Entre La Os E N S Conversando Sobre Div Rcio

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Translational Medicine

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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26

Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.

Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

Disconnected

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Author : Marina Bassi
language : en
Publisher: Inter-American Development Bank
Release Date : 2012-01-01

Disconnected written by Marina Bassi and has been published by Inter-American Development Bank this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-01 with Business & Economics categories.

Disconnected is a path-breaking analysis of the relationship between schooling and employers in Latin America. It is sophisticated in its design, using multiple surveys and multiple methods. It distinguishes carefully among different types of skills and the relationship of each type to employment outcomes and employer needs. It examines both the demand and the supply side of the labor market. And it provides guidance for further work. We commend this book to all readers, scholars, and practitioners concerned with schooling and job markets in Latin America.

Peace And War

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Author : Raymond Aron
language : en
Publisher: Transaction Publishers
Release Date : 2003

Peace And War written by Raymond Aron and has been published by Transaction Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Political Science categories.

Peace and War by Raymond Aron is one of the greatest books ever written on international relations. Aron's starting point is the state of nature that exists between nations, a condition that differs essentially from the civil state that holds within political communities. Ever keeping this brute fact about the life of nations in mind and ranging widely over political history and many disciplines, Aron develops the essential analytical tools to enable us to think clearly about the stakes and possibilities of international relations. In his first section, “Theory,” Aron shows that, while international relations can be mapped, and probabilities discerned, no closed, global “science” of international relations is anything more than a mirage. In the second part, “Sociology,” Aron studies the many ways various subpolitical forces influence foreign policy. He emphasizes that no rigorous determinism is at work: politics—and thus the need for prudent statesmanship—are inescapable in international relations. In part three, “History,” Aron offers a magisterial survey of the twentieth century. He looks at key developments that have had an impact on foreign policy and the emergence of what he calls “universal history,” which brings far-flung peoples into regular contact for the first time. In a final section, “Praxeology,” Aron articulates a normative theory of international relations that rejects both the bleak vision of the Machiavellians, who hold that any means are legitimate, and the naiveté of the idealists, who think foreign policy can be overcome. This new edition of Peace and War includes an informative introduction by Daniel J. Mahoney and Brian C. Anderson, situating Aron's thought in a new post-Cold War context, and evaluating his contribution to the study of politics and international relations.

Common Knowledge Routledge Revivals

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Author : Derek Edwards
language : en
Publisher: Routledge
Release Date : 2013-02-01

Common Knowledge Routledge Revivals written by Derek Edwards and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-01 with Education categories.

First published in 1987, Common Knowledge offers a radical departure from the traditionally individualistic psychologies which have underpinned modern approaches to educational theory and practice. The authors present a study of education as the creation of ‘common knowledge’ or shared understanding between teacher and pupils. They show the presenting, receiving, sharing, controlling, negotiating, understanding and misunderstanding of knowledge in the classroom to be an intrinsically social communicative process which can be revealed only through close analysis of joint activity and classroom talk. Basing this analysis on a detailed examination of video-recorded school lessons with groups of 8 to 10-year-olds, they show how classroom communications take place against a background of implicit under-standing, some of which is never made explicit to pupils, while there develops during the lessons a context of assumed common knowledge about what has been said, done, or understood. This wide-ranging study makes an important contribution to the current debate about both teaching methods and the structure of education. It is essential reading for educationalists and developmental psychologists and has a clear practical relevance to teachers and teacher trainers.

Making News

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Author : Gaye Tuchman
language : en
Publisher: Free Press
Release Date : 1980-10-01

Making News written by Gaye Tuchman and has been published by Free Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980-10-01 with Social Science categories.

From Simon & Schuster, Making News is Gaye Tuchman's exploration into the study in the construction of reality. The Professor of Sociology at Queens College and City University of New York, Tuchman's latest work is one to cherish. As described by Todd Gitlin of Contemporary Sociology, Making News is "simply the most comprehensive book on the social construction of news by an American sociologist to date."

Describing Species

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Author : Judith E. Winston
language : en
Publisher: Columbia University Press
Release Date : 1999-11-04

Describing Species written by Judith E. Winston and has been published by Columbia University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-11-04 with Science categories.

New species are discovered every day—and cataloguing all of them has grown into a nearly insurmountable task worldwide. Now, this definitive reference manual acts as a style guide for writing and filing species descriptions. New collecting techniques and new technology have led to a dramatic increase in the number of species that are discovered. Explorations of unstudied regions and new habitats for almost any group of organisms can result in a large number of new species discoveries—and hence the need to be described. Yet there is no one source a student or researcher can readily consult to learn the basic practical aspects of taxonomic procedures. Species description can present a variety of difficulties: Problems arise when new species are not given names because their discoverers do not know how to write a formal species description or when these species are poorly described. Biologists may also have to deal with nomenclatural problems created by previous workers or resulting from new information generated by their own research. This practical resource for scientists and students contains instructions and examples showing how to describe newly discovered species in both the animal and plant kingdoms. With special chapters on publishing taxonomic papers and on ecology in species description, as well as sections covering subspecies, genus-level, and higher taxa descriptions, Describing Species enhances any writer's taxonomic projects, reports, checklists, floras, faunal surveys, revisions, monographs, or guides. The volume is based on current versions of the International Codes of Zoological and Botanical Nomenclature and recognizes that systematics is a global and multicultural exercise. Though Describing Species has been written for an English-speaking audience, it is useful anywhere Taxonomy is spoken and will be a valuable tool for professionals and students in zoology, botany, ecology, paleontology, and other fields of biology.

Design

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Author : Bernhard E. Bürdek
language : de
Publisher: Birkhäuser
Release Date : 2015-08-31

Design written by Bernhard E. Bürdek and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-31 with Architecture categories.

For students of design, professional product designers, and anyone interested in design equally indispensable: the fully revised and updated edition of the reference work on product design. The book traces the history of product design and its current developments, and presents the most important principles of design theory and methodology, looking in particular at the communicative function of products and highlighting aspects such as corporate and service design, design management, strategic design, interface/interaction design and human design.. From the content: Design and history: The Bauhaus; The Ulm School of Design; The Example of Braun; The Art of Design Design and Globalization Design and Methodology: Epistemological Methods in Design Design and Theory: Aspects of the Disciplinary Design Theory Design and its Context: From Corporate Design to Service Design Product Language and Product Semiotics Architecture and Design Design and Society Design and Technological Progress

A Comparative History Of Literatures In The Iberian Peninsula

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Author : Fernando Cabo Aseguinolaza
language : en
Publisher: John Benjamins Publishing
Release Date : 2010-05-26

A Comparative History Of Literatures In The Iberian Peninsula written by Fernando Cabo Aseguinolaza and has been published by John Benjamins Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-26 with Literary Criticism categories.

A Comparative History of Literatures in the Iberian Peninsula is the second comparative history of a new subseries with a regional focus, published by the Coordinating Committee of the International Comparative Literature Association. As its predecessor for East-Central Europe, this two-volume history distances itself from traditional histories built around periods and movements, and explores, from a comparative viewpoint, a space considered to be a powerful symbol of inter-literary relations. Both the geographical pertinence and its symbolic condition are obviously discussed, when not even contested. Written by an international team of researchers who are specialists in the field, this history is the first attempt at applying a comparative approach to the plurilingual and multicultural literatures in the Iberian Peninsula. The aim of comprehensiveness is abandoned in favor of a diverse and extensive array of key issues for a comparative agenda. A Comparative History of Literatures in the Iberian Peninsula undermines the primacy claimed for national and linguistic boundaries, and provides a geo-cultural account of literary inter-systems which cannot otherwise be explained.

Citizen Subject

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Author : Étienne Balibar
language : en
Publisher: Fordham Univ Press
Release Date : 2016-11-01

Citizen Subject written by Étienne Balibar and has been published by Fordham Univ Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-01 with Philosophy categories.

What can the universals of political philosophy offer to those who experience "the living paradox of an inegalitarian construction of egalitarian citizenship"? Citizen Subject is the summation of Étienne Balibar’s career-long project to think the necessary and necessarily antagonistic relation between the categories of citizen and subject. In this magnum opus, the question of modernity is framed anew with special attention to the self-enunciation of the subject (in Descartes, Locke, Rousseau, and Derrida), the constitution of the community as “we” (in Hegel, Marx, and Tolstoy), and the aporia of the judgment of self and others (in Foucualt, Freud, Kelsen, and Blanchot). After the “humanist controversy” that preoccupied twentieth-century philosophy, Citizen Subject proposes foundations for philosophical anthropology today, in terms of two contrary movements: the becoming-citizen of the subject and the becoming-subject of the citizen. The citizen-subject who is constituted in the claim to a “right to have rights” (Arendt) cannot exist without an underside that contests and defies it. He—or she, because Balibar is concerned throughout this volume with questions of sexual difference—figures not only the social relation but also the discontent or the uneasiness at the heart of this relation. The human can be instituted only if it betrays itself by upholding “anthropological differences” that impose normality and identity as conditions of belonging to the community. The violence of “civil” bourgeois universality, Balibar argues, is greater (and less legitimate, therefore less stable) than that of theological or cosmological universality. Right is thus founded on insubordination, and emancipation derives its force from otherness. Ultimately, Citizen Subject offers a revolutionary rewriting of the dialectic of universality and differences in the bourgeois epoch, revealing in the relationship between the common and the universal a political gap at the heart of the universal itself.

Globalizing Family Values

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Author : Doris Buss
language : en
Publisher: U of Minnesota Press
Release Date : 2003

Globalizing Family Values written by Doris Buss and has been published by U of Minnesota Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Religion categories.

With little fanfare and profound effect, "family values" have gone global, and the influence of the Christian Right is increasingly felt internationally. This is the first comprehensive study of the Christian Right's global reach and its impact on international law and politics. Doris Buss and Didi Herman explore tensions, contradictions, victories, and defeats for the Christian Right's global project, particularly in the United Nations. The authors consult Christian Right materials, from pamphlets to novels; conduct interviews with people in the movement; and provide a firsthand account of the World Congress of Families II in 1999, a key event in formulating Christian Right global policy and strategy. The result is a detailed look at a new global player--its campaigns against women's rights, population policy, and gay and lesbian rights; its efforts to build an alliance of orthodox faiths with non-Christians; and the tensions and strains as it seeks to negotiate a role for conservative Christianity in a changing global order.