Endosomes And Lysosomes A Dynamic Relationship
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Endosomes And Lysosomes A Dynamic Relationship
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Author : B. Storrie
language : en
Publisher:
Release Date : 1993-06
Endosomes And Lysosomes A Dynamic Relationship written by B. Storrie and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-06 with Science categories.
The intent in initiating this volume was to bring together a series of essays which would define our present understanding of the endosome and lysosome and their interrelationship. The editors deliberately encouraged the contributors to be speculative; to strive to put order to the "real" world of incomplete and sometimes conflicting data. Seeing science from the laboratory bench can often be like viewing an impressionistic painting from up close; a series of paint dabs with no apparent order. The contributors to this volume were asked to step back and leave the reader with a sense of the whole as well as the detail. To the extent that this has happened, the credit should go to the individual authors. Our understanding of endosomes and lysosomes has undergone a molecular revolution over the last decade. Hence, we now know much about the molecular features required for internalization of an endocytic receptor, or the function of mannose 6-phosphate receptors in the transport of lysosomal enzymes. We can trace and follow the flow of molecules. In this volume current molecular knowledge concerning the function and relationship of endosomes and lysosomes is presented. Because of this vast increase in knowledge of molecules, we have realized that endosomes in particular are very ephemeral organelles. In fact, endosomes may well not be discrete entities but rather continuously changing and evolving in their molecular composition. The dynamic nature of the relationship between endosomes and lysosomes is the unifying focus of the genetic, biochemical, microscopic, and molecular biological approaches described in the chapters which follow.
Molecular Regulation Of Endocytosis
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Author : Brian Ceresa
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-07-06
Molecular Regulation Of Endocytosis written by Brian Ceresa and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-06 with Science categories.
Molecular Regulation of Endocytosis is a compilation of scientific "short stories" about the entry of external substances into cells. As one can see from the chapters, endocytosis regulates diverse processes such as homeostasis of the cell, signal transduction, entry of pathogens and viruses. In addition to the experimental techniques embedded in each chapter, entire chapters are dedicated to experimental approaches that will be useful to all scientists and their model systems. For those more clinically oriented, the final chapters look to the future and ways of utilizing endocytic pathways for therapeutic purposes.
Spatial Point Patterns
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Author : Adrian Baddeley
language : en
Publisher: CRC Press
Release Date : 2015-11-11
Spatial Point Patterns written by Adrian Baddeley and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-11 with Mathematics categories.
Modern Statistical Methodology and Software for Analyzing Spatial Point PatternsSpatial Point Patterns: Methodology and Applications with R shows scientific researchers and applied statisticians from a wide range of fields how to analyze their spatial point pattern data. Making the techniques accessible to non-mathematicians, the authors draw on th
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
The Molecular And Cellular Basis Of Neurodegenerative Diseases
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Author : Michael S. Wolfe
language : en
Publisher: Academic Press
Release Date : 2018-03-29
The Molecular And Cellular Basis Of Neurodegenerative Diseases written by Michael S. Wolfe and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-29 with Medical categories.
The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts
Pharmaceuticals In Marine And Coastal Environments
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Author : Juan Carlos Duran-Alvarez
language : en
Publisher: Elsevier
Release Date : 2021-06-23
Pharmaceuticals In Marine And Coastal Environments written by Juan Carlos Duran-Alvarez and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-23 with Science categories.
Pharmaceuticals in Marine and Coastal Environments: Occurrence, Effects, and Challenges in a Changing World is divided into three sections that address a) coastal areas as the main entrance of pharmaceuticals into the ocean, b) the occurrence and distribution of pharmaceuticals in the environmental compartments of the ocean media, and c) the effects that such pollutants may cause to the exposed marine organisms. With its comprehensive discussions, the book provides a wide depiction of the current state-of-the-art on these topics in an effort to open new sources of investigation and find suitable solutions. Includes maps edited by the Water Information Network System of the International Hydrological Program (IHP-WINS) Provides a compilation of information regarding the occurrence and distribution of pharmaceuticals in the marine environment which will help establish new and more efficient monitoring programs and new research lines Depicts the most important results of environmental risk assessments that can be used as a first step for further toxicological studies
Lysosomes
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Author : Pooja Dhiman
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-08-30
Lysosomes written by Pooja Dhiman and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-30 with Science categories.
This book covers current advances in disorders associated with lysosomal function along with techniques to study its function. All chapters are complete in themselves but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors on lysosomal diseases and opens new possible research paths.
Cellular Organelles And The Extracellular Matrix
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Author : Edward Bittar
language : en
Publisher: Elsevier
Release Date : 1996-01-04
Cellular Organelles And The Extracellular Matrix written by Edward Bittar and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-01-04 with Science categories.
This volume is in two parts. The first contains the remaining chapters on cellular organelles and several chapters relating to organelle disorders. An account of mitochondriopathis is given in the chapter on the mitochondrion rather than in a separate one. The subject matter of this part of the volume shows quite clearly that the interdisciplinary approach to the study of organelles has shed considerable light on the nature of the mechanisms underlying the etiology and pathobiology of many of these disorders. As an example, mutations in the genes encoding integral membrane proteins are found to lead to disturbances in peroxisome assembly. It is also interesting and significant that mistargeting of protein is now thought to be another cause. It will be revealing to see whether mistargeting is the result of mutations in the genes encoding chaperones. The second part of the volume is concerned with the extracellular matrix. It sets out to show that a vast body of new knowledge of the extracellular matrix is available to us. Take for example the integrin family of cell adhesion receptors. It turns out that integrins play a key role not only in adhesion but also in coupling signals to the nucleus via the cytoskeleton. As for fibronectins, they seem to link the matrix with the cytoskeleton by interacting with integrins. Collagen molecules are dealt with in the last two chapters. The boundaries of collagen in disease are defined by drawing a clear line of demarcation between systemic connective tissue disorders (e.g., scleroderma), better known as autoimmune diseases, and the heritable, and the heritable diseases such as osteogenesis imperfect and the Marfan syndrome. This classification takes into account a second group of acquired disorders of collagen forming tissues in which regional fibrosis is the hallmark. Liver cirrhosis and pulmonary fibrosis are prime examples. The decision to place Volumes 2 and 3 before those dealing with cell chemistry was not easily made. It was based on the view that most students will have had an undergraduate course in biochemistry of cell biology or both courses, and that they could go to Volumes 4-7 in which the subject of cell chemistry is covered, and then return to Volumes 2 and 3.
Lysosomes
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Author : Frederick R. Maxfield
language : en
Publisher: John Wiley & Sons
Release Date : 2016-06-22
Lysosomes written by Frederick R. Maxfield and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-22 with Medical categories.
Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development. • Explores basic principles and properties of lysosomes that allow them to act as regulators of cell metabolism, therapeutic targets, and sites for activation of drug conjugates • Discusses the role of lysosomes in metabolism, drug targeting, apoptosis, cancer, aging, inflammation, autophagy, metabolism, toxicity, and membrane repair • Introduces new pathways in therapeutic development and new mechanisms in drug development
Rosenberg S Molecular And Genetic Basis Of Neurological And Psychiatric Disease
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Author : Roger N. Rosenberg
language : en
Publisher: Elsevier
Release Date : 2014-10-28
Rosenberg S Molecular And Genetic Basis Of Neurological And Psychiatric Disease written by Roger N. Rosenberg and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-28 with Science categories.
Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Fifth Edition provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to the majority of neurologic and psychiatric disease. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. Every chapter has been thoroughly revised or newly commissioned to reflect the latest scientific and medical advances by an international team of leading scientists and clinicians. The contents have been expanded to include disorders for which a genetic basis has been recently identified, together with abundant original illustrations that convey and clarify the key points of the text in an attractive, didactic format. Previous editions have established this book as the leading tutorial reference on neurogenetics. Researchers will find great value in the coverage of genomics, animal models and diagnostic methods along with a better understanding of the clinical implications. Clinicians will rely on the coverage of the basic science of neurogenetics and the methods for evaluating patients with biochemical abnormalities or gene mutations, including links to genetic testing for specific diseases. Comprehensive coverage of the neurogenetic foundation of neurological and psychiatric disease Detailed introduction to both clinical and basic research implications of molecular and genetic understanding of the brain Detailed coverage of genomics, animal models and diagnostic methods with new coverage of evaluating patients with biochemical abnormalities or gene mutations