Drug Treatment Issues In Parkinson S Disease
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Drug Treatment Issues In Parkinson S Disease
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Author : Katherine J. Palmer
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2000
Drug Treatment Issues In Parkinson S Disease written by Katherine J. Palmer and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Antiparkinsonian agents categories.
Parkinson S Disease
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Author : Roger C. Duvoisin
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 1984
Parkinson S Disease written by Roger C. Duvoisin and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Health & Fitness categories.
The most popular and widely acclaimed guide for parkinsonian patients and their families is now in its thoroughly updated Fifth Edition. In layperson's terms, Drs. Duvoisin and Sage explain the pathology, symptoms, and course of Parkinson's Disease, discuss current drug therapies and surgical procedures, and examine the latest research on the genetics of parkinsonism. This edition features completely rewritten chapters on genetics and on surgery for Parkinson's Disease. New drugs and improvements in levodopa therapy are described, and a new chapter addresses the question of whether levodopa affects disease progression. An appendix lists the trade names, generic names, and formulations of commonly prescribed drugs.
The Drug Treatment Of Parkinson S Disease
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Author :
language : en
Publisher:
Release Date : 2008
The Drug Treatment Of Parkinson S Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Parkinson's disease categories.
Parkinson S Disease
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Author : Geoffrey Leader
language : en
Publisher:
Release Date : 2006
Parkinson S Disease written by Geoffrey Leader and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.
This groundbreaking book offers a powerful blending of nutritional and pharmaceutical benefits. In ¿user-friendly¿ style, it aims to reduce distressing symptoms, improve general functional health and promote well-being in people with Parkinson¿s disease. It clearly explains the effects of nutrition and medication on brain and general metabolism, thereby empowering the reader to plan a more predictable and personalised management approach. The authors are recognized internationally as pioneers in the field of nutritional management of Parkinson¿s Disease and have received a ¿Quality of Life in Parkinson¿s Award¿ in the United States. This innovative book is aimed at all people affected by the disease, being suitable for Healthcare Professionals, Parkinson¿s Sufferers and Caregivers alike. It is also an easy-to-follow guide on this complex subject for students of medicine, nutrition and dietetics. ¿This timely volume provides an easily accessible and scientifically referenced source of information on the diverse aspects of drugs and nutrition.¿ Professor Leslie Findley, Medical Advisor to The European Parkinson¿s Disease Association ¿To me, nutrition is now the most important method of managing my health. It forms the platform for drug therapy and other contributory factors to my well-being. To anyone with or touched by Parkinson¿s, I commend this book to you. It is an indispensable tool to help you to help yourself... Read on and reap the benefits!¿ Tom Isaacs, Co-Founder, The Cure Parkinson¿s Trust, UK ¿In timing the L-dopa as the book says, I feel much better!¿ V. R., PD Person, Southampton, UK ¿Above all you have given us hope, help and a means to manage this disease.¿ R. McNally, County Dublin, Ireland The many topics presented in this book include: - Interaction between L-dopa and food - best combinations for effectiveness & reducing dyskinesia - Smoothing out the ¿on-off¿ period - Individualising drug dosage and intervals between administrations with special monitoring charts - Specific nutritional recommendations to improve bowel function, weight control and energy - Biochemical tests to establish deficiencies/excesses at the cellular level - Nutritional supplements and diet for cellular deficiencies or excesses demonstrated - Cooking methods, diet, antioxidants and environmental awareness to reduce harmful free radicals - Simple delicious recipes suitable for L-dopa users with family and friends - Solutions for problems of chewing, swallowing and malabsorption - Sexuality and Sleep - practical and nutritional considerations - Stress management and the ¿dopamine connection¿ - practical and nutritional considerations - Optimum recovery from surgery - peri-operative nutrition - After antibiotics - restoring intestinal immunity with probiotics
The Drug Treatment Of Parkinson S Disease
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Author : Parkinson's Disease Society
language : en
Publisher:
Release Date : 2001
The Drug Treatment Of Parkinson S Disease written by Parkinson's Disease Society and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.
Parkinson S Disease
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Author : Roger C. Duvoisin
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 1996
Parkinson S Disease written by Roger C. Duvoisin and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Health & Fitness categories.
The most popular and widely acclaimed guide for parkinsonian patients and their families is now in its thoroughly updated Fifth Edition. In layperson's terms, Drs. Duvoisin and Sage explain the pathology, symptoms, and course of Parkinson's Disease, discuss current drug therapies and surgical procedures, and examine the latest research on the genetics of parkinsonism. This edition features completely rewritten chapters on genetics and on surgery for Parkinson's Disease. New drugs and improvements in levodopa therapy are described, and a new chapter addresses the question of whether levodopa affects disease progression. An appendix lists the trade names, generic names, and formulations of commonly prescribed drugs.
The Drug Treatment Of Parkinson S Disease
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Author : Parkinsons New Zealand
language : en
Publisher:
Release Date : 2005-01-01
The Drug Treatment Of Parkinson S Disease written by Parkinsons New Zealand and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-01-01 with Parkinson's disease categories.
Parkinson S Disease In Focus
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Author : Charles Tugwell
language : en
Publisher:
Release Date : 2008
Parkinson S Disease In Focus written by Charles Tugwell and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.
Discusses the signs, symptoms, diagnosis of the disease and the management, monitoring, treatment and care of patients. This text enables readers to improve the quality of care provided to patients suffering with Parkinson's Disease by increasing their knowledge and understanding of the clinical management of this condition.
Levodopa Pharmacokinetics From Stomach To Brain
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Author : Maria Nord
language : sv
Publisher: Linköping University Electronic Press
Release Date : 2019-01-07
Levodopa Pharmacokinetics From Stomach To Brain written by Maria Nord and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-07 with categories.
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders and it is caused by a loss of dopamine (DA) producing neurons in the basal ganglia in the brain. The PD patient suffers from motor symptoms such as tremor, bradykinesia and rigidity and treatment with levodopa (LD), the precursor of DA, has positive effects on these symptoms. Several factors affect the availability of orally given LD. Gastric emptying (GE) is one factor and it has been shown to be delayed in PD patients resulting in impaired levodopa uptake. Different enzymes metabolize LD on its way from the gut to the brain resulting in less LD available in the brain and more side effects from the metabolites. By adding dopa decarboxylase inhibitors (carbidopa or benserazide) or COMT-inhibitors (e.g. entacapone) the bioavailability of LD increases significantly and more LD can pass the blood-brain-barrier and be converted to DA in the brain. It has been considered of importance to avoid high levodopa peaks in the brain because this seems to induce changes in postsynaptic dopaminergic neurons causing disabling motor complications in PD patients. More continuously given LD, e.g. duodenal or intravenous (IV) infusions, has been shown to improve these motor complications. Deep brain stimulation of the subthalamic nucleus (STN DBS) has also been proven to improve motor complications and to make it possible to reduce the LD dosage in PD patients. In this doctoral thesis the main purpose is to study the pharmacokinetics of LD in patients with PD and motor complications; in blood and subcutaneous tissue and study the effect of GE and PD stage on LD uptake and the effect of continuously given LD (CDS) on LD uptake and GE; in blood and cerebrospinal fluid (CSF) when adding the peripheral enzyme inhibitors entacapone and carbidopa to LD infusion IV; in brain during STN DBSand during oral or IV LD treatment. To conclude, LD uptake is more favorable in PD patients with less severe disease and GE is delayed in PD patients. No obvious relation between LD uptake and GE or between GE and PD stage is seen and CDS decreases the LD levels. Entacapone increases the maximal concentration of LD in blood and CSF. This is more evident with additional carbidopa and important to consider in avoiding high LD peaks in brain during PD treatment. LD in brain increases during both oral and IV LD treatment and the DA levels follows LD well indicating that PD patients still have capacity to metabolize LD to DA despite probable pronounced nigral degeneration. STN DBS seems to increase putaminal DA levels and together with IV LD treatment also increases LD in brain possibly explaining why it is possible to decrease LD medication after STN DBS surgery. Parkinsons sjukdom (PS) är en av de vanligaste s.k. neurodegenerativasjukdomarna och orsakas av förlust av dopamin(DA)producerande nervceller i hjärnan. Detta orsakar motoriska symptom såsom skakningar, stelhet och förlångsammade rörelser. Levodopa (LD) är ett ämne, som kan omvandlas till DA i hjärnan och ge symptomlindring och det är oftast förstahandsval vid behandling av patienter med PS. Flera faktorer påverkar tillgängligheten av LD, bl.a. den hastighet som magsäcken tömmer sig med och denna verkar förlångsammad hos personer med PS vilket ger sämre tillgänglighet av LD i blodet och därmed i hjärnan. LD bryts även ner i hög grad av olika enzym ute i kroppen vilket leder till mindre mängd LD som hamnar i hjärnan och till fler nedbrytningsprodukter som orsakar biverkningar. Tillägg av enzymhämmare leder till ökad mängd LD som kan nå hjärnan och omvandlas till DA. Det anses viktigt att undvika höga toppar av LD i hjärnan då dessa verkar bidra till utvecklandet av besvärliga motoriska komplikationer hos patienter med PS. Om LD ges mer kontinuerligt, exempelvis som en kontinuerlig infusion in i tarmen eller i blodet, så minskar dessa motoriska komplikationer. Inopererande av stimulatorer i vissa delar av hjärnan (DBS) har också visat sig minska dessa motoriska komplikationer och även resultera i att man kan minska LD-dosen. Huvudsyftet med den här avhandlingen är att studera LD hos patienter med PS; i blod och fettvävnad då LD ges i tablettform och se om det finns något samband med LD-upptag och hastigheten på magsäckstömningen (MT) och om kontinuerligt given LD påverkar LD-upptaget eller MT; i blod och i ryggmärgsvätska då enzymhämmarna entakapon och karbidopa tillsätts LD; i hjärna vid behandling med DBS och då LD ges både som tablett och som infusion i blodet. Sammanfattningsvis kan vi se att LD-upptaget är mer gynnsamt hos patienter med PS i tidigare skede av sjukdomens komplikationsfas. MT är förlångsammad hos patienter med PS och det är inget tydligt samband mellan LD-upptag och MT eller mellan MT och sjukdomsgrad. Kontinuerligt given LD minskar LDnivåerna. Enzymhämmaren entakapon ökar den maximala koncentrationen av LD i blod och ryggmärgsvätska och effekten är mer tydlig vid tillägg av karbidopa vilket är viktigt att ta i beaktande vid behandling av PS för att undvika höga toppar av LD i hjärnan. LD ökar i hjärnan då man behandlar med LD i tablettform och som infusion i blodet och DA-nivåerna i hjärnan följer LD väl vilket visar på att patienter med PS fortfarande kan omvandla LD till DA trots trolig uttalad brist av de DA-producerande nervcellerna i hjärnan. DBS verkar öka DA i vissa områden i hjärnan och tillsammans med LD-infusion i blodet verkar det även öka LD i hjärnan och det kan förklara varför man kan sänka LDdosen efter DBS-operation.
Parkinson S Disease
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Author : Stewart A. Factor
language : en
Publisher: Demos Medical Pub
Release Date : 2002-01-01
Parkinson S Disease written by Stewart A. Factor and has been published by Demos Medical Pub this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-01-01 with Medical categories.
Parkinson's disease (PD) is is the second most common neurodegenerative disease. As the population of the industrialized world ages the impact of this disease on clinical neurology will expand. The growing literature regarding PD reflects this phenomenon. The time is now appropriate for a comprehensive text on PD that provides the reader with an up-to-date review on the multiple aspects of the disease and puts them into perspective. The scholarly contributions from many of the leading researchers in the field has made such a text a reality. This book will be useful to movement disorder specialists, general neurologists and neurology residents, gerontologists, neurosurgeons, neuropsychologists, and neuroscience researchers. The text provides both theoretical and practical approaches to PD. This book is organized to provide a comprehensive view of PD. Sections cover clinical aspects, behavioral and psychiatric manifestations, pathology and neurochemistry, diagnosis, etiology and pathogenesis, drugs, treatment issues, surgery, subtypes of parkinsonism, and social issues.
