Eicosanoids And Radiation
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Eicosanoids And Radiation
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Author : Peter Polgar
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Eicosanoids And Radiation written by Peter Polgar and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin Ez (PGEz), prostacyclin (PGIz) and thromboxane Az (TXAz), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.
Eicosanoids And Other Bioactive Lipids In Cancer Inflammation And Radiation Injury
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Author : Santosh Nigam
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Eicosanoids And Other Bioactive Lipids In Cancer Inflammation And Radiation Injury written by Santosh Nigam and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
In recent decades eicosanoids have been attracting an increasing amount of attention as a result of their important physiological roles in many areas of biology and medicine. The eicosanoids comprise the prostaglandins, thromboxanes and leukotrienes and are products of arachidonic acid, an essential polyunsaturated fatty acid stored in tissue phospholipids. Disturbances of eicosanoids and their metabolic products play a regulatory role in many types of cell injuries and diseases. One of the most exciting areas of eicosanoid research pinpoints their participation in the control of cell proliferation and differentiation. Eicosanoids form a link between different fields of research into such areas as cancer, inflammation and radiation-induced injury. This link provided the impetus for the development of the conference series of which the present volume represents the proceedings of the Second International Conference, held in Berlin in October 1991.
Eicosanoids And Other Bioactive Lipids In Cancer Inflammation And Radiation Injury 4
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Author : Kenneth V. Honn
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-01
Eicosanoids And Other Bioactive Lipids In Cancer Inflammation And Radiation Injury 4 written by Kenneth V. Honn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-01 with Science categories.
This book contains conference presentations regarding the regulation of eicosanoid enzymes and, in particular, cyclooxygenases, lipoxygenases, and phospholipases. The new field of isoprostanes is also represented.
Eicosanoids And Other Bioactive Lipids In Cancer And Radiation Injury
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Author : Kenneth V. Honn
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Eicosanoids And Other Bioactive Lipids In Cancer And Radiation Injury written by Kenneth V. Honn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This volume contains the proceedings of the First International Conference on Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury held in Detroit, Michigan on October 11-14, 1989. The program consisted of 83 oral and 29 poster presentations, 74 of which are included in these proceedings. The major sponsors of the conference were the Armed Forces Radiobiology Research Institute, located in Bethesda, Maryland, the Radiation Oncology Research and Development Center of the Gershenson Radiation Oncology Center, Harper Hospital in Detroit, Michigan, and Schering AG of West Germany. Eighteen other organizations provided additional support. The conference was unique in its attempt to link the eicosanoid and lipid researchers in the radiobiology and cancer disciplines. The diverse roles that eicosanoids and other bioactive lipids play in these biological phenomena including the participation of lipid oxidation in conversion of procarcinogens, positive and negative modulation of tumor growth, immunomodulation, tissue injury, and yet protection and enhancement of cancer therapy, necessitated scientific interaction to sort out and understand these complex and sometimes contradictory observations. The success of this effort is reflected not only through these proceedings, but also through the decision to continue the conference series with a second meeting to be held in Berlin between September 17-21, 1991.
Eicosanoids And Other Bioactive Lipids In Cancer Inflammation And Radiation Injury 3
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Author : Kenneth V. Honn
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-21
Eicosanoids And Other Bioactive Lipids In Cancer Inflammation And Radiation Injury 3 written by Kenneth V. Honn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-21 with Medical categories.
Proceedings of the Fourth International Conference held in Hong Kong, October 4-7, 1995
Eicosanoids And Other Bioactive Lipids In Cancer Inflammation And Radiation Injury 5
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Author : Kenneth V. Honn
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Eicosanoids And Other Bioactive Lipids In Cancer Inflammation And Radiation Injury 5 written by Kenneth V. Honn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This volume represents a collection of contributions from the 6th International Conference on Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Related Diseases held in Boston from September 12-15, 1999. The mission of this meeting was to bring together senior and junior investigators to both announce and examine their recent advancements in cutting-edge research on the roles and actions of lipid mediators and their impact in human physiology and disease pathogenesis. The meeting focused on new concepts in these areas of interest to both clinicians and researchers. The program included several outstanding plenary lectures and presentations by leading experts in the fields of cancer and inflammation. In addition, the Boston meeting presented three Young Investigator awards, one in each of the major focus areas. The meeting was exciting and proved to be very memorable. The program was developed with an emphasis on recent advances in molecular and of lipid mediators relevant in cellular mechanisims involved in the formation and actions inflammation and cancer. Plenary lectures were presented by Prof. Bengt Sammuelsson (Karolinska Institute, Stockholm; 1982 Nobel Laureate in Physiology or Medicine) and Prof. E. 1. Corey (Harvard University; 1990 Nobel Laureate in Chemistry). Both of these plenary lectures were held on Day 1, which set an exciting tone for this meeting. Immediately following these plenary lectures, three simultaneous breakout sessions were held, one of inflammation, a second on cancer and synthesis of novel inhibitors, and a third on enzymes-lipoxygenases/cyclooxygenases and inhibitors.
Eicosanoids And Other Bioactive Lipids In Cancer Inflammation And Radiation Injury 2
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Author : Kenneth V. Honn
language : en
Publisher: Springer
Release Date : 1998-02-28
Eicosanoids And Other Bioactive Lipids In Cancer Inflammation And Radiation Injury 2 written by Kenneth V. Honn and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-02-28 with Science categories.
Over one hundred contributions detail advances in the molecular and cellular biology of eicosanoid production, as well as their role in signal transduction. One of the most exciting developments explored within this collection of articles is the expression of the novel isoform of cyclooxygenase (cox-2), which may play a large role in the development of anti-inflammatory drugs.
Eicosanoids And Other Bioactive Lipids In Cancer Inflammation And Radiation Injury 2
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Author : Kenneth V Honn
language : en
Publisher:
Release Date : 1998-02-28
Eicosanoids And Other Bioactive Lipids In Cancer Inflammation And Radiation Injury 2 written by Kenneth V Honn and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-02-28 with categories.
Eicosanoids And Other Bioactive Lipids In Cancer Inflammation And Radiation Injury
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Author :
language : en
Publisher:
Release Date : 1991
Eicosanoids And Other Bioactive Lipids In Cancer Inflammation And Radiation Injury written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with categories.
Eicosanoids And Other Bioactive Lipids In Cancer Inflammation And Radiation Injury
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Author : Santosh K. Nigam
language : en
Publisher:
Release Date : 1991
Eicosanoids And Other Bioactive Lipids In Cancer Inflammation And Radiation Injury written by Santosh K. Nigam and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with categories.