Drug Development And Conservation Of Biodiversity In West And Central Africa
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Drug Development And Conservation Of Biodiversity In West And Central Africa
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Author :
language : en
Publisher:
Release Date : 1996
Drug Development And Conservation Of Biodiversity In West And Central Africa written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.
The report comprises of projects undertaken by the Bioresources Development and Conservation Programme (BDCP) in pursuant of the objectives of Associate Programs 2 and 5 of the ICBG project entitled Drug Development and Conservation of Biodiversity in West and Central Africa - for Year 2. The accomplishments include training of ethnobotanists, purchase and installation of equipment, and six ethnobotanic surveys which led to the identification of over 120 plants used in traditional medicine for the treatment of malaria, leishmaniasis, viral infections, etc. Plants collected from the ethnobotanical field trips were dereplicated according to a customized protocol. A multi-disciplinary team of experts in botany, chemistry, biology, clinical pharmacology and medical practitioners was used to identify and collect plant species with the greatest potential for biological activity. The collected plants were properly catalogued, voucher specimens obtained, then processed, extracted and tested for biological activity. Extracts have been prepared from some of these samples and submitted for various bioassays including brine shrimp lethality, antifungal bioautography assay, antiviral, antimalarial, antileishmanial, antitrypanosomial, antitrichomonad and cytotoxicity tests. We are also continuing our support for graduate training projects, in phytochemistry, ethnobiology and bioassay screening techniques. The benefit sharing scheme for the ICBG has been fully developed.
Drug Development And Conservation Of Biodiversity In West And Central Africa Performance Of Neurochemical And Radio Receptor Assays Of Plant Extracts Drug Discovery For The Central Nervous System
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Author :
language : en
Publisher:
Release Date : 2004
Drug Development And Conservation Of Biodiversity In West And Central Africa Performance Of Neurochemical And Radio Receptor Assays Of Plant Extracts Drug Discovery For The Central Nervous System written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
The thrust of the CNS assay panel was to identify plant extracts that display moderate to high affinity for selected molecular targets. Target selection was based identifying active plant extracts that would be useful for one or more neuropsyschiatric disorders. We completed a screen for 102 samples belonging to 43 plants. 41 showed activity at one or more CNS targets. Phytochemical studies have been initiated on several active extracts. A total of 12 plants samples which have tested positive for antiplasmodial activity were collected in bulk quantities for detailed phytochemical investigations into antimalarial and trypanocidal activity.
Drug Development And Conversion Of Biodiversity In West And Central Africa
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Author :
language : en
Publisher:
Release Date : 2002
Drug Development And Conversion Of Biodiversity In West And Central Africa written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
This project is being conducted as part of Associated Project #3 of the International Cooperative Biodiversity Group Program under the direction of the Walter Reed Army Institute for Research. The focus of this ICBG Program's study is plants of West and Central Africa. During the reporting period, a total of 41 plant extracts were received from WRAIR, an additional eight compounds were received from the University of Dschang (Cameroon, AP#2). These agents were tested in vitro vs. strains of African trypanosomes (Trypanosoma brucei group) and of pathogenic trichomonads (Trichomonas vaginalis and Tri-trichomonas foetus). An additional 68 extracts were received from WRAIR in late February and are now entering preliminary screening. For the trypanosome screens, 39 of 41 WRAIR extracts and all eight of the AP#2 extracts were tested in vitro vs. three strains. Eight extracts were tested vs. two strains of T. vaginalis and 22 were tested vs. T foetus. For trypanosome studies, 21 of the WRAIR extracts and 4 of 8 of the AP#2 extracts had IC50 values less than or equal to 20 micrograms/ml. Three of the extracts tested vs T vaginalis had minimal inhibitory concentrations of 0.3-0.6 mg/ml, while 2 of 22 tested vs. T foetus had similarly high activity. Extracts active vs. trypanosomes were tested in a mouse model infection of T brucei at a dose range of 1-25 mg/kg i.p for three days. None of the 21 extracts tested were curative, however, two prolonged life. Some of the plant genera showing activity in vitro were: Afromomum, Aspilia, Chamaecrista, Cryptolepis, Enantia, Hoslundia, Icacina, Uvaria, and Pleiocarpa.
Drug Development And Conservation In West And Central Africa Performance Of Neurochemical And Radio Receptor Assays Of Plant Extracts
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Author :
language : en
Publisher:
Release Date : 2002
Drug Development And Conservation In West And Central Africa Performance Of Neurochemical And Radio Receptor Assays Of Plant Extracts written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
The main objective of these studies was to study the CNS activity of these plant fractions using specific radio ligand binding assays to identify their selectivity profiles as well as to determine their functional activities as either a full or partial agonist or antagonist.
In Vitro Cytotoxicity Screening Of Plant Extracts
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Author :
language : en
Publisher:
Release Date : 2002
In Vitro Cytotoxicity Screening Of Plant Extracts written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
AP1 of the ICBG "Drug Development and Conservation of Biodiversity in West and Central Africa," provides data on the variety, distribution, abundance and dynamics of West and Central African flora. Other APs focus primarily on the chemistry and anti-parasitic activities of traditionally used medicinal plants. The research conducted under AP 6 is primarily concerned with development of African medicinal flora for their non-antiparasitic activities. Screening extracts from locally used plants can capitalize on traditional knowledge in order to provide information about the potential alternative uses of known plants. Random screening of West African flora for anticancer activity can provide information on the utility of species not recognized by traditional healers for diseases not regularly usually treated at that level.
Ethnomedicine And Drug Discovery
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Author : M.M. Iwu
language : en
Publisher: Elsevier
Release Date : 2002-03-01
Ethnomedicine And Drug Discovery written by M.M. Iwu and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-03-01 with Science categories.
Approx.344 pages
Biodiversity In Sub Saharan Africa And Its Islands
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Author : S. N. Stuart
language : en
Publisher: IUCN
Release Date : 1990
Biodiversity In Sub Saharan Africa And Its Islands written by S. N. Stuart and has been published by IUCN this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Nature categories.
Novel Plant Bioresources
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Author : Ameenah Gurib-Fakim
language : en
Publisher: John Wiley & Sons
Release Date : 2014-04-03
Novel Plant Bioresources written by Ameenah Gurib-Fakim and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-03 with Technology & Engineering categories.
Novel Plant Bioresources: Applications in Food, Medicine and Cosmetics serves as the definitive source of information on under-utilized plant species, and fills a key niche in our understanding of the relationship of human beings with under-utilized plants. By covering applications in food, medicine and cosmetics, the book has a broad appeal. In a climate of growing awareness about the perils of biodiversity loss, the world is witnessing an unprecedented interest in novel plants, which are increasingly prized for their potential use in aromas, dyes, foods, medicines and cosmetics. This book highlights these plants and their uses. After an introductory section which sets the scene with an overview of the historical and legislative importance of under-utilized plants, the main four parts of the book are dedicated to the diverse potential application of novel plant bioresources in Food, Medicine, Ethnoveterinary Medicine and Cosmetics. Examples and contributors are drawn from Africa, Europe, the USA and Asia. The economic, social, and cultural aspects of under-utilized plant species are addressed, and the book provides a much needed boost to the on-going effort to focus attention on under-utilized plant species and conservation initiatives. By focusing on novel plants and the agenda for sustainable utilization, Novel Plant Bioresources highlights key issues relevant to under-utilized plant genetic resources, and brings together international scholars on this important topic.
Conservation Biology In Sub Saharan Africa
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Author : Richard Primack
language : en
Publisher: Open Book Publishers
Release Date : 2019-09-10
Conservation Biology In Sub Saharan Africa written by Richard Primack and has been published by Open Book Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-10 with Nature categories.
Conservation Biology in Sub-Saharan Africa comprehensively explores the challenges and potential solutions to key conservation issues in Sub-Saharan Africa. Easy to read, this lucid and accessible textbook includes fifteen chapters that cover a full range of conservation topics, including threats to biodiversity, environmental laws, and protected areas management, as well as related topics such as sustainability, poverty, and human-wildlife conflict. This rich resource also includes a background discussion of what conservation biology is, a wide range of theoretical approaches to the subject, and concrete examples of conservation practice in specific African contexts. Strategies are outlined to protect biodiversity whilst promoting economic development in the region. Boxes covering specific themes written by scientists who live and work throughout the region are included in each chapter, together with recommended readings and suggested discussion topics. Each chapter also includes an extensive bibliography. Conservation Biology in Sub-Saharan Africa provides the most up-to-date study in the field. It is an essential resource, available on-line without charge, for undergraduate and graduate students, as well as a handy guide for professionals working to stop the rapid loss of biodiversity in Sub-Saharan Africa and elsewhere.
Wipo Unep Study On The Role Of Intellectual Property Rights In The Sharing Of Benefits Arising From The Use Of Biological Resources And Associated Traditional Knowledge
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Author : Anil K. Gupta (professor.)
language : en
Publisher: WIPO
Release Date : 2004
Wipo Unep Study On The Role Of Intellectual Property Rights In The Sharing Of Benefits Arising From The Use Of Biological Resources And Associated Traditional Knowledge written by Anil K. Gupta (professor.) and has been published by WIPO this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Law categories.
The objective of this study is to identify and explore the role of intellectual property rights in sharing the benefits arising from the use of biological resources and associated traditional knowledge. It was commissioned in response to Decision IV/9 of the Conference of the Parties to the Conventional on Biological Diversity, and highlights the need, when genetic resources are first accessed, for a understanding of intellectual property issues, as they relate to traditional knowledge of biological resources.