Erythropoietin
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Erythropoietin
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Author : Wolfgang Jelkmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Erythropoietin written by Wolfgang Jelkmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The book contains a series of up-to-date review articles on the physiology and pathophysiology of the control of the production of red cells by the hormone erythropoietin. In addition, the results are reported of initial clinical trials using recombinant human erythropoietin (rhuEpo) in the treatment of the anemia of renal failure. The introductory chapter briefly recalls the history of erythropoietin research. The following section on the chemistry and physiology covers details of the structure of the hormone, assay methods, the identification of renal and extrarenal sites of the production of erythropoietin by in situ hybridization and the hypoxic stimulation of its production. A special chapter is devoted to the regulation of erythropoiesis in the neonatal period. There follows a section on pathophysiology, which includes respiratory, renal and malignant diseases in humans. In the final section the pharmacology of rhuEpo is considered. The strategy of the cloning and in vitro expression of the erythropoietin gene is described. Four chapters summarize clinical observations of the effects of rhuEpo in the correction of the anemia of renal failure, including the rise in hematocrit, blood viscosity and possibly hypertension, and the increased physical work capacity of the patients. The monograph will prove useful not only to investigators working in the basic fields of physiology, pharmacology and endocrinology, but also to practising physicians, especially hematologists and nephrologists, who are interested in erythropoietin for diagnostic or therapeutic purposes.
Pathophysiology And Pharmacology Of Erythropoietin
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Author : Horst Pagel
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Pathophysiology And Pharmacology Of Erythropoietin written by Horst Pagel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The book contains a series of about 40 articles reflecting the state-of-the-art of the topic "Pathophysiology and Pharmacology of Erythropoietin". Results from both basic research and clinical studies are described in detail. The papers show that the possible therapeutic spectrum of erythropoietin could be expanded considerably when compared with the present situation.
Recombinant Human Erythropoietin Rhepo In Clinical Oncology
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Author : Mohammad Resa Nowrousian
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Recombinant Human Erythropoietin Rhepo In Clinical Oncology written by Mohammad Resa Nowrousian and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Anemia is a frequent complication of cancer and its treatment. A number of clinical studies shows that the impact of anemia is much greater than previously thought. Beyond clinical symptoms, anemia significantly impairs physical and metabolic functions as well as patients' activity, well-being and quality of life. Life expectancy is also affected. In this book, written by a group of outstanding international experts, the current knowledge on anemia in cancer and its treatment with rhEPO is presented. Future developments are also discussed. Based on a broad spectrum of topics, the book describes the scientific and clinical aspects of anemia in various fields of oncology and gives diagnostic and therapeutic recommendations on when and how to use rhEPO.
Erythropoietin And The Nervous System
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Author : Ahmet Höke
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-09-28
Erythropoietin And The Nervous System written by Ahmet Höke and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-09-28 with Medical categories.
Erythropoietin (EPO) is a chemokine hormone that is widely distributed throughout the body. In addition to its traditional role as a hormone that stimulates red blood cell production, in recent years many laboratories have shown that EPO can act as a neuroprotective compound in a variety of injury paradigms in the nervous system. Past experience with relatively safety profile of this FDA-approved drug makes it an ideal candidate to take it into clinical trials for neuroprotection. We are on the verge of major clinical trials using this drug for neuroprotection in diseases ranging from stroke, to transverse myelitis to chemotherapy-induced peripheral neuropathy. This is the first book of its kind that brings together researchers from many different disciplines of neuroscience to review the current state-of-the-art in EPO and the nervous system. This book will benefit scientists and clinicians interested in neuroprotection in the broadest sense.
Erythropoietin
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Author : Allan J. Erslev
language : en
Publisher:
Release Date : 1991
Erythropoietin written by Allan J. Erslev and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.
The aim of this monograph is to provide an account of the events that led to the transformation of a concept of red cell regulation into an effective treatment of many anemias. Each chapter is authored by investigators who were involved in this transformation and who are still at work on elucidating the origin, kinetics, action, and regulation of this growth hormone. Annotation copyrighted by Book News, Inc., Portland, OR
Molecular And Cellular Aspects Of Erythropoietin And Erythropoiesis
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Author : Ivan N. Rich
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Molecular And Cellular Aspects Of Erythropoietin And Erythropoiesis written by Ivan N. Rich and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
Molecular biology has provided a tool with which problems in cellular differentiation can be answered. Recombinant DNA technology has been used to obtain quantities of the erythropoietic hormone, erythropoietin. The availability of the hormone has provided a much-needed impetus in learning how erythropoiesis is controlled. Knowledge of the genetic components, transcription and translation of the erythropoietin gene and finally the release of the mature hormone under various physiological conditions should be forthcoming in the near future. This volume will give the reader some indication as to the different aspects of erythropoiesis. They include the regulation of production of the hormone under normal and abnormal conditions, ontogeny and cellular interactions and the assay of the hormone itself.
Erythropoietins Erythropoietic Factors And Erythropoiesis
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Author : Steven G. Elliott
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-06-05
Erythropoietins Erythropoietic Factors And Erythropoiesis written by Steven G. Elliott and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-05 with Medical categories.
A comprehensive one-source guide to the most current information on red blood cell formation and the action of recombinant human erythropoietins. Topics covered include: erythropoiesis, recombinant protein discovery and production, and treatment of patients with anemia. The newest theories in erythropoiesis (receptors, signaling), manufacturing, new formulations, and clinical research are discussed. The text is ideal for researchers and clinical investigators in academia, biotechnology, and pharmaceutical companies, as well as clinical research associates, clinical monitors, and physician investigators.
Erythropoietins And Erythropoiesis
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Author : Graham Molineux
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-11-17
Erythropoietins And Erythropoiesis written by Graham Molineux and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-11-17 with Medical categories.
A comprehensive one-source guide to the most current information on red blood cell formation and the action of recombinant human erythropoietins. Topics covered include: erythropoiesis, recombinant protein discovery and production, and treatment of patients with anemia. The newest theories in erythropoiesis (receptors, signaling), manufacturing, new formulations, and clinical research are discussed. The text is ideal for researchers and clinical investigators in academia, biotechnology, and pharmaceutical companies, as well as clinical research associates, clinical monitors, and physician investigators. This softcover volume is an unchanged second printing of the hardcover edition published in 2003.
Erythropoietin
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Author : Arthur J. Sytkowski
language : en
Publisher: John Wiley & Sons
Release Date : 2006-03-06
Erythropoietin written by Arthur J. Sytkowski and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-06 with Science categories.
The use of Epo in medical practice is increasing constantly. It has revolutionized how we think of blood transfusion in medicine and surgery. Moreover, it has become widely known to scientists, physicians, biotech and pharmaceutical executives and the general public. Additionally, the past ten years have seen important advances in our knowledge and understanding of its action both within and outside of the hematopoietic system. Until now, there has been no single source that contains up-to-date information on Epo addressing the array of subjects that this book presents. The book covers all aspects from developmental biology to specific topics such as medical applications of recombinant Epo, receptor biology, mechanisms of Epo activity, structure/activity relationship, disease states and important actions on non-hematopoietic organs and tissues, including the central nervous system, heart, gastrointestinal tract, reproductive organs and endothelium.
Molecular Cellular And Developmental Biology Of Erythropoietin And Erythropoiesis
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Author : Ivan N. Rich
language : en
Publisher:
Release Date : 1994
Molecular Cellular And Developmental Biology Of Erythropoietin And Erythropoiesis written by Ivan N. Rich and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medical categories.
Recombinant DNA technology has allowed the cloning, sequencing and large-scale production of human erythropoietin, which is now used in therapy for the anaemia of renal disease. In addition, there are many ongoing clinical trials in which recombinant human erythropoietin is being investigated. The availability of the recombinant reagent has added great impetus to all areas of erythropoetin and erythropoiesis research. This multidisciplinary work brings together investigators from many fields who discuss past, present and future research in this area. The science here is primarily experimental and should be of interest to biochemists, experimental haematologists, pharmacologists, clinical haematologists and nephrologists.