Examining Nrf2 Expression As A Potential Therapy For Alzheimer S Disease Using An In Vitro Cell Model
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Examining Nrf2 Expression As A Potential Therapy For Alzheimer S Disease Using An In Vitro Cell Model
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Author : Wenyuan Wei
language : en
Publisher:
Release Date : 2020
Examining Nrf2 Expression As A Potential Therapy For Alzheimer S Disease Using An In Vitro Cell Model written by Wenyuan Wei and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
Alzheimer's disease (AD) is a neurodegenerative condition that contributes to the majority of dementia cases worldwide. The exact cause of AD remains elusive, and the study of its disease biology is hampered by the lack of in vitro and in vivo models that are representative of the condition, and the absence of disease-modifying treatments. In this project, we attempted to use the most accurate cellular model of AD currently available to test whether an intervention that reduces oxidative stress, a common pathological feature of AD, can provide therapeutic benefits. The cellular model we used is a 3-dimensional cell matrix formed by differentiated immortalized human neural-progenitors which was previously shown to generate many key feature of AD pathobiology, such as phosphorylated Tau and Ab aggregates. Our therapeutic intervention was the overexpression of Nuclear factor erythroid 2-related factor 2 (NRF2), a transcription factor that counters oxidative stress in normal cells and was found to ameliorate the symptoms of AD in mice. This project first made an attempt to reproduce the 3-dimensional AD cell culture model, and then test the effectiveness of NRF2 overexpression as a treatment option.
Systems Biology Of Free Radicals And Antioxidants
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Author : Ismail Laher
language : en
Publisher: Springer
Release Date : 2014-06-16
Systems Biology Of Free Radicals And Antioxidants written by Ismail Laher and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-16 with Medical categories.
The focus of this collection of illustrated reviews is to discuss the systems biology of free radicals and anti-oxidants. Free radical induced cellular damage in a variety of tissues and organs is reviewed, with detailed discussion of molecular and cellular mechanisms. The collection is aimed at those new to the field, as well as clinicians and scientists with long standing interests in free radical biology. A feature of this collection is that the material also brings insights into various diseases where free radicals are thought to play a role. There is extensive discussion of the success and limitations of the use of antioxidants in several clinical settings.
Role Of Nrf2 In Disease Novel Molecular Mechanisms And Therapeutic Approaches
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Author : Javier Egea
language : en
Publisher: Frontiers Media SA
Release Date : 2020-01-02
Role Of Nrf2 In Disease Novel Molecular Mechanisms And Therapeutic Approaches written by Javier Egea and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-02 with categories.
Oxidative Stress And Neurodegenerative Disorders
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Author : G. Ali Qureshi
language : en
Publisher: Elsevier
Release Date : 2007-03-22
Oxidative Stress And Neurodegenerative Disorders written by G. Ali Qureshi and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-03-22 with Science categories.
Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. * Contains the latest information on the subject of neurodegenerative disorders* Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems
Encyclopedia Of Biomedical Gerontology
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Author :
language : en
Publisher: Academic Press
Release Date : 2019-11-20
Encyclopedia Of Biomedical Gerontology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-20 with Medical categories.
Encyclopedia of Biomedical Gerontology, Three Volume Set presents a wide range of topics, ranging from what happens in the body during aging, the reasons and mechanisms relating to those age-related changes, and their clinical, psychological and social modulators and determinants. The book covers the biological and medical aspects of gerontology within the general framework of the biological basis of assessing age, biological mechanisms of aging, age-related changes in biological systems, human age-related diseases, the biomedical practicality and impracticality of interventions, and finally, the ethics of intervention. Provides a ‘one-stop’ resource to information written by world-leading scholars in the field of biomedical gerontology Fills a critical gap of information in a field that has seen significant progress in the last 10 years
Natural Bioactive Compounds
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Author : Rajeshwar P. Sinha
language : en
Publisher: Academic Press
Release Date : 2020-10-06
Natural Bioactive Compounds written by Rajeshwar P. Sinha and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-06 with Science categories.
Natural Bioactive Compounds: Technological Advancements deals with the latest breakthroughs in the field of screening, characterization and novel applications of natural bioactive compounds from diverse group of organisms ranging from bacteria, viruses, cyanobacteria, algae, fungi, bryophytes, higher plants, sponges, corals and fishes. Written by some of the most reputed scientists in the field, this book introduces the reader to strategies and methods in the search for bioactive natural products. It is an essential read for researchers and students interested in bioactive natural products, their biological and pharmacological properties, their possible use as chemopreventive or chemotherapeutic agents, and other future potential applications. Explores natural sources of bioactive compounds, including cyanobacteria, bacteria, viruses, fungi and higher plants Discusses the potential applications of biological products, such as their use in medicine (antibiotics, cancer research, immunology), as food additives, supplements and technological substances Analyzes the contributions of emerging or developing technologies for the study of bioactive natural compounds (characterization and purification)
Cyclin Dependent Kinase 5 Cdk5
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Author : Nancy Y. Ip
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-02-28
Cyclin Dependent Kinase 5 Cdk5 written by Nancy Y. Ip and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-02-28 with Medical categories.
Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.
Neuroinflammatory And Oxidative Nitrosative Pathways In Neuropsychiatric And Neurological Diseases And Their Possible Neuropharmacological Regulation Volume I
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Author : Javier R. Caso
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-03
Neuroinflammatory And Oxidative Nitrosative Pathways In Neuropsychiatric And Neurological Diseases And Their Possible Neuropharmacological Regulation Volume I written by Javier R. Caso and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-03 with Science categories.
New Technologies For Detection Monitoring And Treatment Of Parkinson S Disease
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Author : Martin J. McKeown
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-22
New Technologies For Detection Monitoring And Treatment Of Parkinson S Disease written by Martin J. McKeown and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-22 with categories.
Nutraceuticals And Natural Product Derivatives
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Author : Mohammad Fahad Ullah
language : en
Publisher: John Wiley & Sons
Release Date : 2019-03-06
Nutraceuticals And Natural Product Derivatives written by Mohammad Fahad Ullah and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-06 with Science categories.
Introduces readers to the growing applications of nutraceuticals and other natural product derivatives This comprehensive book presents a prophylactic and therapeutic approach to chronic disease prevention strategy by highlighting the translational potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies. It also shares the experiences of highly reputed experts working in the area of phytomedicine and nutraceutical agents in chemoprevention, to promote the significance of natural products and dietary factors as an elite priority for containing chronic diseases in the human population. Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery starts by examining natural food sources for the control of glycemia and the prevention of diabetic complications. It then looks at the anti-aging effects of sulfur-containing amino acids and nutraceuticals, and the potential of garcinia fruits to combat metabolic syndrome. Other topics covered include honey- and propolis-mediated regulation of protein networks in cancer cells; recent trends in drug discovery against Alzheimer’s disease; the therapeutic potential of metalloherbal nanoceuticals; and much more. Offers an alternative, natural approach to the prevention of chronic diseases Emphasizes the potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies Features contributions from world-renowned experts in the field of phytomedicine and nutraceutical agents in chemoprevention Includes prevention strategies in normal/risk populations through routine inclusion of specific dietary regimens and as therapeutic strategy for better management through adjuvant interventions with conventional treatment protocols Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery will appeal to graduate students and professionals in cell and molecular biology, translational research, pharmacology/drug discovery, medicinal chemistry, and clinical nutrition.