Erythropoietic Stimulating Agents
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Erythropoietic Stimulating Agents
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Author : Elísio Costa
language : en
Publisher: Bentham Science Publishers
Release Date : 2013-07-25
Erythropoietic Stimulating Agents written by Elísio Costa and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-25 with Medical categories.
The development of new erythropoietic stimulating agents (ESAs) has significantly increased in recent years. Researchers are focused on different and interesting concepts, namely, methods to increase half-life of erythropoietin (EPO), finding different routes of administration and new ESA or modified EPO molecules. Scientific literature presents evidence that EPO has other effects beyond erythropoietic stimulation. These pleiotropic effects of EPO appear to result from the existence of two different EPO receptors (EPOR) with different affinities for EPO. The discovery of new EPO actions beyond the hematopoietic system has opened a new field of investigation with these agents. Several molecules have been developed to present the protective action, without the activation of the hematopoietic system. These agents can be potentially used in several diseases of the brain/central and peripheral nervous system, eye, heart and kidney. This volume of Frontiers in Drug Discovery includes a revision of articles on erythropoiesis and EPO gene regulation, microRNAs and their potential contribution to the development of new therapeutic strategies, animal models for studying kidney disease-associated anemia as well as benefits/risks of ESA therapy. The biological effects of new ESA molecules, heparin-binding erythropoietin and of pHBSP, and the potential applications of ESA, are also elicited in this volume. This volume is, therefore, a useful reference for medicinal chemists and hematologists interested in drug development and medicine related to ESAs.
Erythropoiesis Stimulating Agents For Anemia Of Chronic Kidney Disease
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Author :
language : en
Publisher:
Release Date : 2008
Erythropoiesis Stimulating Agents For Anemia Of Chronic Kidney Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Chronic renal failure categories.
Erythropoiesis Stimulating Agents For Anemia Of Cancer Or Of Chemotherapy
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Author :
language : en
Publisher:
Release Date : 2009
Erythropoiesis Stimulating Agents For Anemia Of Cancer Or Of Chemotherapy written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Cancer categories.
Casebook In Clinical Pharmacokinetics And Drug Dosing
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Author : Henry Cohen
language : en
Publisher: McGraw Hill Professional
Release Date : 2014-10-06
Casebook In Clinical Pharmacokinetics And Drug Dosing written by Henry Cohen and has been published by McGraw Hill Professional this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-06 with Medical categories.
A STEP-BY-STEP APPROACH TO DESIGNING ACCURATE DOSING REGIMENS Casebook in Pharmacokinetics and Drug Dosing uses real-life cases to teach pharmacy students, pharmacists, and clinical pharmacists how to apply pharmacokinetics to formulate proper dosing regimens. In order to be as clinically relevant as possible, the book not only discusses drugs with readily available therapeutic serum levels, but places equal emphasis on high-alert agents with narrow therapeutic indexes. Each drug chapter is written by clinical pharmacists who have hands-on experience in drug dosing and includes an overview of the drug’s pharmacology, including: Indications Mec hanisms of action Toxicities Pharmacokinetics There is comprehensive review and discussion of each drug's bioavailability, volume of distribution, clearance, half-life, therapeutic drug level monitoring, drug interactions, dosing, and availability. Each chapter is enhanced by numerous patient cases with clear step-by-step answers and explanations. Calculations, equations, and dosing recommendations are provided for each case.
Erythropoiesis Stimulating Agents
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Author : Fernando de la Carrera
language : en
Publisher:
Release Date : 2007
Erythropoiesis Stimulating Agents written by Fernando de la Carrera and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.
Introduction To Biological And Small Molecule Drug Research And Development
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Author : Wolfgang Jelkmann
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-05-07
Introduction To Biological And Small Molecule Drug Research And Development written by Wolfgang Jelkmann and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-07 with Science categories.
The renal hormone erythropoietin (Epo) is essential for the viability and proliferation of the erythrocytic progenitors generating reticulocytes in the bone marrow. Human Epo consists of a chain of 165 amino acid residues and four glycans. The synthesis of Epo is strongly stimulated by hypoxia. Epo deficiency is the primary cause of the anaemia in chronic kidney disease (CKD). For anaemia treatment recombinant human Epo (rhEpo/epoetin and epoetin) is very useful. The drug substance is generally manufactured in EPO complementary DNA (cDNA) transfected Chinese hamster ovary cell cultures. rhEpo therapy is beneficial not only for CKD patients but also for anaemic cancer patients receiving chemotherapy. The expiry of the patents for the first original rhEpo formulations has initiated the production of similar biological medicinal products (‘biosimilars’). The term ‘biosimilar’ should only be used for a medicinal product approved on a strict regulatory pathway (i.e. European Medicines Agency, Food and Drug Administration, etc.). Unfortunately, many claimed ‘biosimilars’ have not been through an approval authority. Furthermore, rhEpo analogues with prolonged survival in circulation (‘biobetter’) have been developed and synthetic Epo mimetic peptides have been developed for therapy. The biological role of Epo outside the bone marrow is the focus of current research.
Overview Of Erythropoiesis Stimulating Agents For Anemia Of Chronic Kidney Disease
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Author : Eugenia Palylyk-Colwell
language : en
Publisher:
Release Date : 2008
Overview Of Erythropoiesis Stimulating Agents For Anemia Of Chronic Kidney Disease written by Eugenia Palylyk-Colwell and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Anemia categories.
Erythropoiesis Stimulating Agents In Patients With Hematologic Malignancies In Newfoundland And Labrador
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Author : Dawn Catherine Sheppard
language : en
Publisher:
Release Date : 2008
Erythropoiesis Stimulating Agents In Patients With Hematologic Malignancies In Newfoundland And Labrador written by Dawn Catherine Sheppard and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Anemia categories.
Effectiveness And Cost Effectiveness Of Erythropoiesis Stimulating Agents Epoetin And Darbepoetin For Treating Cancer Treatment Induced Anaemia Including Review Of Technology Appraisal No 142
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Author :
language : en
Publisher:
Release Date : 2016
Effectiveness And Cost Effectiveness Of Erythropoiesis Stimulating Agents Epoetin And Darbepoetin For Treating Cancer Treatment Induced Anaemia Including Review Of Technology Appraisal No 142 written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Safety Of Roxadustat Versus Erythropoiesis Stimulating Agents In Patients With Anemia Of Non Dialysis Dependent Or Incident To Dialysis Chronic Kidney Disease
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Author : Jonathan Barratt
language : en
Publisher:
Release Date : 2023
Safety Of Roxadustat Versus Erythropoiesis Stimulating Agents In Patients With Anemia Of Non Dialysis Dependent Or Incident To Dialysis Chronic Kidney Disease written by Jonathan Barratt and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.