Downstream Industrial Biotechnology
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Downstream Industrial Biotechnology
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Author : Michael C. Flickinger
language : en
Publisher: John Wiley & Sons
Release Date : 2013-07-17
Downstream Industrial Biotechnology written by Michael C. Flickinger and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-17 with Science categories.
DOWNSTREAM INDUSTRIAL BIOTECHNOLOGY An affordable, easily accessible desk reference on biomanufacturing, focused on downstream recovery and purification Advances in the fundamental knowledge surrounding biotechnology, novel materials, and advanced engineering approaches continue to be translated into bioprocesses that bring new products to market at a significantly faster pace than most other industries. Industrial scale biotechnology and new manufacturing methods are revolutionizing medicine, environmental monitoring and remediation, consumer products, food production, agriculture, and forestry, and continue to be a major area of research. The downstream stage in industrial biotechnology refers to recovery, isolation, and purification of the microbial products from cell debris, processing medium and contaminating biomolecules from the upstream process into a finished product such as biopharmaceuticals and vaccines. Downstream process design has the greatest impact on overall biomanufacturing cost because not only does the biochemistry of different products ( e.g., peptides, proteins, hormones, antibiotics, and complex antigens) dictate different methods for the isolation and purification of these products, but contaminating byproducts can also reduce overall process yield, and may have serious consequences on clinical safety and efficacy. Therefore downstream separation scientists and engineers are continually seeking to eliminate, or combine, unit operations to minimize the number of process steps in order to maximize product recovery at a specified concentration and purity. Based on Wiley’s Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology, this volume features fifty articles that provide information on down- stream recovery of cells and protein capture; process development and facility design; equipment; PAT in downstream processes; downstream cGMP operations; and regulatory compliance. It covers: Cell wall disruption and lysis Cell recovery by centrifugation and filtration Large-scale protein chromatography Scale down of biopharmaceutical purification operations Lipopolysaccharide removal Porous media in biotechnology Equipment used in industrial protein purification Affinity chromatography Antibody purification, monoclonal and polyclonal Protein aggregation, precipitation and crystallization Freeze-drying of biopharmaceuticals Biopharmaceutical facility design and validation Pharmaceutical bioburden testing Regulatory requirements Ideal for graduate and advanced undergraduate courses on biomanufacturing, biochemical engineering, biopharmaceutical facility design, biochemistry, industrial microbiology, gene expression technology, and cell culture technology, Downstream Industrial Biotechnology is also a highly recommended resource for industry professionals and libraries.
Downstream Processing Of Proteins
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Author : Mohamed A. Desai
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-05
Downstream Processing Of Proteins written by Mohamed A. Desai and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-05 with Science categories.
Considerable effort and time is allocated to introducing cell culture and fermentation technology to undergraduate students in academia, generally through a range of courses in industrial biotechnology and related disciplines. Similarly, a large number of textbooks are available to describe the appli- tions of these technologies in industry. However, there has been a general lack of appreciation of the significant developments in downstream processing and isolation technology, the need for which is largely driven by the stringent re- latory requirements for purity and quality of injectable biopharmaceuticals. This is particularly reflected by the general absence of coverage of this s- ject in many biotechnology and related courses in educational institutions. For a considerable while I have felt that there is increasing need for an introductory text to various aspects of downstream processing, particularly with respect to the needs of the biopharmaceutical and biotechnology ind- try. Although there are numerous texts that cover various aspects of protein purification techniques in isolation, there is a need for a work that covers the broad range of isolation technology in an industrial setting. It is anticipated that Downstream Processing of Proteins: Methods and Protocols will play a small part in filling this gap and thus prove a useful contribution to the field. It is also designed to encourage educational strategists to broaden the coverage of these topics in industrial biotechnology courses by including accounts of this important and rapidly developing element of the industrial process.
Upstream And Downstream Industrial Biotechnology 3v Bundle
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Author : Michael C. Flickinger
language : en
Publisher: Wiley
Release Date : 2013-04-15
Upstream And Downstream Industrial Biotechnology 3v Bundle written by Michael C. Flickinger and has been published by Wiley this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-15 with Science categories.
The Upstream and Downstream Industrial Biotechnology 3 Volume Bundle consists of the following two key references: • Upstream Industrial Biotechnology, 2 Volume Set, and • Downstream Industrial Biotechnology: Recovery and Purification. The title is based on the Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology, which is available in print and online, and offers you all you a complete overview about Upstream and Downstream Industrial Biotechnology. The references are available for purchase individually, or you can SAVE by buying the comprehensive 3 Volume Bundle!
Downstream Processing In Biotechnology
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Author : Venko N. Beschkov
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2021-06-21
Downstream Processing In Biotechnology written by Venko N. Beschkov and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-21 with Science categories.
The current book gives an excellent insight into downstream processing technology and explains how to establish a successful strategy for an efficient recovery, isolation and purification of biosynthetic products. In addition to the overview of purification steps and unit operations, the authors provide practical information on capital and operating costs related to downstream processing.
Biotechnology Handbook
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Author : NIIR Board
language : en
Publisher: ASIA PACIFIC BUSINESS PRESS Inc.
Release Date : 2003-08-09
Biotechnology Handbook written by NIIR Board and has been published by ASIA PACIFIC BUSINESS PRESS Inc. this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-08-09 with Technology & Engineering categories.
Biotechnology is a field of applied biology that involves the use of living organisms and bioprocesses in engineering, technology, medicine and other fields requiring bio products. Biotechnology also utilizes these products for manufacturing purpose. Modern use of similar terms includes genetic engineering as well as cell and tissue culture technologies. Biotechnology draws on the pure biological sciences and in many instances is also dependent on knowledge and methods from outside the sphere of biology. Conversely, modern biological sciences are intimately entwined and dependent on the methods developed through biotechnology and what is commonly thought of as the life sciences industry. It has a major application in modern brewing technology which includes the production of whisky, traditional fermented soybean foods bacterial biomass, cheese starters, cheese technology, L glutamic acid fermentation etc. Biotechnology and cell molecular biology have developed and emerged in to a major discipline during last two decades. Biotechnology is also used to recycle, treat waste, microbial treatment and utilization a waste. The growing global demand for biotechnology products, India has rich biodiversity that drives its clinical trials industry and forms a strong base for pharmaceutical research. In recent years, the worldwide biotechnology based products market has grown at an annual average rate of 15%. This book majorly deals with introduction to basic biotechnology, downstream processing in biotechnology, modern brewing technology, industrial chemicals, biochemical and fuels, microbial flavours and fragrances, biodegradation of non cellulosic wastes for environmental conservation and fuel production, landfills for treatment of solid wastes etc. This book also consists of addresses of machinery suppliers, addresses of chemical suppliers, list of universities, conducting Biotechnology courses in the directory section. This is a unique book, concise, up to date resource offering an innovative, adoptive and valuable presentation of the subject. It covers all important biotechnological topics of industrial and academic interests. This book will be very use full for industry people, students, and libraries and for those who want to venture in to manufacturing of biotechnological products. TAGS Opportunities in Industrial Biotechnology, Whisky, Soybean Foods, Cheese, Lyine, Tryptophan, Aspartic Acid, Citric Acid, Acetic Acid, Gluconic and Itaconic Acids, Lactic Acid, Glucose Isomerase, Ethanol, Acetone and Butanol, Enzymes, Antibiotics, Biogas, Best small and cottage scale industries, Biogas and waste treatment, Biogas and waste treatment, Biogas production, Biotechnological potential of brewing industry by-products, Biotechnology - India in business, Biotechnology applications in beverage production, Biotechnology based profitable , Biotechnology based small scale industries projects, Biotechnology books, Biotechnology business ideas, Biotechnology business opportunities, Biotechnology business plan, Biotechnology business, Biotechnology downstream processing, Biotechnology entrepreneurship, Biotechnology for biotechnology for beginners, Biotechnology for fuels and chemicals, Biotechnology for production of chemicals, Biotechnology for production of fuels, Biotechnology ideas for projects, Biotechnology ideas future, Biotechnology industry in India, Biotechnology processing projects, Biotechnology small business manufacturing, Biotechnology startups in India, Brewing and biotechnology, Business consultancy, Business consultant, Business guidance to clients, Business guidance for bio technology, Business plan for a startup business, Business related to biotechnology, Business start-up, Downstream processing in biotech industry, Downstream processing in bio-technology, Downstream processing in the biotechnology industry, Downstream processing of biotechnology products, How is biotechnology used in beer, How is biotechnology used in wine, How to start a biotechnology industry?, How to start a biotechnology production business, How to start a small scale biotech industry in India?, How to start a successful biotechnology business, How to start biotechnology business, How to start biotechnology industry in India, Ideas for biotech startups, Industrial biotechnology in renewable chemicals, Industrial biotechnology: tools and applications, Industrial chemicals, biochemical and fuels, List of universities, conducting 'bio-technology' courses, Modern brewing technology, Modern small and cottage scale industries, Most profitable biotechnology business ideas, Need biotech business idea, New small scale ideas in biotechnology industry, Opportunities in biotechnology and business, Preparation of project profiles, Process technology books, Profitable biotechnology business ideas, Profitable biotechnology small scale manufacturing, Profitable small and cottage scale industries, Project for startups, Project identification and selection, Setting up and opening your biotechnology business, Small biotech business ideas, Small business ideas in the biotechnology industry, Small scale biotechnology processing projects, Small scale biotechnology production line, Small start-up business project, Start up India, stand up India, Starting a biotech company, Starting a biotechnology processing business, Start-up business plan for biotechnology, Startup ideas, Startup project for biotechnology, Startup project plan, Startup project, Startup, What makes a biotech entrepreneur
Downstream Process Technology A New Horizon In Biotechnology
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Author : Krishna Kant Prasad
language : en
Publisher: PHI Learning Pvt. Ltd.
Release Date : 2010-01-30
Downstream Process Technology A New Horizon In Biotechnology written by Krishna Kant Prasad and has been published by PHI Learning Pvt. Ltd. this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-30 with Mathematics categories.
Today, biochemical process industry demands fast and economic processes for the partitioning and purification of biomolecules that give high yield and high purity of the product. An integral and cost intensive part of these processes is associated with downstream processing for product isolation and purification. The aim of this comprehensive text is to provide an insightful overview of the whole aspects of downstream processing for biochemical product recovery. Intended for undergraduate and postgraduate students of biotechnology and chemical engineering, this self-contained text includes the chapters based on the recent developments in the industry and academics. It covers the importance of the downstream processing in terms of its relevancy to modern days ever-changing consumer needs, process design criteria relevance to set objectives, and physicochemical factors that help to formulate the strategy to develop a configuration among the raw material, methodology and instruments. This overview is followed by different downstream processing steps. The text concludes with the discussion on stabilization of the product to improve the shelf life of the product. Key Features Includes detailed biological, mathematical, chemical and physical aspects of downstream processing. Distinguishes downstream processing from analytical bioseparation. Contains numerous illustrations and solved problems.
Industrial Biotechnology
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Author : Wim Soetaert
language : en
Publisher: John Wiley & Sons
Release Date : 2010-03-30
Industrial Biotechnology written by Wim Soetaert and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-30 with Technology & Engineering categories.
Describing all topics of white biotechnology admitted to the 7th EU Frame Programme and new industrial production processes aiming towards the Kyoto objectives, this comprehensive overview covers the technology, applications, economic potential and implications for society. Directed at readers with a general interest in a specific technology, this is equally suitable as an introductory handbook to a wide range of industries, including chemicals, biotechnology and pharmaceuticals, food and feed, paper and pulp, personal care, energy and agriculture.
Bioprocess Engineering
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Author : Pau Loke Show
language : en
Publisher: CRC Press
Release Date : 2019-06-13
Bioprocess Engineering written by Pau Loke Show and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-13 with Medical categories.
Bioprocess Engineering: Downstream Processing is the first book to present the principles of bioprocess engineering, focusing on downstream bioprocessing. It aims to provide the latest bioprocess technology and explain process analysis from an engineering point of view, using worked examples related to biological systems. This book introduces the commonly used technologies for downstream processing of biobased products. The covered topics include centrifugation, filtration, membrane separation, reverse osmosis, chromatography, biosorption, liquid-liquid separation, and drying. The basic principles and mechanism of separation are covered in each of the topics, wherein the engineering concept and design are emphasized. This book is aimed at bioprocess engineers and professionals who wish to perform downstream processing for their feedstock, as well as students.
Sustainable Downstream Processing Of Microalgae For Industrial Application
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Author : Kalyan Gayen
language : en
Publisher: CRC Press
Release Date : 2019-09-05
Sustainable Downstream Processing Of Microalgae For Industrial Application written by Kalyan Gayen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-05 with Medical categories.
Microalgae can be future resource for industrial biotechnology In current energy crisis era, microalgae are under tremendous research focus for the production of biodiesel due to their high photosynthetic efficiency, growth rate and high lipid content compared to territorial plants. However, the large-scale production of algal biomass and downstream processing of harvested algae towards bio-fuels are facing several challenges from economic viability perspective. Apart from bio-fuels, the microalgae synthesize number of bio-molecules such as pigments (e.g., chlorophyll, carotenoid), protein (e.g., lectin, phycobiliprotein), and carbohydrates (e.g., agar, carrageenan, alginate, fucodian) which are available in the various forms of microalgal products. Therefore, developing a strategy for large-scale production and use of algal biomass for the co-production of these value-added macromolecules is thus imperative for the improvement of the economics of algal biorefinery. In the above context, this book covers three major areas (i) commercial-scale production of bio-molecules from microalgae, (ii) sustainable approach for industrial-scale operation, and (iii) optimization of downstream processes. Each of these sections is composed of several chapters written by the renowned academicians/industry experts. Furthermore, in this book, a significant weightage is given to the industry experts (around 50%) to enrich the industrial perspectives. We hope that amalgamate of fundamental knowledge from academicians and applied research information from industry experts will be useful for forthcoming implementation of a sustainable integrated microalgal biorefinery. This book highlights following. Explores biomolecules from microalgae and their applications Discusses microalgae cultivations and harvesting Examines downstream processing of biomolecules Explores sustainable integrated approaches for industrial scale operations Examines purification techniques specific for microalgal proteins, Omega 3 fatty Acids, carbohydrates, and pigments
Upstream And Downstream Processing Of Bioproducts
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Author : R. Puvanakrishnan
language : en
Publisher: MJP Publisher
Release Date : 2019-06-20
Upstream And Downstream Processing Of Bioproducts written by R. Puvanakrishnan and has been published by MJP Publisher this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-20 with Technology & Engineering categories.
Microorganisms have been exploited for many centuries for the production of fermented foods and beverages and for bread-making. The production of alcoholic beverages using microbes was the first major industrialized process. The technology developed for large-scale brewing was adapted for other anaerobic processes such as acetone and butanol in the early 1900s. With the discovery of penicillins, rapid developments were made in the technology of submerged culture fermentation of aerobic microorganisms under controlled conditions. The advancements in microbiology and process biochemistry improved our ability to harness the potential of microorganisms through improved bioprocessing methods to manufacture new products with economic viability. Microbial derived bioproducts have been gaining importance in the food, pharmaceutical, textile, leather, cosmetic and chemical industries, and most important among them are therapeutic proteins and peptides, enzymes, antigens, vaccines, antibiotics, drugs, etc.Not all microbial production processes involve culture of the organism in liquid medium. Instead, the organism can be grown on the surface of a solid substrate. Solid substrate (or solid state) fermentation (SSF) is an established traditional technology in many countries, producing edible mushrooms, fungal- fermented foods and soy sauce. Before the development of processes in liquid culture, citric acid and some microbial enzymes were produced by SSF. Carbon composting is also a form of SSF.