Elastomeric Proteins
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Elastomeric Proteins
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Author : Peter R. Shewry
language : en
Publisher: Cambridge University Press
Release Date : 2010-02-04
Elastomeric Proteins written by Peter R. Shewry and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-02-04 with Science categories.
This book was originally published in 2002. Elastic proteins occur in a wide range of biological systems where they have evolved to fulfil precise biological roles. The best known include proteins in vertebrate muscles and connective tissues, such as titin, elastin and fibrillin, and spider silks. However, other examples include byssus and abductin from bivalve molluscs, resilin from arthropods and gluten from wheat. Interest in elastomeric proteins has been high for several reasons. Firstly, their biological and medical significance, particularly in human disease. Secondly, the unusual properties of proteins such as spider silks provide opportunities to develop materials. Thirdly, the development of scanning probe microscopy makes it possible to study structures and biomechanical properties of these proteins at the single molecule level. This book will be of value to anyone with an interest in the various aspects of elastomeric proteins.
Biomimetic Protein Based Elastomers
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Author : Namita Roy Choudhury
language : en
Publisher: Royal Society of Chemistry
Release Date : 2022-04-20
Biomimetic Protein Based Elastomers written by Namita Roy Choudhury and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-20 with Science categories.
Elastomeric proteins are ubiquitous in nature, where they have evolved precise structures and properties that are necessary to perform specific biological roles and functions. This book emphasizes the impact of amino acid sequence on modulating protein structure, properties, and function. Examples include conformational ensemble dynamics, environmental responsiveness, self-assembly, physico-mechanical properties, morphology, and properties tailored for biomedical applications. This foundational framework is not only critical to advance scientific understanding and knowledge on elastomeric proteins but also enables the conceptualization, rational design, and development of biosynthetic elastomers and their analogous polypeptides for a variety of applications. Edited and contributed by pioneering researchers in the field, the book provides a timely overview of the materials, along with the synthesis techniques, the unique characteristics of elastomeric proteins, and biomedical and industrial applications. The book will provide a reference for graduate students and researchers interested in designing biomimetic proteins tailored for various functions.
Elastomeric Proteins
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Author : Royal Society (Great Britain). Discussion Meeting
language : en
Publisher:
Release Date : 2002
Elastomeric Proteins written by Royal Society (Great Britain). Discussion Meeting and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Elastomers categories.
Elastomeric Proteins
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Author : Royal Society (Great Britain). Discussion Meeting
language : en
Publisher:
Release Date : 2002
Elastomeric Proteins written by Royal Society (Great Britain). Discussion Meeting and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Biology categories.
Fibrous Proteins Coiled Coils Collagen And Elastomers
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Author : David A.D. Parry
language : en
Publisher: Gulf Professional Publishing
Release Date : 2005-05-06
Fibrous Proteins Coiled Coils Collagen And Elastomers written by David A.D. Parry and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-05-06 with Science categories.
Fibrous Protein: Coiled-Coils, Collagen and Elastomers is the first of a three-part series on Fibrous Proteins. The books are based on a very successful workshop in Alpbach, Austria on the general topic of Fibrous Proteins that gave rise to the award winning issue of Journal of Structural Biology. Part II will contain an extensive discussion of Molecular Motors and Muscle, Part III on Amyloids, Prions and Beta Proteins. Advances in Protein Chemistry is available online on ScienceDirect - full-text online of volumes 53 onwards. Reveals new structural and functional aspects of fibrous proteins Based on Fibrous Protein workshop in Alpbach, Austria that gave rise to 2003 Nobel Prize winners in Chemistry
Engineering Proteins Of Novel Mechanical Properties
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Author :
language : en
Publisher:
Release Date : 2004
Engineering Proteins Of Novel Mechanical Properties written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Elastomeric proteins are an important class of mechanical proteins that take care of the strength, elasticity and extensibility of tissues and biological machineries. Elastomeric proteins are also essential building blocks of materials with outstanding mechanical properties. However, it was largely unknown how elastomeric proteins achieve the remarkable mechanical stability until the advent of single molecule force spectroscopy techniques, such as single molecule atomic force microscopy (AFM). Single molecule AFM has enabled the direct characterization of the mechanical properties of elastomeric proteins at the single molecule level and led to the new promising research area of single protein mechanics and engineering. Combined with molecular dynamics simulation and protein engineering, single molecule AFM has provided rich information about the mechanical design of elastomeric proteins. This dissertation focuses on engineering proteins with novel mechanical properties and makes use of this new technique. It is demonstrated how a non-mechanical protein GB1, the B1 immunoglobulin (IgG) binding domain of protein G from Streptococcus, shows superb mechanical stability. We also investigated the effect of denaturant, guanidium hydrochloride (GdmCl), on the mechanical stability of GB1. It was found that the mechanical stability of GB1 decreases with the increase of GdmCl concentration. Using GB1 as a model system, we demonstrated two ways to enhance the mechanical stability of proteins: by metal chelation and by stabilizing protein-protein interactions. It is revealed that preferentially stabilizing the native state over the mechanical unfolding transition state of proteins is the key to achieve enhanced mechanical stability. We also showed two applications of engineered elastomeric proteins. One is the design of an artificial elastomeric protein with dual mechanical stability that can be regulated reversibly by protein-protein interactions. We introduced proline mutation.
Elastomeric Proteins Structures Biomechanical Properties And Biological Roles
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Author : Allen J. Bailey
language : en
Publisher:
Release Date : 2002
Elastomeric Proteins Structures Biomechanical Properties And Biological Roles written by Allen J. Bailey and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
Mechanics Of Elastic Biomolecules
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Author : W.A. Linke
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Mechanics Of Elastic Biomolecules written by W.A. Linke and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
A representative cross-section of elastic biomolecules is covered in this volume, which combines seventeen contributions from leading research groups. State-of-the-art molecular mechanics experiments are described dealing with the elasticity of DNA and nucleoprotein complexes, titin and titin-like proteins in muscle, as well as proteins of the cytoskeleton and the extracellular matrix. The book speaks particularly to cell biologists, biophysicists, or bioengineers, and to senior researchers and graduate students alike, who are interested in recent advances in single-molecule technology (optical tweezers technique, atomic force microscopy), EM imaging, and computer simulation approaches to study nanobiomechanics. The findings discussed here have redefined our view of the role mechanical signals play in cellular functions and have greatly helped improve our understanding of biological elasticity in general.
Fibrous Proteins Amyloids Prions And Beta Proteins
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Author : John M. Squire
language : en
Publisher: Elsevier
Release Date : 2006-12-12
Fibrous Proteins Amyloids Prions And Beta Proteins written by John M. Squire and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-12 with Science categories.
Amyloids, Prions and Beta Proteins is the last volume of the three-part thematic series on Fibrous Proteins in the Advances in Protein Chemistry serial. Fibrous proteins act as molecular scaffolds in cells providing the supporting structures of our skeletons, bones, tendons, cartilage, and skin. They define the mechanical properties of our internal hollow organs such as the intestines, heart, and blood vessels. This volume covers such topics as Beta-Structures in Fibrous Proteins; B-Silks: Enhancing and Controlling Aggregation; Beta-Rolls, Beta-Helices and Other Beta-Solenoid Proteins; Natural Triple B-Stranded Fibrous Folds; Structure, Function and Amyloidogenesis of Fungal Prions: Filament Polymorphism and Prion Variants; X-Ray Fiber and powder Diffraction of PRP Prion Peptides; From the Polymorphism of Amyloid Fibrils to Their Assembly Mechanism and Cytotoxicity; Structural Models of Amyloid-like Fibrils.
Fuzziness
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Author : Monika Fuxreiter
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-03-07
Fuzziness written by Monika Fuxreiter and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-07 with Medical categories.
Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.
