Exogenous Factors Affecting Thrombosis And Hemostasis
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Exogenous Factors Affecting Thrombosis And Hemostasis
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Author : R. Manjunatha Kini
language : en
Publisher:
Release Date : 2005
Exogenous Factors Affecting Thrombosis And Hemostasis written by R. Manjunatha Kini and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Hemostasis categories.
Blood circulation is vital for our survival and any imbalance in the circulatory system or in hemostasis may either lead to death or severe debility. Thus, there is a great demand for therapeutic agents for cardiovascular and hematological disorders. This publication highlights recent research on the biochemistry, molecular biology, structure, function and mechanism of action of exogenous factors affecting thrombosis and hemostasis. These exogenous factors, evolved over millions of years, include numerous components of snake venoms, which can either activate or inhibit platelets or coagulation factors, and antihemostatic compounds from the salvia of blood-feeding arthropods. This special issue consolidates the efforts in this area and gives new insights into exogenous factors and their development as therapeutic agents. Hematologists, biochemists, molecular biologists, protein chemists, enzymologists and drug developers will appreciate the comprehensive overview of this important field of research provided by these proceedings.
Exogenous Factors Affecting Thrombosis And Hemostasis
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Author :
language : en
Publisher:
Release Date : 2005
Exogenous Factors Affecting Thrombosis And Hemostasis written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
International Conference On Exogenous Factors Affecting Thrombosis And Haemostasis
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Author :
language : en
Publisher:
Release Date : 2002
International Conference On Exogenous Factors Affecting Thrombosis And Haemostasis written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
International Conference On Exogenous Factors Affecting Thrombosis And Haemostasis
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Author : Cassian Bon
language : en
Publisher:
Release Date : 2002
International Conference On Exogenous Factors Affecting Thrombosis And Haemostasis written by Cassian Bon and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Hemostasis categories.
This publication highlights recent research on the biochemistry, molecular biology, structure, function and mechanism of action of exogenous factors affecting thrombosis and haemostasis. These factors include numerous components of snake venoms, which can either activate or inhibit platelets or coagulation factors, and anti-haemostatic compounds from the saliva of blood-feeding arthropods. Comprising four sections devoted to fibrinolysis, substances that affect platelet aggregation, procoagulant proteins and anticoagulant proteins, this publication also deals with the development of therapeutic and diagnostic agents from exogenous factors and their clinical actions. Hematologists, biochemists, molecular biologists, protein scientists, toxicologists and toxinologists will appreciate the comprehensive overview of this important field of research provided by these proceedings.
International Congress On Exogenous Factors Affecting Thrombosis And Haemostasis Paris July 12 13 2001
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Author : International Conference on Exogenous Factors Affecting Thrombosis and Haemostasis
language : en
Publisher:
Release Date : 2001
International Congress On Exogenous Factors Affecting Thrombosis And Haemostasis Paris July 12 13 2001 written by International Conference on Exogenous Factors Affecting Thrombosis and Haemostasis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.
Toxins And Hemostasis
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Author : R. Manjunatha Kini
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-10-19
Toxins And Hemostasis written by R. Manjunatha Kini and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-19 with Medical categories.
Circulation of blood is vital for the survival of vertebrates, including man. Mainly, it plays an important role in carrying food nutrients and oxygen to every tissue and organ and in removing all waste products and carbon dioxide. Any imbalance in the hemostatic and cardiovascular systems can lead to death and severe debility. A number of animals have developed mechanisms to target these systems and exploit the vulnerability. In some species (for example, snakes), such mechanisms are used to immobilize and kill the victim/prey, whereas in others (for example, insects, such as leaches, mosquitoes and ticks), they are used to provide a continuous supply of blood. These mechanisms include, but are not limited to, procoagulant and anticoagulant actions that affect the coagulation cascade and platelet aggregation, as well as altering vasodilatory responses. In all these various animals, these mechanisms have evolved to perfection over millions of years to support their survival. In last 3-4 decades, due to the efforts of scientists from various backgrounds including biology, protein chemistry, molecular biology, pharmacology, hematology, and structural biology, significant progress in understanding the structure-function relationships, as well as the mechanism of action have been made in a number of exogenous factors that affect blood coagulation, platelet aggregation and vasodilation from various animals. These exogenous factors have contributed significantly to the development of research tools as well as providing new therapeutic agents. With the increase average age of the population coupled with changes in life style in recent years, there has been a significant increase in cardiovascular and hematological disorders. Thus scientists in both academic institutions as well as the pharmaceutical industry are developing better therapeutic agents to improve the quality of life. This impetus has lead to the search for novel agents from various sources that interfere with cardiovascular and hematalogical processes. Although at first glance exogenous factors appear to function as ‘villains’, several life-saving drugs have been developed based upon these factors. Such drugs or drug leads include those that inhibit the angiotensin converting enzymes (Captopril and Enalapril), that block platelet receptors (Eptifibatide and Tirofiban), or that digest thrombotic plugs (Alfimeprase and bat plasminogen activator) to name a few. Several new and exciting success stories are currently unfolding. In this book, recent studies on some of the exogenous factors that play crucial roles in cardiovascular and hematological disorders are reviewed in order to consolidate the efforts in this area of research and to recruit new, talented researchers. The 25-30 review chapters, each written by experts in their field, compiled herein are devoted to exogenous factors affecting platelet aggregation, anticoagulant and procoagulant proteins, fibrinolytic proteins and hypotensive agents (For details see, Contents of the Book). This book is intended to help to create elevated awareness and enthusiasm in the field of exogenous factors. I believe that this book will provide greater impetus to the search for novel proteins based on naturally occurring exogenous factors. This will be the first book dealing extensively with exogenous factors in the last 25 years. The book will provide a ready reference to the different approaches used to solve complex problems in protein chemistry and pharmacology of exogenous factors. The book will update our understanding of the structure-function relationships and mechanisms of action of exogenous factors and provide great insights into future directions for solving the remaining challenges.
5th International Conference On Exogenous Factors Affecting Thrombosis And Hemostatis Efath 2013 5 6 July 2013 Amsterdam
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Author :
language : en
Publisher:
Release Date : 2014
5th International Conference On Exogenous Factors Affecting Thrombosis And Hemostatis Efath 2013 5 6 July 2013 Amsterdam written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Cancer Associated Thrombosis
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Author : Alok A. Khorana
language : en
Publisher: CRC Press
Release Date : 2007-09-26
Cancer Associated Thrombosis written by Alok A. Khorana and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-26 with Medical categories.
Showcasing the expertise of top-tier specialists who contributed to the newly released guidelines for the care of thrombosis in cancer patients, this exciting guide was written and edited by members of the American Society of Clinical Oncology panel, (ASCO), on the prevention and treatment of cancer-associated thrombosis, among others, and provides
Mechanisms Of Vascular Disease
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Author : Robert Fitridge
language : en
Publisher: University of Adelaide Press
Release Date : 2011
Mechanisms Of Vascular Disease written by Robert Fitridge and has been published by University of Adelaide Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Quality In Laboratory Hemostasis And Thrombosis
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Author : Steve Kitchen
language : en
Publisher: John Wiley & Sons
Release Date : 2011-08-24
Quality In Laboratory Hemostasis And Thrombosis written by Steve Kitchen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-24 with Medical categories.
"Over the last decades, major progress has been made in quality assurance of hemostatic laboratory assays. This book will be an indispensable part of every hemostasis laboratory, where, given its hands-on nature, it will rarely sit to get dusty on the shelves." —Frits R. Rosendaal, Leiden University Medical Center The hemostasis laboratory has a vital role in the diagnosis and management of patients with familial and acquired hemorrhagic and thrombotic disorders. Its role in the monitoring traditional anticoagulant therapy as well as therapy using new anticoagulants presents new challenges to the laboratory. Quality in Laboratory Hemostasis and Thrombosis not only addresses these important issues, but also covers international guidelines for testing, the development of international standard materials, management of hemostasis testing from the laboratory to the point of care as well as molecular genetic testing. Designed as a guide for all those working in hemostasis laboratories, this book details a quality program that, when put into place, will help to improve standards in testing. All of the authors are internationally recognised for their work in hemostasis and thrombosis. Using their experience, they provide information on standards, equipment and methods that will guide the development of a quality program to support all activities in the hemostasis laboratory.