Erythroid Cells
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Erythroid Cells
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Author : J. Robin Harris
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Erythroid Cells written by J. Robin Harris and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
This series of books, devoted to aspects of blood cell biochemistry, development, immu nology, and ultrastructure, has evolved and separated from the long-established Plenum series Subcellular Biochemistry. It is the intention of these volumes to draw together related areas of investigation and to provide, in the fullness of time, complete coverage of this rapidly advancing important biomedical discipline. Both fundamental and medically applied topics, dealing with normal and pathological cells, will be included. This, the first volume of the series, contains a diverse collection of chapters, all of which relate to erythroid cells. The range of material included is extremely broad and the authors have used contrasting technical approaches, both within their personal experimen tal studies and within their manuscripts. This has led to the production of a very interest ing compilation, which does, nevertheless, possess a strong overall thematic unity. As with all edited volumes, some topics of importance and interest are not included. This may be because of oversight on my part, as editor, or because the authors originally selected failed to submit their manuscript by the agreed-upon submission date. For these omissions I take full responsibility and trust that at least some of the topics omitted, for instance membrane cation transport systems, will be covered within a future volume of the series. This book commences with two chapters of a developmental nature.
Erythroid Cells Advances In Research And Application 2011 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09
Erythroid Cells Advances In Research And Application 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Medical categories.
Erythroid Cells: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Erythroid Cells in a concise format. The editors have built Erythroid Cells: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Erythroid Cells in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Erythroid Cells: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Erythroid Cells Advances In Research And Application 2013 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2013-06-21
Erythroid Cells Advances In Research And Application 2013 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-21 with Medical categories.
Erythroid Cells—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Erythroid Cells—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Erythroid Cells—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
In Vitro Aspects Of Erythropoiesis
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Author : M.J. Jr. Murphy
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
In Vitro Aspects Of Erythropoiesis written by M.J. Jr. Murphy and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Nature categories.
vitro methodology for the cultivation of erythroid The purpose of In Vitro Aspects of Erythropoiesis is to broaden our understanding of the regulation of stem cells. The second series of papers treats cellular normal and neoplastic hematopoietic cells by means and soluble factors which affect erythroid stem cell of a synthesis of different techniques, divergent no differentiation. Hormonal modulation of in vitro menclature as well as a closer standardization of re erythropoiesis is the theme of the third session fol agents and methods which had heretofore produced lowed by a series of papers in the fourth which fo vagaries of results among different laboratories. cuses on erythropoiesis after transformation by ei Hence the papers, discussions and appendices pre ther Friend or Rauscher viruses. The fifth session deals with serum inhibitors to erythropoiesis and the sented in this volume will be of value and interest to investigators and clinicians as well as to students and role of the macrophage in red blood cell production. teachers of hematology. Finally, the sixth session concentrates on the biogen In Vitro Aspects of Erythropoiesis is comprised of esis of erythropoietin in vivo and in vitro. thirty papers delivered by twenty invited contribu Each of the six sections is followed by a discus tors at a three day conference which was held in sion which was transcribed and initially edited at the Capri, Italy in October of 1977. The contributors meeting."
Erythroid Cells Advances In Research And Application 2012 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-12-26
Erythroid Cells Advances In Research And Application 2012 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-26 with Medical categories.
Erythroid Cells—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Erythroid Cells in a concise format. The editors have built Erythroid Cells—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Erythroid Cells in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Erythroid Cells—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Erythroid Precursor Cells Advances In Research And Application 2011 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09
Erythroid Precursor Cells Advances In Research And Application 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Science categories.
Erythroid Precursor Cells: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Erythroid Precursor Cells in a compact format. The editors have built Erythroid Precursor Cells: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Erythroid Precursor Cells in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Erythroid Precursor Cells: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Erythrocytes
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Author : Florian Lang
language : en
Publisher: World Scientific Publishing Company
Release Date : 2012-07-23
Erythrocytes written by Florian Lang and has been published by World Scientific Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-23 with Medical categories.
The book covers the functional significance and properties of erythrocytes, their generation, senescence, and suicidal death. It further summarizes knowledge about hormones influencing erythrocyte formation including erythropoietin as well as disorders affecting and involving erythrocytes such as anemia, malaria, and sepsis. This seminal work forms a unique reference on the most abundant cell type in mammals and will be an invaluable resource for students in the life sciences.
Erythroid Precursor Cells Advances In Research And Application 2012 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-12-26
Erythroid Precursor Cells Advances In Research And Application 2012 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-26 with Science categories.
Erythroid Precursor Cells—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Erythroid Precursor Cells in a concise format. The editors have built Erythroid Precursor Cells—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Erythroid Precursor Cells in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Erythroid Precursor Cells—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Molecular And Cellular Aspects Of Erythropoietin And Erythropoiesis
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Author : Ivan N. Rich
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Molecular And Cellular Aspects Of Erythropoietin And Erythropoiesis written by Ivan N. Rich and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
Molecular biology has provided a tool with which problems in cellular differentiation can be answered. Recombinant DNA technology has been used to obtain quantities of the erythropoietic hormone, erythropoietin. The availability of the hormone has provided a much-needed impetus in learning how erythropoiesis is controlled. Knowledge of the genetic components, transcription and translation of the erythropoietin gene and finally the release of the mature hormone under various physiological conditions should be forthcoming in the near future. This volume will give the reader some indication as to the different aspects of erythropoiesis. They include the regulation of production of the hormone under normal and abnormal conditions, ontogeny and cellular interactions and the assay of the hormone itself.
Metabolic And Immunomodulatory Control Of Stress Erythroid Progenitors Ensures Effective Erythroid Regeneration
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Author : Baiye Ruan
language : en
Publisher:
Release Date : 2022
Metabolic And Immunomodulatory Control Of Stress Erythroid Progenitors Ensures Effective Erythroid Regeneration written by Baiye Ruan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
Hematopoiesis in adult bone marrow is the primary source of erythroid production during steady state conditions. However, in the course of infection or tissue injuries, elevated pro-inflammatory cytokines reshape the composition of hematopoietic lineages to increase the myeloid output at the expense of steady-state erythroid production. In addition, inflammation can directly inhibit the erythroid cell development and life span. To compensate for the reduction of steady-state erythropoiesis, an alternative response pathway, stress erythropoiesis, is induced. During inflammation, increased erythrophagocytosis produces chemokine CCL2 to recruit monocytes into the spleen where they form the early stress erythroid niche. Through cell-cell interactions, niche cells provide inflammatory cytokines and growth factors to promote the rapid expansion of early stress erythroid progenitors while inhibiting their erythroid differentiation potential. The subsequent increase of serum erythropoietin (Epo) level resolves the inflammatory signals in the niche, and changes of niche signals result in the transition of stress erythroid progenitors from proliferation to differentiation. In this dissertation, we applied integrated analysis between transcriptomics and metabolic profiling to examine the changes occurring at different stages of stress erythropoiesis. These analyses allow for identification of key signaling crosstalk between cell metabolism and immunomodulating molecules that involves in regulating the expansion and cell-fate transition of stress erythroid progenitors. The work described in Chapter 2 shows that the immature stress erythroid progenitors undergo profound metabolic changes during their rapid proliferation. These changes include a Warburg-like profile marked by increased engagement of glycolysis and decreased pyruvate entry into TCA cycle. This strategy provides sufficient glycolytic intermediates that are shunted into pentose phosphate pathway (PPP) and serine/glycine pathway to replenish biosynthetic precursors required for rapid cell proliferation. In addition, immature progenitors utilize the anaplerotic pathway referred to as glutaminolysis to replenish TCA cycle and generate substrates for nitric oxide ( NO) production. Similar to the niche cells, immature progenitors express robust levels of toll-like receptors (TLRs) and receptors for pro-inflammatory cytokines to sense inflammatory signals. This feature enables both niche and progenitors to respond to inflammation by increasing the inducible nitric oxide synthase (Nos2 or iNOS)-dependent NO production. NO serves as a critical metabolic regulator that maintains the glycolytic and anabolic metabolism to support the expansion of early progenitors. NO-dependent metabolism also functions to inhibit the erythroid transcriptional program. In contrast, the cell-fate transition from proliferation to differentiation is marked by a decrease of iNOS-derived NO production. This transition response is governed by the activation of nuclear factor erythroid 2-related factor 2 (Nfe2l2 or Nrf2), which removes NO-dependent erythroid inhibition and allows the differentiation of stress erythroid progenitors. Built on abovementioned data, work in Chapter 3 further shows that the transition of progenitors from expansion to differentiation is contingent upon a switch of progenitor cell signaling from one dominated by inflammatory signals to one dominated by resolving signals. Furthermore, our data suggest that this signaling switch is tightly controlled by itaconate, an immunomodulatory metabolite. During the expansion stage, the production of itaconate is suppressed, allowing for the increased production of TNF-[alpha]-dependent reactive oxygen species (ROS) and iNOS-dependent NO. These two inflammation-induced signaling molecules act synergistically to promote the expansion of immature progenitors. In contrast, the transition to differentiation couples with increased production of resolving signals itaconate and IL-10. These two immunomodulating mediators, via activating Nrf2, resolve inflammation-mediated erythroid inhibition, which in turn enables the commitment of stress erythroid progenitors. Collectively, these results suggest that the same inflammatory signals that suppress steady-state erythropoiesis serve to induce a compensatory stress erythropoiesis pathway by amplifying a large pool of immature progenitors prior to differentiation. A timely resolution of inflammatory signals in the subsequent differentiation stage is critical for an effective transition from immature progenitors to committed erythroid cells. The regulatory network that coordinates the expansion of early progenitors with differentiation of mature progenitors involves in dynamic changes of intracellular metabolism to support the growth as well as instruct the cell fate of stress erythroid progenitors. These data provide a foundation to appreciate the distinct responses between stress and steady-state progenitors to inflammatory stimuli, and may lead to new therapeutic targets to treat various types of anemia associated with inflammatory complications, such as anemia of chronic disease (ACD) and sickle cell anemia (SCA).