Env7p Localizes To The Vacuole Membrane And Plays A Role In Vacuolar Protein Processing
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Env7p Localizes To The Vacuole Membrane And Plays A Role In Vacuolar Protein Processing
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Author : Maribeth Serranilla
language : en
Publisher:
Release Date : 2012
Env7p Localizes To The Vacuole Membrane And Plays A Role In Vacuolar Protein Processing written by Maribeth Serranilla and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Lysosomal storage diseases categories.
Abstract: The vacuole of the yeast Saccharomyces cerevisiae functions comparably to the mammalian lysosome. Its functions include protein degradation, pH/ion homeostasis, down regulation of cell surface receptors, and the ability to adapt to different environmental stresses. Defects in lysosomal trafficking are implicated with neurodegenerative diseases; therefore, understanding vacuolar trafficking will lead to more insight into lysosomal trafficking. Through our genome wide screen to identify mutants defective in the late stages of vacuolar trafficking, our lab has uncovered several previously uncharacterized ENdosome and Vacuole interface (ENV) genes. This study is focused on the characterization of ENV7, a putative serine/threonine kinase that has 29% identity to the human STK16 kinase whose function is unknown. Complementation experiments show that ENV7 is responsible for correct processing of Carboxypeptidase Y. Overexpression of the gene results in no pleiotropic phenotypes within the parameters tested. Env7p localizes at the vacuolar membrane which led to further examination of the deletion mutant, env7[delta], in vacuolar events. Microscopic analyses of env7[delta] reveal no vacuolar morphology, bulk endocytic trafficking, and acidification function defects comparable to WT (BY4742). Growth assays reveal no fitness survival, and pH/ion homeostasis defects associated with env7[delta]. Overall, this study establishes that ENV7 is localized to the vacuolar membrane and is involved in vacuolar protein processing independent of vacuolar morphology and acidification functions.
The Normal And Pathological Fetal Brain
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Author : Jean-Philippe Bault
language : en
Publisher: Springer
Release Date : 2015-08-11
The Normal And Pathological Fetal Brain written by Jean-Philippe Bault and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-11 with Medical categories.
This book provides assistance in preparing for and conducting screening or diagnostic ultrasound examinations of the fetal brain in all stages of pregnancy. Readers are provided with: abundantly illustrated descriptions of studies conducted on normal brain structures using all conventional and 3D/4D ultrasound techniques; a detailed description of the main structures of the brain; photographs of fetal pathology specimens that may be used to compare the results of imaging techniques with the anatomical reality; and practical advice and technical tips. The second part of this book presents a clear and informative overview of fetal brain pathologies, combining a wealth of detailed images and precise descriptions.
The Political Economy Of Social Choices
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Author : Maria Gallego
language : en
Publisher: Springer
Release Date : 2018-06-14
The Political Economy Of Social Choices written by Maria Gallego and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-14 with Political Science categories.
This book presents state-of-the-art research in political economy dealing with the decision making process under different political institutions. It focuses on the role that states and governments have on political outcomes and on the well-being of individuals, taking into account the differences that arise across autocracies and democracies and within political regimes. The research in this book is embedded with the political economy and social choice traditions and uses the rigorous frameworks of economics, political science and social choice theory to show how institutional settings shape social choices of a group of individuals or a nation. The contributions in this volume use a variety of cutting-edge game theory and mathematical tools as well as data and simulations that coupled with statistical techniques help us gain greater insights into these issues.