Entre A Raz O E A Experi Ncia
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Human Cognitive Neuropsychology
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Author : Andrew W. Ellis
language : en
Publisher: Psychology Press
Release Date : 1996
Human Cognitive Neuropsychology written by Andrew W. Ellis and has been published by Psychology Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Psychology categories.
An extended version of the first edition, this book includes a set of research review papers which supplement the contents of each chapter by providing a discussion of current research issues and detailed investigations of individual cases.
Gu A De Climas Paisajes Y Suelos Para Agr Nomos En La Amazon A El Piedemonte Andino Brasil Central Y Orinoco
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Author : Thomas T. Cochrane
language : es
Publisher:
Release Date : 1985
Gu A De Climas Paisajes Y Suelos Para Agr Nomos En La Amazon A El Piedemonte Andino Brasil Central Y Orinoco written by Thomas T. Cochrane and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Agriculture categories.
Land - system mapping for seed-based agrotechnology transfer; Description of the land systems map and landscape facets; Climate; Landscapes; Soil classification; Soil physical and chemical properties; Adapting seed-based agrotechnology to local conditions: some guidelines.
Preclinical Safety Evaluation Of Biopharmaceuticals
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Author : Joy A. Cavagnaro
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-07
Preclinical Safety Evaluation Of Biopharmaceuticals written by Joy A. Cavagnaro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.
"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.
Negroes In Brazil
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Author : Donald Pierson
language : en
Publisher:
Release Date : 1944
Negroes In Brazil written by Donald Pierson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1944 with Blacks categories.
Design
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Author : Bernhard E. Bürdek
language : de
Publisher: Birkhäuser
Release Date : 2015-08-31
Design written by Bernhard E. Bürdek and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-31 with Architecture categories.
For students of design, professional product designers, and anyone interested in design equally indispensable: the fully revised and updated edition of the reference work on product design. The book traces the history of product design and its current developments, and presents the most important principles of design theory and methodology, looking in particular at the communicative function of products and highlighting aspects such as corporate and service design, design management, strategic design, interface/interaction design and human design.. From the content: Design and history: The Bauhaus; The Ulm School of Design; The Example of Braun; The Art of Design Design and Globalization Design and Methodology: Epistemological Methods in Design Design and Theory: Aspects of the Disciplinary Design Theory Design and its Context: From Corporate Design to Service Design Product Language and Product Semiotics Architecture and Design Design and Society Design and Technological Progress
Historical Jesus
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Author : Anthony Le Donne
language : en
Publisher: Wm. B. Eerdmans Publishing
Release Date : 2011-02-01
Historical Jesus written by Anthony Le Donne and has been published by Wm. B. Eerdmans Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-01 with Religion categories.
Historical Jesus asks two primary questions: What does “historical” mean? and How should we apply this to Jesus? Anthony Le Donne begins with the unusual step of considering human perception — how sensory data from sight, sound, touch, taste, and smell are interpreted from the very beginning by what we expect, what we’ve learned, and how we categorize the world. In this way Le Donne shows how historical memories are initially formed. He continues with the nature of human memory and how it interacts with group memories. Finally, he offers a philosophy of history and uses it to outline three dimensions from the life of Jesus: his dysfunctional family, his politics, and his final confrontation in Jerusalem. This little book is ideal for those with no background in religious studies — even those with no faith — who wish to better understand who Jesus was and how we can know what we do know about him.
Contemporary Political Philosophy
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Author : Will Kymlicka
language : en
Publisher: Oxford : Oxford University Press
Release Date : 2002
Contemporary Political Philosophy written by Will Kymlicka and has been published by Oxford : Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Philosophy categories.
This new edition of Will Kymlicka's best selling critical introduction to contemporary political theory has been fully revised to include many of the most significant developments in Anglo-American political philosophy in the last 11 years, particularly the new debates over issues of democratic citizenship and cultural pluralism. The book now includes two new chapters on citizenship theory and multiculturalism, in addition to updated chapters on utilitarianism, liberal egalitarianism, libertarianism, socialism, communitarianism, and feminism. The many thinkers discussed include G. A. Cohen, Ronald Dworkin, William Galdston, Carol Gilligan, R. M. Hare, Chandran Kukathas, Catherine Mackinnon, David Miller, Philippe Van Parijs, Susan Okin, Robert Nozick, John Rawls, John Roemer, Michael Sandel, Charles Taylor, Michael Walzer, and Iris Young. Extended guides to further reading have been added at the end of each chapter, listing the most important books and articles on each school of thought, as well as relevant journals and websites. Covering some of the most advanced contemporary thinking, Will Kymlicka writes in an engaging, accessible, and non-technical way to ensure the book is suitable for students approaching these difficult concepts for the first time. This second edition promises to build on the original edition's success as a key text in the teaching of modern political theory.
Considerations On Western Marxism
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Author : Perry Anderson
language : en
Publisher: Verso Books
Release Date : 2016-02-23
Considerations On Western Marxism written by Perry Anderson and has been published by Verso Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-23 with Political Science categories.
This synoptic essay considers the nature and evolution of the Marxist theory that developed in Western Europe, after the defeat of the proletarian rebellions in the West and the isolation of the Russian Revolution in the East in the early 1920s. It focuses particularly on the work of Lukcs, Korsch and Gramsci; Adorno, Marcuse and Benjamin; Sartre and Althusser; and Della Volpe and Colletti, together with other figures within Western Marxism from 1920 to 1975. The theoretical production of each of these thinkers is related simultaneously to the practical fate of working-class struggles and to the cultural mutations of bourgeois thought in their time. The philosophical antecedents of the various school within this tradition - Lukcsian, Gramscian, Frankfurt, Sartrean, Althusserian and Della Volpean - are compared, and the specific innovations of their respective systems surveyed. The structural unity of 'Western Marxism', beyond the diversity of its individual thinkers, is then assessed, in a balance-sheet that contrasts its heritage with the tradition of 'classical' Marxism that preceded it, and with the commanding problems which will confront any historical materialism to succeed it.
A Tropical Belle Epoque
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Author : Jeffrey D. Needell
language : en
Publisher: Cambridge University Press
Release Date : 1987
A Tropical Belle Epoque written by Jeffrey D. Needell and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with History categories.
This book, originally published in 1987, is a socio-cultural analysis of a tropical belle epoque: Rio de Janeiro between 1898 and 1914. It relates how the city's elite evolved from the semi-rural, slave-owning patriarchy of the coffee-port seat of a monarchy into an urbane, professional, rentier upper crust dominating the centre of a 'modernising' oligarchical republic. It explores such varied topics as architecture, literature, prostitution, urban reform, the family, secondary schools, and the salon. It evokes a milieu increasingly marked by Europe, demonstrating how French and English culture permeated the lives of elite members who adapted it to their needs and perspectives as a dominant stratum of relatively recent and varied origin. This exploration of cultural 'dependency' in a unique, cosmopolitan, fin-de-siecle urban culture will also interest those concerned with the broader questions of culture and colonialism during the high tide of European imperialism.