role of dopamine in the autonomic nervous system. This volume is comprised of 36 chapters and opens with a discussion on the dopamine vascular receptor, along with its agonists and antagonists. The reader is then introduced to the physiological and clinical implications of free and conjugated dopamine; dopamine-sensitive adenylate cyclase in the renal artery of dogs; dopamine-induced relaxation of isolated dog arteries; and concentration and function of dopamine in normal and diseased blood vessels. The following chapters explore the possible involvement of endogenous substances in the cardiovascular actions of dopamine; the role of dopamine receptors as mediators of the neurogenic vasodilatation by dopaminergic agents; and implications of renal and adrenal dopamine for the role of conjugated dopamine. Studies on the peripheral cardiovascular activity of dopamine in the rat are also presented. This book will be of interest to practitioners in biosciences, pharmacology, physiology, and medicine.
Dopamine Receptors
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Author : Ian Creese
language : en
Publisher:
Release Date : 1987
Dopamine Receptors written by Ian Creese and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Dopamine categories.
"Dopamine Receptors" precisely chronicles the research being done on dopamine receptors, appraises the techniques and strategies being used, and provides thoughts on future trends. This volume is unique for its multidisciplinary coverage of dopamine receptors, with contributions ranging from physiological and behavioral studies to the biological characterization of dopamine receptors. Examines classifications of receptor subtypes based on ligand binding and adenylate cyclase studies, biochemical analysis, electrophysiological observations and autoradiography. This book also summarizes dopamine receptor involvement in a number of diseases and covers the role of autoreceptors in modulation of dopaminergic systems.
Dopamine Receptor Agonists
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Author : George Poste
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Dopamine Receptor Agonists written by George Poste and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
Dopamine, in addition to its importance as a precursor of norepinephrine, is now known to be an important neurotransmitter in regulating functional activities in a number of major organ systems, including the central ner vous system. the cardiovascular system, the kidney, and the gut. Recent advances in our understanding of the functional role of dopamine, its mechanism of action and the pharmacology of dopaminergic agents have occurred on a broad front. The last few years have witnessed significant progress in the identification and classification of central and peripheral dopamine receptors and the factors that affect their responsiveness to inhibitory and stimulatory ligands. These advances have been paralleled by new insights into the contribution of alterations in dopaminergic reg ulation in causing disease and the utility of dopamine agonists and an tagonists as therapeutic modalities. This volume, the first in a series of publications arising from the annual Smith Kline and French Research Symposium on New Horizons in Therapeutics, provides a comprehensive survey of current research on peripheral dopamine receptors and the physiologic and therapeutic con sequences of stimulating pre-and postsynaptic dopamine receptors. Research in dopamine pharmacology mirrors the remarkable ad vances that are occurring in the field of pharmacology at large as a con sequence of the involvement of an ever-larger number of scientific dis ciplines in the study of drug action.
Dopaminergic Systems And Their Regulation
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Author : G.N. Woodruff
language : en
Publisher: Springer
Release Date : 2016-01-15
Dopaminergic Systems And Their Regulation written by G.N. Woodruff and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-15 with Medical categories.