Epithelial Mesenchymal Transition And Metabolic Reprogramming In Human Breast Cancer Cells
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Epithelial Mesenchymal Transition And Metabolic Reprogramming In Human Breast Cancer Cells
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Author : Yuvabharath Kondaveeti
language : en
Publisher:
Release Date : 2015
Epithelial Mesenchymal Transition And Metabolic Reprogramming In Human Breast Cancer Cells written by Yuvabharath Kondaveeti and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Epithelial Mesenchymal Plasticity In Cancer Metastasis
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Author : Mohit Kumar Jolly
language : en
Publisher: MDPI
Release Date : 2020-12-29
Epithelial Mesenchymal Plasticity In Cancer Metastasis written by Mohit Kumar Jolly and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-29 with Medical categories.
Recent studies have highlighted that epithelial-mesenchymal transition (EMT) is not only about cell migration and invasion, but it can also govern many other important elements such as immunosuppression, metabolic reprogramming, senescence-associated secretory phenotype (SASP), stem cell properties, therapy resistance, and tumor microenvironment interactions. With the on-going debate about the requirement of EMT for cancer metastasis, an emerging focus on intermediate states of EMT and its reverse process mesenchymal-epithelial transition (MET) offer new ideas for metastatic requirements and the dynamics of EMT/MET during the entire metastatic cascade. Therefore, we would like to initiate discussions on viewing EMT and its downstream signaling networks as a fulcrum of cellular plasticity, and a facilitator of the adaptive responses of cancer cells to distant organ microenvironments and various therapeutic assaults. We hereby invite scientists who have prominently contributed to this field, and whose valuable insights have led to the appreciation of epithelial-mesenchymal plasticity as a more comprehensive mediator of the adaptive response of cancer cells, with huge implications in metastasis, drug resistance, tumor relapse, and patient survival.
Insights Into Metabolic Reprogramming By The Epithelial Mesenchymal Transition In Breast Cancer
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Author : James Michael Arnold
language : en
Publisher:
Release Date : 2018
Insights Into Metabolic Reprogramming By The Epithelial Mesenchymal Transition In Breast Cancer written by James Michael Arnold and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Breast categories.
Cell Stress Metabolic Reprogramming And Cancer
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Author : Sergio Giannattasio
language : en
Publisher: Frontiers Media SA
Release Date : 2018-08-31
Cell Stress Metabolic Reprogramming And Cancer written by Sergio Giannattasio and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-31 with categories.
The present eBook presents one review, five mini-reviews, and an opinion article on the achievements and perspectives of studies on important aspects of cancer cell metabolic reprogramming whose mechanisms and regulation are still largely elusive. It also sheds light on certain novel functional components, which rewires cell metabolism in tumor transformation.
The Heterogeneity Of Cancer Metabolism
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Author : Anne Le
language : en
Publisher: Springer
Release Date : 2018-06-26
The Heterogeneity Of Cancer Metabolism written by Anne Le and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-26 with Medical categories.
Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Epigenetic And Metabolic Regulators Of Breast Carcinogenesis
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Author : Iman Mamdouh Talaat
language : en
Publisher: Frontiers Media SA
Release Date : 2024-07-23
Epigenetic And Metabolic Regulators Of Breast Carcinogenesis written by Iman Mamdouh Talaat and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-23 with Medical categories.
Breast cancer is the most common tumor in females worldwide. Cancer epigenetics and metabolic reprogramming are known cancer hallmarks. Recent advances in the field of epigenetics include histone modification, DNA methylation, and non-coding RNAs. In contrast to genetic modifications, epigenetics refers to a set of dynamic alterations. By controlling the on and off states of oncogenes and tumor suppressor genes, as well as re-engineering the tumor microenvironment, epigenetics plays a crucial role in the initiation and progression of carcinogenesis. Additionally, the complex process of metabolic reprogramming is required for both malignant transformation and tumor development, including invasion and metastasis. Furthermore, reprogrammed metabolic activities have been utilized to diagnose, monitor, and treat cancer patients. In tumor tissues, metabolic heterogeneity was found to take a role in the adaptation to the microenvironment drastic changes resulting from current therapeutic modalities.
The Regulation Of Lactate Metabolism In Epithelial Mesenchymal Transition Of Human Breast Cancer Cells
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Author : Denisse Tafur
language : en
Publisher:
Release Date : 2017
The Regulation Of Lactate Metabolism In Epithelial Mesenchymal Transition Of Human Breast Cancer Cells written by Denisse Tafur and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Electronic dissertations categories.
Lactate is both a metabolite of glycolysis, and a component of several signaling pathways. Although recent studies indicate that lactate is a critical regulator of cancer development, very little is known about lactate metabolism in the context of metastatic cancer. Epithelial-to mesenchymal transition (EMT) promotes metastasis by inducing invasive properties in epithelial tumors. To determine whether EMT induces metabolic alterations, we have studied two epithelial breast cancer cell lines and their respective EMT-induced mesenchymal progeny for changes in lactate metabolism. Metabolic analysis revealed that EMT induced an enhanced glycolytic profile in mesenchymal breast cancer cells. In contrast, epithelial breast cancer cells preferentially use oxidative phosphorylation (OXPHOS) to produce ATP. The strong expression of the lactate importer MCT1 in epithelial breast cancer cells may involve the ERα-inducible GATA3 transcription factor. We detected a specific GATA3 binding site in the DNAse-hypersensitive region within the promoter of MCT1 gene and found that knockdown of GATA3 represses MCT1 expression. We also observed that the endogenous lactate receptor, G-protein coupled receptor 81 (GPR81), was highly expressed in epithelial breast cancer cell lines and hormone-positive breast cancer tumors. GPR81 regulated MCT1 expression and lactate uptake in epithelial breast cancer cells and its expression was crucial for cell proliferation and survival under nutrient-limited conditions. This study provides an overview of specific metabolic changes induced by EMT in two independent and substantially different epithelial breast cancer cell lines. In addition, we propose GPR81 as a potential prognostic marker and therapeutic target in hormone positive epithelial breast cancer.
The Epithelial To Mesenchymal Transition Emt In Cancer
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Author : Joëlle Roche
language : en
Publisher: MDPI
Release Date : 2018-04-09
The Epithelial To Mesenchymal Transition Emt In Cancer written by Joëlle Roche and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-09 with Electronic book categories.
This book is a printed edition of the Special Issue "The Epithelial-to-Mesenchymal Transition (EMT) in Cancer" that was published in Cancers
Epithelial Mesenchymal Plasticity In Cancer Metastasis
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Author : Mohit Kumar Jolly
language : en
Publisher:
Release Date : 2020
Epithelial Mesenchymal Plasticity In Cancer Metastasis written by Mohit Kumar Jolly and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
Recent studies have highlighted that epithelial-mesenchymal transition (EMT) is not only about cell migration and invasion, but it can also govern many other important elements such as immunosuppression, metabolic reprogramming, senescence-associated secretory phenotype (SASP), stem cell properties, therapy resistance, and tumor microenvironment interactions. With the on-going debate about the requirement of EMT for cancer metastasis, an emerging focus on intermediate states of EMT and its reverse process mesenchymal-epithelial transition (MET) offer new ideas for metastatic requirements and the dynamics of EMT/MET during the entire metastatic cascade. Therefore, we would like to initiate discussions on viewing EMT and its downstream signaling networks as a fulcrum of cellular plasticity, and a facilitator of the adaptive responses of cancer cells to distant organ microenvironments and various therapeutic assaults. We hereby invite scientists who have prominently contributed to this field, and whose valuable insights have led to the appreciation of epithelial-mesenchymal plasticity as a more comprehensive mediator of the adaptive response of cancer cells, with huge implications in metastasis, drug resistance, tumor relapse, and patient survival.
Metabolic Reprogramming During Breast Cancer Progression
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Author : Albert Mao Li
language : en
Publisher:
Release Date : 2022
Metabolic Reprogramming During Breast Cancer Progression written by Albert Mao Li and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
Cancer cells exhibit altered nutrient requirements and utilization compared to normal cells. A comprehensive understanding of the causes and consequences of these altered metabolic features can help inform the development of novel therapeutics aimed at impairing cancer cell proliferation and promoting differentiation, in addition to enriching our understanding of how cancer comes to be. In this thesis, we utilized breast cancer as a model to study how altered cell metabolism relates to differences in proliferative capacity and cell lineage identity. Using a targeted metabolomics approach, we discovered a metabolic signature suggestive of elevated serine and one-carbon (1C) unit metabolism in the aggressive, tissue-tropic metastatic subpopulations of triple-negative breast cancer cells. In line with previous reports, we confirmed a role for the oncogene c-Myc in driving the enhanced proliferation of the metastatic subclones compared to parental cells. Functional validation using genetic and pharmacologic inhibition approaches uncovered an exquisite dependency of metastatic cells on this mitochondrial pathway for growth in vitro and in vivo. Analyses of human breast cancer patient data further identified a significant association between high expression of mitochondrial serine and 1C unit pathway genes with patient mortality. In follow-up work, we determined that low serine levels drives a metabolic signature associated with breast cancer cell aggressiveness characterized by the transcriptional induction of genes involved in de novo serine synthesis and mitochondrial serine and 1C unit metabolism. A global transcriptome analysis uncovered serine starvation-mediated repression of estrogen receptor (ER) signaling in ER+ breast cancer cells, effectively converting them to an ER-- like state. Metabolomics, isotope tracing, and chromatin immunoprecipitation assays revealed a defect in glucose-derived central carbon flux leading to a loss of histone acetylation and silencing of ER pathway genes. Acetate supplementation rescued histone hypoacetylation and ER pathway activity, demonstrating that serine starvation influences breast cancer cell state through a metabolic and epigenetic regulatory axis.